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Decreased urine guanidinoacetic acid level

MedGen UID:
1841797
•Concept ID:
C5826738
•
Finding
HPO: HP:0034888

Definition

The concentration of guanidinoacetic acid in the urine, normalized for urine concentration, is below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased urine guanidinoacetic acid level

Recent clinical studies

Etiology

Dietary guanidinoacetic acid increases brain creatine levels in healthy men.
Ostojic SM, Ostojic J, Drid P, Vranes M, Jovanov P
Nutrition 2017 Jan;33:149-156. Epub 2016 Jun 8 doi: 10.1016/j.nut.2016.06.001. PMID: 27497517

Diagnosis

Guanidinoacetate and creatine/creatinine levels in controls and patients with urea cycle defects.
Arias A, Garcia-Villoria J, Ribes A
Mol Genet Metab 2004 Jul;82(3):220-3. doi: 10.1016/j.ymgme.2004.04.009. PMID: 15234335
Effect of cisplatin treatment on the urinary excretion of guanidinoacetic acid, creatinine and creatine in patients with urinary tract neoplasm, and on superoxide generation in human neutrophils.
Yasuda M, Sugahara K, Zhang J, Shuin T, Kodama H
Physiol Chem Phys Med NMR 2000;32(2):119-25. PMID: 11383133
Plasma creatinine assessment in creatine deficiency: A diagnostic pitfall.
Verhoeven NM, Guérand WS, Struys EA, Bouman AA, van der Knaap MS, Jakobs C
J Inherit Metab Dis 2000 Dec;23(8):835-40. doi: 10.1023/a:1026764703486. PMID: 11196109
Guanidino compounds in serum and urine of nondialyzed patients with chronic renal insufficiency.
Marescau B, Nagels G, Possemiers I, De Broe ME, Becaus I, Billiouw JM, Lornoy W, De Deyn PP
Metabolism 1997 Sep;46(9):1024-31. doi: 10.1016/s0026-0495(97)90273-0. PMID: 9284891
Clinical test of renal guanidinoacetic acid metabolism by oral citrulline and creatine loading.
Kadono K, Yamaguchi T, Tetsutani T, Yasunaga K
Clin Chim Acta 1992 Jul 31;209(1-2):9-17. doi: 10.1016/0009-8981(92)90328-n. PMID: 1395042

Therapy

Dietary guanidinoacetic acid increases brain creatine levels in healthy men.
Ostojic SM, Ostojic J, Drid P, Vranes M, Jovanov P
Nutrition 2017 Jan;33:149-156. Epub 2016 Jun 8 doi: 10.1016/j.nut.2016.06.001. PMID: 27497517
Lean-seafood intake decreases urinary markers of mitochondrial lipid and energy metabolism in healthy subjects: Metabolomics results from a randomized crossover intervention study.
Schmedes M, Aadland EK, Sundekilde UK, Jacques H, Lavigne C, Graff IE, Eng Ø, Holthe A, Mellgren G, Young JF, Bertram HC, Liaset B, Clausen MR
Mol Nutr Food Res 2016 Jul;60(7):1661-72. Epub 2016 May 4 doi: 10.1002/mnfr.201500785. PMID: 26873789
Plasma guanidino compounds are altered by oral creatine supplementation in healthy humans.
Derave W, Marescau B, Vanden Eede E, Eijnde BO, De Deyn PP, Hespel P
J Appl Physiol (1985) 2004 Sep;97(3):852-7. Epub 2004 Apr 23 doi: 10.1152/japplphysiol.00206.2004. PMID: 15107411
Effect of cisplatin treatment on the urinary excretion of guanidinoacetic acid, creatinine and creatine in patients with urinary tract neoplasm, and on superoxide generation in human neutrophils.
Yasuda M, Sugahara K, Zhang J, Shuin T, Kodama H
Physiol Chem Phys Med NMR 2000;32(2):119-25. PMID: 11383133
Plasma concentration and urinary excretion of guanidine derivatives in normal subjects and patients with renal failure.
Sawynok J, Dawborn JK
Clin Exp Pharmacol Physiol 1975 Jan-Feb;2(1):1-15. doi: 10.1111/j.1440-1681.1975.tb02368.x. PMID: 1126056

Prognosis

Dietary guanidinoacetic acid increases brain creatine levels in healthy men.
Ostojic SM, Ostojic J, Drid P, Vranes M, Jovanov P
Nutrition 2017 Jan;33:149-156. Epub 2016 Jun 8 doi: 10.1016/j.nut.2016.06.001. PMID: 27497517

Clinical prediction guides

Biochemical validation of a rat model for polycystic kidney disease: comparison of guanidino compound profile with the human condition.
Torremans A, Marescau B, Kränzlin B, Gretz N, Billiouw JM, Vanholder R, De Smet R, Bouwman K, Brouns R, De Deyn PP
Kidney Int 2006 Jun;69(11):2003-12. doi: 10.1038/sj.ki.5000443. PMID: 16641922

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