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Hippocampal microinfarct

MedGen UID:
1814105
•Concept ID:
C5558368
•
Pathologic Function
HPO: HP:0033989

Definition

An infarct located in the structure of the cerebrum involved with memory storage and spatial navigation that can only be observed microscopically. [from HPO]

Professional guidelines

PubMed

Consensus recommendations on pathologic changes in the hippocampus: a postmortem multicenter inter-rater study.
Rauramaa T, Pikkarainen M, Englund E, Ince PG, Jellinger K, Paetau A, Alafuzoff I
J Neuropathol Exp Neurol 2013 Jun;72(6):452-61. doi: 10.1097/NEN.0b013e318292492a. PMID: 23656988

Recent clinical studies

Etiology

What have we learned from cognition in the oldest-old.
Kawas CH, Legdeur N, Corrada MM
Curr Opin Neurol 2021 Apr 1;34(2):258-265. doi: 10.1097/WCO.0000000000000910. PMID: 33560671Free PMC Article
Common age-related neuropathologies and yearly variability in cognition.
Yu L, Wang T, Wilson RS, Leurgans S, Schneider JA, Bennett DA, Boyle PA
Ann Clin Transl Neurol 2019 Nov;6(11):2140-2149. Epub 2019 Sep 30 doi: 10.1002/acn3.50857. PMID: 31568713Free PMC Article
Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies.
Boyle PA, Yu L, Leurgans SE, Wilson RS, Brookmeyer R, Schneider JA, Bennett DA
Ann Neurol 2019 Jan;85(1):114-124. Epub 2018 Dec 19 doi: 10.1002/ana.25380. PMID: 30421454Free PMC Article
Impact of multiple pathologies on the threshold for clinically overt dementia.
Kapasi A, DeCarli C, Schneider JA
Acta Neuropathol 2017 Aug;134(2):171-186. Epub 2017 May 9 doi: 10.1007/s00401-017-1717-7. PMID: 28488154Free PMC Article
Key neuroanatomical structures for post-stroke cognitive impairment.
Grysiewicz R, Gorelick PB
Curr Neurol Neurosci Rep 2012 Dec;12(6):703-8. doi: 10.1007/s11910-012-0315-2. PMID: 23070618

Diagnosis

Poststroke Seizure and Epilepsy: A Review of Incidence, Risk Factors, Diagnosis, Pathophysiology, and Pharmacological Therapies.
Phan J, Ramos M, Soares T, Parmar MS
Oxid Med Cell Longev 2022;2022:7692215. Epub 2022 Oct 26 doi: 10.1155/2022/7692215. PMID: 36338344Free PMC Article
Impact of multiple pathologies on the threshold for clinically overt dementia.
Kapasi A, DeCarli C, Schneider JA
Acta Neuropathol 2017 Aug;134(2):171-186. Epub 2017 May 9 doi: 10.1007/s00401-017-1717-7. PMID: 28488154Free PMC Article
Radiological-Pathological Correlation in Alzheimer's Disease: Systematic Review of Antemortem Magnetic Resonance Imaging Findings.
Dallaire-Théroux C, Callahan BL, Potvin O, Saikali S, Duchesne S
J Alzheimers Dis 2017;57(2):575-601. doi: 10.3233/JAD-161028. PMID: 28282807
Seven-Tesla MRI and neuroimaging biomarkers for Alzheimer's disease.
Ali R, Goubran M, Choudhri O, Zeineh MM
Neurosurg Focus 2015 Nov;39(5):E4. doi: 10.3171/2015.9.FOCUS15326. PMID: 26646928
Towards defining the neuropathological substrates of vascular dementia.
Kalaria RN, Kenny RA, Ballard CG, Perry R, Ince P, Polvikoski T
J Neurol Sci 2004 Nov 15;226(1-2):75-80. doi: 10.1016/j.jns.2004.09.019. PMID: 15537525

Therapy

Poststroke Seizure and Epilepsy: A Review of Incidence, Risk Factors, Diagnosis, Pathophysiology, and Pharmacological Therapies.
Phan J, Ramos M, Soares T, Parmar MS
Oxid Med Cell Longev 2022;2022:7692215. Epub 2022 Oct 26 doi: 10.1155/2022/7692215. PMID: 36338344Free PMC Article
To what degree is late life cognitive decline driven by age-related neuropathologies?
Boyle PA, Wang T, Yu L, Wilson RS, Dawe R, Arfanakis K, Schneider JA, Bennett DA
Brain 2021 Aug 17;144(7):2166-2175. doi: 10.1093/brain/awab092. PMID: 33742668Free PMC Article
Chronic Cortical Cerebral Microinfarcts Slow Down Cognitive Recovery After Acute Ischemic Stroke.
Sagnier S, Okubo G, Catheline G, Munsch F, Bigourdan A, Debruxelles S, Poli M, Olindo S, Renou P, Rouanet F, Dousset V, Tourdias T, Sibon I
Stroke 2019 Jun;50(6):1430-1436. Epub 2019 May 14 doi: 10.1161/STROKEAHA.118.024672. PMID: 31084336
Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies.
Boyle PA, Yu L, Leurgans SE, Wilson RS, Brookmeyer R, Schneider JA, Bennett DA
Ann Neurol 2019 Jan;85(1):114-124. Epub 2018 Dec 19 doi: 10.1002/ana.25380. PMID: 30421454Free PMC Article
Enriched Brain Omega-3 Polyunsaturated Fatty Acids Confer Neuroprotection against Microinfarction.
Luo C, Ren H, Yao X, Shi Z, Liang F, Kang JX, Wan JB, Pei Z, Su KP, Su H
EBioMedicine 2018 Jun;32:50-61. Epub 2018 Jun 5 doi: 10.1016/j.ebiom.2018.05.028. PMID: 29880270Free PMC Article

