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Recurrent Primary Systemic Anaplastic Large Cell Lymphoma, ALK-Positive

MedGen UID:
1793249
•Concept ID:
C5556808
•
Neoplastic Process

Definition

The reemergence of primary systemic anaplastic large cell lymphoma, ALK-positive after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Primary Systemic Anaplastic Large Cell Lymphoma, ALK-Positive

Recent clinical studies

Etiology

Ceritinib in paediatric patients with anaplastic lymphoma kinase-positive malignancies: an open-label, multicentre, phase 1, dose-escalation and dose-expansion study.
Fischer M, Moreno L, Ziegler DS, Marshall LV, Zwaan CM, Irwin MS, Casanova M, Sabado C, Wulff B, Stegert M, Wang L, Hurtado FK, Branle F, Geoerger B, Schulte JH
Lancet Oncol 2021 Dec;22(12):1764-1776. Epub 2021 Nov 12 doi: 10.1016/S1470-2045(21)00536-2. PMID: 34780709
ALK-positive primary cutaneous anaplastic large cell lymphoma: a case report and review of the literature.
Geller S, Canavan TN, Pulitzer M, Moskowitz AJ, Myskowski PL
Int J Dermatol 2018 May;57(5):515-520. Epub 2017 Oct 23 doi: 10.1111/ijd.13804. PMID: 29057463Free PMC Article
Clinicopathologic features of primary lymphoma in soft tissue.
Yang J, Zhang F, Fang H, Ye Z, Lin S, Han A
Leuk Lymphoma 2010 Nov;51(11):2039-46. Epub 2010 Oct 7 doi: 10.3109/10428194.2010.520049. PMID: 20929318

Diagnosis

Primary Leptomeningeal Lymphoma: Clinicopathologic Features of 2 Rare Phenotypes.
Vizcaino MA, Giannini C, King RL, Johnson DR, Yang T, Raghunathan A
J Neuropathol Exp Neurol 2022 Nov 16;81(12):1002-1007. doi: 10.1093/jnen/nlac084. PMID: 36102830
Ceritinib in paediatric patients with anaplastic lymphoma kinase-positive malignancies: an open-label, multicentre, phase 1, dose-escalation and dose-expansion study.
Fischer M, Moreno L, Ziegler DS, Marshall LV, Zwaan CM, Irwin MS, Casanova M, Sabado C, Wulff B, Stegert M, Wang L, Hurtado FK, Branle F, Geoerger B, Schulte JH
Lancet Oncol 2021 Dec;22(12):1764-1776. Epub 2021 Nov 12 doi: 10.1016/S1470-2045(21)00536-2. PMID: 34780709
ALK-positive primary cutaneous anaplastic large cell lymphoma: a case report and review of the literature.
Geller S, Canavan TN, Pulitzer M, Moskowitz AJ, Myskowski PL
Int J Dermatol 2018 May;57(5):515-520. Epub 2017 Oct 23 doi: 10.1111/ijd.13804. PMID: 29057463Free PMC Article
Primary rare anaplastic large cell lymphoma, ALK positive in small intestine: case report and review of the literature.
Cao Q, Liu F, Li S, Liu N, Li L, Li C, Peng T
Diagn Pathol 2016 Sep 9;11(1):83. doi: 10.1186/s13000-016-0539-6. PMID: 27612448Free PMC Article
ALK-positive primary cutaneous T-cell-lymphoma (CTCL) with unusual clinical presentation and aggressive course.
Wehkamp U, Oschlies I, Nagel I, Brasch J, Kneba M, Günther A, Klapper W, Weichenthal M
J Cutan Pathol 2015 Nov;42(11):870-7. Epub 2015 Jun 25 doi: 10.1111/cup.12547. PMID: 26053561

Therapy

Efficacy and safety of crizotinib in ALK-positive systemic anaplastic large-cell lymphoma in children, adolescents, and adult patients: results of the French AcSé-crizotinib trial.
Brugières L, Cozic N, Houot R, Rigaud C, Sibon D, Arfi-Rouche J, Bories P, Cottereau AS, Delmer A, Ducassou S, Garnier N, Lamant L, Leruste A, Millot F, Moalla S, Morschhauser F, Nolla M, Pagnier A, Reguerre Y, Renaud L, Schmitt A, Simonin M, Verschuur A, Hoog Labouret N, Mahier Ait Oukhatar C, Vassal G
Eur J Cancer 2023 Sep;191:112984. Epub 2023 Jul 17 doi: 10.1016/j.ejca.2023.112984. PMID: 37549532
Primary Leptomeningeal Lymphoma: Clinicopathologic Features of 2 Rare Phenotypes.
Vizcaino MA, Giannini C, King RL, Johnson DR, Yang T, Raghunathan A
J Neuropathol Exp Neurol 2022 Nov 16;81(12):1002-1007. doi: 10.1093/jnen/nlac084. PMID: 36102830
Long-term remission of primary refractory ALK-positive anaplastic large cell lymphoma after allogeneic hematopoietic stem cell transplantation.
Miyazaki M, Ichikawa S, Onishi Y, Fukuhara N, Furukawa E, Onodera K, Yokoyama H, Ichinohasama R, Harigae H
J Clin Exp Hematop 2022 Sep 28;62(3):164-168. Epub 2022 Jun 22 doi: 10.3960/jslrt.22003. PMID: 35732409Free PMC Article
Ceritinib in paediatric patients with anaplastic lymphoma kinase-positive malignancies: an open-label, multicentre, phase 1, dose-escalation and dose-expansion study.
Fischer M, Moreno L, Ziegler DS, Marshall LV, Zwaan CM, Irwin MS, Casanova M, Sabado C, Wulff B, Stegert M, Wang L, Hurtado FK, Branle F, Geoerger B, Schulte JH
Lancet Oncol 2021 Dec;22(12):1764-1776. Epub 2021 Nov 12 doi: 10.1016/S1470-2045(21)00536-2. PMID: 34780709
Primary rare anaplastic large cell lymphoma, ALK positive in small intestine: case report and review of the literature.
Cao Q, Liu F, Li S, Liu N, Li L, Li C, Peng T
Diagn Pathol 2016 Sep 9;11(1):83. doi: 10.1186/s13000-016-0539-6. PMID: 27612448Free PMC Article

