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Elevated circulating DOPA concentration

MedGen UID:
1842027
•Concept ID:
C5826516
•
Finding
Synonyms: DOPA high in blood; Elevated circulating 3,4-dihydroxyphenylalanine concentration
 
HPO: HP:0034604

Definition

Concentration of DOPA (3,4-dihydroxyphenylalanine) in the blood circulation above the upper limit of normal. [from HPO]

Professional guidelines

PubMed

A technology evaluation of CVT-301 (Inbrija): an inhalable therapy for treatment of Parkinson's disease.
Lipp MM, Hickey AJ, Langer R, LeWitt PA
Expert Opin Drug Deliv 2021 Nov;18(11):1559-1569. Epub 2021 Sep 10 doi: 10.1080/17425247.2021.1960820. PMID: 34311641

Recent clinical studies

Etiology

A metabolomics study in aqueous humor discloses altered arginine metabolism in Parkinson's disease.
Serrano-Marín J, Marin S, Bernal-Casas D, Lillo A, González-Subías M, Navarro G, Cascante M, Sánchez-Navés J, Franco R
Fluids Barriers CNS 2023 Dec 4;20(1):90. doi: 10.1186/s12987-023-00494-5. PMID: 38049870Free PMC Article
Plasma catechols and monoamine oxidase metabolites in untreated Parkinson's and Alzheimer's diseases.
Ahlskog JE, Uitti RJ, Tyce GM, O'Brien JF, Petersen RC, Kokmen E
J Neurol Sci 1996 Mar;136(1-2):162-8. doi: 10.1016/0022-510x(95)00318-v. PMID: 8815165
Catecholamine metabolism in heart failure patients and healthy control subjects.
Lehmann M, Hasenfuss G, Samek L, Gastmann M
Arzneimittelforschung 1990 Dec;40(12):1310-8. PMID: 2095127
Distribution of catecholamines between fetal and maternal compartments during human pregnancy with emphasis on L-dopa and dopamine.
Peleg D, Munsick RA, Diker D, Goldman JA, Ben-Jonathan N
J Clin Endocrinol Metab 1986 May;62(5):911-4. doi: 10.1210/jcem-62-5-911. PMID: 3958127

Diagnosis

A metabolomics study in aqueous humor discloses altered arginine metabolism in Parkinson's disease.
Serrano-Marín J, Marin S, Bernal-Casas D, Lillo A, González-Subías M, Navarro G, Cascante M, Sánchez-Navés J, Franco R
Fluids Barriers CNS 2023 Dec 4;20(1):90. doi: 10.1186/s12987-023-00494-5. PMID: 38049870Free PMC Article
The broader view: catecholamine abnormalities.
Vincent S, Robertson D
Clin Auton Res 2002 May;12 Suppl 1:I44-9. doi: 10.1007/s102860200018. PMID: 12102462
Immunoreactive growth hormone-releasing hormone (IR-GHRH) in the feto-placental circulation and differential effects of L-dopa, L-arginine and somatostatin-14 on the plasma levels of IR-GHRH in normal adults.
Saito H, Hosoi E, Yamasaki R, Kameyama K, Irahara M, Ohno Y, Saito S
Horm Metab Res 1997 Apr;29(4):184-9. doi: 10.1055/s-2007-979018. PMID: 9178029
Disorders of prolactin and growth hormone secretion.
Ho KY, Evans WS, Thorner MO
Clin Endocrinol Metab 1985 Feb;14(1):1-32. doi: 10.1016/s0300-595x(85)80063-3. PMID: 3926353
DOPA metabolism in neuroblastoma.
Helson L, Johnson GA, Smith R
Med Pediatr Oncol 1980;8(4):317-22. doi: 10.1002/mpo.2950080402. PMID: 6779102

Therapy

New approaches to evaluate sympathoadrenal system activity in experiments on earth and in space.
Kvetnansky R, Noskov VB, Blazicek P, Macho L, Grigoriev AI, Goldstein DS, Kopin IJ
Acta Astronaut 1994 Oct;34:243-54. doi: 10.1016/0094-5765(94)90261-5. PMID: 11540743
Disorders of prolactin and growth hormone secretion.
Ho KY, Evans WS, Thorner MO
Clin Endocrinol Metab 1985 Feb;14(1):1-32. doi: 10.1016/s0300-595x(85)80063-3. PMID: 3926353
Amenorrhea, hyperprolactinemia and pituitary enlargement secondary to primary hypothyroidism. Successful treatment with thyroid replacement.
Keye WR, Yuen BH, Knopf RF, Jaffe RB
Obstet Gynecol 1976 Dec;48(6):697-702. PMID: 825796

Prognosis

DOPA metabolism in neuroblastoma.
Helson L, Johnson GA, Smith R
Med Pediatr Oncol 1980;8(4):317-22. doi: 10.1002/mpo.2950080402. PMID: 6779102
Amenorrhea, hyperprolactinemia and pituitary enlargement secondary to primary hypothyroidism. Successful treatment with thyroid replacement.
Keye WR, Yuen BH, Knopf RF, Jaffe RB
Obstet Gynecol 1976 Dec;48(6):697-702. PMID: 825796

Clinical prediction guides

Monoamine metabolism and sympathetic nervous activation following subarachnoid haemorrhage: influence of gender and hydrocephalus.
Lambert G, Naredi S, Edén E, Rydenhag B, Friberg P
Brain Res Bull 2002 May;58(1):77-82. doi: 10.1016/s0361-9230(02)00762-1. PMID: 12121816
Immunoreactive growth hormone-releasing hormone (IR-GHRH) in the feto-placental circulation and differential effects of L-dopa, L-arginine and somatostatin-14 on the plasma levels of IR-GHRH in normal adults.
Saito H, Hosoi E, Yamasaki R, Kameyama K, Irahara M, Ohno Y, Saito S
Horm Metab Res 1997 Apr;29(4):184-9. doi: 10.1055/s-2007-979018. PMID: 9178029
DOPA metabolism in neuroblastoma.
Helson L, Johnson GA, Smith R
Med Pediatr Oncol 1980;8(4):317-22. doi: 10.1002/mpo.2950080402. PMID: 6779102
Inhibition of cyclic gonadotropin secretion by endogenous human prolactin.
Tyson JE, Khojandi M, Huth J, Smith B, Thomas P
Am J Obstet Gynecol 1975 Feb 1;121(3):375-9. doi: 10.1016/0002-9378(75)90015-0. PMID: 1115151

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