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Decreased circulating apolipoprotein concentration

MedGen UID:
1788103
•Concept ID:
C5539611
•
Finding
Synonym: Decreased apolipoprotein level
 
HPO: HP:0033459

Definition

Reduced concentration in the blood circulation of a lipid-transport protein (apoliprotein). [from HPO]

Professional guidelines

PubMed

Apolipoprotein(a) Antisense Oligonucleotides: A New Treatment Option for Lowering Elevated Lipoprotein(a)?
Schreml J, Gouni-Berthold I
Curr Pharm Des 2017;23(10):1562-1570. doi: 10.2174/1381612823666170125160108. PMID: 28128058
Lipoprotein(a) Management: Pharmacological and Apheretic Treatment.
Hanssen R, Gouni-Berthold I
Curr Med Chem 2017;24(10):957-968. doi: 10.2174/0929867324666170112110928. PMID: 28078998
Is there a role for estrogen replacement therapy in the prevention and treatment of dementia?
Birge SJ
J Am Geriatr Soc 1996 Jul;44(7):865-70. doi: 10.1111/j.1532-5415.1996.tb03749.x. PMID: 8675940

Recent clinical studies

Etiology

Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
Atherogenic Lipoproteins for the Statin Residual Cardiovascular Disease Risk.
Yanai H, Adachi H, Hakoshima M, Katsuyama H
Int J Mol Sci 2022 Nov 4;23(21) doi: 10.3390/ijms232113499. PMID: 36362288Free PMC Article
Albumin and fibrinogen kinetics in sepsis: a prospective observational study.
Omiya K, Sato H, Sato T, Wykes L, Hong M, Hatzakorzian R, Kristof AS, Schricker T
Crit Care 2021 Dec 17;25(1):436. doi: 10.1186/s13054-021-03860-7. PMID: 34920728Free PMC Article
Meta-Analysis of Randomized Controlled Trials of Red Meat Consumption in Comparison With Various Comparison Diets on Cardiovascular Risk Factors.
Guasch-Ferré M, Satija A, Blondin SA, Janiszewski M, Emlen E, O'Connor LE, Campbell WW, Hu FB, Willett WC, Stampfer MJ
Circulation 2019 Apr 9;139(15):1828-1845. doi: 10.1161/CIRCULATIONAHA.118.035225. PMID: 30958719
Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study.
Jadoon KA, Ratcliffe SH, Barrett DA, Thomas EL, Stott C, Bell JD, O'Sullivan SE, Tan GD
Diabetes Care 2016 Oct;39(10):1777-86. Epub 2016 Aug 29 doi: 10.2337/dc16-0650. PMID: 27573936

Diagnosis

Novel Insights into the Role of HDL-Associated Sphingosine-1-Phosphate in Cardiometabolic Diseases.
Diarte-Añazco EMG, Méndez-Lara KA, Pérez A, Alonso N, Blanco-Vaca F, Julve J
Int J Mol Sci 2019 Dec 12;20(24) doi: 10.3390/ijms20246273. PMID: 31842389Free PMC Article
Meta-Analysis of Randomized Controlled Trials of Red Meat Consumption in Comparison With Various Comparison Diets on Cardiovascular Risk Factors.
Guasch-Ferré M, Satija A, Blondin SA, Janiszewski M, Emlen E, O'Connor LE, Campbell WW, Hu FB, Willett WC, Stampfer MJ
Circulation 2019 Apr 9;139(15):1828-1845. doi: 10.1161/CIRCULATIONAHA.118.035225. PMID: 30958719
A proteomic approach to identify novel disease biomarkers in LCAT deficiency.
Simonelli S, Ossoli A, Banfi C, Pavanello C, Calabresi L, Gianazza E
J Proteomics 2019 Apr 30;198:113-118. Epub 2018 Dec 6 doi: 10.1016/j.jprot.2018.12.005. PMID: 30529744
Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study.
Jadoon KA, Ratcliffe SH, Barrett DA, Thomas EL, Stott C, Bell JD, O'Sullivan SE, Tan GD
Diabetes Care 2016 Oct;39(10):1777-86. Epub 2016 Aug 29 doi: 10.2337/dc16-0650. PMID: 27573936
The relationship between high density lipoprotein subclass profile and apolipoprotein concentrations.
Tian L, Fu M
J Endocrinol Invest 2011 Jun;34(6):461-72. doi: 10.1007/BF03346714. PMID: 21747218

