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Short N2 sleep

MedGen UID:
1853173
•Concept ID:
C5872995
•
Finding
Synonym: Short subdued state of NREM
 
HPO: HP:5200307

Definition

Decreased duration of phase N2 of nonrapid eye movement (NREM) sleep. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVShort N2 sleep

Professional guidelines

PubMed

Intensive Sleep Retraining Treatment of Insomnia.
Lack L, Scott H, Lovato N
Sleep Med Clin 2019 Jun;14(2):245-252. Epub 2019 Apr 2 doi: 10.1016/j.jsmc.2019.01.005. PMID: 31029190
Safety and tolerability profile of new antiepileptic drug treatment in children with epilepsy.
Moavero R, Pisani LR, Pisani F, Curatolo P
Expert Opin Drug Saf 2018 Oct;17(10):1015-1028. Epub 2018 Sep 17 doi: 10.1080/14740338.2018.1518427. PMID: 30169997
Sensor-based evaluation and treatment of nocturnal hypokinesia in Parkinson's disease: An evidence-based review.
Bhidayasiri R, Sringean J, Thanawattano C
Parkinsonism Relat Disord 2016 Jan;22 Suppl 1:S127-33. Epub 2015 Sep 30 doi: 10.1016/j.parkreldis.2015.09.049. PMID: 26453387

Recent clinical studies

Etiology

Dysautonomia: A Forgotten Condition - Part 1.
Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AAL, Elias Neto J
Arq Bras Cardiol 2021 Apr;116(4):814-835. doi: 10.36660/abc.20200420. PMID: 33886735Free PMC Article
Sleepiness and Driving: Benefits of Treatment.
McCall CA, Watson NF
Sleep Med Clin 2019 Dec;14(4):469-478. Epub 2019 Sep 26 doi: 10.1016/j.jsmc.2019.07.001. PMID: 31640875
Role of Leptin in Obstructive Sleep Apnea.
Imayama I, Prasad B
Ann Am Thorac Soc 2017 Nov;14(11):1607-1621. doi: 10.1513/AnnalsATS.201702-181FR. PMID: 28796527
Cognitive Performance, Sleepiness, and Mood in Partially Sleep Deprived Adolescents: The Need for Sleep Study.
Lo JC, Ong JL, Leong RL, Gooley JJ, Chee MW
Sleep 2016 Mar 1;39(3):687-98. doi: 10.5665/sleep.5552. PMID: 26612392Free PMC Article
Biomarkers of Parkinson's disease: present and future.
Miller DB, O'Callaghan JP
Metabolism 2015 Mar;64(3 Suppl 1):S40-6. Epub 2014 Oct 31 doi: 10.1016/j.metabol.2014.10.030. PMID: 25510818Free PMC Article

Diagnosis

Dysautonomia: A Forgotten Condition - Part 1.
Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AAL, Elias Neto J
Arq Bras Cardiol 2021 Apr;116(4):814-835. doi: 10.36660/abc.20200420. PMID: 33886735Free PMC Article
Behavioural and psychological symptoms of dementia in patients with Alzheimer's disease and family caregiver burden: a path analysis.
Kim B, Noh GO, Kim K
BMC Geriatr 2021 Mar 5;21(1):160. doi: 10.1186/s12877-021-02109-w. PMID: 33663416Free PMC Article
Short or Long Sleep Duration and CKD: A Mendelian Randomization Study.
Park S, Lee S, Kim Y, Lee Y, Kang MW, Kim K, Kim YC, Han SS, Lee H, Lee JP, Joo KW, Lim CS, Kim YS, Kim DK
J Am Soc Nephrol 2020 Dec;31(12):2937-2947. Epub 2020 Oct 1 doi: 10.1681/ASN.2020050666. PMID: 33004418Free PMC Article
Biomarkers of Parkinson's disease: present and future.
Miller DB, O'Callaghan JP
Metabolism 2015 Mar;64(3 Suppl 1):S40-6. Epub 2014 Oct 31 doi: 10.1016/j.metabol.2014.10.030. PMID: 25510818Free PMC Article
Agrypnia excitata.
Provini F
Curr Neurol Neurosci Rep 2013 Apr;13(4):341. doi: 10.1007/s11910-013-0341-8. PMID: 23423537

Therapy

Short or Long Sleep Duration and CKD: A Mendelian Randomization Study.
Park S, Lee S, Kim Y, Lee Y, Kang MW, Kim K, Kim YC, Han SS, Lee H, Lee JP, Joo KW, Lim CS, Kim YS, Kim DK
J Am Soc Nephrol 2020 Dec;31(12):2937-2947. Epub 2020 Oct 1 doi: 10.1681/ASN.2020050666. PMID: 33004418Free PMC Article
Intensive Sleep Retraining Treatment of Insomnia.
Lack L, Scott H, Lovato N
Sleep Med Clin 2019 Jun;14(2):245-252. Epub 2019 Apr 2 doi: 10.1016/j.jsmc.2019.01.005. PMID: 31029190
Cognitive Performance, Sleepiness, and Mood in Partially Sleep Deprived Adolescents: The Need for Sleep Study.
Lo JC, Ong JL, Leong RL, Gooley JJ, Chee MW
Sleep 2016 Mar 1;39(3):687-98. doi: 10.5665/sleep.5552. PMID: 26612392Free PMC Article
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.
Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, Schmidlkofer S, Westwood M, Kleijnen J
JAMA 2015 Jun 23-30;313(24):2456-73. doi: 10.1001/jama.2015.6358. PMID: 26103030
Biomarkers of Parkinson's disease: present and future.
Miller DB, O'Callaghan JP
Metabolism 2015 Mar;64(3 Suppl 1):S40-6. Epub 2014 Oct 31 doi: 10.1016/j.metabol.2014.10.030. PMID: 25510818Free PMC Article

