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Refractory Thyroid Gland Medullary Carcinoma

MedGen UID:
1792783
•Concept ID:
C5556342
•
Neoplastic Process

Definition

Thyroid gland medullary carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Thyroid Gland Medullary Carcinoma

Professional guidelines

PubMed

Update on thyroid cancer treatment.
Regalbuto C, Frasca F, Pellegriti G, Malandrino P, Marturano I, Di Carlo I, Pezzino V
Future Oncol 2012 Oct;8(10):1331-48. doi: 10.2217/fon.12.123. PMID: 23130931
All-trans-retinoic acid treatment inhibits the growth of retinoic acid receptor beta messenger ribonucleic acid expressing thyroid cancer cell lines but does not reinduce the expression of thyroid-specific genes.
Elisei R, Vivaldi A, Agate L, Ciampi R, Molinaro E, Piampiani P, Romei C, Faviana P, Basolo F, Miccoli P, Capodanno A, Collecchi P, Pacini F, Pinchera A
J Clin Endocrinol Metab 2005 Apr;90(4):2403-11. Epub 2004 Dec 28 doi: 10.1210/jc.2004-0969. PMID: 15623821
Molecular elements of apoptosis-regulating pathways in follicular thyroid cells: mining for novel therapeutic targets in the treatment of thyroid carcinoma.
Sarlis NJ, Gourgiotis L
Curr Drug Targets Immune Endocr Metabol Disord 2004 Sep;4(3):187-98. doi: 10.2174/1568008043339866. PMID: 15379722

Recent clinical studies

Etiology

Peptide receptor radionuclide therapy in patients with medullary thyroid carcinoma: predictors and pitfalls.
Beukhof CM, Brabander T, van Nederveen FH, van Velthuysen MF, de Rijke YB, Hofland LJ, Franssen GJH, Fröberg LAC, Kam BLR, Visser WE, de Herder WW, Peeters RP
BMC Cancer 2019 Apr 5;19(1):325. doi: 10.1186/s12885-019-5540-5. PMID: 30953466Free PMC Article
Chronic refractory diarrhoea: a manifestation of endocrine disorders.
Alam MJ
Dig Dis 1994 Jan-Feb;12(1):46-61. doi: 10.1159/000171436. PMID: 8200124

Diagnosis

Molecular elements of apoptosis-regulating pathways in follicular thyroid cells: mining for novel therapeutic targets in the treatment of thyroid carcinoma.
Sarlis NJ, Gourgiotis L
Curr Drug Targets Immune Endocr Metabol Disord 2004 Sep;4(3):187-98. doi: 10.2174/1568008043339866. PMID: 15379722
Chronic refractory diarrhoea: a manifestation of endocrine disorders.
Alam MJ
Dig Dis 1994 Jan-Feb;12(1):46-61. doi: 10.1159/000171436. PMID: 8200124

Therapy

Molecular basis and targeted therapy in thyroid cancer: Progress and opportunities.
Zhang L, Feng Q, Wang J, Tan Z, Li Q, Ge M
Biochim Biophys Acta Rev Cancer 2023 Jul;1878(4):188928. Epub 2023 May 29 doi: 10.1016/j.bbcan.2023.188928. PMID: 37257629
Peptide receptor radionuclide therapy in patients with medullary thyroid carcinoma: predictors and pitfalls.
Beukhof CM, Brabander T, van Nederveen FH, van Velthuysen MF, de Rijke YB, Hofland LJ, Franssen GJH, Fröberg LAC, Kam BLR, Visser WE, de Herder WW, Peeters RP
BMC Cancer 2019 Apr 5;19(1):325. doi: 10.1186/s12885-019-5540-5. PMID: 30953466Free PMC Article
Early prediction of lenvatinib treatment efficacy by using (18)F-FDG PET/CT in patients with unresectable or advanced thyroid carcinoma that is refractory to radioiodine treatment: a protocol for a non-randomized single-arm multicenter observational study.
Takeuchi S, Shiga T, Hirata K, Taguchi J, Magota K, Ariga S, Gouda T, Ohhara Y, Homma R, Shimizu Y, Kinoshita I, Tsuji Y, Homma A, Iijima H, Tamaki N, Dosaka-Akita H
BMJ Open 2018 Aug 30;8(8):e021001. doi: 10.1136/bmjopen-2017-021001. PMID: 30166292Free PMC Article
Sorafenib in Japanese Patients with Locally Advanced or Metastatic Medullary Thyroid Carcinoma and Anaplastic Thyroid Carcinoma.
Ito Y, Onoda N, Ito KI, Sugitani I, Takahashi S, Yamaguchi I, Kabu K, Tsukada K
Thyroid 2017 Sep;27(9):1142-1148. Epub 2017 Jul 24 doi: 10.1089/thy.2016.0621. PMID: 28635560Free PMC Article
Update on thyroid cancer treatment.
Regalbuto C, Frasca F, Pellegriti G, Malandrino P, Marturano I, Di Carlo I, Pezzino V
Future Oncol 2012 Oct;8(10):1331-48. doi: 10.2217/fon.12.123. PMID: 23130931

