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Rhinitis

MedGen UID:
19782
Concept ID:
C0035455
Disease or Syndrome
Synonyms: Catarrh, Nasal; Catarrhs, Nasal; Nasal Catarrh; Nasal Catarrhs; Rhinitides
SNOMED CT: Rhinitis (70076002)
 
HPO: HP:0012384
Monarch Initiative: MONDO:0003014

Definition

Inflammation of the nasal mucosa with nasal congestion. [from HPO]

Conditions with this feature

Hypohidrotic X-linked ectodermal dysplasia
MedGen UID:
57890
Concept ID:
C0162359
Disease or Syndrome
Hypohidrotic ectodermal dysplasia (HED) is characterized by hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth). The cardinal features of classic HED become obvious during childhood. The scalp hair is thin, lightly pigmented, and slow growing. Sweating, although present, is greatly deficient, leading to episodes of hyperthermia until the affected individual or family acquires experience with environmental modifications to control temperature. Only a few abnormally formed teeth erupt, at a later-than-average age. Physical growth and psychomotor development are otherwise within normal limits. Mild HED is characterized by mild manifestations of any or all the characteristic features.
Ectodermal dysplasia 11B, hypohidrotic/hair/tooth type, autosomal recessive
MedGen UID:
761671
Concept ID:
C3539920
Disease or Syndrome
Hypohidrotic ectodermal dysplasia (HED) is characterized by hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth). The cardinal features of classic HED become obvious during childhood. The scalp hair is thin, lightly pigmented, and slow growing. Sweating, although present, is greatly deficient, leading to episodes of hyperthermia until the affected individual or family acquires experience with environmental modifications to control temperature. Only a few abnormally formed teeth erupt, at a later-than-average age. Physical growth and psychomotor development are otherwise within normal limits. Mild HED is characterized by mild manifestations of any or all the characteristic features.
Primary ciliary dyskinesia 18
MedGen UID:
762331
Concept ID:
C3543825
Disease or Syndrome
Primary ciliary dyskinesia-18 is an autosomal recessive disorder characterized by early infantile onset of recurrent sinopulmonary infections due to ciliary dysfunction and impaired airway clearance. Males are infertile and about half of patients have situs inversus. Electron microscopy of cilia shows a defect of the outer and inner dynein arms and impaired ciliary function (summary by Horani et al., 2012).
Primary ciliary dyskinesia 19
MedGen UID:
762332
Concept ID:
C3543826
Disease or Syndrome
Primary ciliary dyskinesia-19 (CILD19) is an autosomal recessive ciliopathy characterized by chronic sinopulmonary infections, asthenospermia, and immotile cilia. Respiratory epithelial cells and sperm flagella of affected individuals lack both the inner and outer dynein arms. About 50% of patients have situs inversus (summary by Kott et al., 2012). For a phenotypic description and a discussion of genetic heterogeneity of primary ciliary dyskinesia, see 244400.
Primary ciliary dyskinesia 22
MedGen UID:
815873
Concept ID:
C3809543
Disease or Syndrome
Primary ciliary dyskinesia-22 (CILD22) is an autosomal recessive disorder caused by defective structure and function of cilia or flagella. Ciliary dysfunction causes respiratory distress in term neonates, impaired mucociliary clearance, chronic cough, sinusitis, bronchiectasis, and male infertility. Defective motility of embryonic nodal cilia leads to situs abnormalities in about 50% of patients. CILD22 is characterized by defects of the inner and outer dynein arms (summary by Zariwala et al., 2013). For a phenotypic description and a discussion of genetic heterogeneity of primary ciliary dyskinesia, see CILD1 (244400).
Primary ciliary dyskinesia 26
MedGen UID:
816014
Concept ID:
C3809684
Disease or Syndrome
Primary ciliary dyskinesia-26 is an autosomal recessive disorder caused by defective ciliary movement. Affected individuals have neonatal respiratory distress, recurrent upper and lower airway disease, and bronchiectasis. About half of patients show laterality defects, including situs inversus totalis. Respiratory cilia from patients show defects in the inner and outer dynein arms (summary by Austin-Tse et al., 2013). For a general phenotypic description and a discussion of genetic heterogeneity of primary ciliary dyskinesia, see 244400.
Primary ciliary dyskinesia 27
MedGen UID:
816031
Concept ID:
C3809701
Disease or Syndrome
Primary ciliary dyskinesia-27 is an autosomal recessive disorder caused by defective ciliary movement. Affected individuals have neonatal respiratory distress, recurrent upper and lower airway disease, and bronchiectasis. Respiratory cilia from patients show defects in the inner dynein arms and nexin links. Situs inversus has not been reported in these patients (summary by Austin-Tse et al., 2013). For a general phenotypic description and a discussion of genetic heterogeneity of primary ciliary dyskinesia, see 244400.
Primary ciliary dyskinesia 28
MedGen UID:
816036
Concept ID:
C3809706
Disease or Syndrome
Primary ciliary dyskinesia-28 (CILD28) is an autosomal recessive disorder caused by defective ciliary movement. Affected individuals have recurrent upper and lower airway disease, bronchiectasis, and decreased fertility. About half of patients show laterality defects, including situs inversus. Respiratory cilia from patients show defects in both the inner and outer dynein arms (summary by Knowles et al., 2013). For a general phenotypic description and a discussion of genetic heterogeneity of primary ciliary dyskinesia, see CILD1 (244400).
Ciliary dyskinesia, primary, 38
MedGen UID:
1648465
Concept ID:
C4748052
Disease or Syndrome
Primary ciliary dyskinesia-38 is an autosomal recessive disorder characterized by chronic airway disease and recurrent sinopulmonary infections beginning in infancy and caused by defective ciliary function. Affected individuals often have neonatal respiratory distress and may later have infertility. About half of patients have laterality defects due to ciliary dysfunction in early embryonic development (summary by Fassad et al., 2018 and Hoben et al., 2018). For a general phenotypic description and a discussion of genetic heterogeneity of primary ciliary dyskinesia, see CILD1 (244400).
DEGCAGS syndrome
MedGen UID:
1794177
Concept ID:
C5561967
Disease or Syndrome
DEGCAGS syndrome is an autosomal recessive syndromic neurodevelopmental disorder characterized by global developmental delay, coarse and dysmorphic facial features, and poor growth and feeding apparent from infancy. Affected individuals have variable systemic manifestations often with significant structural defects of the cardiovascular, genitourinary, gastrointestinal, and/or skeletal systems. Additional features may include sensorineural hearing loss, hypotonia, anemia or pancytopenia, and immunodeficiency with recurrent infections. Death in childhood may occur (summary by Bertoli-Avella et al., 2021).

