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Decreased circulating apolipoprotein E concentration

MedGen UID:
1841592
•Concept ID:
C5826761
•
Finding
HPO: HP:0034911

Definition

Concentration of apolipoprotein E below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating apolipoprotein E concentration

Professional guidelines

PubMed

Apolipoprotein E genotypes, circulating C-reactive protein and angiographic coronary artery disease: the Ludwigshafen Risk and Cardiovascular Health Study.
Grammer TB, Hoffmann MM, Renner W, Kleber ME, Winkelmann BR, Böhm BO, März W
Atherosclerosis 2011 Apr;215(2):487-93. Epub 2011 Jan 21 doi: 10.1016/j.atherosclerosis.2011.01.005. PMID: 21310412
Long-term tacrine treatment in three mild Alzheimer patients: effects on nicotinic receptors, cerebral blood flow, glucose metabolism, EEG, and cognitive abilities.
Nordberg A, Amberla K, Shigeta M, Lundqvist H, Viitanen M, Hellström-Lindahl E, Johansson M, Andersson J, Hartvig P, Lilja A, Långström B, Winblad B
Alzheimer Dis Assoc Disord 1998 Sep;12(3):228-37. doi: 10.1097/00002093-199809000-00017. PMID: 9772028

Recent clinical studies

Etiology

GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling.
Lin YF, Li MH, Huang RH, Zhang SZ, Xu XF, Zhou HM, Liu MH, Liao XX, Liao LZ, Guo Y, Zhuang XD
Int J Cardiol 2023 Sep 15;387:131109. Epub 2023 Jun 2 doi: 10.1016/j.ijcard.2023.05.059. PMID: 37271284
Circulating Vascular Growth Factors and Magnetic Resonance Imaging Markers of Small Vessel Disease and Atrophy in Middle-Aged Adults.
Raman MR, Himali JJ, Conner SC, DeCarli C, Vasan RS, Beiser AS, Seshadri S, Maillard P, Satizabal CL
Stroke 2018 Sep;49(9):2227-2229. doi: 10.1161/STROKEAHA.118.022613. PMID: 30354979Free PMC Article
Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review.
Oscarsson J, Hurt-Camejo E
Lipids Health Dis 2017 Aug 10;16(1):149. doi: 10.1186/s12944-017-0541-3. PMID: 28797250Free PMC Article
Apolipoprotein E genotypes, circulating C-reactive protein and angiographic coronary artery disease: the Ludwigshafen Risk and Cardiovascular Health Study.
Grammer TB, Hoffmann MM, Renner W, Kleber ME, Winkelmann BR, Böhm BO, März W
Atherosclerosis 2011 Apr;215(2):487-93. Epub 2011 Jan 21 doi: 10.1016/j.atherosclerosis.2011.01.005. PMID: 21310412
Decreased HDL2 and HDL3 cholesterol, Apo A-I and Apo A-II, and increased risk of myocardial infarction.
Buring JE, O'Connor GT, Goldhaber SZ, Rosner B, Herbert PN, Blum CB, Breslow JL, Hennekens CH
Circulation 1992 Jan;85(1):22-9. doi: 10.1161/01.cir.85.1.22. PMID: 1728453

Diagnosis

Whole-Blood Levels of MicroRNA-9 Are Decreased in Patients With Late-Onset Alzheimer Disease.
Souza VC, Morais GS Jr, Henriques AD, Machado-Silva W, Perez DIV, Brito CJ, Camargos EF, Moraes CF, Nóbrega OT
Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520911573. doi: 10.1177/1533317520911573. PMID: 32301334Free PMC Article
Blood-based microcirculation markers in Alzheimer's disease-diagnostic value of midregional pro-atrial natriuretic peptide/C-terminal endothelin-1 precursor fragment ratio.
Buerger K, Ernst A, Ewers M, Uspenskaya O, Omerovic M, Morgenthaler NG, Knauer K, Bergmann A, Hampel H
Biol Psychiatry 2009 Jun 1;65(11):979-84. Epub 2009 Apr 2 doi: 10.1016/j.biopsych.2009.01.032. PMID: 19344890
An altered pattern of circulating apolipoprotein E3 isoforms is implicated in preeclampsia.
Atkinson KR, Blumenstein M, Black MA, Wu SH, Kasabov N, Taylor RS, Cooper GJ, North RA; SCOPE Consortium
J Lipid Res 2009 Jan;50(1):71-80. Epub 2008 Aug 25 doi: 10.1194/jlr.M800296-JLR200. PMID: 18725658
Statins of different brain penetrability differentially affect CSF PLTP activity.
Vuletic S, Riekse RG, Marcovina SM, Peskind ER, Hazzard WR, Albers JJ
Dement Geriatr Cogn Disord 2006;22(5-6):392-8. Epub 2006 Sep 7 doi: 10.1159/000095679. PMID: 16960448
Increased plasma levels of soluble CD40, together with the decrease of TGF beta 1, as possible differential markers of Alzheimer disease.
Mocali A, Cedrola S, Della Malva N, Bontempelli M, Mitidieri VA, Bavazzano A, Comolli R, Paoletti F, La Porta CA
Exp Gerontol 2004 Oct;39(10):1555-61. doi: 10.1016/j.exger.2004.07.007. PMID: 15501026