Therapy

Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
Atherogenic Lipoproteins for the Statin Residual Cardiovascular Disease Risk.
Yanai H, Adachi H, Hakoshima M, Katsuyama H
Int J Mol Sci 2022 Nov 4;23(21) doi: 10.3390/ijms232113499. PMID: 36362288Free PMC Article
Dietary fructose and dyslipidemia: new mechanisms involving apolipoprotein CIII.
Hieronimus B, Stanhope KL
Curr Opin Lipidol 2020 Feb;31(1):20-26. doi: 10.1097/MOL.0000000000000653. PMID: 31789670Free PMC Article
Meta-Analysis of Randomized Controlled Trials of Red Meat Consumption in Comparison With Various Comparison Diets on Cardiovascular Risk Factors.
Guasch-Ferré M, Satija A, Blondin SA, Janiszewski M, Emlen E, O'Connor LE, Campbell WW, Hu FB, Willett WC, Stampfer MJ
Circulation 2019 Apr 9;139(15):1828-1845. doi: 10.1161/CIRCULATIONAHA.118.035225. PMID: 30958719
Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study.
Jadoon KA, Ratcliffe SH, Barrett DA, Thomas EL, Stott C, Bell JD, O'Sullivan SE, Tan GD
Diabetes Care 2016 Oct;39(10):1777-86. Epub 2016 Aug 29 doi: 10.2337/dc16-0650. PMID: 27573936

Prognosis

Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
A proteomic approach to identify novel disease biomarkers in LCAT deficiency.
Simonelli S, Ossoli A, Banfi C, Pavanello C, Calabresi L, Gianazza E
J Proteomics 2019 Apr 30;198:113-118. Epub 2018 Dec 6 doi: 10.1016/j.jprot.2018.12.005. PMID: 30529744
Increased concentration of clusterin/apolipoprotein J (apoJ) in hyperlipemic serum is paradoxically associated with decreased apoJ content in lipoproteins.
Rull A, Martínez-Bujidos M, Pérez-Cuellar M, Pérez A, Ordóñez-Llanos J, Sánchez-Quesada JL
Atherosclerosis 2015 Aug;241(2):463-70. Epub 2015 Jun 6 doi: 10.1016/j.atherosclerosis.2015.06.003. PMID: 26081122
Thematic review series: The immune system and atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease?
Chait A, Han CY, Oram JF, Heinecke JW
J Lipid Res 2005 Mar;46(3):389-403. Epub 2005 Feb 1 doi: 10.1194/jlr.R400017-JLR200. PMID: 15722558
Decreased HDL2 and HDL3 cholesterol, Apo A-I and Apo A-II, and increased risk of myocardial infarction.
Buring JE, O'Connor GT, Goldhaber SZ, Rosner B, Herbert PN, Blum CB, Breslow JL, Hennekens CH
Circulation 1992 Jan;85(1):22-9. doi: 10.1161/01.cir.85.1.22. PMID: 1728453

Clinical prediction guides

Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
Attenuation of obesity-induced hyperlipidemia reduces tumor growth.
Hussain A, Lian J, Watts R, Gutiérrez T, Nelson R, Goping IS, Lehner R
Biochim Biophys Acta Mol Cell Biol Lipids 2022 Apr;1867(4):159124. Epub 2022 Feb 9 doi: 10.1016/j.bbalip.2022.159124. PMID: 35150894
Albumin and fibrinogen kinetics in sepsis: a prospective observational study.
Omiya K, Sato H, Sato T, Wykes L, Hong M, Hatzakorzian R, Kristof AS, Schricker T
Crit Care 2021 Dec 17;25(1):436. doi: 10.1186/s13054-021-03860-7. PMID: 34920728Free PMC Article
Dietary fructose and dyslipidemia: new mechanisms involving apolipoprotein CIII.
Hieronimus B, Stanhope KL
Curr Opin Lipidol 2020 Feb;31(1):20-26. doi: 10.1097/MOL.0000000000000653. PMID: 31789670Free PMC Article
Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review.
Oscarsson J, Hurt-Camejo E
Lipids Health Dis 2017 Aug 10;16(1):149. doi: 10.1186/s12944-017-0541-3. PMID: 28797250Free PMC Article

Recent systematic reviews

Meta-Analysis of Randomized Controlled Trials of Red Meat Consumption in Comparison With Various Comparison Diets on Cardiovascular Risk Factors.
Guasch-Ferré M, Satija A, Blondin SA, Janiszewski M, Emlen E, O'Connor LE, Campbell WW, Hu FB, Willett WC, Stampfer MJ
Circulation 2019 Apr 9;139(15):1828-1845. doi: 10.1161/CIRCULATIONAHA.118.035225. PMID: 30958719
Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials.
Sahebkar A, Simental-Mendía LE, Mikhailidis DP, Pirro M, Banach M, Sirtori CR, Ruscica M, Reiner Ž
J Clin Lipidol 2018 May-Jun;12(3):801-809. Epub 2018 Feb 1 doi: 10.1016/j.jacl.2018.01.008. PMID: 29580713

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