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Advanced Vaginal Adenosquamous Carcinoma

MedGen UID:
1793233
•Concept ID:
C5556792
•
Neoplastic Process

Definition

Vaginal adenosquamous carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Vaginal Adenosquamous Carcinoma

Professional guidelines

PubMed

Cervical cancer in women under 25 years of age and outside the screening age: Diagnosis profile and long-term outcomes.
Teixeira JC, Santos DZ, Campos CS, Vale DB, Bragança JF, Zeferino LC
Int J Gynaecol Obstet 2021 Jul;154(1):150-156. Epub 2021 Jan 27 doi: 10.1002/ijgo.13553. PMID: 33341962
Management and outcomes of primary vaginal Cancer.
Yang J, Delara R, Magrina J, Magtibay P, Langstraat C, Dinh T, Karlin N, Vora SA, Butler K
Gynecol Oncol 2020 Nov;159(2):456-463. Epub 2020 Sep 22 doi: 10.1016/j.ygyno.2020.08.036. PMID: 32972784
Combined external and intracavitary irradiation in treatment of advanced cervical carcinomas: predictive factors for treatment outcome and early and late radiation reactions.
Bohr Mordhorst L, Karlsson L, Bärmark B, Sorbe B
Int J Gynecol Cancer 2014 Sep;24(7):1268-75. doi: 10.1097/IGC.0000000000000208. PMID: 25078336

Recent clinical studies

Therapy

Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study.
Pötter R, Tanderup K, Schmid MP, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Ristl R, Petric P, Nesvacil N, Kirchheiner K, Kirisits C, Lindegaard JC; EMBRACE Collaborative Group
Lancet Oncol 2021 Apr;22(4):538-547. doi: 10.1016/S1470-2045(20)30753-1. PMID: 33794207
Management and outcomes of primary vaginal Cancer.
Yang J, Delara R, Magrina J, Magtibay P, Langstraat C, Dinh T, Karlin N, Vora SA, Butler K
Gynecol Oncol 2020 Nov;159(2):456-463. Epub 2020 Sep 22 doi: 10.1016/j.ygyno.2020.08.036. PMID: 32972784
Outcomes analysis of pre-brachytherapy MRI in patients with locally advanced cervical cancer.
Murofushi K, Yoshioka Y, Sumi M, Ishikawa H, Oguchi M, Sakurai H
Int J Gynecol Cancer 2020 Apr;30(4):473-479. Epub 2020 Mar 11 doi: 10.1136/ijgc-2019-000925. PMID: 32165406
External Beam Radiation Therapy and Brachytherapy for Cervical Cancer: The Experience of the National Centre for Radiotherapy in Accra, Ghana.
Vulpe H, Asamoah FA, Maganti M, Vanderpuye V, Fyles A, Yarney J
Int J Radiat Oncol Biol Phys 2018 Apr 1;100(5):1246-1253. Epub 2017 Dec 21 doi: 10.1016/j.ijrobp.2017.12.270. PMID: 29395628

Prognosis

Cervical cancer in women under 25 years of age and outside the screening age: Diagnosis profile and long-term outcomes.
Teixeira JC, Santos DZ, Campos CS, Vale DB, Bragança JF, Zeferino LC
Int J Gynaecol Obstet 2021 Jul;154(1):150-156. Epub 2021 Jan 27 doi: 10.1002/ijgo.13553. PMID: 33341962
Management and outcomes of primary vaginal Cancer.
Yang J, Delara R, Magrina J, Magtibay P, Langstraat C, Dinh T, Karlin N, Vora SA, Butler K
Gynecol Oncol 2020 Nov;159(2):456-463. Epub 2020 Sep 22 doi: 10.1016/j.ygyno.2020.08.036. PMID: 32972784
Combined external and intracavitary irradiation in treatment of advanced cervical carcinomas: predictive factors for treatment outcome and early and late radiation reactions.
Bohr Mordhorst L, Karlsson L, Bärmark B, Sorbe B
Int J Gynecol Cancer 2014 Sep;24(7):1268-75. doi: 10.1097/IGC.0000000000000208. PMID: 25078336
Impact of post-radiation biopsies on development of fistulae in patients with cervical cancer.
Feddock J, Randall M, Kudrimoti M, Baldwin L, Shah P, Weiss H, Desimone C
Gynecol Oncol 2014 May;133(2):263-7. Epub 2014 Feb 11 doi: 10.1016/j.ygyno.2014.02.005. PMID: 24525114
(Laterally) extended endopelvic resection: surgical treatment of locally advanced and recurrent cancer of the uterine cervix and vagina based on ontogenetic anatomy.
Höckel M, Horn LC, Einenkel J
Gynecol Oncol 2012 Nov;127(2):297-302. Epub 2012 Aug 1 doi: 10.1016/j.ygyno.2012.07.120. PMID: 22864112

Clinical prediction guides

Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study.
Pötter R, Tanderup K, Schmid MP, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Ristl R, Petric P, Nesvacil N, Kirchheiner K, Kirisits C, Lindegaard JC; EMBRACE Collaborative Group
Lancet Oncol 2021 Apr;22(4):538-547. doi: 10.1016/S1470-2045(20)30753-1. PMID: 33794207
Manifestation pattern of early-late vaginal morbidity after definitive radiation (chemo)therapy and image-guided adaptive brachytherapy for locally advanced cervical cancer: an analysis from the EMBRACE study.
Kirchheiner K, Nout RA, Tanderup K, Lindegaard JC, Westerveld H, Haie-Meder C, Petrič P, Mahantshetty U, Dörr W, Pötter R
Int J Radiat Oncol Biol Phys 2014 May 1;89(1):88-95. doi: 10.1016/j.ijrobp.2014.01.032. PMID: 24725693
Impact of post-radiation biopsies on development of fistulae in patients with cervical cancer.
Feddock J, Randall M, Kudrimoti M, Baldwin L, Shah P, Weiss H, Desimone C
Gynecol Oncol 2014 May;133(2):263-7. Epub 2014 Feb 11 doi: 10.1016/j.ygyno.2014.02.005. PMID: 24525114
(Laterally) extended endopelvic resection: surgical treatment of locally advanced and recurrent cancer of the uterine cervix and vagina based on ontogenetic anatomy.
Höckel M, Horn LC, Einenkel J
Gynecol Oncol 2012 Nov;127(2):297-302. Epub 2012 Aug 1 doi: 10.1016/j.ygyno.2012.07.120. PMID: 22864112

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