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Decreased circulating apolipoprotein concentration

MedGen UID:
1788103
•Concept ID:
C5539611
•
Finding
Synonym: Decreased apolipoprotein level
 
HPO: HP:0033459

Definition

Reduced concentration in the blood circulation of a lipid-transport protein (apoliprotein). [from HPO]

Professional guidelines

PubMed

Apolipoprotein(a) Antisense Oligonucleotides: A New Treatment Option for Lowering Elevated Lipoprotein(a)?
Schreml J, Gouni-Berthold I
Curr Pharm Des 2017;23(10):1562-1570. doi: 10.2174/1381612823666170125160108. PMID: 28128058
Lipoprotein(a) Management: Pharmacological and Apheretic Treatment.
Hanssen R, Gouni-Berthold I
Curr Med Chem 2017;24(10):957-968. doi: 10.2174/0929867324666170112110928. PMID: 28078998
Is there a role for estrogen replacement therapy in the prevention and treatment of dementia?
Birge SJ
J Am Geriatr Soc 1996 Jul;44(7):865-70. doi: 10.1111/j.1532-5415.1996.tb03749.x. PMID: 8675940

Recent clinical studies

Etiology

Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials.
Sahebkar A, Simental-Mendía LE, Mikhailidis DP, Pirro M, Banach M, Sirtori CR, Ruscica M, Reiner Ž
J Clin Lipidol 2018 May-Jun;12(3):801-809. Epub 2018 Feb 1 doi: 10.1016/j.jacl.2018.01.008. PMID: 29580713
HDL genetic defects.
Nair DR, Nair A, Jain A
Curr Pharm Des 2014;20(40):6230-7. doi: 10.2174/1381612820666140620122412. PMID: 24953397
Clinical significance of lipoprotein size and risk for coronary atherosclerosis.
Roheim PS, Asztalos BF
Clin Chem 1995 Jan;41(1):147-52. PMID: 7813070
Importance of apolipoproteins in lipid metabolism.
Cham BE
Chem Biol Interact 1978 Mar;20(3):263-77. doi: 10.1016/0009-2797(78)90105-9. PMID: 207449

Diagnosis

Causal associations between insulin and Lp(a) levels in Caucasian population: a Mendelian randomization study.
Lejawa M, Goławski M, Fronczek M, Osadnik T, Paneni F, Ruscica M, Pawlas N, Lisik M, Banach M
Cardiovasc Diabetol 2024 Aug 29;23(1):316. doi: 10.1186/s12933-024-02389-7. PMID: 39210428Free PMC Article
Whole-Blood Levels of MicroRNA-9 Are Decreased in Patients With Late-Onset Alzheimer Disease.
Souza VC, Morais GS Jr, Henriques AD, Machado-Silva W, Perez DIV, Brito CJ, Camargos EF, Moraes CF, Nóbrega OT
Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520911573. doi: 10.1177/1533317520911573. PMID: 32301334Free PMC Article
Novel Insights into the Role of HDL-Associated Sphingosine-1-Phosphate in Cardiometabolic Diseases.
Diarte-Añazco EMG, Méndez-Lara KA, Pérez A, Alonso N, Blanco-Vaca F, Julve J
Int J Mol Sci 2019 Dec 12;20(24) doi: 10.3390/ijms20246273. PMID: 31842389Free PMC Article
Meta-Analysis of Randomized Controlled Trials of Red Meat Consumption in Comparison With Various Comparison Diets on Cardiovascular Risk Factors.
Guasch-Ferré M, Satija A, Blondin SA, Janiszewski M, Emlen E, O'Connor LE, Campbell WW, Hu FB, Willett WC, Stampfer MJ
Circulation 2019 Apr 9;139(15):1828-1845. doi: 10.1161/CIRCULATIONAHA.118.035225. PMID: 30958719
Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials.
Sahebkar A, Simental-Mendía LE, Mikhailidis DP, Pirro M, Banach M, Sirtori CR, Ruscica M, Reiner Ž
J Clin Lipidol 2018 May-Jun;12(3):801-809. Epub 2018 Feb 1 doi: 10.1016/j.jacl.2018.01.008. PMID: 29580713

