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Multiple sclerosis, susceptibility to, 2(MS2)

MedGen UID:
436444
•Concept ID:
C2675478
•
Finding
Synonym: MS2
 
Monarch Initiative: MONDO:0012956
OMIM®: 612594

Term Hierarchy

Professional guidelines

PubMed

Multilocus evaluation of genetic predictors of multiple sclerosis.
Timasheva Y, Nasibullin TR, Tuktarova IA, Erdman VV, Galiullin TR, Zaplakhova OV, Bakhtiiarova KZ
Gene 2022 Jan 30;809:146008. Epub 2021 Oct 14 doi: 10.1016/j.gene.2021.146008. PMID: 34656742
Childhood multiple sclerosis: clinical features and recent developments on treatment choices and outcomes.
An Q, Fan CH, Xu SM
Eur Rev Med Pharmacol Sci 2018 Sep;22(17):5747-5754. doi: 10.26355/eurrev_201809_15843. PMID: 30229853
Genotype/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States.
Au KS, Williams AT, Roach ES, Batchelor L, Sparagana SP, Delgado MR, Wheless JW, Baumgartner JE, Roa BB, Wilson CM, Smith-Knuppel TK, Cheung MY, Whittemore VH, King TM, Northrup H
Genet Med 2007 Feb;9(2):88-100. doi: 10.1097/gim.0b013e31803068c7. PMID: 17304050

Curated

UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

Recent clinical studies

Etiology

Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.
Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N; University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR
Brain 2023 Feb 13;146(2):645-656. doi: 10.1093/brain/awac092. PMID: 35253861Free PMC Article
Multiple sclerosis.
Files DK, Jausurawong T, Katrajian R, Danoff R
Prim Care 2015 Jun;42(2):159-75. Epub 2015 Mar 20 doi: 10.1016/j.pop.2015.01.007. PMID: 25979578
Individual and joint action of environmental factors and risk of MS.
van der Mei IA, Simpson S Jr, Stankovich J, Taylor BV
Neurol Clin 2011 May;29(2):233-55. doi: 10.1016/j.ncl.2010.12.007. PMID: 21439439
The role of vitamin D in multiple sclerosis.
Kampman MT, Steffensen LH
J Photochem Photobiol B 2010 Nov 3;101(2):137-41. Epub 2010 Apr 21 doi: 10.1016/j.jphotobiol.2010.04.003. PMID: 20471852
MGAT5 alters the severity of multiple sclerosis.
Brynedal B, Wojcik J, Esposito F, Debailleul V, Yaouanq J, Martinelli-Boneschi F, Edan G, Comi G, Hillert J, Abderrahim H
J Neuroimmunol 2010 Mar 30;220(1-2):120-4. Epub 2010 Feb 1 doi: 10.1016/j.jneuroim.2010.01.003. PMID: 20117844

Diagnosis

Physical activity and risk of multiple sclerosis: A Mendelian randomization study.
Li C, Lin J, Yang T, Xiao Y, Jiang Q, Shang H
Front Immunol 2022;13:872126. Epub 2022 Sep 21 doi: 10.3389/fimmu.2022.872126. PMID: 36211369Free PMC Article
Therapeutic Opportunities of Interleukin-33 in the Central Nervous System.
Sun Y, Wen Y, Wang L, Wen L, You W, Wei S, Mao L, Wang H, Chen Z, Yang X
Front Immunol 2021;12:654626. Epub 2021 May 17 doi: 10.3389/fimmu.2021.654626. PMID: 34079543Free PMC Article
Three-dimensional MRI sequences in MS diagnosis and research.
Hu XY, Rajendran L, Lapointe E, Tam R, Li D, Traboulsee A, Rauscher A
Mult Scler 2019 Nov;25(13):1700-1709. Epub 2019 May 22 doi: 10.1177/1352458519848100. PMID: 31116071
Hypertension and kidneys: unraveling complex molecular mechanisms underlying hypertensive renal damage.
Mennuni S, Rubattu S, Pierelli G, Tocci G, Fofi C, Volpe M
J Hum Hypertens 2014 Feb;28(2):74-9. Epub 2013 Jun 27 doi: 10.1038/jhh.2013.55. PMID: 23803592
Pediatric multiple sclerosis.
Chitnis T, Krupp L, Yeh A, Rubin J, Kuntz N, Strober JB, Chabas D, Weinstock-Guttmann B, Ness J, Rodriguez M, Waubant E
Neurol Clin 2011 May;29(2):481-505. doi: 10.1016/j.ncl.2011.01.004. PMID: 21439455

Therapy

Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.
Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N; University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR
Brain 2023 Feb 13;146(2):645-656. doi: 10.1093/brain/awac092. PMID: 35253861Free PMC Article
The gut microbiome in neurological disorders.
Cryan JF, O'Riordan KJ, Sandhu K, Peterson V, Dinan TG
Lancet Neurol 2020 Feb;19(2):179-194. Epub 2019 Nov 18 doi: 10.1016/S1474-4422(19)30356-4. PMID: 31753762
An update on multiple sclerosis.
Hauser SL
J Neurol Sci 2005 Feb 15;228(2):193-4. Epub 2004 Dec 8 doi: 10.1016/j.jns.2004.10.007. PMID: 15694203
Autoimmune diseases and vaccinations.
Vial T, Descotes J
Eur J Dermatol 2004 Mar-Apr;14(2):86-90. PMID: 15196997
Candidate autoantigens in multiple sclerosis.
Schmidt S
Mult Scler 1999 Jun;5(3):147-60. doi: 10.1177/135245859900500303. PMID: 10408714

