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Multiple sclerosis, susceptibility to, 4(MS4)

MedGen UID:
436443
•Concept ID:
C2675476
•
Finding
Synonym: MS4
 
Monarch Initiative: MONDO:0012958
OMIM®: 612596

Term Hierarchy

Professional guidelines

PubMed

Natalizumab in Multiple Sclerosis Treatment: From Biological Effects to Immune Monitoring.
Khoy K, Mariotte D, Defer G, Petit G, Toutirais O, Le Mauff B
Front Immunol 2020;11:549842. Epub 2020 Sep 24 doi: 10.3389/fimmu.2020.549842. PMID: 33072089Free PMC Article
The clinical utility of QSM: disease diagnosis, medical management, and surgical planning.
Eskreis-Winkler S, Zhang Y, Zhang J, Liu Z, Dimov A, Gupta A, Wang Y
NMR Biomed 2017 Apr;30(4) Epub 2016 Dec 1 doi: 10.1002/nbm.3668. PMID: 27906525
Genotype/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States.
Au KS, Williams AT, Roach ES, Batchelor L, Sparagana SP, Delgado MR, Wheless JW, Baumgartner JE, Roa BB, Wilson CM, Smith-Knuppel TK, Cheung MY, Whittemore VH, King TM, Northrup H
Genet Med 2007 Feb;9(2):88-100. doi: 10.1097/gim.0b013e31803068c7. PMID: 17304050

Curated

UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

Recent clinical studies

Etiology

Epstein-Barr virus as a cause of multiple sclerosis: opportunities for prevention and therapy.
Aloisi F, Giovannoni G, Salvetti M
Lancet Neurol 2023 Apr;22(4):338-349. Epub 2023 Feb 7 doi: 10.1016/S1474-4422(22)00471-9. PMID: 36764322
Environmental risk factors in multiple sclerosis: bridging Mendelian randomization and observational studies.
Vandebergh M, Degryse N, Dubois B, Goris A
J Neurol 2022 Aug;269(8):4565-4574. Epub 2022 Apr 2 doi: 10.1007/s00415-022-11072-4. PMID: 35366084
Lifestyle and Environmental Factors in Multiple Sclerosis.
Alfredsson L, Olsson T
Cold Spring Harb Perspect Med 2019 Apr 1;9(4) doi: 10.1101/cshperspect.a028944. PMID: 29735578Free PMC Article
Multiple Sclerosis: Mechanisms and Immunotherapy.
Baecher-Allan C, Kaskow BJ, Weiner HL
Neuron 2018 Feb 21;97(4):742-768. doi: 10.1016/j.neuron.2018.01.021. PMID: 29470968
Aetiology: Neighbourhood watch.
Brown C
Nature 2016 Nov 30;540(7631):S4-S6. doi: 10.1038/540S4a. PMID: 27902678

Diagnosis

Epstein-Barr virus as a cause of multiple sclerosis: opportunities for prevention and therapy.
Aloisi F, Giovannoni G, Salvetti M
Lancet Neurol 2023 Apr;22(4):338-349. Epub 2023 Feb 7 doi: 10.1016/S1474-4422(22)00471-9. PMID: 36764322
Natalizumab in Multiple Sclerosis Treatment: From Biological Effects to Immune Monitoring.
Khoy K, Mariotte D, Defer G, Petit G, Toutirais O, Le Mauff B
Front Immunol 2020;11:549842. Epub 2020 Sep 24 doi: 10.3389/fimmu.2020.549842. PMID: 33072089Free PMC Article
Epstein-Barr virus and its association with disease - a review of relevance to general practice.
Fugl A, Andersen CL
BMC Fam Pract 2019 May 14;20(1):62. doi: 10.1186/s12875-019-0954-3. PMID: 31088382Free PMC Article
Advanced techniques using contrast media in neuroimaging.
Ferré JC, Shiroishi MS, Law M
Magn Reson Imaging Clin N Am 2012 Nov;20(4):699-713. Epub 2012 Sep 25 doi: 10.1016/j.mric.2012.07.007. PMID: 23088946Free PMC Article
Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS).
Constantinescu CS, Farooqi N, O'Brien K, Gran B
Br J Pharmacol 2011 Oct;164(4):1079-106. doi: 10.1111/j.1476-5381.2011.01302.x. PMID: 21371012Free PMC Article

Therapy

Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.
Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N; University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR
Brain 2023 Feb 13;146(2):645-656. doi: 10.1093/brain/awac092. PMID: 35253861Free PMC Article
Environmental risk factors in multiple sclerosis: bridging Mendelian randomization and observational studies.
Vandebergh M, Degryse N, Dubois B, Goris A
J Neurol 2022 Aug;269(8):4565-4574. Epub 2022 Apr 2 doi: 10.1007/s00415-022-11072-4. PMID: 35366084
Natalizumab in Multiple Sclerosis Treatment: From Biological Effects to Immune Monitoring.
Khoy K, Mariotte D, Defer G, Petit G, Toutirais O, Le Mauff B
Front Immunol 2020;11:549842. Epub 2020 Sep 24 doi: 10.3389/fimmu.2020.549842. PMID: 33072089Free PMC Article
Lifestyle and Environmental Factors in Multiple Sclerosis.
Alfredsson L, Olsson T
Cold Spring Harb Perspect Med 2019 Apr 1;9(4) doi: 10.1101/cshperspect.a028944. PMID: 29735578Free PMC Article
Potential Environmental Factors in Amyotrophic Lateral Sclerosis.
Oskarsson B, Horton DK, Mitsumoto H
Neurol Clin 2015 Nov;33(4):877-88. doi: 10.1016/j.ncl.2015.07.009. PMID: 26515627Free PMC Article

