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Female Reproductive System Smooth Muscle Tumor of Uncertain Malignant Potential

MedGen UID:
1793823
•Concept ID:
C5557382
•
Neoplastic Process
Synonyms: Female Reproductive System Smooth Muscle Neoplasm of Uncertain Malignant Potential; Female Reproductive System STUMP

Definition

A smooth muscle neoplasm that arises from any part of the female reproductive system and cannot be reliably diagnosed as benign or malignant because of the presence of ambiguous morphologic findings. [from NCI]

Professional guidelines

PubMed

A Review of Current Management of Placental Site Trophoblastic Tumor and Epithelioid Trophoblastic Tumor.
Burkett WC, Soper JT
Obstet Gynecol Surv 2022 Feb;77(2):101-110. doi: 10.1097/OGX.0000000000000978. PMID: 35201361
The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium.
Rubisz P, Ciebiera M, Hirnle L, Zgliczyńska M, Łoziński T, Dzięgiel P, Kobierzycki C
Int J Mol Sci 2019 Mar 6;20(5) doi: 10.3390/ijms20051136. PMID: 30845657Free PMC Article
Criteria for malignancy in nonvisceral smooth muscle tumors.
Hornick JL, Fletcher CD
Ann Diagn Pathol 2003 Feb;7(1):60-6. doi: 10.1053/adpa.2003.50010. PMID: 12616476

Recent clinical studies

Etiology

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.
Richtarova A, Boudova B, Dundr P, Lisa Z, Hlinecka K, Zizka Z, Fruhauf F, Kuzel D, Slama J, Mara M
Int J Gynecol Cancer 2023 May 1;33(5):701-706. doi: 10.1136/ijgc-2022-004038. PMID: 36898699Free PMC Article
Dedifferentiated leiomyosarcoma of the uterus: a clinicopathologic and immunohistochemical analysis of 23 cases.
Chapel DB, Maccio L, Bragantini E, Zannoni GF, Quade BJ, Parra-Herran C, Nucci MR
Histopathology 2023 May;82(6):812-825. Epub 2023 Feb 8 doi: 10.1111/his.14870. PMID: 36704944
Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.
Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
Mass lesions of the myometrium: interpretation and management of unexpected pathology.
Porter AE, Kho KA, Gwin K
Curr Opin Obstet Gynecol 2019 Oct;31(5):349-355. doi: 10.1097/GCO.0000000000000569. PMID: 31425175
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439

Diagnosis

Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP): A Comprehensive Multidisciplinary Update.
Tinelli A, D'Oria O, Civino E, Morciano A, Hashmi AA, Baldini GM, Stefanovic R, Malvasi A, Pecorella G
Medicina (Kaunas) 2023 Jul 27;59(8) doi: 10.3390/medicina59081371. PMID: 37629661Free PMC Article
Single-cell sequencing reveals novel cellular heterogeneity in uterine leiomyomas.
Goad J, Rudolph J, Zandigohar M, Tae M, Dai Y, Wei JJ, Bulun SE, Chakravarti D, Rajkovic A
Hum Reprod 2022 Sep 30;37(10):2334-2349. doi: 10.1093/humrep/deac183. PMID: 36001050Free PMC Article
Ultrasound Features of Uterine Sarcomas.
Oh J, Park SB, Park HJ, Lee ES
Ultrasound Q 2019 Dec;35(4):376-384. doi: 10.1097/RUQ.0000000000000454. PMID: 31094892
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439
Review of the pathophysiology, diagnosis, and therapy of vulvar leiomyoma, a rare gynecological tumor.
Sun C, Zou J, Wang Q, Wang Q, Han L, Batchu N, Ulain Q, Du J, Lv S, Song Q, Li Q
J Int Med Res 2018 Feb;46(2):663-674. Epub 2017 Sep 6 doi: 10.1177/0300060517721796. PMID: 28875758Free PMC Article