Professional guidelines

PubMed

Wise SK, Damask C, Roland LT, Ebert C, Levy JM, Lin S, Luong A, Rodriguez K, Sedaghat AR, Toskala E, Villwock J, Abdullah B, Akdis C, Alt JA, Ansotegui IJ, Azar A, Baroody F, Benninger MS, Bernstein J, Brook C, Campbell R, Casale T, Chaaban MR, Chew FT, Chambliss J, Cianferoni A, Custovic A, Davis EM, DelGaudio JM, Ellis AK, Flanagan C, Fokkens WJ, Franzese C, Greenhawt M, Gill A, Halderman A, Hohlfeld JM, Incorvaia C, Joe SA, Joshi S, Kuruvilla ME, Kim J, Klein AM, Krouse HJ, Kuan EC, Lang D, Larenas-Linnemann D, Laury AM, Lechner M, Lee SE, Lee VS, Loftus P, Marcus S, Marzouk H, Mattos J, McCoul E, Melen E, Mims JW, Mullol J, Nayak JV, Oppenheimer J, Orlandi RR, Phillips K, Platt M, Ramanathan M Jr, Raymond M, Rhee CS, Reitsma S, Ryan M, Sastre J, Schlosser RJ, Schuman TA, Shaker MS, Sheikh A, Smith KA, Soyka MB, Takashima M, Tang M, Tantilipikorn P, Taw MB, Tversky J, Tyler MA, Veling MC, Wallace D, Wang Y, White A, Zhang L
Int Forum Allergy Rhinol 2023 Apr;13(4):293-859. Epub 2023 Mar 6 doi: 10.1002/alr.23090. PMID: 36878860
Siddiqui ZA, Walker A, Pirwani MM, Tahiri M, Syed I
Br J Hosp Med (Lond) 2022 Feb 2;83(2):1-9. Epub 2022 Feb 23 doi: 10.12968/hmed.2021.0570. PMID: 35243888
Dykewicz MS, Wallace DV, Amrol DJ, Baroody FM, Bernstein JA, Craig TJ, Dinakar C, Ellis AK, Finegold I, Golden DBK, Greenhawt MJ, Hagan JB, Horner CC, Khan DA, Lang DM, Larenas-Linnemann DES, Lieberman JA, Meltzer EO, Oppenheimer JJ, Rank MA, Shaker MS, Shaw JL, Steven GC, Stukus DR, Wang J; Chief Editor(s):, Dykewicz MS, Wallace DV; Joint Task Force on Practice Parameters:, Dinakar C, Ellis AK, Golden DBK, Greenhawt MJ, Horner CC, Khan DA, Lang DM, Lieberman JA, Oppenheimer JJ, Rank MA, Shaker MS, Stukus DR, Wang J; Workgroup Contributors:, Dykewicz MS, Wallace DV, Amrol DJ, Baroody FM, Bernstein JA, Craig TJ, Finegold I, Hagan JB, Larenas-Linnemann DES, Meltzer EO, Shaw JL, Steven GC
J Allergy Clin Immunol 2020 Oct;146(4):721-767. Epub 2020 Jul 22 doi: 10.1016/j.jaci.2020.07.007. PMID: 32707227

