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Pediatric multiple sclerosis

MedGen UID:
1799994
Concept ID:
C5568571
Disease or Syndrome
Synonym: Pediatric MS
SNOMED CT: Pediatric multiple sclerosis (1186728004)
 
Monarch Initiative: MONDO:0018784
Orphanet: ORPHA477738

Definition

A rare multiple sclerosis (MS) variant with characteristics of the onset of one or multiple episodes of clinical central nervous system (CNS) symptoms consistent with acquired CNS demyelination, with radiologically proven dissemination of inflammatory lesions in space and time, following exclusion of other disorders before the age of 18 years old. Patients present a predominantly relapsing-remitting course with the first attack usually consisting of optic neuritis, transverse myelitis, acute disseminated encephalomyelitis and monofocal or polyfocal neurological deficits. A high burden of T2-hyperintense lesions on initial MRI, primarily of the supratentorial region and/or of the cervical spinal cord has been reported. [from SNOMEDCT_US]

Professional guidelines

PubMed

Brola W, Steinborn B
Neurol Neurochir Pol 2020;54(6):508-517. Epub 2020 Sep 17 doi: 10.5603/PJNNS.a2020.0069. PMID: 32940341
Kornek B
Neuropediatrics 2013 Dec;44(6):309-13. Epub 2013 Nov 7 doi: 10.1055/s-0033-1359308. PMID: 24203855
Krupp LB, Tardieu M, Amato MP, Banwell B, Chitnis T, Dale RC, Ghezzi A, Hintzen R, Kornberg A, Pohl D, Rostasy K, Tenembaum S, Wassmer E; International Pediatric Multiple Sclerosis Study Group
Mult Scler 2013 Sep;19(10):1261-7. Epub 2013 Apr 9 doi: 10.1177/1352458513484547. PMID: 23572237

Recent clinical studies

Etiology

Ziemssen T, Bhan V, Chataway J, Chitnis T, Campbell Cree BA, Havrdova EK, Kappos L, Labauge P, Miller A, Nakahara J, Oreja-Guevara C, Palace J, Singer B, Trojano M, Patil A, Rauser B, Hach T
Neurol Neuroimmunol Neuroinflamm 2023 Jan;10(1) Epub 2022 Nov 22 doi: 10.1212/NXI.0000000000200064. PMID: 36414428Free PMC Article
Graves JS, Krysko KM, Hua LH, Absinta M, Franklin RJM, Segal BM
Lancet Neurol 2023 Jan;22(1):66-77. Epub 2022 Oct 7 doi: 10.1016/S1474-4422(22)00184-3. PMID: 36216015
Fadda G, Armangue T, Hacohen Y, Chitnis T, Banwell B
Lancet Neurol 2021 Feb;20(2):136-149. Epub 2021 Jan 20 doi: 10.1016/S1474-4422(20)30432-4. PMID: 33484648
Alroughani R, Boyko A
BMC Neurol 2018 Mar 9;18(1):27. doi: 10.1186/s12883-018-1026-3. PMID: 29523094Free PMC Article
Krupp LB, Tardieu M, Amato MP, Banwell B, Chitnis T, Dale RC, Ghezzi A, Hintzen R, Kornberg A, Pohl D, Rostasy K, Tenembaum S, Wassmer E; International Pediatric Multiple Sclerosis Study Group
Mult Scler 2013 Sep;19(10):1261-7. Epub 2013 Apr 9 doi: 10.1177/1352458513484547. PMID: 23572237

Diagnosis

Kornbluh AB, Kahn I
Semin Pediatr Neurol 2023 Jul;46:101054. Epub 2023 May 11 doi: 10.1016/j.spen.2023.101054. PMID: 37451754
Ziemssen T, Bhan V, Chataway J, Chitnis T, Campbell Cree BA, Havrdova EK, Kappos L, Labauge P, Miller A, Nakahara J, Oreja-Guevara C, Palace J, Singer B, Trojano M, Patil A, Rauser B, Hach T
Neurol Neuroimmunol Neuroinflamm 2023 Jan;10(1) Epub 2022 Nov 22 doi: 10.1212/NXI.0000000000200064. PMID: 36414428Free PMC Article
Fadda G, Armangue T, Hacohen Y, Chitnis T, Banwell B
Lancet Neurol 2021 Feb;20(2):136-149. Epub 2021 Jan 20 doi: 10.1016/S1474-4422(20)30432-4. PMID: 33484648
Brola W, Steinborn B
Neurol Neurochir Pol 2020;54(6):508-517. Epub 2020 Sep 17 doi: 10.5603/PJNNS.a2020.0069. PMID: 32940341
Alroughani R, Boyko A
BMC Neurol 2018 Mar 9;18(1):27. doi: 10.1186/s12883-018-1026-3. PMID: 29523094Free PMC Article

