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Decreased circulating apolipoprotein concentration

MedGen UID:
1788103
•Concept ID:
C5539611
•
Finding
Synonym: Decreased apolipoprotein level
 
HPO: HP:0033459

Definition

Reduced concentration in the blood circulation of a lipid-transport protein (apoliprotein). [from HPO]

Professional guidelines

PubMed

Apolipoprotein(a) Antisense Oligonucleotides: A New Treatment Option for Lowering Elevated Lipoprotein(a)?
Schreml J, Gouni-Berthold I
Curr Pharm Des 2017;23(10):1562-1570. doi: 10.2174/1381612823666170125160108. PMID: 28128058
Lipoprotein(a) Management: Pharmacological and Apheretic Treatment.
Hanssen R, Gouni-Berthold I
Curr Med Chem 2017;24(10):957-968. doi: 10.2174/0929867324666170112110928. PMID: 28078998
Is there a role for estrogen replacement therapy in the prevention and treatment of dementia?
Birge SJ
J Am Geriatr Soc 1996 Jul;44(7):865-70. doi: 10.1111/j.1532-5415.1996.tb03749.x. PMID: 8675940

Recent clinical studies

Etiology

GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling.
Lin YF, Li MH, Huang RH, Zhang SZ, Xu XF, Zhou HM, Liu MH, Liao XX, Liao LZ, Guo Y, Zhuang XD
Int J Cardiol 2023 Sep 15;387:131109. Epub 2023 Jun 2 doi: 10.1016/j.ijcard.2023.05.059. PMID: 37271284
Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
Dietary fructose and dyslipidemia: new mechanisms involving apolipoprotein CIII.
Hieronimus B, Stanhope KL
Curr Opin Lipidol 2020 Feb;31(1):20-26. doi: 10.1097/MOL.0000000000000653. PMID: 31789670Free PMC Article
Meta-Analysis of Randomized Controlled Trials of Red Meat Consumption in Comparison With Various Comparison Diets on Cardiovascular Risk Factors.
Guasch-Ferré M, Satija A, Blondin SA, Janiszewski M, Emlen E, O'Connor LE, Campbell WW, Hu FB, Willett WC, Stampfer MJ
Circulation 2019 Apr 9;139(15):1828-1845. doi: 10.1161/CIRCULATIONAHA.118.035225. PMID: 30958719
HDL genetic defects.
Nair DR, Nair A, Jain A
Curr Pharm Des 2014;20(40):6230-7. doi: 10.2174/1381612820666140620122412. PMID: 24953397

Diagnosis

Novel Insights into the Role of HDL-Associated Sphingosine-1-Phosphate in Cardiometabolic Diseases.
Diarte-Añazco EMG, Méndez-Lara KA, Pérez A, Alonso N, Blanco-Vaca F, Julve J
Int J Mol Sci 2019 Dec 12;20(24) doi: 10.3390/ijms20246273. PMID: 31842389Free PMC Article
Meta-Analysis of Randomized Controlled Trials of Red Meat Consumption in Comparison With Various Comparison Diets on Cardiovascular Risk Factors.
Guasch-Ferré M, Satija A, Blondin SA, Janiszewski M, Emlen E, O'Connor LE, Campbell WW, Hu FB, Willett WC, Stampfer MJ
Circulation 2019 Apr 9;139(15):1828-1845. doi: 10.1161/CIRCULATIONAHA.118.035225. PMID: 30958719
A proteomic approach to identify novel disease biomarkers in LCAT deficiency.
Simonelli S, Ossoli A, Banfi C, Pavanello C, Calabresi L, Gianazza E
J Proteomics 2019 Apr 30;198:113-118. Epub 2018 Dec 6 doi: 10.1016/j.jprot.2018.12.005. PMID: 30529744
Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study.
Jadoon KA, Ratcliffe SH, Barrett DA, Thomas EL, Stott C, Bell JD, O'Sullivan SE, Tan GD
Diabetes Care 2016 Oct;39(10):1777-86. Epub 2016 Aug 29 doi: 10.2337/dc16-0650. PMID: 27573936
The relationship between high density lipoprotein subclass profile and apolipoprotein concentrations.
Tian L, Fu M
J Endocrinol Invest 2011 Jun;34(6):461-72. doi: 10.1007/BF03346714. PMID: 21747218