Recent clinical studies

Etiology

Zhang Y, Lan F, Zhang L
Allergy 2022 Nov;77(11):3309-3319. Epub 2022 Aug 4 doi: 10.1111/all.15454. PMID: 35892225
Zhang Y, Lan F, Zhang L
Allergy 2021 Nov;76(11):3383-3389. Epub 2021 Aug 17 doi: 10.1111/all.15044. PMID: 34379805
Schuler Iv CF, Montejo JM
Pediatr Clin North Am 2019 Oct;66(5):981-993. Epub 2019 Aug 5 doi: 10.1016/j.pcl.2019.06.004. PMID: 31466686
Chirakalwasan N, Ruxrungtham K
Asian Pac J Allergy Immunol 2014 Dec;32(4):276-86. PMID: 25543037
Greiner AN, Hellings PW, Rotiroti G, Scadding GK
Lancet 2011 Dec 17;378(9809):2112-22. Epub 2011 Jul 23 doi: 10.1016/S0140-6736(11)60130-X. PMID: 21783242

Diagnosis

Czech EJ, Overholser A, Schultz P
Prim Care 2023 Jun;50(2):159-178. Epub 2023 Mar 8 doi: 10.1016/j.pop.2023.01.003. PMID: 37105599
Ponda P, Carr T, Rank MA, Bousquet J
J Allergy Clin Immunol Pract 2023 Jan;11(1):35-42. Epub 2022 Sep 21 doi: 10.1016/j.jaip.2022.09.010. PMID: 36152989
Okubo K, Kurono Y, Ichimura K, Enomoto T, Okamoto Y, Kawauchi H, Suzaki H, Fujieda S, Masuyama K; Japanese Society of Allergology
Allergol Int 2020 Jul;69(3):331-345. Epub 2020 May 27 doi: 10.1016/j.alit.2020.04.001. PMID: 32473790
Hoyte FCL, Nelson HS
F1000Res 2018;7 Epub 2018 Aug 23 doi: 10.12688/f1000research.15367.1. PMID: 30210782Free PMC Article
Beard S
Prim Care 2014 Mar;41(1):33-46. Epub 2013 Nov 28 doi: 10.1016/j.pop.2013.10.005. PMID: 24439879Free PMC Article

Therapy

Schaefer M, Enck P
BMJ Open 2019 Oct 28;9(10):e031339. doi: 10.1136/bmjopen-2019-031339. PMID: 31662387Free PMC Article
Lemiengre MB, van Driel ML, Merenstein D, Liira H, Mäkelä M, De Sutter AI
Cochrane Database Syst Rev 2018 Sep 10;9(9):CD006089. doi: 10.1002/14651858.CD006089.pub5. PMID: 30198548Free PMC Article
West CE
Benef Microbes 2016;7(2):171-9. Epub 2015 Dec 21 doi: 10.3920/BM2015.0073. PMID: 26689229
King D, Mitchell B, Williams CP, Spurling GK
Cochrane Database Syst Rev 2015 Apr 20;2015(4):CD006821. doi: 10.1002/14651858.CD006821.pub3. PMID: 25892369Free PMC Article
Braido F, Arcadipane F, Marugo F, Hayashi M, Pawankar R
Curr Opin Allergy Clin Immunol 2014 Apr;14(2):168-76. doi: 10.1097/ACI.0000000000000043. PMID: 24535140

