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Splenic xanthomatosis

MedGen UID:
1842145
Concept ID:
C5826534
Disease or Syndrome
Synonym: Spleen xanthomas
 
HPO: HP:0034623

Definition

Lipid deposits localized within the spleen. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSplenic xanthomatosis

Recent clinical studies

Etiology

Schönhaar K, Schledzewski K, Michel J, Dollt C, Gkaniatsou C, Géraud C, Kzhyshkowska J, Goerdt S, Schmieder A
Int J Clin Exp Pathol 2014;7(4):1625-34. Epub 2014 Mar 15 PMID: 24817959Free PMC Article
Samuel P, Perl W, Holtzman CM, Rochman ND, Lieberman S
J Clin Invest 1972 Feb;51(2):266-78. doi: 10.1172/JCI106811. PMID: 5009114Free PMC Article

Diagnosis

Nagata K, Nakamura K, Iida T, Iwasaki J, Ito R, Asai S, Ishihara M, Hata T, Itami A, Kyogoku T
Clin J Gastroenterol 2024 Jun;17(3):580-586. Epub 2024 Mar 8 doi: 10.1007/s12328-024-01930-1. PMID: 38457070
Sinha P, Sandhu S, Sen A, Sood A
Indian J Dermatol Venereol Leprol 2020 Jul-Aug;86(4):382-385. doi: 10.4103/ijdvl.IJDVL_633_17. PMID: 30785120
Melling N, Bruder E, Dimmler A, Hohenberger W, Aigner T
Int J Colorectal Dis 2007 Nov;22(11):1401-4. Epub 2007 Jul 5 doi: 10.1007/s00384-007-0348-1. PMID: 17611762
Umbert I, Winkelmann RK
Br J Dermatol 1995 Sep;133(3):438-43. doi: 10.1111/j.1365-2133.1995.tb02674.x. PMID: 8547001
Raafat F, Hashemian MP, Abrishami MA
Am J Clin Pathol 1973 Apr;59(4):490-7. doi: 10.1093/ajcp/59.4.490. PMID: 4692977

Therapy

Abdou AG, Kandil M, Eldien MS, Abdallah R
Pathologica 2016 Sep;108(3):140-143. PMID: 28195266
Oumeish OY, Oumeish I, Tarawneh M, Salman T, Sharaiha A
Int J Dermatol 2006 Mar;45(3):306-10. doi: 10.1111/j.1365-4632.2006.02575.x. PMID: 16533236

Prognosis

Umbert I, Winkelmann RK
Br J Dermatol 1995 Sep;133(3):438-43. doi: 10.1111/j.1365-2133.1995.tb02674.x. PMID: 8547001
Cywes S, Davies MR, Louw JH, Berger GM, Bonnici F, Joffe HS
S Afr Med J 1976 Feb 21;50(8):239-43. PMID: 176738
Samuel P, Perl W, Holtzman CM, Rochman ND, Lieberman S
J Clin Invest 1972 Feb;51(2):266-78. doi: 10.1172/JCI106811. PMID: 5009114Free PMC Article
Nyholm K, Reed G, Sjolin KE
Acta Pathol Microbiol Scand 1967;70(4):481-500. PMID: 5582374

Clinical prediction guides

Ferrans VJ, Buja LM, Roberts WC, Fredrickson DS
Am J Pathol 1971 Jul;64(1):67-96. PMID: 4326635Free PMC Article
Eto Y, Kitagawa T
J Pediatr 1970 Nov;77(5):862-7. doi: 10.1016/s0022-3476(70)80248-7. PMID: 5504079

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