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Abnormal circulating coenzyme concentration

MedGen UID:: 1841701
•Concept ID:: C5826527
•: Finding

HPO:	HP:0034616

Definition

Concentration of a coenzyme (an organic molecule that binds to the active sites of an enzyme to promote the catalysis of a reaction) is above or below the limits of normal. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal circulating coenzyme concentration

Phenotypic abnormality
- Abnormality of metabolism/homeostasis
  - Abnormal circulating metabolite concentration
    - Abnormal circulating organic compound concentration
      - Abnormal circulating coenzyme concentration
        Elevated circulating S-adenosyl methionine concentration

Professional guidelines

PubMed

Reconstituted HDL (Milano) Treatment Efficaciously Reverses Heart Failure with Preserved Ejection Fraction in Mice.

Mishra M, Muthuramu I, Aboumsallem JP, Kempen H, De Geest B
Int J Mol Sci 2018 Oct 30;19(11) doi: 10.3390/ijms19113399. PMID: 30380754 Free PMC Article

Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism.

Christensen MH, Pedersen EK, Nordbø Y, Varhaug JE, Midttun Ø, Ueland PM, Nygård OK, Mellgren G, Lien EA
J Intern Med 2012 Dec;272(6):583-91. Epub 2012 Aug 5 doi: 10.1111/j.1365-2796.2012.02570.x. PMID: 22757621

Liver involvement in human schistosomiasis mansoni. Regression of immunological and biochemical disease markers after specific treatment.

Zwingenberger K, Harms G, Feldmeier H, Müller O, Steiner A, Bienzle U
Acta Trop 1988 Sep;45(3):263-75. PMID: 2903628

See all (3)

Recent clinical studies

Etiology

Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?

Obeid R, Holzgreve W, Pietrzik K
J Perinat Med 2013 Sep 1;41(5):469-83. doi: 10.1515/jpm-2012-0256. PMID: 23482308

The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome.

Manning PJ, Sutherland WH, Williams SM, Walker RJ, Berry EA, De Jong SA, Ryalls AR
Nutr Metab Cardiovasc Dis 2013 Jun;23(6):543-9. Epub 2012 Mar 7 doi: 10.1016/j.numecd.2011.11.006. PMID: 22402059

Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism.

Cytokine network and acute primary HIV-1 infection.

Sinicco A, Biglino A, Sciandra M, Forno B, Pollono AM, Raiteri R, Gioannini P
AIDS 1993 Sep;7(9):1167-72. doi: 10.1097/00002030-199309000-00003. PMID: 8216972

Abnormal regulation of plasma pyridoxal 5'-phosphate in patients with liver disease.

Mitchell D, Wagner C, Stone WJ, Wilkinson GR, Schenker S
Gastroenterology 1976 Dec;71(6):1043-9. PMID: 992265

See all (10)

Diagnosis

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.

Bedi KC Jr, Snyder NW, Brandimarto J, Aziz M, Mesaros C, Worth AJ, Wang LL, Javaheri A, Blair IA, Margulies KB, Rame JE
Circulation 2016 Feb 23;133(8):706-16. Epub 2016 Jan 27 doi: 10.1161/CIRCULATIONAHA.115.017545. PMID: 26819374 Free PMC Article

Rapid effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition on coronary endothelial function.

Wassmann S, Faul A, Hennen B, Scheller B, Böhm M, Nickenig G
Circ Res 2003 Oct 31;93(9):e98-103. Epub 2003 Oct 9 doi: 10.1161/01.RES.0000099503.13312.7B. PMID: 14551237

Plasma concentrations of coenzyme Q10 and tocopherols in cervical intraepithelial neoplasia and cervical cancer.

Palan PR, Mikhail MS, Shaban DW, Romney SL
Eur J Cancer Prev 2003 Aug;12(4):321-6. doi: 10.1097/00008469-200308000-00013. PMID: 12883386

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

Prentki M, Corkey BE
Diabetes 1996 Mar;45(3):273-83. doi: 10.2337/diab.45.3.273. PMID: 8593930

Reappearance of beriberi heart disease in Japan. A study of 23 cases.

