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Sinoatrial block

MedGen UID:
19984
•Concept ID:
C0037188
•
Disease or Syndrome
Synonyms: Block, Sinoatrial; Block, Sinoatrial Exit; Blocks, Sinoatrial; Blocks, Sinoatrial Exit; Exit Block, Sinoatrial; Exit Blocks, Sinoatrial; Sinoatrial Block; Sinoatrial Blocks; Sinoatrial Exit Block; Sinoatrial Exit Blocks
SNOMED CT: Sinoatrial block (65778007); Sinoauricular block (65778007); Sinoatrial exit block (65778007)
 
HPO: HP:0012723
Monarch Initiative: MONDO:0020806

Definition

Disturbance in the atrial activation that is caused by transient failure of impulse conduction from the sinoatrial node to the cardiac atria. [from HPO]

Conditions with this feature

Intellectual disability, keratoconus, febrile seizures, and sinoatrial block
MedGen UID:
324455
•Concept ID:
C1836202
•
Disease or Syndrome
See: Condition Record
Sick sinus syndrome 4
MedGen UID:
1794159
•Concept ID:
C5561949
•
Disease or Syndrome
Sick sinus syndrome-4 (SSS4) is characterized by early and progressive sinus node and atrioventricular conduction dysfunction. Patients show bradycardia and chronotropic incompetence, and may experience syncope. Atrioventricular conduction block ranges from mild to severe, and some patients also have intermittent atrial fibrillation. Many require implantation of a pacemaker, but sudden cardiac death has not been reported (Stallmeyer et al., 2017). For a general phenotypic description and discussion of genetic heterogeneity of sick sinus syndrome, see SSS1 (608567).
See: Condition Record
Intellectual disability, keratoconus, febrile seizures, and sinoatrial block
Sick sinus syndrome 4

Professional guidelines

PubMed

Management of arrhythmias in patients with Takotsubo cardiomyopathy: Is the implantation of permanent devices necessary?
Stiermaier T, Rommel KP, Eitel C, Möller C, Graf T, Desch S, Thiele H, Eitel I
Heart Rhythm 2016 Oct;13(10):1979-86. Epub 2016 Jun 11 doi: 10.1016/j.hrthm.2016.06.013. PMID: 27298201
Diagnosis and treatment of sick sinus syndrome.
Adán V, Crown LA
Am Fam Physician 2003 Apr 15;67(8):1725-32. PMID: 12725451
Treatment of sick sinus syndrome with permanent cardiac pacemaker. (Sick sinus syndrome and artificial pacemaker).
Matsura Y, Yamashina H, Mishima H, Futakawa S, Sekiguchi Y, Takizawa I
J Cardiovasc Surg (Torino) 1977 Sep-Oct;18(5):447-52. PMID: 591551

Recent clinical studies

Etiology

EvaLuation Using Cardiac Insertable Devices And TelephonE in Hypertrophic Cardiomyopathy (ELUCIDATE HCM): A prospective observational study on incidence of arrhythmias.
Magnusson P, Mörner S
J Cardiovasc Electrophysiol 2021 Jan;32(1):129-135. Epub 2020 Nov 4 doi: 10.1111/jce.14792. PMID: 33108031Free PMC Article
Grouped beats: what's the mechanism?
Baranchuk A, Miranda R, Rana J, Michael KA
Pacing Clin Electrophysiol 2012 Jan;35(1):95-6. Epub 2011 Jul 28 doi: 10.1111/j.1540-8159.2011.03175.x. PMID: 21797901
Sinus node disease. Current concepts in diagnosis and therapy.
Sneddon JF, Camm AJ
Drugs 1992 Nov;44(5):728-37. doi: 10.2165/00003495-199244050-00005. PMID: 1280565
Sinus node arrest and sino--atrial block.
Shaw DB, Southall DP
Eur Heart J 1984 Mar;5 Suppl A:83-7. doi: 10.1093/eurheartj/5.suppl_a.83. PMID: 6373289
A study on sinoatrial conduction in the aged.
Ueda K, Kamata C, Matsuo H, Ohkawa S, Okimoto T
Jpn Heart J 1977 Mar;18(2):143-53. doi: 10.1536/ihj.18.143. PMID: 870724

