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Advanced Microsatellite Stable Ovarian Carcinoma

MedGen UID:
1792733
•Concept ID:
C5556292
•
Neoplastic Process

Definition

Microsatellite stable ovarian carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Microsatellite Stable Ovarian Carcinoma

Recent clinical studies

Etiology

Phase 1/2 study of monalizumab plus durvalumab in patients with advanced solid tumors.
Patel SP, Alonso-Gordoa T, Banerjee S, Wang D, Naidoo J, Standifer NE, Palmer DC, Cheng LY, Kourtesis P, Ascierto ML, Das M, Diamond JR, Hellmann MD, Carneiro BA
J Immunother Cancer 2024 Feb 2;12(2) doi: 10.1136/jitc-2023-007340. PMID: 38309722Free PMC Article
Durable response to olaparib combined low-dose cisplatin in advanced hepatocellular carcinoma with FANCA mutation: A case report.
Lai YH, Tung KC, Chen SC
Medicine (Baltimore) 2022 Sep 30;101(39):e30719. doi: 10.1097/MD.0000000000030719. PMID: 36181052Free PMC Article
Evaluation of Micro Satellite Instability and Mismatch Repair Status in Different Solid Tumors: A Multicenter Analysis in a Real World Setting.
Malapelle U, Parente P, Pepe F, De Luca C, Pisapia P, Sgariglia R, Nacchio M, Gragnano G, Russo G, Conticelli F, Bellevicine C, Vigliar E, Iaccarino A, Covelli C, Balistreri M, Clemente C, Perrone G, Danza A, Scaramuzzi F, Fassan M, Troncone G, Graziano P
Cells 2021 Jul 24;10(8) doi: 10.3390/cells10081878. PMID: 34440647Free PMC Article
Genomic aberrations in borderline ovarian tumors.
Micci F, Haugom L, Ahlquist T, Andersen HK, Abeler VM, Davidson B, Trope CG, Lothe RA, Heim S
J Transl Med 2010 Feb 26;8:21. doi: 10.1186/1479-5876-8-21. PMID: 20184781Free PMC Article
Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes.
Chan TL, Curtis LC, Leung SY, Farrington SM, Ho JW, Chan AS, Lam PW, Tse CW, Dunlop MG, Wyllie AH, Yuen ST
Oncogene 2001 Aug 9;20(35):4871-6. doi: 10.1038/sj.onc.1204653. PMID: 11521198

Diagnosis

Durable response to olaparib combined low-dose cisplatin in advanced hepatocellular carcinoma with FANCA mutation: A case report.
Lai YH, Tung KC, Chen SC
Medicine (Baltimore) 2022 Sep 30;101(39):e30719. doi: 10.1097/MD.0000000000030719. PMID: 36181052Free PMC Article
Evaluation of Micro Satellite Instability and Mismatch Repair Status in Different Solid Tumors: A Multicenter Analysis in a Real World Setting.
Malapelle U, Parente P, Pepe F, De Luca C, Pisapia P, Sgariglia R, Nacchio M, Gragnano G, Russo G, Conticelli F, Bellevicine C, Vigliar E, Iaccarino A, Covelli C, Balistreri M, Clemente C, Perrone G, Danza A, Scaramuzzi F, Fassan M, Troncone G, Graziano P
Cells 2021 Jul 24;10(8) doi: 10.3390/cells10081878. PMID: 34440647Free PMC Article
Recurrent urothelial carcinoma-like FGFR3 genomic alterations in malignant Brenner tumors of the ovary.
Lin DI, Killian JK, Venstrom JM, Ramkissoon SH, Ross JS, Elvin JA
Mod Pathol 2021 May;34(5):983-993. Epub 2020 Oct 19 doi: 10.1038/s41379-020-00699-1. PMID: 33077920
Microsatellite instability and ploidy status define three categories with distinctive prognostic impact in endometrioid endometrial cancer.
Bilbao-Sieyro C, Ramírez R, Rodríguez-González G, Falcón O, León L, Torres S, Fernández L, Alonso S, Díaz-Chico N, Perucho M, Díaz-Chico JC
Oncotarget 2014 Aug 15;5(15):6206-17. doi: 10.18632/oncotarget.2187. PMID: 25026289Free PMC Article
Absence of MGMT promoter methylation in endometrial cancer.
Rimel BJ, Huettner P, Powell MA, Mutch DG, Goodfellow PJ
Gynecol Oncol 2009 Jan;112(1):224-8. Epub 2008 Oct 29 doi: 10.1016/j.ygyno.2008.08.038. PMID: 18973931Free PMC Article