Kawai C, Wakabayashi A, Matsumura T, Yui Y
Am J Med 1980 Sep;69(3):383-6. doi: 10.1016/0002-9343(80)90008-x. PMID: 7416185

See all (6)

Therapy

Hypophosphatasia in Adults: Clinical Spectrum and Its Association With Genetics and Metabolic Substrates.

Lefever E, Witters P, Gielen E, Vanclooster A, Meersseman W, Morava E, Cassiman D, Laurent MR
J Clin Densitom 2020 Jul-Sep;23(3):340-348. Epub 2018 Dec 21 doi: 10.1016/j.jocd.2018.12.006. PMID: 30655187

Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?

Obeid R, Holzgreve W, Pietrzik K
J Perinat Med 2013 Sep 1;41(5):469-83. doi: 10.1515/jpm-2012-0256. PMID: 23482308

The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome.

Manning PJ, Sutherland WH, Williams SM, Walker RJ, Berry EA, De Jong SA, Ryalls AR
Nutr Metab Cardiovasc Dis 2013 Jun;23(6):543-9. Epub 2012 Mar 7 doi: 10.1016/j.numecd.2011.11.006. PMID: 22402059

Blood glucose and lipid control as risk factors in the progression of renal damage in type 2 diabetes.

Nosadini R, Tonolo G
J Nephrol 2003 Nov-Dec;16 Suppl 7:S42-7. PMID: 14733300

Increased thromboxane biosynthesis in type IIa hypercholesterolemia.

Davì G, Averna M, Catalano I, Barbagallo C, Ganci A, Notarbartolo A, Ciabattoni G, Patrono C
Circulation 1992 May;85(5):1792-8. doi: 10.1161/01.cir.85.5.1792. PMID: 1572035

See all (12)

Prognosis

Blood glucose and lipid control as risk factors in the progression of renal damage in type 2 diabetes.

Nosadini R, Tonolo G
J Nephrol 2003 Nov-Dec;16 Suppl 7:S42-7. PMID: 14733300

Plasma levels of the soluble fraction of tumor necrosis factor receptors 1 and 2 are independent determinants of plasma cholesterol and LDL-cholesterol concentrations in healthy subjects.

Fernández-Real JM, Gutiérrez C, Ricart W, Castiñeira MJ, Vendrell J, Richart C
Atherosclerosis 1999 Oct;146(2):321-7. doi: 10.1016/s0021-9150(99)00156-2. PMID: 10532687

Activated immune system in patients with Huntington's disease.

Leblhuber F, Walli J, Jellinger K, Tilz GP, Widner B, Laccone F, Fuchs D
Clin Chem Lab Med 1998 Oct;36(10):747-50. doi: 10.1515/CCLM.1998.132. PMID: 9853799

Cytokine network and acute primary HIV-1 infection.

Sinicco A, Biglino A, Sciandra M, Forno B, Pollono AM, Raiteri R, Gioannini P
AIDS 1993 Sep;7(9):1167-72. doi: 10.1097/00002030-199309000-00003. PMID: 8216972

See all (4)

Clinical prediction guides

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.

Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism.

Plasma concentrations of coenzyme Q10 and tocopherols in cervical intraepithelial neoplasia and cervical cancer.

Palan PR, Mikhail MS, Shaban DW, Romney SL
Eur J Cancer Prev 2003 Aug;12(4):321-6. doi: 10.1097/00008469-200308000-00013. PMID: 12883386

Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells.

Mu YM, Yanase T, Nishi Y, Tanaka A, Saito M, Jin CH, Mukasa C, Okabe T, Nomura M, Goto K, Nawata H
Endocrinology 2001 Aug;142(8):3590-7. doi: 10.1210/endo.142.8.8293. PMID: 11459807

Increased de novo hepatic lipogenesis in human immunodeficiency virus infection.

Hellerstein MK, Grunfeld C, Wu K, Christiansen M, Kaempfer S, Kletke C, Shackleton CH
J Clin Endocrinol Metab 1993 Mar;76(3):559-65. doi: 10.1210/jcem.76.3.8445011. PMID: 8445011

See all (6)

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Abnormal circulating coenzyme concentration

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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