Therapy

Nosadini M, Eyre M, Molteni E, Thomas T, Irani SR, Dalmau J, Dale RC, Lim M; International NMDAR Antibody Encephalitis Consensus Group, Anlar B, Armangue T, Benseler S, Cellucci T, Deiva K, Gallentine W, Gombolay G, Gorman MP, Hacohen Y, Jiang Y, Lim BC, Muscal E, Ndondo A, Neuteboom R, Rostásy K, Sakuma H, Sartori S, Sharma S, Tenembaum SN, Van Mater HA, Wells E, Wickstrom R, Yeshokumar AK
JAMA Neurol 2021 Nov 1;78(11):1333-1344. doi: 10.1001/jamaneurol.2021.3188. PMID: 34542573Free PMC Article
Fadda G, Armangue T, Hacohen Y, Chitnis T, Banwell B
Lancet Neurol 2021 Feb;20(2):136-149. Epub 2021 Jan 20 doi: 10.1016/S1474-4422(20)30432-4. PMID: 33484648
Otallah S, Banwell B
Curr Neurol Neurosci Rep 2018 Sep 18;18(11):76. doi: 10.1007/s11910-018-0886-7. PMID: 30229541
Alroughani R, Boyko A
BMC Neurol 2018 Mar 9;18(1):27. doi: 10.1186/s12883-018-1026-3. PMID: 29523094Free PMC Article
Banwell BL
Handb Clin Neurol 2013;112:1263-74. doi: 10.1016/B978-0-444-52910-7.00049-0. PMID: 23622337

Prognosis

Kornbluh AB, Kahn I
Semin Pediatr Neurol 2023 Jul;46:101054. Epub 2023 May 11 doi: 10.1016/j.spen.2023.101054. PMID: 37451754
Ziemssen T, Bhan V, Chataway J, Chitnis T, Campbell Cree BA, Havrdova EK, Kappos L, Labauge P, Miller A, Nakahara J, Oreja-Guevara C, Palace J, Singer B, Trojano M, Patil A, Rauser B, Hach T
Neurol Neuroimmunol Neuroinflamm 2023 Jan;10(1) Epub 2022 Nov 22 doi: 10.1212/NXI.0000000000200064. PMID: 36414428Free PMC Article
Graves JS, Krysko KM, Hua LH, Absinta M, Franklin RJM, Segal BM
Lancet Neurol 2023 Jan;22(1):66-77. Epub 2022 Oct 7 doi: 10.1016/S1474-4422(22)00184-3. PMID: 36216015
Brola W, Steinborn B
Neurol Neurochir Pol 2020;54(6):508-517. Epub 2020 Sep 17 doi: 10.5603/PJNNS.a2020.0069. PMID: 32940341
Alroughani R, Boyko A
BMC Neurol 2018 Mar 9;18(1):27. doi: 10.1186/s12883-018-1026-3. PMID: 29523094Free PMC Article

Clinical prediction guides

Bibinoğlu Amirov C, Saltık S, Yalçınkaya C, Tütüncü M, Saip S, Siva A, Uygunoğlu U
Eur J Paediatr Neurol 2023 Mar;43:1-5. Epub 2023 Jan 27 doi: 10.1016/j.ejpn.2023.01.011. PMID: 36724688
Nosadini M, Eyre M, Molteni E, Thomas T, Irani SR, Dalmau J, Dale RC, Lim M; International NMDAR Antibody Encephalitis Consensus Group, Anlar B, Armangue T, Benseler S, Cellucci T, Deiva K, Gallentine W, Gombolay G, Gorman MP, Hacohen Y, Jiang Y, Lim BC, Muscal E, Ndondo A, Neuteboom R, Rostásy K, Sakuma H, Sartori S, Sharma S, Tenembaum SN, Van Mater HA, Wells E, Wickstrom R, Yeshokumar AK
JAMA Neurol 2021 Nov 1;78(11):1333-1344. doi: 10.1001/jamaneurol.2021.3188. PMID: 34542573Free PMC Article
Otallah S, Banwell B
Curr Neurol Neurosci Rep 2018 Sep 18;18(11):76. doi: 10.1007/s11910-018-0886-7. PMID: 30229541
Ghezzi A, Amato MP, Makhani N, Shreiner T, Gärtner J, Tenembaum S
Neurology 2016 Aug 30;87(9 Suppl 2):S97-S102. doi: 10.1212/WNL.0000000000002823. PMID: 27572869
Verhey LH, Shroff M, Banwell B
Neuroimaging Clin N Am 2013 May;23(2):227-43. Epub 2013 Jan 21 doi: 10.1016/j.nic.2012.12.004. PMID: 23608687

Recent systematic reviews

Niculae AŞ, Niculae LE, Văcăraş C, Văcăraş V
J Neurol 2023 Oct;270(10):4753-4762. Epub 2023 Jul 2 doi: 10.1007/s00415-023-11841-9. PMID: 37394516
Ow N, Mozafarinia M, Mayo NE
Dev Med Child Neurol 2021 Sep;63(9):1051-1058. Epub 2021 Mar 26 doi: 10.1111/dmcn.14870. PMID: 33769574
Yan K, Balijepalli C, Desai K, Gullapalli L, Druyts E
Mult Scler Relat Disord 2020 Sep;44:102260. Epub 2020 Jun 4 doi: 10.1016/j.msard.2020.102260. PMID: 32540746
Vitaliti G, Tabatabaie O, Matin N, Ledda C, Pavone P, Lubrano R, Serra A, Di Mauro P, Cocuzza S, Falsaperla R
Hum Vaccin Immunother 2015;11(12):2749-63. doi: 10.1080/21645515.2015.1061161. PMID: 26266339Free PMC Article

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