Therapy

Phase 1/2 study of monalizumab plus durvalumab in patients with advanced solid tumors.
Patel SP, Alonso-Gordoa T, Banerjee S, Wang D, Naidoo J, Standifer NE, Palmer DC, Cheng LY, Kourtesis P, Ascierto ML, Das M, Diamond JR, Hellmann MD, Carneiro BA
J Immunother Cancer 2024 Feb 2;12(2) doi: 10.1136/jitc-2023-007340. PMID: 38309722Free PMC Article
Durable response to olaparib combined low-dose cisplatin in advanced hepatocellular carcinoma with FANCA mutation: A case report.
Lai YH, Tung KC, Chen SC
Medicine (Baltimore) 2022 Sep 30;101(39):e30719. doi: 10.1097/MD.0000000000030719. PMID: 36181052Free PMC Article
Phase IB study of ziv-aflibercept plus pembrolizumab in patients with advanced solid tumors.
Rahma OE, Tyan K, Giobbie-Hurder A, Brohl AS, Bedard PL, Renouf DJ, Sharon E, Streicher H, Hathaway E, Cunningham R, Manos M, Severgnini M, Rodig S, Stephen Hodi F
J Immunother Cancer 2022 Mar;10(3) doi: 10.1136/jitc-2021-003569. PMID: 35264434Free PMC Article
Optimizing immunotherapy for gynecologic cancers.
Rubinstein MM, Makker V
Curr Opin Obstet Gynecol 2020 Feb;32(1):1-8. doi: 10.1097/GCO.0000000000000603. PMID: 31833942Free PMC Article
Comprehensive genomic sequencing of paired ovarian cancers reveals discordance in genes that determine clinical trial eligibility.
Fehniger JE, Berger AA, Juckett L, Elvin J, Levine DA, Zajchowski DA
Gynecol Oncol 2019 Dec;155(3):473-482. Epub 2019 Nov 6 doi: 10.1016/j.ygyno.2019.10.004. PMID: 31703812

Prognosis

Evaluation of Micro Satellite Instability and Mismatch Repair Status in Different Solid Tumors: A Multicenter Analysis in a Real World Setting.
Malapelle U, Parente P, Pepe F, De Luca C, Pisapia P, Sgariglia R, Nacchio M, Gragnano G, Russo G, Conticelli F, Bellevicine C, Vigliar E, Iaccarino A, Covelli C, Balistreri M, Clemente C, Perrone G, Danza A, Scaramuzzi F, Fassan M, Troncone G, Graziano P
Cells 2021 Jul 24;10(8) doi: 10.3390/cells10081878. PMID: 34440647Free PMC Article
Mutational spectrum in clinically aggressive low-grade serous carcinoma/serous borderline tumors of the ovary-Clinical significance of BRCA2 gene variants in genomically stable tumors.
Zhang X, Devins K, Ko EM, Reyes MC, Simpkins F, Drapkin R, Schwartz LE, Yoon JY
Gynecol Oncol 2021 Jun;161(3):762-768. Epub 2021 Mar 24 doi: 10.1016/j.ygyno.2021.03.019. PMID: 33773808
Recurrent urothelial carcinoma-like FGFR3 genomic alterations in malignant Brenner tumors of the ovary.
Lin DI, Killian JK, Venstrom JM, Ramkissoon SH, Ross JS, Elvin JA
Mod Pathol 2021 May;34(5):983-993. Epub 2020 Oct 19 doi: 10.1038/s41379-020-00699-1. PMID: 33077920
Absence of MGMT promoter methylation in endometrial cancer.
Rimel BJ, Huettner P, Powell MA, Mutch DG, Goodfellow PJ
Gynecol Oncol 2009 Jan;112(1):224-8. Epub 2008 Oct 29 doi: 10.1016/j.ygyno.2008.08.038. PMID: 18973931Free PMC Article
Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes.
Chan TL, Curtis LC, Leung SY, Farrington SM, Ho JW, Chan AS, Lam PW, Tse CW, Dunlop MG, Wyllie AH, Yuen ST
Oncogene 2001 Aug 9;20(35):4871-6. doi: 10.1038/sj.onc.1204653. PMID: 11521198

Clinical prediction guides

Phase 1/2 study of monalizumab plus durvalumab in patients with advanced solid tumors.
Patel SP, Alonso-Gordoa T, Banerjee S, Wang D, Naidoo J, Standifer NE, Palmer DC, Cheng LY, Kourtesis P, Ascierto ML, Das M, Diamond JR, Hellmann MD, Carneiro BA
J Immunother Cancer 2024 Feb 2;12(2) doi: 10.1136/jitc-2023-007340. PMID: 38309722Free PMC Article
Evaluation of Micro Satellite Instability and Mismatch Repair Status in Different Solid Tumors: A Multicenter Analysis in a Real World Setting.
Malapelle U, Parente P, Pepe F, De Luca C, Pisapia P, Sgariglia R, Nacchio M, Gragnano G, Russo G, Conticelli F, Bellevicine C, Vigliar E, Iaccarino A, Covelli C, Balistreri M, Clemente C, Perrone G, Danza A, Scaramuzzi F, Fassan M, Troncone G, Graziano P
Cells 2021 Jul 24;10(8) doi: 10.3390/cells10081878. PMID: 34440647Free PMC Article
Comprehensive genomic sequencing of paired ovarian cancers reveals discordance in genes that determine clinical trial eligibility.
Fehniger JE, Berger AA, Juckett L, Elvin J, Levine DA, Zajchowski DA
Gynecol Oncol 2019 Dec;155(3):473-482. Epub 2019 Nov 6 doi: 10.1016/j.ygyno.2019.10.004. PMID: 31703812
Different types of microsatellite instability in ovarian carcinoma.
Singer G, Kallinowski T, Hartmann A, Dietmaier W, Wild PJ, Schraml P, Sauter G, Mihatsch MJ, Moch H
Int J Cancer 2004 Nov 20;112(4):643-6. doi: 10.1002/ijc.20455. PMID: 15382045
Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes.
Chan TL, Curtis LC, Leung SY, Farrington SM, Ho JW, Chan AS, Lam PW, Tse CW, Dunlop MG, Wyllie AH, Yuen ST
Oncogene 2001 Aug 9;20(35):4871-6. doi: 10.1038/sj.onc.1204653. PMID: 11521198

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