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Hypnagogic sleep paralysis

MedGen UID:
1853209
•Concept ID:
C5873010
•
Mental or Behavioral Dysfunction
Synonyms: Inability to move while falling asleep; Predormital sleep paralysis
 
HPO: HP:5200352

Definition

Sleep paralysis that occurs when falling asleep. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypnagogic sleep paralysis

Professional guidelines

PubMed

Evaluating pitolisant as a narcolepsy treatment option.
de Biase S, Pellitteri G, Gigli GL, Valente M
Expert Opin Pharmacother 2021 Feb;22(2):155-162. Epub 2020 Sep 17 doi: 10.1080/14656566.2020.1817387. PMID: 32941089
Investigational therapies for the treatment of narcolepsy.
de Biase S, Nilo A, Gigli GL, Valente M
Expert Opin Investig Drugs 2017 Aug;26(8):953-963. Epub 2017 Jul 20 doi: 10.1080/13543784.2017.1356819. PMID: 28726523
Management of narcolepsy.
Bhat A, El Solh AA
Expert Opin Pharmacother 2008 Jul;9(10):1721-33. doi: 10.1517/14656566.9.10.1721. PMID: 18570605

Recent clinical studies

Etiology

REM sleep in narcolepsy.
Thorpy MJ, Siegel JM, Dauvilliers Y
Sleep Med Rev 2024 Oct;77:101976. Epub 2024 Aug 3 doi: 10.1016/j.smrv.2024.101976. PMID: 39186901
Prevalence, incidence, evolution and associated factors of sleep paralysis in a longitudinal study of the US general population.
Ohayon MM, Pakpour AH
Sleep Med 2022 Oct;98:62-67. Epub 2022 Jun 11 doi: 10.1016/j.sleep.2022.06.003. PMID: 35785587
Status cataplecticus as initial presentation of late onset narcolepsy.
Panda S
J Clin Sleep Med 2014 Feb 15;10(2):207-9. doi: 10.5664/jcsm.3456. PMID: 24533005Free PMC Article
Autonomic disturbances in narcolepsy.
Plazzi G, Moghadam KK, Maggi LS, Donadio V, Vetrugno R, Liguori R, Zoccoli G, Poli F, Pizza F, Pagotto U, Ferri R
Sleep Med Rev 2011 Jun;15(3):187-96. Epub 2010 Jul 14 doi: 10.1016/j.smrv.2010.05.002. PMID: 20634114
The treatment of sleep disorders.
Smeyatsky N, Baldwin D, Botros W, Gura R, Kurian T, Lambert MT, Patel AG, Steinert J, Priest RG
S Afr Med J 1992 May 2;Suppl:1-8. PMID: 1585214

Diagnosis

REM sleep in narcolepsy.
Thorpy MJ, Siegel JM, Dauvilliers Y
Sleep Med Rev 2024 Oct;77:101976. Epub 2024 Aug 3 doi: 10.1016/j.smrv.2024.101976. PMID: 39186901
REM sleep, REM parasomnias, REM sleep behaviour disorder.
Szûcs A, Mutti C, Papp A, Halász P, Parrino L
Ideggyogy Sz 2022 May 30;75(5-06):171-182. doi: 10.18071/isz.75.0171. PMID: 35819343
Status cataplecticus as initial presentation of late onset narcolepsy.
Panda S
J Clin Sleep Med 2014 Feb 15;10(2):207-9. doi: 10.5664/jcsm.3456. PMID: 24533005Free PMC Article
Neuroimaging of narcolepsy.
Dang-Vu TT, Desseilles M, Schwartz S, Maquet P
CNS Neurol Disord Drug Targets 2009 Aug;8(4):254-63. doi: 10.2174/187152709788921708. PMID: 19689307
Narcolepsy in children.
Challamel MJ, Mazzola ME, Nevsimalova S, Cannard C, Louis J, Revol M
Sleep 1994 Dec;17(8 Suppl):S17-20. doi: 10.1093/sleep/17.suppl_8.s17. PMID: 7701194

Therapy

Clinical features, diagnosis and treatment of narcolepsy.
Ahmed I, Thorpy M
Clin Chest Med 2010 Jun;31(2):371-81. doi: 10.1016/j.ccm.2010.02.014. PMID: 20488294
Pharmacological management of narcolepsy.
Lammers GJ, Overeem S
Expert Opin Pharmacother 2003 Oct;4(10):1739-46. doi: 10.1517/14656566.4.10.1739. PMID: 14521484
Pharmacokinetics of gammahydroxybutyrate (GHB) in narcoleptic patients.
Scharf MB, Lai AA, Branigan B, Stover R, Berkowitz DB
Sleep 1998 Aug 1;21(5):507-14. doi: 10.1093/sleep/21.5.507. PMID: 9703591
Narcolepsy-cataplexy and loss of sphincter control.
Vgontzas AN, Sollenberger SE, Kales A, Bixler EO, Vela-Bueno A
Postgrad Med J 1996 Aug;72(850):493-4. doi: 10.1136/pgmj.72.850.493. PMID: 8796217Free PMC Article
Narcolepsy following cerebral hypoxic ischemia.
Rivera VM, Meyer JS, Hata T, Ishikawa Y, Imai A
Ann Neurol 1986 May;19(5):505-8. doi: 10.1002/ana.410190516. PMID: 3717910