Therapy

GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling.
Lin YF, Li MH, Huang RH, Zhang SZ, Xu XF, Zhou HM, Liu MH, Liao XX, Liao LZ, Guo Y, Zhuang XD
Int J Cardiol 2023 Sep 15;387:131109. Epub 2023 Jun 2 doi: 10.1016/j.ijcard.2023.05.059. PMID: 37271284
Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
Atherogenic Lipoproteins for the Statin Residual Cardiovascular Disease Risk.
Yanai H, Adachi H, Hakoshima M, Katsuyama H
Int J Mol Sci 2022 Nov 4;23(21) doi: 10.3390/ijms232113499. PMID: 36362288Free PMC Article
Dietary fructose and dyslipidemia: new mechanisms involving apolipoprotein CIII.
Hieronimus B, Stanhope KL
Curr Opin Lipidol 2020 Feb;31(1):20-26. doi: 10.1097/MOL.0000000000000653. PMID: 31789670Free PMC Article
Meta-Analysis of Randomized Controlled Trials of Red Meat Consumption in Comparison With Various Comparison Diets on Cardiovascular Risk Factors.
Guasch-Ferré M, Satija A, Blondin SA, Janiszewski M, Emlen E, O'Connor LE, Campbell WW, Hu FB, Willett WC, Stampfer MJ
Circulation 2019 Apr 9;139(15):1828-1845. doi: 10.1161/CIRCULATIONAHA.118.035225. PMID: 30958719

Prognosis

Systemic Metabolic Signatures of Oral Diseases.
Salminen A, Määttä AM, Mäntylä P, Leskelä J, Pietiäinen M, Buhlin K, Suominen AL, Paju S, Sattler W, Sinisalo J, Pussinen PJ
J Dent Res 2024 Jan;103(1):13-21. Epub 2023 Nov 15 doi: 10.1177/00220345231203562. PMID: 37968796Free PMC Article
Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
A proteomic approach to identify novel disease biomarkers in LCAT deficiency.
Simonelli S, Ossoli A, Banfi C, Pavanello C, Calabresi L, Gianazza E
J Proteomics 2019 Apr 30;198:113-118. Epub 2018 Dec 6 doi: 10.1016/j.jprot.2018.12.005. PMID: 30529744
Increased concentration of clusterin/apolipoprotein J (apoJ) in hyperlipemic serum is paradoxically associated with decreased apoJ content in lipoproteins.
Rull A, Martínez-Bujidos M, Pérez-Cuellar M, Pérez A, Ordóñez-Llanos J, Sánchez-Quesada JL
Atherosclerosis 2015 Aug;241(2):463-70. Epub 2015 Jun 6 doi: 10.1016/j.atherosclerosis.2015.06.003. PMID: 26081122
Thematic review series: The immune system and atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease?
Chait A, Han CY, Oram JF, Heinecke JW
J Lipid Res 2005 Mar;46(3):389-403. Epub 2005 Feb 1 doi: 10.1194/jlr.R400017-JLR200. PMID: 15722558

Clinical prediction guides

Systemic Metabolic Signatures of Oral Diseases.
Salminen A, Määttä AM, Mäntylä P, Leskelä J, Pietiäinen M, Buhlin K, Suominen AL, Paju S, Sattler W, Sinisalo J, Pussinen PJ
J Dent Res 2024 Jan;103(1):13-21. Epub 2023 Nov 15 doi: 10.1177/00220345231203562. PMID: 37968796Free PMC Article
GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling.
Lin YF, Li MH, Huang RH, Zhang SZ, Xu XF, Zhou HM, Liu MH, Liao XX, Liao LZ, Guo Y, Zhuang XD
Int J Cardiol 2023 Sep 15;387:131109. Epub 2023 Jun 2 doi: 10.1016/j.ijcard.2023.05.059. PMID: 37271284
Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation.
Silbernagel G, Chen YQ, Rief M, Kleber ME, Hoffmann MM, Stojakovic T, Stang A, Sarzynski MA, Bouchard C, März W, Qian YW, Scharnagl H, Konrad RJ
Eur Heart J 2023 Jul 1;44(25):2335-2345. doi: 10.1093/eurheartj/ehad261. PMID: 37155355
Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
Dietary fructose and dyslipidemia: new mechanisms involving apolipoprotein CIII.
Hieronimus B, Stanhope KL
Curr Opin Lipidol 2020 Feb;31(1):20-26. doi: 10.1097/MOL.0000000000000653. PMID: 31789670Free PMC Article

Recent systematic reviews

Meta-Analysis of Randomized Controlled Trials of Red Meat Consumption in Comparison With Various Comparison Diets on Cardiovascular Risk Factors.
Guasch-Ferré M, Satija A, Blondin SA, Janiszewski M, Emlen E, O'Connor LE, Campbell WW, Hu FB, Willett WC, Stampfer MJ
Circulation 2019 Apr 9;139(15):1828-1845. doi: 10.1161/CIRCULATIONAHA.118.035225. PMID: 30958719
Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials.
Sahebkar A, Simental-Mendía LE, Mikhailidis DP, Pirro M, Banach M, Sirtori CR, Ruscica M, Reiner Ž
J Clin Lipidol 2018 May-Jun;12(3):801-809. Epub 2018 Feb 1 doi: 10.1016/j.jacl.2018.01.008. PMID: 29580713

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