Prognosis

Dysautonomia: A Forgotten Condition - Part 1.
Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AAL, Elias Neto J
Arq Bras Cardiol 2021 Apr;116(4):814-835. doi: 10.36660/abc.20200420. PMID: 33886735Free PMC Article
Association between sleep duration during pregnancy and gestational diabetes mellitus: a meta-analysis.
Xu YH, Shi L, Bao YP, Chen SJ, Shi J, Zhang RL, Lu L
Sleep Med 2018 Dec;52:67-74. Epub 2018 Aug 22 doi: 10.1016/j.sleep.2018.07.021. PMID: 30286382
Biomarkers of Parkinson's disease: present and future.
Miller DB, O'Callaghan JP
Metabolism 2015 Mar;64(3 Suppl 1):S40-6. Epub 2014 Oct 31 doi: 10.1016/j.metabol.2014.10.030. PMID: 25510818Free PMC Article
Migraine in women.
Brandes JL
Continuum (Minneap Minn) 2012 Aug;18(4):835-52. doi: 10.1212/01.CON.0000418646.70149.71. PMID: 22868545
Human sleep/wake regulation.
Gillberg M
Acta Anaesthesiol Scand Suppl 1997;110:8-10. doi: 10.1111/j.1399-6576.1997.tb05482.x. PMID: 9248514

Clinical prediction guides

Sleep architecture and sleep-disordered breathing in fatal insomnia.
Pérez-Carbonell L, Muñoz-Lopetegi A, Sánchez-Valle R, Gelpi E, Farré R, Gaig C, Iranzo A, Santamaria J
Sleep Med 2022 Dec;100:311-346. Epub 2022 Sep 20 doi: 10.1016/j.sleep.2022.08.027. PMID: 36182725
Short or Long Sleep Duration and CKD: A Mendelian Randomization Study.
Park S, Lee S, Kim Y, Lee Y, Kang MW, Kim K, Kim YC, Han SS, Lee H, Lee JP, Joo KW, Lim CS, Kim YS, Kim DK
J Am Soc Nephrol 2020 Dec;31(12):2937-2947. Epub 2020 Oct 1 doi: 10.1681/ASN.2020050666. PMID: 33004418Free PMC Article
Cognitive Performance, Sleepiness, and Mood in Partially Sleep Deprived Adolescents: The Need for Sleep Study.
Lo JC, Ong JL, Leong RL, Gooley JJ, Chee MW
Sleep 2016 Mar 1;39(3):687-98. doi: 10.5665/sleep.5552. PMID: 26612392Free PMC Article
Biomarkers of Parkinson's disease: present and future.
Miller DB, O'Callaghan JP
Metabolism 2015 Mar;64(3 Suppl 1):S40-6. Epub 2014 Oct 31 doi: 10.1016/j.metabol.2014.10.030. PMID: 25510818Free PMC Article
Migraine in women.
Brandes JL
Continuum (Minneap Minn) 2012 Aug;18(4):835-52. doi: 10.1212/01.CON.0000418646.70149.71. PMID: 22868545

Recent systematic reviews

Aquatic therapy improves self-reported sleep quality in fibromyalgia patients: a systematic review and meta-analysis.
Bravo C, Rubí-Carnacea F, Colomo I, Sánchez-de-la-Torre M, Fernández-Lago H, Climent-Sanz C
Sleep Breath 2024 May;28(2):565-583. Epub 2023 Oct 17 doi: 10.1007/s11325-023-02933-x. PMID: 37847348Free PMC Article
Automatic sleep staging by cardiorespiratory signals: a systematic review.
Ebrahimi F, Alizadeh I
Sleep Breath 2022 Jun;26(2):965-981. Epub 2021 Jul 29 doi: 10.1007/s11325-021-02435-8. PMID: 34322822
Systematic review of light exposure impact on human circadian rhythm.
Tähkämö L, Partonen T, Pesonen AK
Chronobiol Int 2019 Feb;36(2):151-170. Epub 2018 Oct 12 doi: 10.1080/07420528.2018.1527773. PMID: 30311830
A systematic review of the sleep, sleepiness, and performance implications of limited wake shift work schedules.
Short MA, Agostini A, Lushington K, Dorrian J
Scand J Work Environ Health 2015 Sep 1;41(5):425-40. Epub 2015 Jun 23 doi: 10.5271/sjweh.3509. PMID: 26103467
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.
Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, Schmidlkofer S, Westwood M, Kleijnen J
JAMA 2015 Jun 23-30;313(24):2456-73. doi: 10.1001/jama.2015.6358. PMID: 26103030

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