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Elevated circulating S-adenosyl methionine concentration

MedGen UID:
1841833
•Concept ID:
C5826528
•
Finding
Synonym: S-adenosylmethionine high in blood
 
HPO: HP:0034617

Definition

Concentration of S-adenosyl methionine (SAM) in the blood circulation above the upper limit of normal. SAM is a cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating S-adenosyl methionine concentration

Professional guidelines

PubMed

Clinical and metabolic findings in patients with methionine adenosyltransferase I/III deficiency detected by newborn screening.
Couce ML, Bóveda MD, García-Jimémez C, Balmaseda E, Vives I, Castiñeiras DE, Fernández-Marmiesse A, Fraga JM, Mudd SH, Corrales FJ
Mol Genet Metab 2013 Nov;110(3):218-21. Epub 2013 Aug 14 doi: 10.1016/j.ymgme.2013.08.003. PMID: 23993429

Recent clinical studies

Etiology

Homocysteine, methylenetetrahydrofolate reductase, folate status and atherothrombosis: A mechanistic and clinical perspective.
Santilli F, Davì G, Patrono C
Vascul Pharmacol 2016 Mar;78:1-9. Epub 2015 Jun 22 doi: 10.1016/j.vph.2015.06.009. PMID: 26111718
Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease.
Kayacelebi AA, Willers J, Pham VV, Hahn A, Schneider JY, Rothmann S, Frölich JC, Tsikas D
Amino Acids 2015 Sep;47(9):1885-91. Epub 2015 Jan 25 doi: 10.1007/s00726-015-1915-3. PMID: 25618752
Clinical and metabolic findings in patients with methionine adenosyltransferase I/III deficiency detected by newborn screening.
Couce ML, Bóveda MD, García-Jimémez C, Balmaseda E, Vives I, Castiñeiras DE, Fernández-Marmiesse A, Fraga JM, Mudd SH, Corrales FJ
Mol Genet Metab 2013 Nov;110(3):218-21. Epub 2013 Aug 14 doi: 10.1016/j.ymgme.2013.08.003. PMID: 23993429
Metabolic consequences of hyperhomocysteinemia in uremia.
Perna AF, Ingrosso D, Satta E, Romano M, Cimmino A, Galletti P, Zappia V, De Santo NG
Am J Kidney Dis 2001 Oct;38(4 Suppl 1):S85-90. doi: 10.1053/ajkd.2001.27411. PMID: 11576929

Diagnosis

Clinical and metabolic findings in patients with methionine adenosyltransferase I/III deficiency detected by newborn screening.
Couce ML, Bóveda MD, García-Jimémez C, Balmaseda E, Vives I, Castiñeiras DE, Fernández-Marmiesse A, Fraga JM, Mudd SH, Corrales FJ
Mol Genet Metab 2013 Nov;110(3):218-21. Epub 2013 Aug 14 doi: 10.1016/j.ymgme.2013.08.003. PMID: 23993429

Therapy

Homocysteine, methylenetetrahydrofolate reductase, folate status and atherothrombosis: A mechanistic and clinical perspective.
Santilli F, Davì G, Patrono C
Vascul Pharmacol 2016 Mar;78:1-9. Epub 2015 Jun 22 doi: 10.1016/j.vph.2015.06.009. PMID: 26111718
Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease.
Kayacelebi AA, Willers J, Pham VV, Hahn A, Schneider JY, Rothmann S, Frölich JC, Tsikas D
Amino Acids 2015 Sep;47(9):1885-91. Epub 2015 Jan 25 doi: 10.1007/s00726-015-1915-3. PMID: 25618752

Prognosis

Homocysteine, methylenetetrahydrofolate reductase, folate status and atherothrombosis: A mechanistic and clinical perspective.
Santilli F, Davì G, Patrono C
Vascul Pharmacol 2016 Mar;78:1-9. Epub 2015 Jun 22 doi: 10.1016/j.vph.2015.06.009. PMID: 26111718
Clinical and metabolic findings in patients with methionine adenosyltransferase I/III deficiency detected by newborn screening.
Couce ML, Bóveda MD, García-Jimémez C, Balmaseda E, Vives I, Castiñeiras DE, Fernández-Marmiesse A, Fraga JM, Mudd SH, Corrales FJ
Mol Genet Metab 2013 Nov;110(3):218-21. Epub 2013 Aug 14 doi: 10.1016/j.ymgme.2013.08.003. PMID: 23993429

Clinical prediction guides

Homocysteine, methylenetetrahydrofolate reductase, folate status and atherothrombosis: A mechanistic and clinical perspective.
Santilli F, Davì G, Patrono C
Vascul Pharmacol 2016 Mar;78:1-9. Epub 2015 Jun 22 doi: 10.1016/j.vph.2015.06.009. PMID: 26111718

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