Prognosis

Long-term remission of primary refractory ALK-positive anaplastic large cell lymphoma after allogeneic hematopoietic stem cell transplantation.
Miyazaki M, Ichikawa S, Onishi Y, Fukuhara N, Furukawa E, Onodera K, Yokoyama H, Ichinohasama R, Harigae H
J Clin Exp Hematop 2022 Sep 28;62(3):164-168. Epub 2022 Jun 22 doi: 10.3960/jslrt.22003. PMID: 35732409Free PMC Article
Ceritinib in paediatric patients with anaplastic lymphoma kinase-positive malignancies: an open-label, multicentre, phase 1, dose-escalation and dose-expansion study.
Fischer M, Moreno L, Ziegler DS, Marshall LV, Zwaan CM, Irwin MS, Casanova M, Sabado C, Wulff B, Stegert M, Wang L, Hurtado FK, Branle F, Geoerger B, Schulte JH
Lancet Oncol 2021 Dec;22(12):1764-1776. Epub 2021 Nov 12 doi: 10.1016/S1470-2045(21)00536-2. PMID: 34780709
ALK-positive primary cutaneous anaplastic large cell lymphoma: a case report and review of the literature.
Geller S, Canavan TN, Pulitzer M, Moskowitz AJ, Myskowski PL
Int J Dermatol 2018 May;57(5):515-520. Epub 2017 Oct 23 doi: 10.1111/ijd.13804. PMID: 29057463Free PMC Article
Primary rare anaplastic large cell lymphoma, ALK positive in small intestine: case report and review of the literature.
Cao Q, Liu F, Li S, Liu N, Li L, Li C, Peng T
Diagn Pathol 2016 Sep 9;11(1):83. doi: 10.1186/s13000-016-0539-6. PMID: 27612448Free PMC Article
ALK-positive primary cutaneous T-cell-lymphoma (CTCL) with unusual clinical presentation and aggressive course.
Wehkamp U, Oschlies I, Nagel I, Brasch J, Kneba M, Günther A, Klapper W, Weichenthal M
J Cutan Pathol 2015 Nov;42(11):870-7. Epub 2015 Jun 25 doi: 10.1111/cup.12547. PMID: 26053561

Clinical prediction guides

Ceritinib in paediatric patients with anaplastic lymphoma kinase-positive malignancies: an open-label, multicentre, phase 1, dose-escalation and dose-expansion study.
Fischer M, Moreno L, Ziegler DS, Marshall LV, Zwaan CM, Irwin MS, Casanova M, Sabado C, Wulff B, Stegert M, Wang L, Hurtado FK, Branle F, Geoerger B, Schulte JH
Lancet Oncol 2021 Dec;22(12):1764-1776. Epub 2021 Nov 12 doi: 10.1016/S1470-2045(21)00536-2. PMID: 34780709
Primary central nervous system ALK-positive anaplastic large cell lymphoma in an adult: A rare case report.
Dong X, Li J, Huo N, Wang Y, Wu Z, Lin X, Zhao H
Medicine (Baltimore) 2016 Dec;95(49):e5534. doi: 10.1097/MD.0000000000005534. PMID: 27930548Free PMC Article
Primary rare anaplastic large cell lymphoma, ALK positive in small intestine: case report and review of the literature.
Cao Q, Liu F, Li S, Liu N, Li L, Li C, Peng T
Diagn Pathol 2016 Sep 9;11(1):83. doi: 10.1186/s13000-016-0539-6. PMID: 27612448Free PMC Article
Three different histological subtypes of Epstein-Barr virus-negative post-transplant lymphoproliferative disorder in a patient with hepatitis C infection.
Kobayashi M, Asano N, Fukushima M, Honda T
Int J Hematol 2014 Sep;100(3):307-11. Epub 2014 May 31 doi: 10.1007/s12185-014-1599-6. PMID: 24879033

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