Prognosis

B cell depletion therapy does not resolve chronic active multiple sclerosis lesions.
Maggi P, Bulcke CV, Pedrini E, Bugli C, Sellimi A, Wynen M, Stölting A, Mullins WA, Kalaitzidis G, Lolli V, Perrotta G, El Sankari S, Duprez T, Li X, Calabresi PA, van Pesch V, Reich DS, Absinta M
EBioMedicine 2023 Aug;94:104701. Epub 2023 Jul 10 doi: 10.1016/j.ebiom.2023.104701. PMID: 37437310Free PMC Article
Epstein-Barr virus as a cause of multiple sclerosis: opportunities for prevention and therapy.
Aloisi F, Giovannoni G, Salvetti M
Lancet Neurol 2023 Apr;22(4):338-349. Epub 2023 Feb 7 doi: 10.1016/S1474-4422(22)00471-9. PMID: 36764322
Glymphatic system impairment in multiple sclerosis: relation with brain damage and disability.
Carotenuto A, Cacciaguerra L, Pagani E, Preziosa P, Filippi M, Rocca MA
Brain 2022 Aug 27;145(8):2785-2795. doi: 10.1093/brain/awab454. PMID: 34919648
Genetic Syndromes with Pancreatic Manifestations.
Pittman ME, Brosens LA, Wood LD
Surg Pathol Clin 2016 Dec;9(4):705-715. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.012. PMID: 27926368
Epidemiology of Multiple Sclerosis: From Risk Factors to Prevention-An Update.
Ascherio A, Munger KL
Semin Neurol 2016 Apr;36(2):103-14. Epub 2016 Apr 26 doi: 10.1055/s-0036-1579693. PMID: 27116717

Clinical prediction guides

Vitamin D: immune function, inflammation, infections and auto-immunity.
Johnson CR, Thacher TD
Paediatr Int Child Health 2023 Nov;43(4):29-39. Epub 2023 Mar 1 doi: 10.1080/20469047.2023.2171759. PMID: 36857810
Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.
Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N; University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR
Brain 2023 Feb 13;146(2):645-656. doi: 10.1093/brain/awac092. PMID: 35253861Free PMC Article
Environmental risk factors in multiple sclerosis: bridging Mendelian randomization and observational studies.
Vandebergh M, Degryse N, Dubois B, Goris A
J Neurol 2022 Aug;269(8):4565-4574. Epub 2022 Apr 2 doi: 10.1007/s00415-022-11072-4. PMID: 35366084
Epidemiology of Multiple Sclerosis: From Risk Factors to Prevention-An Update.
Ascherio A, Munger KL
Semin Neurol 2016 Apr;36(2):103-14. Epub 2016 Apr 26 doi: 10.1055/s-0036-1579693. PMID: 27116717
Endoplasmic reticulum stress in disorders of myelinating cells.
Lin W, Popko B
Nat Neurosci 2009 Apr;12(4):379-85. Epub 2009 Mar 15 doi: 10.1038/nn.2273. PMID: 19287390Free PMC Article

Recent systematic reviews

Quantitative susceptibility mapping in multiple sclerosis: A systematic review and meta-analysis.
Voon CC, Wiltgen T, Wiestler B, Schlaeger S, Mühlau M
Neuroimage Clin 2024;42:103598. Epub 2024 Mar 25 doi: 10.1016/j.nicl.2024.103598. PMID: 38582068Free PMC Article
Reliability of paramagnetic rim lesion classification on quantitative susceptibility mapping (QSM) in people with multiple sclerosis: Single-site experience and systematic review.
Reeves JA, Mohebbi M, Zivadinov R, Bergsland N, Dwyer MG, Salman F, Schweser F, Jakimovski D
Mult Scler Relat Disord 2023 Nov;79:104968. Epub 2023 Sep 14 doi: 10.1016/j.msard.2023.104968. PMID: 37716210Free PMC Article
The Involvement of HLA Class II Alleles in Multiple Sclerosis: A Systematic Review with Meta-analysis.
De Silvestri A, Capittini C, Mallucci G, Bergamaschi R, Rebuffi C, Pasi A, Martinetti M, Tinelli C
Dis Markers 2019;2019:1409069. Epub 2019 Nov 6 doi: 10.1155/2019/1409069. PMID: 31781296Free PMC Article
MtDNA T4216C variation in multiple sclerosis: a systematic review and meta-analysis.
Andalib S, Emamhadi M, Yousefzadeh-Chabok S, Salari A, Sigaroudi AE, Vafaee MS
Acta Neurol Belg 2016 Dec;116(4):439-443. Epub 2016 Jul 25 doi: 10.1007/s13760-016-0675-5. PMID: 27457485
Frequency and clinical patterns of multiple sclerosis in Arab countries: a systematic review.
Benamer HT, Ahmed ES, Al-Din AS, Grosset DG
J Neurol Sci 2009 Mar 15;278(1-2):1-4. Epub 2009 Jan 9 doi: 10.1016/j.jns.2008.12.001. PMID: 19135686

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

    Consumer resources

    Reviews

    Related information

    • NCBI Bookshelf
      Related information in NCBI Bookshelf
    • OMIM
      Related records in OMIM
    • PMC Articles
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