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Female Reproductive System Smooth Muscle Tumor of Uncertain Malignant Potential

MedGen UID:
1793823
•Concept ID:
C5557382
•
Neoplastic Process
Synonym: Female Reproductive System Smooth Muscle Neoplasm of Uncertain Malignant Potential

Definition

A smooth muscle neoplasm that arises from any part of the female reproductive system and cannot be reliably diagnosed as benign or malignant, because of the presence of ambiguous morphologic findings. [from NCI]

Professional guidelines

PubMed

A Review of Current Management of Placental Site Trophoblastic Tumor and Epithelioid Trophoblastic Tumor.
Burkett WC, Soper JT
Obstet Gynecol Surv 2022 Feb;77(2):101-110. doi: 10.1097/OGX.0000000000000978. PMID: 35201361
Epithelioid Leiomyosarcoma of the Uterus: Modern Outcome-based Appraisal of Diagnostic Criteria in a Large Institutional Series.
Chapel DB, Nucci MR, Quade BJ, Parra-Herran C
Am J Surg Pathol 2022 Apr 1;46(4):464-475. doi: 10.1097/PAS.0000000000001795. PMID: 34419987
The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium.
Rubisz P, Ciebiera M, Hirnle L, Zgliczyńska M, Łoziński T, Dzięgiel P, Kobierzycki C
Int J Mol Sci 2019 Mar 6;20(5) doi: 10.3390/ijms20051136. PMID: 30845657Free PMC Article

Recent clinical studies

Etiology

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.
Richtarova A, Boudova B, Dundr P, Lisa Z, Hlinecka K, Zizka Z, Fruhauf F, Kuzel D, Slama J, Mara M
Int J Gynecol Cancer 2023 May 1;33(5):701-706. doi: 10.1136/ijgc-2022-004038. PMID: 36898699Free PMC Article
Dedifferentiated leiomyosarcoma of the uterus: a clinicopathologic and immunohistochemical analysis of 23 cases.
Chapel DB, Maccio L, Bragantini E, Zannoni GF, Quade BJ, Parra-Herran C, Nucci MR
Histopathology 2023 May;82(6):812-825. Epub 2023 Feb 8 doi: 10.1111/his.14870. PMID: 36704944
A Review of Current Management of Placental Site Trophoblastic Tumor and Epithelioid Trophoblastic Tumor.
Burkett WC, Soper JT
Obstet Gynecol Surv 2022 Feb;77(2):101-110. doi: 10.1097/OGX.0000000000000978. PMID: 35201361
Mass lesions of the myometrium: interpretation and management of unexpected pathology.
Porter AE, Kho KA, Gwin K
Curr Opin Obstet Gynecol 2019 Oct;31(5):349-355. doi: 10.1097/GCO.0000000000000569. PMID: 31425175
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439

Diagnosis

Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP): A Comprehensive Multidisciplinary Update.
Tinelli A, D'Oria O, Civino E, Morciano A, Hashmi AA, Baldini GM, Stefanovic R, Malvasi A, Pecorella G
Medicina (Kaunas) 2023 Jul 27;59(8) doi: 10.3390/medicina59081371. PMID: 37629661Free PMC Article
Uterine smooth muscle tumor of uncertain malignant potential: A review of current knowledge.
Liu HT, Wong CN, Wong CN, Liu FS
Taiwan J Obstet Gynecol 2022 Nov;61(6):935-940. doi: 10.1016/j.tjog.2022.08.003. PMID: 36427995
Single-cell sequencing reveals novel cellular heterogeneity in uterine leiomyomas.
Goad J, Rudolph J, Zandigohar M, Tae M, Dai Y, Wei JJ, Bulun SE, Chakravarti D, Rajkovic A
Hum Reprod 2022 Sep 30;37(10):2334-2349. doi: 10.1093/humrep/deac183. PMID: 36001050Free PMC Article
Ultrasound Features of Uterine Sarcomas.
Oh J, Park SB, Park HJ, Lee ES
Ultrasound Q 2019 Dec;35(4):376-384. doi: 10.1097/RUQ.0000000000000454. PMID: 31094892
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439