Therapy

GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling.
Lin YF, Li MH, Huang RH, Zhang SZ, Xu XF, Zhou HM, Liu MH, Liao XX, Liao LZ, Guo Y, Zhuang XD
Int J Cardiol 2023 Sep 15;387:131109. Epub 2023 Jun 2 doi: 10.1016/j.ijcard.2023.05.059. PMID: 37271284
Acacetin exerts antioxidant potential against atherosclerosis through Nrf2 pathway in apoE(-/-) Mice.
Wu Y, Song F, Li Y, Li J, Cui Y, Hong Y, Han W, Wu W, Lakhani I, Li G, Wang Y
J Cell Mol Med 2021 Jan;25(1):521-534. Epub 2020 Nov 26 doi: 10.1111/jcmm.16106. PMID: 33241629Free PMC Article
Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review.
Oscarsson J, Hurt-Camejo E
Lipids Health Dis 2017 Aug 10;16(1):149. doi: 10.1186/s12944-017-0541-3. PMID: 28797250Free PMC Article
Pegylation of high-density lipoprotein decreases plasma clearance and enhances antiatherogenic activity.
Murphy AJ, Funt S, Gorman D, Tall AR, Wang N
Circ Res 2013 Jun 21;113(1):e1-e9. Epub 2013 Apr 23 doi: 10.1161/CIRCRESAHA.113.301112. PMID: 23613182Free PMC Article
Bioenergetic and antioxidant properties of coenzyme Q10: recent developments.
Littarru GP, Tiano L
Mol Biotechnol 2007 Sep;37(1):31-7. doi: 10.1007/s12033-007-0052-y. PMID: 17914161

Prognosis

CYP7A1-rs3808607 and APOE isoform associate with LDL cholesterol lowering after plant sterol consumption in a randomized clinical trial.
MacKay DS, Eck PK, Gebauer SK, Baer DJ, Jones PJ
Am J Clin Nutr 2015 Oct;102(4):951-7. Epub 2015 Sep 2 doi: 10.3945/ajcn.115.109231. PMID: 26333513
Acute dyslipoproteinemia induced by interleukin-2: lecithin:cholesteryl acyltransferase, lipoprotein lipase, and hepatic lipase deficiencies.
Kwong LK, Ridinger DN, Bandhauer M, Ward JH, Samlowski WE, Iverius PH, Pritchard H, Wilson DE
J Clin Endocrinol Metab 1997 May;82(5):1572-81. doi: 10.1210/jcem.82.5.3937. PMID: 9141552
Decreased HDL2 and HDL3 cholesterol, Apo A-I and Apo A-II, and increased risk of myocardial infarction.
Buring JE, O'Connor GT, Goldhaber SZ, Rosner B, Herbert PN, Blum CB, Breslow JL, Hennekens CH
Circulation 1992 Jan;85(1):22-9. doi: 10.1161/01.cir.85.1.22. PMID: 1728453

Clinical prediction guides

GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling.
Lin YF, Li MH, Huang RH, Zhang SZ, Xu XF, Zhou HM, Liu MH, Liao XX, Liao LZ, Guo Y, Zhuang XD
Int J Cardiol 2023 Sep 15;387:131109. Epub 2023 Jun 2 doi: 10.1016/j.ijcard.2023.05.059. PMID: 37271284
Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review.
Oscarsson J, Hurt-Camejo E
Lipids Health Dis 2017 Aug 10;16(1):149. doi: 10.1186/s12944-017-0541-3. PMID: 28797250Free PMC Article
Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance.
Liao D, Tan H, Hui R, Li Z, Jiang X, Gaubatz J, Yang F, Durante W, Chan L, Schafer AI, Pownall HJ, Yang X, Wang H
Circ Res 2006 Sep 15;99(6):598-606. Epub 2006 Aug 24 doi: 10.1161/01.RES.0000242559.42077.22. PMID: 16931800Free PMC Article
Circulating triacylglycerol and apoE levels in response to EPA and docosahexaenoic acid supplementation in adult human subjects.
Buckley R, Shewring B, Turner R, Yaqoob P, Minihane AM
Br J Nutr 2004 Sep;92(3):477-83. doi: 10.1079/bjn20041235. PMID: 15469651
Decreased HDL2 and HDL3 cholesterol, Apo A-I and Apo A-II, and increased risk of myocardial infarction.
Buring JE, O'Connor GT, Goldhaber SZ, Rosner B, Herbert PN, Blum CB, Breslow JL, Hennekens CH
Circulation 1992 Jan;85(1):22-9. doi: 10.1161/01.cir.85.1.22. PMID: 1728453

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