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Decreased circulating apolipoprotein A-II concentration

MedGen UID:
1842105
•Concept ID:
C5826514
•
Finding
Synonym: Apolipoprotein A-II low in blood
 
HPO: HP:0034602

Definition

Concentration of apolipoprotein A-II below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating apolipoprotein A-II concentration

Recent clinical studies

Etiology

Nosocomial infections after severe trauma are associated with lower apolipoproteins B and AII.
Femling JK, West SD, Hauswald EK, Gresham HD, Hall PR
J Trauma Acute Care Surg 2013 Apr;74(4):1067-73. doi: 10.1097/TA.0b013e3182826be0. PMID: 23511146Free PMC Article
Apolipoprotein A-II is inversely associated with risk of future coronary artery disease.
Birjmohun RS, Dallinga-Thie GM, Kuivenhoven JA, Stroes ES, Otvos JD, Wareham NJ, Luben R, Kastelein JJ, Khaw KT, Boekholdt SM
Circulation 2007 Oct 30;116(18):2029-35. Epub 2007 Oct 8 doi: 10.1161/CIRCULATIONAHA.107.704031. PMID: 17923573
Decreased HDL2 and HDL3 cholesterol, Apo A-I and Apo A-II, and increased risk of myocardial infarction.
Buring JE, O'Connor GT, Goldhaber SZ, Rosner B, Herbert PN, Blum CB, Breslow JL, Hennekens CH
Circulation 1992 Jan;85(1):22-9. doi: 10.1161/01.cir.85.1.22. PMID: 1728453

Therapy

Influence of bezafibrate on plasma lipoproteins, biliary lipids and fecal sterols in healthy men.
Kohlmeier M, Hill T, Remer P, Schlierf G
Atherosclerosis 1986 Apr;60(1):29-35. doi: 10.1016/0021-9150(86)90084-5. PMID: 3707671

Prognosis

Nosocomial infections after severe trauma are associated with lower apolipoproteins B and AII.
Femling JK, West SD, Hauswald EK, Gresham HD, Hall PR
J Trauma Acute Care Surg 2013 Apr;74(4):1067-73. doi: 10.1097/TA.0b013e3182826be0. PMID: 23511146Free PMC Article
Apolipoprotein A-II is inversely associated with risk of future coronary artery disease.
Birjmohun RS, Dallinga-Thie GM, Kuivenhoven JA, Stroes ES, Otvos JD, Wareham NJ, Luben R, Kastelein JJ, Khaw KT, Boekholdt SM
Circulation 2007 Oct 30;116(18):2029-35. Epub 2007 Oct 8 doi: 10.1161/CIRCULATIONAHA.107.704031. PMID: 17923573
Decreased HDL2 and HDL3 cholesterol, Apo A-I and Apo A-II, and increased risk of myocardial infarction.
Buring JE, O'Connor GT, Goldhaber SZ, Rosner B, Herbert PN, Blum CB, Breslow JL, Hennekens CH
Circulation 1992 Jan;85(1):22-9. doi: 10.1161/01.cir.85.1.22. PMID: 1728453

Clinical prediction guides

Nosocomial infections after severe trauma are associated with lower apolipoproteins B and AII.
Femling JK, West SD, Hauswald EK, Gresham HD, Hall PR
J Trauma Acute Care Surg 2013 Apr;74(4):1067-73. doi: 10.1097/TA.0b013e3182826be0. PMID: 23511146Free PMC Article
Apolipoprotein A-II is inversely associated with risk of future coronary artery disease.
Birjmohun RS, Dallinga-Thie GM, Kuivenhoven JA, Stroes ES, Otvos JD, Wareham NJ, Luben R, Kastelein JJ, Khaw KT, Boekholdt SM
Circulation 2007 Oct 30;116(18):2029-35. Epub 2007 Oct 8 doi: 10.1161/CIRCULATIONAHA.107.704031. PMID: 17923573
Decreased HDL2 and HDL3 cholesterol, Apo A-I and Apo A-II, and increased risk of myocardial infarction.
Buring JE, O'Connor GT, Goldhaber SZ, Rosner B, Herbert PN, Blum CB, Breslow JL, Hennekens CH
Circulation 1992 Jan;85(1):22-9. doi: 10.1161/01.cir.85.1.22. PMID: 1728453

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