Diagnosis

Sick Sinus Syndrome.
De Ponti R, Marazzato J, Bagliani G, Leonelli FM, Padeletti L
Card Electrophysiol Clin 2018 Jun;10(2):183-195. doi: 10.1016/j.ccep.2018.02.002. PMID: 29784479
The Wenckebach phenomenon.
Conner RP
Heart Lung 1987 Sep;16(5):506-18. PMID: 3654242
Sinus node arrest and sino--atrial block.
Shaw DB, Southall DP
Eur Heart J 1984 Mar;5 Suppl A:83-7. doi: 10.1093/eurheartj/5.suppl_a.83. PMID: 6373289
Fetal cardiac arrhythmias.
Shenker L
Obstet Gynecol Surv 1979 Aug;34(8):561-72. doi: 10.1097/00006254-197908000-00001. PMID: 384305
The tachycardia-bradycardia syndrome.
Kaplan BM
Med Clin North Am 1976 Jan;60(1):81-99. doi: 10.1016/s0025-7125(16)31921-6. PMID: 1107695

Therapy

Update on sick sinus syndrome, a cardiac disorder of aging.
Rodriguez RD, Schocken DD
Geriatrics 1990 Jan;45(1):26-30, 33-6. PMID: 2403955
Circulatory and metabolic aspects of beta-adrenoceptor blockade.
Frishman WH
Am Heart J 1988 Nov;116(5 Pt 2):1393-400. doi: 10.1016/0002-8703(88)90129-9. PMID: 2903649
Amiodarone-induced sinoatrial block.
Strasberg B, Davidson E, Berand M
Int J Cardiol 1985 Jun;8(2):214-6. doi: 10.1016/0167-5273(85)90291-8. PMID: 4008111
The tachycardia-bradycardia syndrome.
Kaplan BM
Med Clin North Am 1976 Jan;60(1):81-99. doi: 10.1016/s0025-7125(16)31921-6. PMID: 1107695
Drug-aggravated sinoatrial block.
Evans TR, Krikler DM
Proc R Soc Med 1975 Dec;68(12):808-9. PMID: 1219757Free PMC Article

Prognosis

Diagnosis and treatment of sick sinus syndrome.
Adán V, Crown LA
Am Fam Physician 2003 Apr 15;67(8):1725-32. PMID: 12725451
Update on sick sinus syndrome, a cardiac disorder of aging.
Rodriguez RD, Schocken DD
Geriatrics 1990 Jan;45(1):26-30, 33-6. PMID: 2403955
Sinus node arrest and sino--atrial block.
Shaw DB, Southall DP
Eur Heart J 1984 Mar;5 Suppl A:83-7. doi: 10.1093/eurheartj/5.suppl_a.83. PMID: 6373289
Atrial fibrillation in children.
Radford DJ, Izukawa T
Pediatrics 1977 Feb;59(2):250-6. PMID: 834508
The tachycardia-bradycardia syndrome.
Kaplan BM
Med Clin North Am 1976 Jan;60(1):81-99. doi: 10.1016/s0025-7125(16)31921-6. PMID: 1107695

Clinical prediction guides

EvaLuation Using Cardiac Insertable Devices And TelephonE in Hypertrophic Cardiomyopathy (ELUCIDATE HCM): A prospective observational study on incidence of arrhythmias.
Magnusson P, Mörner S
J Cardiovasc Electrophysiol 2021 Jan;32(1):129-135. Epub 2020 Nov 4 doi: 10.1111/jce.14792. PMID: 33108031Free PMC Article
Amiodarone-induced sinoatrial block.
Strasberg B, Davidson E, Berand M
Int J Cardiol 1985 Jun;8(2):214-6. doi: 10.1016/0167-5273(85)90291-8. PMID: 4008111
A study on sinoatrial conduction in the aged.
Ueda K, Kamata C, Matsuo H, Ohkawa S, Okimoto T
Jpn Heart J 1977 Mar;18(2):143-53. doi: 10.1536/ihj.18.143. PMID: 870724
Atrial fibrillation in children.
Radford DJ, Izukawa T
Pediatrics 1977 Feb;59(2):250-6. PMID: 834508
The sick sinus syndrome.
Sauerwein HP, Roos JC, Becker AE, Dunning AJ
Acta Med Scand 1976;199(6):467-73. doi: 10.1111/j.0954-6820.1976.tb06765.x. PMID: 937072

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