Therapy

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.
Richtarova A, Boudova B, Dundr P, Lisa Z, Hlinecka K, Zizka Z, Fruhauf F, Kuzel D, Slama J, Mara M
Int J Gynecol Cancer 2023 May 1;33(5):701-706. doi: 10.1136/ijgc-2022-004038. PMID: 36898699Free PMC Article
Persistent activation of signal transducer and activator of transcription 3 via interleukin-6 trans-signaling is involved in fibrosis of endometriosis.
Matsuzaki S, Pouly JL, Canis M
Hum Reprod 2022 Jun 30;37(7):1489-1504. doi: 10.1093/humrep/deac098. PMID: 35551394
Wnt/β-catenin signaling pathway in uterine leiomyoma: role in tumor biology and targeting opportunities.
El Sabeh M, Saha SK, Afrin S, Islam MS, Borahay MA
Mol Cell Biochem 2021 Sep;476(9):3513-3536. Epub 2021 May 17 doi: 10.1007/s11010-021-04174-6. PMID: 33999334Free PMC Article
Non-random adenomatoid tumours of the female genital system: A comparative clinicopathologic analysis of 14 cases.
Ersan Erdem B, Yaprak Bayrak B, Vural C, Muezzinoglu B
Ann Diagn Pathol 2020 Aug;47:151553. Epub 2020 Jun 17 doi: 10.1016/j.anndiagpath.2020.151553. PMID: 32580034
Hormonal manipulation of benign metastasizing leiomyomas: report of two cases and review of the literature.
Rivera JA, Christopoulos S, Small D, Trifiro M
J Clin Endocrinol Metab 2004 Jul;89(7):3183-8. doi: 10.1210/jc.2003-032021. PMID: 15240591

Prognosis

Uterine smooth muscle tumor of uncertain malignant potential: A review of current knowledge.
Liu HT, Wong CN, Wong CN, Liu FS
Taiwan J Obstet Gynecol 2022 Nov;61(6):935-940. doi: 10.1016/j.tjog.2022.08.003. PMID: 36427995
Telomere shortening and expression of TRF1 and TRF2 in uterine leiomyoma.
Oh BK, Choi Y, Choi JS
Mol Med Rep 2021 Aug;24(2) Epub 2021 Jun 29 doi: 10.3892/mmr.2021.12243. PMID: 34184077
Gynecological Sarcomas: Molecular Characteristics, Behavior, and Histology-Driven Therapy.
Libertini M, Hallin M, Thway K, Noujaim J, Benson C, van der Graaf W, Jones RL
Int J Surg Pathol 2021 Feb;29(1):4-20. Epub 2020 Sep 10 doi: 10.1177/1066896920958120. PMID: 32909482
The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium.
Rubisz P, Ciebiera M, Hirnle L, Zgliczyńska M, Łoziński T, Dzięgiel P, Kobierzycki C
Int J Mol Sci 2019 Mar 6;20(5) doi: 10.3390/ijms20051136. PMID: 30845657Free PMC Article
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439

Clinical prediction guides

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.
Richtarova A, Boudova B, Dundr P, Lisa Z, Hlinecka K, Zizka Z, Fruhauf F, Kuzel D, Slama J, Mara M
Int J Gynecol Cancer 2023 May 1;33(5):701-706. doi: 10.1136/ijgc-2022-004038. PMID: 36898699Free PMC Article
A Review of Current Management of Placental Site Trophoblastic Tumor and Epithelioid Trophoblastic Tumor.
Burkett WC, Soper JT
Obstet Gynecol Surv 2022 Feb;77(2):101-110. doi: 10.1097/OGX.0000000000000978. PMID: 35201361
Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.
Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
Gynecological Sarcomas: Molecular Characteristics, Behavior, and Histology-Driven Therapy.
Libertini M, Hallin M, Thway K, Noujaim J, Benson C, van der Graaf W, Jones RL
Int J Surg Pathol 2021 Feb;29(1):4-20. Epub 2020 Sep 10 doi: 10.1177/1066896920958120. PMID: 32909482
The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium.
Rubisz P, Ciebiera M, Hirnle L, Zgliczyńska M, Łoziński T, Dzięgiel P, Kobierzycki C
Int J Mol Sci 2019 Mar 6;20(5) doi: 10.3390/ijms20051136. PMID: 30845657Free PMC Article

Recent systematic reviews

The Uterine Plexiform Lesions Revisited.
Karpathiou G, Papoudou-Bai A, Clemenson A, Chauleur C, Peoc'h M
Am J Clin Pathol 2020 Jul 7;154(2):178-189. doi: 10.1093/ajcp/aqaa054. PMID: 32459343

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