Prognosis

Peptide receptor radionuclide therapy in patients with medullary thyroid carcinoma: predictors and pitfalls.
Beukhof CM, Brabander T, van Nederveen FH, van Velthuysen MF, de Rijke YB, Hofland LJ, Franssen GJH, Fröberg LAC, Kam BLR, Visser WE, de Herder WW, Peeters RP
BMC Cancer 2019 Apr 5;19(1):325. doi: 10.1186/s12885-019-5540-5. PMID: 30953466Free PMC Article
Early prediction of lenvatinib treatment efficacy by using (18)F-FDG PET/CT in patients with unresectable or advanced thyroid carcinoma that is refractory to radioiodine treatment: a protocol for a non-randomized single-arm multicenter observational study.
Takeuchi S, Shiga T, Hirata K, Taguchi J, Magota K, Ariga S, Gouda T, Ohhara Y, Homma R, Shimizu Y, Kinoshita I, Tsuji Y, Homma A, Iijima H, Tamaki N, Dosaka-Akita H
BMJ Open 2018 Aug 30;8(8):e021001. doi: 10.1136/bmjopen-2017-021001. PMID: 30166292Free PMC Article

Clinical prediction guides

Peptide receptor radionuclide therapy in patients with medullary thyroid carcinoma: predictors and pitfalls.
Beukhof CM, Brabander T, van Nederveen FH, van Velthuysen MF, de Rijke YB, Hofland LJ, Franssen GJH, Fröberg LAC, Kam BLR, Visser WE, de Herder WW, Peeters RP
BMC Cancer 2019 Apr 5;19(1):325. doi: 10.1186/s12885-019-5540-5. PMID: 30953466Free PMC Article
Early prediction of lenvatinib treatment efficacy by using (18)F-FDG PET/CT in patients with unresectable or advanced thyroid carcinoma that is refractory to radioiodine treatment: a protocol for a non-randomized single-arm multicenter observational study.
Takeuchi S, Shiga T, Hirata K, Taguchi J, Magota K, Ariga S, Gouda T, Ohhara Y, Homma R, Shimizu Y, Kinoshita I, Tsuji Y, Homma A, Iijima H, Tamaki N, Dosaka-Akita H
BMJ Open 2018 Aug 30;8(8):e021001. doi: 10.1136/bmjopen-2017-021001. PMID: 30166292Free PMC Article
All-trans-retinoic acid treatment inhibits the growth of retinoic acid receptor beta messenger ribonucleic acid expressing thyroid cancer cell lines but does not reinduce the expression of thyroid-specific genes.
Elisei R, Vivaldi A, Agate L, Ciampi R, Molinaro E, Piampiani P, Romei C, Faviana P, Basolo F, Miccoli P, Capodanno A, Collecchi P, Pacini F, Pinchera A
J Clin Endocrinol Metab 2005 Apr;90(4):2403-11. Epub 2004 Dec 28 doi: 10.1210/jc.2004-0969. PMID: 15623821

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