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Rheumatic nodule

MedGen UID:
19780
•Concept ID:
C0035441
•
Pathologic Function
Synonyms: Nodule, Rheumatic; Nodules, Rheumatic; Rheumatic Nodule; Rheumatic Nodules
SNOMED CT: Rheumatic nodule (89050001)

Definition

A small round or oval, mostly subcutaneous nodule made up chiefly of a mass of Aschoff bodies and seen in cases of rheumatic fever. It is differentiated from the RHEUMATOID NODULE which appears in rheumatoid arthritis, most frequently over bony prominences. (From Dorland, 27th ed) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRheumatic nodule

Professional guidelines

PubMed

Recent advances in nonsurgical treatment of pulmonary ground-glass nodules.
Kong Y, Xu H, Huang Y, Lv X, Ye X
J Cancer Res Ther 2022 Apr;18(2):323-328. doi: 10.4103/jcrt.jcrt_2030_21. PMID: 35645096
Diagnosis of rheumatic fever: current status of Jones Criteria and role of echocardiography.
Saxena A
Indian J Pediatr 2000 Mar;67(3 Suppl):S11-4. PMID: 11129913
Diagnostic and activity criteria of rheumatoid arthritis evaluated with factor analysis.
Aho K, Isomaki H, Jarnfelt M, Laine V, Martio J, Sievers K, Soini E
Scand J Rheumatol 1972;1(3):101-8. doi: 10.3109/03009747209103006. PMID: 4667925

Recent clinical studies

Etiology

Different T cell subsets in the nodule and synovial membrane: absence of interleukin-17A in rheumatoid nodules.
Stamp LK, Easson A, Lehnigk U, Highton J, Hessian PA
Arthritis Rheum 2008 Jun;58(6):1601-8. doi: 10.1002/art.23455. PMID: 18512780
Anti-cyclic citrullinated peptide antibody, smoking, alcohol consumption, and disease duration as risk factors for extraarticular manifestations in Korean patients with rheumatoid arthritis.
Kim SK, Park SH, Shin IH, Choe JY
J Rheumatol 2008 Jun;35(6):995-1001. Epub 2008 May 1 PMID: 18464311
Cough, fever, joint pain and tender nodules: what is your call?
Turchin I, Nguyen K, Ménard HA
CMAJ 2008 Jan 15;178(2):151-2. doi: 10.1503/cmaj.071255. PMID: 18195287Free PMC Article
The prevalence of palpable finger joint nodules in diffuse idiopathic skeletal hyperostosis (DISH). A controlled study.
Schlapbach P, Beyeler C, Gerber NJ, van der Linden S, Bürgi U, Fuchs WA, Ehrengruber H
Br J Rheumatol 1992 Aug;31(8):531-4. doi: 10.1093/rheumatology/31.8.531. PMID: 1643450
Immunohistochemical characterization of Aschoff nodules and endomyocardial inflammatory infiltrates in resected left atrial appendages.
Bhan A, Das B, Venugopal P, Sampathkumar A, Chopra P
Indian Heart J 1990 Nov-Dec;42(6):415-7. PMID: 2098313

Diagnosis

Nodules on the Knuckles.
Pippin M
Am Fam Physician 2020 Jan 1;101(1):47-48. PMID: 31894943
Subcutaneous Nodules in Acute Rheumatic Fever.
Poonia A, Giridhara P, Sheoran D
J Pediatr 2019 Oct;213:242-242.e1. Epub 2019 Jul 10 doi: 10.1016/j.jpeds.2019.04.049. PMID: 31301851
Laryngeal involvement in systemic lupus erythematosus.
Teitel AD, MacKenzie CR, Stern R, Paget SA
Semin Arthritis Rheum 1992 Dec;22(3):203-14. doi: 10.1016/0049-0172(92)90020-e. PMID: 1295093
Rheumatoid arthritis.
JAMA 1973 Apr 30;224(5 Suppl):687-70. PMID: 4573028
Rheumatic fever.
JAMA 1973 Apr 30;224(5 Suppl):736-9. PMID: 4550028

Therapy

Nodules on the Knuckles.
Pippin M
Am Fam Physician 2020 Jan 1;101(1):47-48. PMID: 31894943
Rheumatoid nodules of the larynx.
Sørensen WT, Møller-Andersen K, Behrendt N
J Laryngol Otol 1998 Jun;112(6):573-4. doi: 10.1017/s002221510014112x. PMID: 9764301
Laryngeal involvement in systemic lupus erythematosus.
Teitel AD, MacKenzie CR, Stern R, Paget SA
Semin Arthritis Rheum 1992 Dec;22(3):203-14. doi: 10.1016/0049-0172(92)90020-e. PMID: 1295093
Rheumatoid arthritis.
JAMA 1973 Apr 30;224(5 Suppl):687-70. PMID: 4573028
Rheumatic fever.
JAMA 1973 Apr 30;224(5 Suppl):736-9. PMID: 4550028

Prognosis

Cough, fever, joint pain and tender nodules: what is your call?
Turchin I, Nguyen K, Ménard HA
CMAJ 2008 Jan 15;178(2):151-2. doi: 10.1503/cmaj.071255. PMID: 18195287Free PMC Article
NERDS syndrome: an additional case report.
Zenarola P, Melillo L, Bisceglia M, Carotenuto M, Lomuto M
Dermatology 1995;191(2):133-8. doi: 10.1159/000246531. PMID: 8520060
Laryngeal involvement in systemic lupus erythematosus.
Teitel AD, MacKenzie CR, Stern R, Paget SA
Semin Arthritis Rheum 1992 Dec;22(3):203-14. doi: 10.1016/0049-0172(92)90020-e. PMID: 1295093
HLA DR antigens in rheumatoid arthritis.
Gran JT, Husby G, Thorsby E
Scand J Rheumatol 1983;12(3):241-5. doi: 10.3109/03009748309098541. PMID: 6604939
The natural history of acute rheumatism.
Perry CB
Ann Rheum Dis 1969 Sep;28(5):471-6. doi: 10.1136/ard.28.5.471. PMID: 5307412Free PMC Article

Clinical prediction guides

Potential role of Anitschkow cells in cardiovascular disease in human and veterinary medicine: A review of the literature.
Colombino E, Biasato I, Biasibetti E, Sereno A, Chiappino L, Evangelista R, Cenacchi G, Guarda F, Capucchio MT
Anat Histol Embryol 2019 May;48(3):201-206. Epub 2019 Feb 17 doi: 10.1111/ahe.12433. PMID: 30772944
Different T cell subsets in the nodule and synovial membrane: absence of interleukin-17A in rheumatoid nodules.
Stamp LK, Easson A, Lehnigk U, Highton J, Hessian PA
Arthritis Rheum 2008 Jun;58(6):1601-8. doi: 10.1002/art.23455. PMID: 18512780
Anitschkow myocytes or cardiac histiocytes in human hearts.
Stehbens WE, Zuccollo JM
Pathology 1999 May;31(2):98-101. doi: 10.1080/003130299105269. PMID: 10399163
HLA DR antigens in rheumatoid arthritis.
Gran JT, Husby G, Thorsby E
Scand J Rheumatol 1983;12(3):241-5. doi: 10.3109/03009748309098541. PMID: 6604939
The occurrence of leucocyte-platelet thrombosis in rheumatic carditis.
STETSON CA Jr
J Exp Med 1951 Dec 1;94(6):493-500. doi: 10.1084/jem.94.6.493. PMID: 14897995Free PMC Article

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