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HER2-Low Breast Carcinoma

MedGen UID:
1792206
•Concept ID:
C5555765
•
Neoplastic Process
Synonyms: HER2 Low Breast Adenocarcinoma; HER2 Low Breast Carcinoma; HER2-Low Breast Adenocarcinoma

Definition

Breast adenocarcinoma defined by low expression of HER2 (IHC1+ or IHC2+; FISH negative). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHER2-Low Breast Carcinoma

Professional guidelines

PubMed

ESMO expert consensus statements (ECS) on the definition, diagnosis, and management of HER2-low breast cancer.
Tarantino P, Viale G, Press MF, Hu X, Penault-Llorca F, Bardia A, Batistatou A, Burstein HJ, Carey LA, Cortes J, Denkert C, Diéras V, Jacot W, Koutras AK, Lebeau A, Loibl S, Modi S, Mosele MF, Provenzano E, Pruneri G, Reis-Filho JS, Rojo F, Salgado R, Schmid P, Schnitt SJ, Tolaney SM, Trapani D, Vincent-Salomon A, Wolff AC, Pentheroudakis G, André F, Curigliano G
Ann Oncol 2023 Aug;34(8):645-659. Epub 2023 Jun 1 doi: 10.1016/j.annonc.2023.05.008. PMID: 37269905
Biology and Treatment of HER2-Low Breast Cancer.
Nicolò E, Tarantino P, Curigliano G
Hematol Oncol Clin North Am 2023 Feb;37(1):117-132. doi: 10.1016/j.hoc.2022.08.013. PMID: 36435605
Optimizing treatment management of trastuzumab deruxtecan in clinical practice of breast cancer.
Rugo HS, Bianchini G, Cortes J, Henning JW, Untch M
ESMO Open 2022 Aug;7(4):100553. Epub 2022 Aug 11 doi: 10.1016/j.esmoop.2022.100553. PMID: 35964548Free PMC Article

Recent clinical studies

Diagnosis

Concordance between pathologists and between specimen types in detection of HER2-low breast carcinoma by immunohistochemistry.
Wang J, Yoon E, Krishnamurthy S
Ann Diagn Pathol 2024 Jun;70:152288. Epub 2024 Mar 2 doi: 10.1016/j.anndiagpath.2024.152288. PMID: 38452457

Clinical prediction guides

Concordance between pathologists and between specimen types in detection of HER2-low breast carcinoma by immunohistochemistry.
Wang J, Yoon E, Krishnamurthy S
Ann Diagn Pathol 2024 Jun;70:152288. Epub 2024 Mar 2 doi: 10.1016/j.anndiagpath.2024.152288. PMID: 38452457
Digital image analysis and assisted reading of the HER2 score display reduced concordance: pitfalls in the categorisation of HER2-low breast cancer.
Sode M, Thagaard J, Eriksen JO, Laenkholm AV
Histopathology 2023 May;82(6):912-924. Epub 2023 Mar 1 doi: 10.1111/his.14877. PMID: 36737248

Supplemental Content

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