Therapy

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.
Richtarova A, Boudova B, Dundr P, Lisa Z, Hlinecka K, Zizka Z, Fruhauf F, Kuzel D, Slama J, Mara M
Int J Gynecol Cancer 2023 May 1;33(5):701-706. doi: 10.1136/ijgc-2022-004038. PMID: 36898699Free PMC Article
Persistent activation of signal transducer and activator of transcription 3 via interleukin-6 trans-signaling is involved in fibrosis of endometriosis.
Matsuzaki S, Pouly JL, Canis M
Hum Reprod 2022 Jun 30;37(7):1489-1504. doi: 10.1093/humrep/deac098. PMID: 35551394
Wnt/β-catenin signaling pathway in uterine leiomyoma: role in tumor biology and targeting opportunities.
El Sabeh M, Saha SK, Afrin S, Islam MS, Borahay MA
Mol Cell Biochem 2021 Sep;476(9):3513-3536. Epub 2021 May 17 doi: 10.1007/s11010-021-04174-6. PMID: 33999334Free PMC Article
Non-random adenomatoid tumours of the female genital system: A comparative clinicopathologic analysis of 14 cases.
Ersan Erdem B, Yaprak Bayrak B, Vural C, Muezzinoglu B
Ann Diagn Pathol 2020 Aug;47:151553. Epub 2020 Jun 17 doi: 10.1016/j.anndiagpath.2020.151553. PMID: 32580034
Hormonal manipulation of benign metastasizing leiomyomas: report of two cases and review of the literature.
Rivera JA, Christopoulos S, Small D, Trifiro M
J Clin Endocrinol Metab 2004 Jul;89(7):3183-8. doi: 10.1210/jc.2003-032021. PMID: 15240591

Prognosis

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.
Richtarova A, Boudova B, Dundr P, Lisa Z, Hlinecka K, Zizka Z, Fruhauf F, Kuzel D, Slama J, Mara M
Int J Gynecol Cancer 2023 May 1;33(5):701-706. doi: 10.1136/ijgc-2022-004038. PMID: 36898699Free PMC Article
Dedifferentiated leiomyosarcoma of the uterus: a clinicopathologic and immunohistochemical analysis of 23 cases.
Chapel DB, Maccio L, Bragantini E, Zannoni GF, Quade BJ, Parra-Herran C, Nucci MR
Histopathology 2023 May;82(6):812-825. Epub 2023 Feb 8 doi: 10.1111/his.14870. PMID: 36704944
Uterine smooth muscle tumor of uncertain malignant potential: A review of current knowledge.
Liu HT, Wong CN, Wong CN, Liu FS
Taiwan J Obstet Gynecol 2022 Nov;61(6):935-940. doi: 10.1016/j.tjog.2022.08.003. PMID: 36427995
The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium.
Rubisz P, Ciebiera M, Hirnle L, Zgliczyńska M, Łoziński T, Dzięgiel P, Kobierzycki C
Int J Mol Sci 2019 Mar 6;20(5) doi: 10.3390/ijms20051136. PMID: 30845657Free PMC Article
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439

Clinical prediction guides

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.
Richtarova A, Boudova B, Dundr P, Lisa Z, Hlinecka K, Zizka Z, Fruhauf F, Kuzel D, Slama J, Mara M
Int J Gynecol Cancer 2023 May 1;33(5):701-706. doi: 10.1136/ijgc-2022-004038. PMID: 36898699Free PMC Article
Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.
Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
Gynecological Sarcomas: Molecular Characteristics, Behavior, and Histology-Driven Therapy.
Libertini M, Hallin M, Thway K, Noujaim J, Benson C, van der Graaf W, Jones RL
Int J Surg Pathol 2021 Feb;29(1):4-20. Epub 2020 Sep 10 doi: 10.1177/1066896920958120. PMID: 32909482
The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium.
Rubisz P, Ciebiera M, Hirnle L, Zgliczyńska M, Łoziński T, Dzięgiel P, Kobierzycki C
Int J Mol Sci 2019 Mar 6;20(5) doi: 10.3390/ijms20051136. PMID: 30845657Free PMC Article
Therapeutic effect of human umbilical cord-derived mesenchymal stem cells on injured rat endometrium during its chronic phase.
Zhang L, Li Y, Guan CY, Tian S, Lv XD, Li JH, Ma X, Xia HF
Stem Cell Res Ther 2018 Feb 13;9(1):36. doi: 10.1186/s13287-018-0777-5. PMID: 29433563Free PMC Article

Recent systematic reviews

The Uterine Plexiform Lesions Revisited.
Karpathiou G, Papoudou-Bai A, Clemenson A, Chauleur C, Peoc'h M
Am J Clin Pathol 2020 Jul 7;154(2):178-189. doi: 10.1093/ajcp/aqaa054. PMID: 32459343

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