Prognosis

Nocerino R, Bedogni G, Carucci L, Cosenza L, Cozzolino T, Paparo L, Palazzo S, Riva L, Verduci E, Berni Canani R
J Pediatr 2021 May;232:183-191.e3. Epub 2021 Jan 29 doi: 10.1016/j.jpeds.2021.01.059. PMID: 33524387
Lyons-Weiler J, Thomas P
Int J Environ Res Public Health 2020 Nov 22;17(22) doi: 10.3390/ijerph17228674. PMID: 33266457Free PMC Article
Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Teraguchi K, Okano M, Otori N, Yoshikawa M, Hirakawa K, Haruna S, Himi T, Ikeda K, Ishitoya J, Iino Y, Kawata R, Kawauchi H, Kobayashi M, Yamasoba T, Miwa T, Urashima M, Tamari M, Noguchi E, Ninomiya T, Imoto Y, Morikawa T, Tomita K, Takabayashi T, Fujieda S
Allergy 2015 Aug;70(8):995-1003. Epub 2015 May 26 doi: 10.1111/all.12644. PMID: 25945591Free PMC Article
Gautrin D, Desrosiers M, Castano R
Curr Opin Allergy Clin Immunol 2006 Apr;6(2):77-84. doi: 10.1097/01.all.0000216848.87699.38. PMID: 16520669
Strachan DP
BMJ 1989 Nov 18;299(6710):1259-60. doi: 10.1136/bmj.299.6710.1259. PMID: 2513902Free PMC Article

Clinical prediction guides

Vrljičak A, Penezić A, Gregurić T, Grgić MV, Baudoin T, Kalogjera L
Acta Clin Croat 2022 Oct;61(Suppl 4):63-69. doi: 10.20471/acc.2022.61.s4.8. PMID: 37250669Free PMC Article
Zissler UM, Schmidt-Weber CB
Front Immunol 2020;11:1826. Epub 2020 Aug 25 doi: 10.3389/fimmu.2020.01826. PMID: 32983092Free PMC Article
Alvarado SA, Nassiri M, Bahna SL
Allergy Asthma Proc 2019 Mar 1;40(2):93-102. Epub 2018 Dec 18 doi: 10.2500/aap.2019.40.4196. PMID: 30563587
Li L, Qian J, Zhou Y, Cui Y
Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418804095. doi: 10.1177/2058738418804095. PMID: 30350752Free PMC Article
Shamji MH, Durham SR
J Allergy Clin Immunol 2017 Dec;140(6):1485-1498. doi: 10.1016/j.jaci.2017.10.010. PMID: 29221580

Recent systematic reviews

Mayoral K, Lizano-Barrantes C, Zamora V, Pont A, Miret C, Barrufet C, Caballero-Rabasco MA, Praena-Crespo M, Bercedo A, Valdesoiro-Navarrete L, Guerra MT, Pardo Y, Martínez Zapata MJ, Garin O, Ferrer M; ARCA Group
Eur Respir Rev 2023 Dec 31;32(170) Epub 2023 Oct 18 doi: 10.1183/16000617.0124-2023. PMID: 37852659Free PMC Article
Luo C, Peng S, Li M, Ao X, Liu Z
Front Immunol 2022;13:848279. Epub 2022 May 19 doi: 10.3389/fimmu.2022.848279. PMID: 35663980Free PMC Article
He M, Qin W, Qin Z, Zhao C
Eur J Med Res 2022 Apr 25;27(1):58. doi: 10.1186/s40001-022-00682-3. PMID: 35462555Free PMC Article
Li S, Wu W, Wang G, Zhang X, Guo Q, Wang B, Cao S, Yan M, Pan X, Xue T, Gong J, Duan X
Environ Res 2022 Apr 1;205:112472. Epub 2021 Dec 1 doi: 10.1016/j.envres.2021.112472. PMID: 34863689
Liu J, Zhang X, Zhao Y, Wang Y
PLoS One 2020;15(2):e0228533. Epub 2020 Feb 13 doi: 10.1371/journal.pone.0228533. PMID: 32053609Free PMC Article

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