Prognosis

Poststroke Seizure and Epilepsy: A Review of Incidence, Risk Factors, Diagnosis, Pathophysiology, and Pharmacological Therapies.
Phan J, Ramos M, Soares T, Parmar MS
Oxid Med Cell Longev 2022;2022:7692215. Epub 2022 Oct 26 doi: 10.1155/2022/7692215. PMID: 36338344Free PMC Article
Cognitive deficit, and neuropathological correlates, in the oldest-old.
Verny M, Duyckaerts C
Rev Neurol (Paris) 2020 Nov;176(9):670-676. Epub 2020 Mar 13 doi: 10.1016/j.neurol.2020.01.355. PMID: 32178879
Impact of multiple pathologies on the threshold for clinically overt dementia.
Kapasi A, DeCarli C, Schneider JA
Acta Neuropathol 2017 Aug;134(2):171-186. Epub 2017 May 9 doi: 10.1007/s00401-017-1717-7. PMID: 28488154Free PMC Article
Towards defining the neuropathological substrates of vascular dementia.
Kalaria RN, Kenny RA, Ballard CG, Perry R, Ince P, Polvikoski T
J Neurol Sci 2004 Nov 15;226(1-2):75-80. doi: 10.1016/j.jns.2004.09.019. PMID: 15537525
Neuropathologic substrates of ischemic vascular dementia.
Vinters HV, Ellis WG, Zarow C, Zaias BW, Jagust WJ, Mack WJ, Chui HC
J Neuropathol Exp Neurol 2000 Nov;59(11):931-45. doi: 10.1093/jnen/59.11.931. PMID: 11089571

Clinical prediction guides

Common age-related neuropathologies and yearly variability in cognition.
Yu L, Wang T, Wilson RS, Leurgans S, Schneider JA, Bennett DA, Boyle PA
Ann Clin Transl Neurol 2019 Nov;6(11):2140-2149. Epub 2019 Sep 30 doi: 10.1002/acn3.50857. PMID: 31568713Free PMC Article
Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer's disease and cerebrovascular disease pathologies.
Katsumata Y, Fardo DW, Kukull WA, Nelson PT
Acta Neuropathol Commun 2018 Dec 19;6(1):142. doi: 10.1186/s40478-018-0641-y. PMID: 30567576Free PMC Article
Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function.
Pleiss MM, Sompol P, Kraner SD, Abdul HM, Furman JL, Guttmann RP, Wilcock DM, Nelson PT, Norris CM
Biochim Biophys Acta 2016 Sep;1862(9):1521-32. Epub 2016 May 20 doi: 10.1016/j.bbadis.2016.05.007. PMID: 27212416Free PMC Article
Consensus recommendations on pathologic changes in the hippocampus: a postmortem multicenter inter-rater study.
Rauramaa T, Pikkarainen M, Englund E, Ince PG, Jellinger K, Paetau A, Alafuzoff I
J Neuropathol Exp Neurol 2013 Jun;72(6):452-61. doi: 10.1097/NEN.0b013e318292492a. PMID: 23656988
Neuropathologic substrates of ischemic vascular dementia.
Vinters HV, Ellis WG, Zarow C, Zaias BW, Jagust WJ, Mack WJ, Chui HC
J Neuropathol Exp Neurol 2000 Nov;59(11):931-45. doi: 10.1093/jnen/59.11.931. PMID: 11089571

Recent systematic reviews

Cognitive decline and diabetes: a systematic review of the neuropathological correlates accounting for cognition at death.
Hadley G, Zhang J, Harris-Skillman E, Alexopoulou Z, DeLuca GC, Pendlebury ST
J Neurol Neurosurg Psychiatry 2022 Mar;93(3):246-253. Epub 2022 Jan 27 doi: 10.1136/jnnp-2021-328158. PMID: 35086942
Radiological-Pathological Correlation in Alzheimer's Disease: Systematic Review of Antemortem Magnetic Resonance Imaging Findings.
Dallaire-Théroux C, Callahan BL, Potvin O, Saikali S, Duchesne S
J Alzheimers Dis 2017;57(2):575-601. doi: 10.3233/JAD-161028. PMID: 28282807
Experimental models of vascular dementia and vascular cognitive impairment: a systematic review.
Jiwa NS, Garrard P, Hainsworth AH
J Neurochem 2010 Nov;115(4):814-28. Epub 2010 Oct 7 doi: 10.1111/j.1471-4159.2010.06958.x. PMID: 20731763

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