Prognosis

The Immunological Therapeutic Strategies for Controlling Multiple Sclerosis: Considerations during the COVID-19 Pandemic.
Azimzadeh M, Möhn N, Ghane Ezabadi S, Moghimi Esfandabadi Z, Soleimani A, Ranjbar E, Jahromi M, Seyedebrahimi R, Skripuletz T, Moharrami Kasmaie F
Biomolecules 2021 Sep 17;11(9) doi: 10.3390/biom11091372. PMID: 34572585Free PMC Article
Epidemiology of Multiple Sclerosis: From Risk Factors to Prevention-An Update.
Ascherio A, Munger KL
Semin Neurol 2016 Apr;36(2):103-14. Epub 2016 Apr 26 doi: 10.1055/s-0036-1579693. PMID: 27116717
Pediatric multiple sclerosis.
Chitnis T, Krupp L, Yeh A, Rubin J, Kuntz N, Strober JB, Chabas D, Weinstock-Guttmann B, Ness J, Rodriguez M, Waubant E
Neurol Clin 2011 May;29(2):481-505. doi: 10.1016/j.ncl.2011.01.004. PMID: 21439455
The phakomatoses.
Korf BR
Clin Dermatol 2005 Jan-Feb;23(1):78-84. doi: 10.1016/j.clindermatol.2004.09.007. PMID: 15708292
Genetics of multiple sclerosis.
Fukazawa T, Sasaki H, Kikuchi S, Hamada T, Tashiro K
Biomed Pharmacother 2000 Mar;54(2):103-6. doi: 10.1016/S0753-3322(00)88860-5. PMID: 10759295

Clinical prediction guides

Locus for severity implicates CNS resilience in progression of multiple sclerosis.
International Multiple Sclerosis Genetics Consortium; MultipleMS Consortium
Nature 2023 Jul;619(7969):323-331. Epub 2023 Jun 28 doi: 10.1038/s41586-023-06250-x. PMID: 37380766Free PMC Article
Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis.
Calvi A, Clarke MA, Prados F, Chard D, Ciccarelli O, Alberich M, Pareto D, Rodríguez Barranco M, Sastre-Garriga J, Tur C, Rovira A, Barkhof F
Mult Scler 2023 Mar;29(3):352-362. Epub 2022 Dec 14 doi: 10.1177/13524585221141964. PMID: 36515487Free PMC Article
Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.
Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N; University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR
Brain 2023 Feb 13;146(2):645-656. doi: 10.1093/brain/awac092. PMID: 35253861Free PMC Article
Epidemiology of Multiple Sclerosis: From Risk Factors to Prevention-An Update.
Ascherio A, Munger KL
Semin Neurol 2016 Apr;36(2):103-14. Epub 2016 Apr 26 doi: 10.1055/s-0036-1579693. PMID: 27116717
Genetics of multiple sclerosis.
Fukazawa T, Sasaki H, Kikuchi S, Hamada T, Tashiro K
Biomed Pharmacother 2000 Mar;54(2):103-6. doi: 10.1016/S0753-3322(00)88860-5. PMID: 10759295

Recent systematic reviews

Quantitative susceptibility mapping in multiple sclerosis: A systematic review and meta-analysis.
Voon CC, Wiltgen T, Wiestler B, Schlaeger S, Mühlau M
Neuroimage Clin 2024;42:103598. Epub 2024 Mar 25 doi: 10.1016/j.nicl.2024.103598. PMID: 38582068Free PMC Article
Reliability of paramagnetic rim lesion classification on quantitative susceptibility mapping (QSM) in people with multiple sclerosis: Single-site experience and systematic review.
Reeves JA, Mohebbi M, Zivadinov R, Bergsland N, Dwyer MG, Salman F, Schweser F, Jakimovski D
Mult Scler Relat Disord 2023 Nov;79:104968. Epub 2023 Sep 14 doi: 10.1016/j.msard.2023.104968. PMID: 37716210Free PMC Article
Association between VDR polymorphisms and multiple sclerosis: systematic review and updated meta-analysis of case-control studies.
Zhang YJ, Zhang L, Chen SY, Yang GJ, Huang XL, Duan Y, Yang LJ, Ye DQ, Wang J
Neurol Sci 2018 Feb;39(2):225-234. Epub 2017 Nov 6 doi: 10.1007/s10072-017-3175-3. PMID: 29110148
Association between Helicobacter pylori infection and multiple sclerosis: A systematic review and meta-analysis.
Jaruvongvanich V, Sanguankeo A, Jaruvongvanich S, Upala S
Mult Scler Relat Disord 2016 May;7:92-7. Epub 2016 Mar 30 doi: 10.1016/j.msard.2016.03.013. PMID: 27237767
Frequency and clinical patterns of multiple sclerosis in Arab countries: a systematic review.
Benamer HT, Ahmed ES, Al-Din AS, Grosset DG
J Neurol Sci 2009 Mar 15;278(1-2):1-4. Epub 2009 Jan 9 doi: 10.1016/j.jns.2008.12.001. PMID: 19135686

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

    Consumer resources

    Reviews

    Related information

    • NCBI Bookshelf
      Related information in NCBI Bookshelf
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