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Recurrent Primary Malignant Neoplasm

MedGen UID:: 1371282
•Concept ID:: C4331231
•: Neoplastic Process

Definition

The reemergence of a primary malignant neoplasm after a period of remission. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRecurrent Primary Malignant Neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Malignant neoplastic disease
        Recurrent Malignant Neoplasm
        Recurrent Primary Malignant Neoplasm
        Recurrent Adult Liver Carcinoma
        Recurrent Adult Hepatocellular Carcinoma
        Recurrent Breast Lymphoma
        Recurrent Breast Implant-Associated Anaplastic Large Cell Lymphoma
        Recurrent Childhood Central Nervous System Embryonal Neoplasm
        Recurrent Childhood Medulloblastoma
        Recurrent Childhood Pineoblastoma
        Recurrent Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified
        Recurrent Childhood Malignant Liver Neoplasm
        Recurrent Childhood Hepatocellular Carcinoma
        Recurrent Hepatoblastoma
        Recurrent Combined Thymic Epithelial Neoplasm
        Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
        Recurrent Ewing Sarcoma
        Recurrent Bone Ewing Sarcoma
        Recurrent Extraskeletal Ewing Sarcoma
        Recurrent Peripheral Primitive Neuroectodermal Tumor
        Recurrent Peripheral Primitive Neuroectodermal Tumor of Bone
        Recurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
        Recurrent Hepatocellular Carcinoma
        Recurrent Fibrolamellar Carcinoma
        Recurrent Hepatosplenic T-Cell Lymphoma
        Recurrent Kidney Wilms Tumor
        Recurrent Malignant Glioma
        Recurrent Diffuse Intrinsic Pontine Glioma
        Recurrent Diffuse Midline Glioma, H3 K27M-Mutant
        Recurrent Glioblastoma
        Recurrent Childhood Glioblastoma
        Recurrent Giant Cell Glioblastoma
        Recurrent Gliosarcoma
        Recurrent Small Cell Glioblastoma
        Recurrent Supratentorial Glioblastoma
        Recurrent WHO Grade 3 Glioma
        Recurrent Anaplastic Astrocytoma
        Recurrent Anaplastic Ependymoma
        Recurrent Anaplastic Oligoastrocytoma
        Recurrent Anaplastic Oligodendroglioma
        Recurrent Anaplastic Pleomorphic Xanthoastrocytoma
        Recurrent Malignant Neoplasm of Multiple Primary Sites
        Recurrent Medulloblastoma
        Recurrent Medulloblastoma, SHH-Activated
        Recurrent Medulloblastoma, WNT-Activated
        Recurrent Melanoma
        Recurrent Cutaneous Melanoma of the Extremity
        Recurrent Acral Lentiginous Melanoma
        Recurrent Lentigo Maligna Melanoma
        Recurrent Non-Cutaneous Melanoma
        Recurrent Mucosal Melanoma
        Recurrent Ocular Melanoma
        Recurrent Primary Amyloidosis
        Recurrent AL Amyloidosis
        Recurrent Primary Bone Lymphoma
        Recurrent Primary Cutaneous Lymphoma
        Recurrent Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type
        Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
        Recurrent Mycosis Fungoides
        Recurrent Primary Cutaneous Anaplastic Large Cell Lymphoma
        Recurrent Subcutaneous Panniculitis-Like T-Cell Lymphoma
        Recurrent Primary Effusion Lymphoma
        Recurrent Primary Mediastinal (Thymic) Large B-Cell Lymphoma
        Recurrent Primary Peritoneal Carcinoma
        Recurrent Platinum-Resistant Primary Peritoneal Carcinoma
        Recurrent Primary Peritoneal Adenocarcinoma
        Recurrent Primary Peritoneal Clear Cell Adenocarcinoma
        Recurrent Primary Peritoneal Endometrioid Adenocarcinoma
        Recurrent Primary Peritoneal Serous Adenocarcinoma
        Recurrent Primary Peritoneal Transitional Cell Carcinoma
        Recurrent Primary Peritoneal Undifferentiated Carcinoma
        Recurrent Primary Systemic Anaplastic Large Cell Lymphoma, ALK-Positive
        Recurrent Primitive Neuroectodermal Tumor
        Recurrent Ganglioneuroblastoma
        Recurrent Neuroblastoma
        Recurrent Olfactory Neuroblastoma
        Recurrent Splenic Marginal Zone Lymphoma
        Recurrent Testicular Lymphoma

Professional guidelines

PubMed

European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics: Update 2022.

Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Höller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Jul;170:236-255. Epub 2022 May 12 doi: 10.1016/j.ejca.2022.03.008. PMID: 35570085

Testicular Cancer: Diagnosis and Treatment.

Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline.

Lenders JW, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH, Naruse M, Pacak K, Young WF Jr; Endocrine Society
J Clin Endocrinol Metab 2014 Jun;99(6):1915-42. doi: 10.1210/jc.2014-1498. PMID: 24893135

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Recent clinical studies

Etiology

The role of tumor microenvironment and exosomes in dormancy and relapse.