Prognosis

Investigational therapies for the treatment of narcolepsy.
de Biase S, Nilo A, Gigli GL, Valente M
Expert Opin Investig Drugs 2017 Aug;26(8):953-963. Epub 2017 Jul 20 doi: 10.1080/13543784.2017.1356819. PMID: 28726523
The diagnosis and treatment of pediatric narcolepsy.
Nevsimalova S
Curr Neurol Neurosci Rep 2014 Aug;14(8):469. doi: 10.1007/s11910-014-0469-1. PMID: 24954623
Status cataplecticus as initial presentation of late onset narcolepsy.
Panda S
J Clin Sleep Med 2014 Feb 15;10(2):207-9. doi: 10.5664/jcsm.3456. PMID: 24533005Free PMC Article
Narcolepsy-cataplexy and loss of sphincter control.
Vgontzas AN, Sollenberger SE, Kales A, Bixler EO, Vela-Bueno A
Postgrad Med J 1996 Aug;72(850):493-4. doi: 10.1136/pgmj.72.850.493. PMID: 8796217Free PMC Article
Narcolepsy.
Murray TJ, Foley A
Can Med Assoc J 1974 Jan 5;110(1):63-6. PMID: 4809449Free PMC Article

Clinical prediction guides

Sodium Oxybate Treatment in Pediatric Type 1 Narcolepsy.
Moresco M, Pizza F, Antelmi E, Plazzi G
Curr Drug Metab 2018;19(13):1073-1079. doi: 10.2174/1389200219666180305153134. PMID: 29512449
The diagnosis and treatment of pediatric narcolepsy.
Nevsimalova S
Curr Neurol Neurosci Rep 2014 Aug;14(8):469. doi: 10.1007/s11910-014-0469-1. PMID: 24954623
Status cataplecticus as initial presentation of late onset narcolepsy.
Panda S
J Clin Sleep Med 2014 Feb 15;10(2):207-9. doi: 10.5664/jcsm.3456. PMID: 24533005Free PMC Article
Familial narcolepsy.
Stepień A, Staszewski J, Domzał TM, Rzeski M, Skrobowska E, Warczyńska A
Neurol Neurochir Pol 2007 Mar-Apr;41(2):134-40. PMID: 17530575
Differences in neuropsychological correlates between normals and those experiencing "Old Hag Attacks".
Kettlewell N, Lipscomb S, Evans E
Percept Mot Skills 1993 Jun;76(3 Pt 1):839-45; discussion 846. doi: 10.2466/pms.1993.76.3.839. PMID: 8321596

Recent systematic reviews

The therapeutic potential of opioids in narcolepsy type 1: A systematic literature review and questionnaire study.
Gool JK, van Heese EM, Schinkelshoek MS, Remmerswaal A, Lammers GJ, van Dijk KD, Fronczek R
Sleep Med 2023 Sep;109:118-127. Epub 2023 Jun 26 doi: 10.1016/j.sleep.2023.06.008. PMID: 37437491
Evaluating pitolisant as a narcolepsy treatment option.
de Biase S, Pellitteri G, Gigli GL, Valente M
Expert Opin Pharmacother 2021 Feb;22(2):155-162. Epub 2020 Sep 17 doi: 10.1080/14656566.2020.1817387. PMID: 32941089
Pitolisant for treating patients with narcolepsy.
Li S, Yang J
Expert Rev Clin Pharmacol 2020 Feb;13(2):79-84. Epub 2020 Jan 23 doi: 10.1080/17512433.2020.1714435. PMID: 31937172
Health-Related Quality of Life in Patients With Narcolepsy: A Review of the Literature.
Raggi A, Plazzi G, Ferri R
J Nerv Ment Dis 2019 Feb;207(2):84-99. doi: 10.1097/NMD.0000000000000918. PMID: 30672873
Narcolepsy and effectiveness of gamma-hydroxybutyrate (GHB): a systematic review and meta-analysis of randomized controlled trials.
Boscolo-Berto R, Viel G, Montagnese S, Raduazzo DI, Ferrara SD, Dauvilliers Y
Sleep Med Rev 2012 Oct;16(5):431-43. Epub 2011 Nov 4 doi: 10.1016/j.smrv.2011.09.001. PMID: 22055895

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