Therapy

Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
Pegylation of high-density lipoprotein decreases plasma clearance and enhances antiatherogenic activity.
Murphy AJ, Funt S, Gorman D, Tall AR, Wang N
Circ Res 2013 Jun 21;113(1):e1-e9. Epub 2013 Apr 23 doi: 10.1161/CIRCRESAHA.113.301112. PMID: 23613182Free PMC Article
Lack of significant effects of methionine loading on endothelial function in elderly volunteers.
Hart SR, Mangoni AA, Swift CG, Jackson SH
Heart Lung Circ 2006 Dec;15(6):358-61. Epub 2006 Oct 12 doi: 10.1016/j.hlc.2006.08.001. PMID: 17046324
Mechanism of action of fibrates on lipid and lipoprotein metabolism.
Staels B, Dallongeville J, Auwerx J, Schoonjans K, Leitersdorf E, Fruchart JC
Circulation 1998 Nov 10;98(19):2088-93. doi: 10.1161/01.cir.98.19.2088. PMID: 9808609
The effects of insulin on plasma mevalonate concentrations in man.
Lala A, Scoppola A, Ricci A, Frontoni S, Gambardella S, Menzinger G
Ann Nutr Metab 1994;38(5):257-62. doi: 10.1159/000177819. PMID: 7710260

Prognosis

Causal associations between insulin and Lp(a) levels in Caucasian population: a Mendelian randomization study.
Lejawa M, Goławski M, Fronczek M, Osadnik T, Paneni F, Ruscica M, Pawlas N, Lisik M, Banach M
Cardiovasc Diabetol 2024 Aug 29;23(1):316. doi: 10.1186/s12933-024-02389-7. PMID: 39210428Free PMC Article
Systemic Metabolic Signatures of Oral Diseases.
Salminen A, Määttä AM, Mäntylä P, Leskelä J, Pietiäinen M, Buhlin K, Suominen AL, Paju S, Sattler W, Sinisalo J, Pussinen PJ
J Dent Res 2024 Jan;103(1):13-21. Epub 2023 Nov 15 doi: 10.1177/00220345231203562. PMID: 37968796Free PMC Article
Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease.
Levin MG, Zuber V, Walker VM, Klarin D, Lynch J, Malik R, Aday AW, Bottolo L, Pradhan AD, Dichgans M, Chang KM, Rader DJ, Tsao PS, Voight BF, Gill D, Burgess S, Damrauer SM
Circulation 2021 Aug 3;144(5):353-364. Epub 2021 Jun 18 doi: 10.1161/CIRCULATIONAHA.121.053797. PMID: 34139859Free PMC Article
Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle.
Pulawa LK, Jensen DR, Coates A, Eckel RH
J Lipid Res 2007 Jan;48(1):145-51. Epub 2006 Oct 3 doi: 10.1194/jlr.M600384-JLR200. PMID: 17018885

Clinical prediction guides

Systemic Metabolic Signatures of Oral Diseases.
Salminen A, Määttä AM, Mäntylä P, Leskelä J, Pietiäinen M, Buhlin K, Suominen AL, Paju S, Sattler W, Sinisalo J, Pussinen PJ
J Dent Res 2024 Jan;103(1):13-21. Epub 2023 Nov 15 doi: 10.1177/00220345231203562. PMID: 37968796Free PMC Article
Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle.
Pulawa LK, Jensen DR, Coates A, Eckel RH
J Lipid Res 2007 Jan;48(1):145-51. Epub 2006 Oct 3 doi: 10.1194/jlr.M600384-JLR200. PMID: 17018885
Heparin extracorporeal LDL precipitation (HELP): an effective apheresis procedure for lowering Lp(a) levels.
Armstrong VW, Schuff-Werner P, Eisenhauer T, Helmhold M, Stix M, Seidel D
Chem Phys Lipids 1994 Jan;67-68:315-21. doi: 10.1016/0009-3084(94)90152-x. PMID: 8187229
Alterations of rat hepatic cholesterogenesis by heterologous lipoproteins.
Jakoi L, Quarfordt SH
J Biol Chem 1977 Oct 10;252(19):6856-60. PMID: 197106

Recent systematic reviews

Meta-Analysis of Randomized Controlled Trials of Red Meat Consumption in Comparison With Various Comparison Diets on Cardiovascular Risk Factors.
Guasch-Ferré M, Satija A, Blondin SA, Janiszewski M, Emlen E, O'Connor LE, Campbell WW, Hu FB, Willett WC, Stampfer MJ
Circulation 2019 Apr 9;139(15):1828-1845. doi: 10.1161/CIRCULATIONAHA.118.035225. PMID: 30958719
Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials.
Sahebkar A, Simental-Mendía LE, Mikhailidis DP, Pirro M, Banach M, Sirtori CR, Ruscica M, Reiner Ž
J Clin Lipidol 2018 May-Jun;12(3):801-809. Epub 2018 Feb 1 doi: 10.1016/j.jacl.2018.01.008. PMID: 29580713

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