Attaran S, Bissell MJ
Semin Cancer Biol 2022 Jan;78:35-44. Epub 2021 Oct 30 doi: 10.1016/j.semcancer.2021.09.008. PMID: 34757184 Free PMC Article

Immune Checkpoint Inhibitor Rechallenge After Immune-Related Adverse Events in Patients With Cancer.

Dolladille C, Ederhy S, Sassier M, Cautela J, Thuny F, Cohen AA, Fedrizzi S, Chrétien B, Da-Silva A, Plane AF, Legallois D, Milliez PU, Lelong-Boulouard V, Alexandre J
JAMA Oncol 2020 Jun 1;6(6):865-871. doi: 10.1001/jamaoncol.2020.0726. PMID: 32297899 Free PMC Article

Contralateral Limberg flap reconstruction for pilonidal disease recurrence.

Özcan B, İlkgül Ö
Asian J Surg 2019 Aug;42(8):787-791. Epub 2019 Jan 31 doi: 10.1016/j.asjsur.2018.12.008. PMID: 30711442

Persistent and recurrent hyperparathyroidism.

Guerin C, Paladino NC, Lowery A, Castinetti F, Taieb D, Sebag F
Updates Surg 2017 Jun;69(2):161-169. Epub 2017 Apr 22 doi: 10.1007/s13304-017-0447-7. PMID: 28434176

Tumor markers.

Seleznick MJ
Prim Care 1992 Dec;19(4):715-26. PMID: 1281552

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Diagnosis

Role of ultrasound in the diagnosis of primary and recurrent dermatofibrosarcoma protuberans.

Zou MH, Huang Q, Yang T, Jiang Y, Zhang LJ, Xie Y, Zheng RQ
BMC Cancer 2021 Aug 10;21(1):909. doi: 10.1186/s12885-021-08476-2. PMID: 34376150 Free PMC Article

Disease recurrence after gut transplantation.

Osman M, Parekh N, Fujiki M, D'Amico G, Abu-Elmagd K
Curr Opin Organ Transplant 2021 Apr 1;26(2):207-219. doi: 10.1097/MOT.0000000000000856. PMID: 33528222

Persistent and recurrent hyperparathyroidism.

Guerin C, Paladino NC, Lowery A, Castinetti F, Taieb D, Sebag F
Updates Surg 2017 Jun;69(2):161-169. Epub 2017 Apr 22 doi: 10.1007/s13304-017-0447-7. PMID: 28434176

Chondrosarcoma of bone.

Leddy LR, Holmes RE
Cancer Treat Res 2014;162:117-30. doi: 10.1007/978-3-319-07323-1_6. PMID: 25070233

Malignant pericardial effusion.

Burazor I, Imazio M, Markel G, Adler Y
Cardiology 2013;124(4):224-32. Epub 2013 Apr 5 doi: 10.1159/000348559. PMID: 23571453

See all (28924)

Therapy

Stereotactic ablative radiotherapy with or without immunotherapy for early-stage or isolated lung parenchymal recurrent node-negative non-small-cell lung cancer: an open-label, randomised, phase 2 trial.

Chang JY, Lin SH, Dong W, Liao Z, Gandhi SJ, Gay CM, Zhang J, Chun SG, Elamin YY, Fossella FV, Blumenschein G, Cascone T, Le X, Pozadzides JV, Tsao A, Verma V, Welsh JW, Chen AB, Altan M, Mehran RJ, Vaporciyan AA, Swisher SG, Balter PA, Fujimoto J, Wistuba II, Feng L, Lee JJ, Heymach JV
Lancet 2023 Sep 9;402(10405):871-881. Epub 2023 Jul 18 doi: 10.1016/S0140-6736(23)01384-3. PMID: 37478883 Free PMC Article

Phase 3, randomized, open-label study of pembrolizumab plus lenvatinib versus chemotherapy for first-line treatment of advanced or recurrent endometrial cancer: ENGOT-en9/LEAP-001.

Marth C, Tarnawski R, Tyulyandina A, Pignata S, Gilbert L, Kaen D, Rubio MJ, Frentzas S, Beiner M, Magallanes-Maciel M, Farrelly L, Choi CH, Berger R, Lee C, Vulsteke C, Hasegawa K, Braicu EI, Wu X, McKenzie J, Lee JJ, Makker V
Int J Gynecol Cancer 2022 Jan;32(1):93-100. Epub 2021 Nov 19 doi: 10.1136/ijgc-2021-003017. PMID: 34799418 Free PMC Article

How did lomustine become standard of care in recurrent glioblastoma?

Weller M, Le Rhun E
Cancer Treat Rev 2020 Jul;87:102029. Epub 2020 May 4 doi: 10.1016/j.ctrv.2020.102029. PMID: 32408220

Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism.

Raskob GE, van Es N, Verhamme P, Carrier M, Di Nisio M, Garcia D, Grosso MA, Kakkar AK, Kovacs MJ, Mercuri MF, Meyer G, Segers A, Shi M, Wang TF, Yeo E, Zhang G, Zwicker JI, Weitz JI, Büller HR; Hokusai VTE Cancer Investigators
N Engl J Med 2018 Feb 15;378(7):615-624. Epub 2017 Dec 12 doi: 10.1056/NEJMoa1711948. PMID: 29231094

Definitions, End Points, and Clinical Trial Designs for Non-Muscle-Invasive Bladder Cancer: Recommendations From the International Bladder Cancer Group.

Kamat AM, Sylvester RJ, Böhle A, Palou J, Lamm DL, Brausi M, Soloway M, Persad R, Buckley R, Colombel M, Witjes JA
J Clin Oncol 2016 Jun 1;34(16):1935-44. Epub 2016 Jan 25 doi: 10.1200/JCO.2015.64.4070. PMID: 26811532 Free PMC Article

See all (25569)

Prognosis

Disease recurrence after gut transplantation.

Osman M, Parekh N, Fujiki M, D'Amico G, Abu-Elmagd K
Curr Opin Organ Transplant 2021 Apr 1;26(2):207-219. doi: 10.1097/MOT.0000000000000856. PMID: 33528222

Prognosis of Primary and Recurrent Chondrosarcoma of the Rib.

Roos E, van Coevorden F, Verhoef C, Wouters MW, Kroon HM, Hogendoorn PC, van Houdt WJ
Ann Surg Oncol 2016 Mar;23(3):811-7. Epub 2015 Oct 23 doi: 10.1245/s10434-015-4932-2. PMID: 26498768

Follow-up: the evidence.

D'Ugo D, Biondi A, Tufo A, Persiani R
Dig Surg 2013;30(2):159-68. Epub 2013 Jul 18 doi: 10.1159/000350878. PMID: 23867593

Malignant pericardial effusion.

Burazor I, Imazio M, Markel G, Adler Y
Cardiology 2013;124(4):224-32. Epub 2013 Apr 5 doi: 10.1159/000348559. PMID: 23571453

Conjunctival melanoma.

Seregard S
Surv Ophthalmol 1998 Jan-Feb;42(4):321-50. doi: 10.1016/s0039-6257(97)00122-7. PMID: 9493274

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Clinical prediction guides

Disease recurrence after gut transplantation.

Osman M, Parekh N, Fujiki M, D'Amico G, Abu-Elmagd K
Curr Opin Organ Transplant 2021 Apr 1;26(2):207-219. doi: 10.1097/MOT.0000000000000856. PMID: 33528222

Do not break a sweat: avoiding pitfalls in the diagnosis of sweat gland tumors.

Brenn T
Mod Pathol 2020 Jan;33(Suppl 1):25-41. Epub 2019 Sep 26 doi: 10.1038/s41379-019-0377-7. PMID: 31558783

Prognostic and predictive factors in recurrent and/or metastatic head and neck squamous cell carcinoma: A review of the literature.

Bossi P, Alfieri S, Strojan P, Takes RP, López F, Mäkitie A, Saba NF, Rodrigo JP, Bradford C, Suarez C, Zafereo M, Forastiere AA, Vermorken JB, Quer M, Sanabria A, Simo R, de Bree R, Rinaldo A, Ferlito A
Crit Rev Oncol Hematol 2019 May;137:84-91. Epub 2019 Feb 13 doi: 10.1016/j.critrevonc.2019.01.018. PMID: 31014517

Fibroepithelial lesions; The WHO spectrum.

Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536

Tumor markers.

Seleznick MJ
Prim Care 1992 Dec;19(4):715-26. PMID: 1281552

See all (23614)

Recent systematic reviews

Hyperthermic intraperitoneal chemotherapy (HIPEC) for the management of primary advanced and recurrent ovarian cancer: a systematic review and meta-analysis of randomized trials.

Filis P, Mauri D, Markozannes G, Tolia M, Filis N, Tsilidis K
ESMO Open 2022 Oct;7(5):100586. Epub 2022 Sep 16 doi: 10.1016/j.esmoop.2022.100586. PMID: 36116421 Free PMC Article

Malignant phyllodes tumor of the breast: a systematic review.

Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723 Free PMC Article

Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.

Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310

Treatment options for progression or recurrence of glioblastoma: a network meta-analysis.

McBain C, Lawrie TA, Rogozińska E, Kernohan A, Robinson T, Jefferies S
Cochrane Database Syst Rev 2021 May 4;5(1):CD013579. doi: 10.1002/14651858.CD013579.pub2. PMID: 34559423 Free PMC Article

American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline.

Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, Cannady RS, Pratt-Chapman ML, Edge SB, Jacobs LA, Hurria A, Marks LB, LaMonte SJ, Warner E, Lyman GH, Ganz PA
CA Cancer J Clin 2016 Jan-Feb;66(1):43-73. Epub 2015 Dec 7 doi: 10.3322/caac.21319. PMID: 26641959

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MedGen

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Recurrent Primary Malignant Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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