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Sinoatrial block

MedGen UID:
19984
•Concept ID:
C0037188
•
Disease or Syndrome
Synonyms: Block, Sinoatrial; Block, Sinoatrial Exit; Blocks, Sinoatrial; Blocks, Sinoatrial Exit; Exit Block, Sinoatrial; Exit Blocks, Sinoatrial; Sinoatrial Block; Sinoatrial Blocks; Sinoatrial Exit Block; Sinoatrial Exit Blocks
SNOMED CT: Sinoatrial block (65778007); Sinoauricular block (65778007); Sinoatrial exit block (65778007)
 
HPO: HP:0012723
Monarch Initiative: MONDO:0020806

Definition

Disturbance in the atrial activation that is caused by transient failure of impulse conduction from the sinoatrial node to the cardiac atria. [from HPO]

Conditions with this feature

Intellectual disability, keratoconus, febrile seizures, and sinoatrial block
MedGen UID:
324455
•Concept ID:
C1836202
•
Disease or Syndrome
See: Condition Record
Sick sinus syndrome 4
MedGen UID:
1794159
•Concept ID:
C5561949
•
Disease or Syndrome
Sick sinus syndrome-4 (SSS4) is characterized by early and progressive sinus node and atrioventricular conduction dysfunction. Patients show bradycardia and chronotropic incompetence, and may experience syncope. Atrioventricular conduction block ranges from mild to severe, and some patients also have intermittent atrial fibrillation. Many require implantation of a pacemaker, but sudden cardiac death has not been reported (Stallmeyer et al., 2017). For a general phenotypic description and discussion of genetic heterogeneity of sick sinus syndrome, see SSS1 (608567).
See: Condition Record
Intellectual disability, keratoconus, febrile seizures, and sinoatrial block
Sick sinus syndrome 4

Professional guidelines

PubMed

Management of arrhythmias in patients with Takotsubo cardiomyopathy: Is the implantation of permanent devices necessary?
Stiermaier T, Rommel KP, Eitel C, Möller C, Graf T, Desch S, Thiele H, Eitel I
Heart Rhythm 2016 Oct;13(10):1979-86. Epub 2016 Jun 11 doi: 10.1016/j.hrthm.2016.06.013. PMID: 27298201
Diagnosis and treatment of sick sinus syndrome.
Adán V, Crown LA
Am Fam Physician 2003 Apr 15;67(8):1725-32. PMID: 12725451
Long-term ventricular pacing in treatment of sinoatrial block.
Bayley TJ
Br Med J 1971 Aug;3(5772):456-8. doi: 10.1136/bmj.3.5772.456. PMID: 5567769Free PMC Article

Recent clinical studies

Etiology

Genetic predictors of sick sinus syndrome.
Timasheva Y, Badykov M, Akhmadishina L, Nasibullin T, Badykova E, Pushkareva A, Plechev V, Sagitov I, Zagidullin N
Mol Biol Rep 2021 Jun;48(6):5355-5362. Epub 2021 Jun 30 doi: 10.1007/s11033-021-06517-4. PMID: 34195885
The scoring of cardiac events during sleep.
Caples SM, Rosen CL, Shen WK, Gami AS, Cotts W, Adams M, Dorostkar P, Shivkumar K, Somers VK, Morgenthaler TI, Stepanski EJ, Iber C
J Clin Sleep Med 2007 Mar 15;3(2):147-54. PMID: 17557424
Sick sinus syndrome.
Brignole M
Clin Geriatr Med 2002 May;18(2):211-27. doi: 10.1016/s0749-0690(02)00006-x. PMID: 12180244
Sinus node arrest and sino--atrial block.
Shaw DB, Southall DP
Eur Heart J 1984 Mar;5 Suppl A:83-7. doi: 10.1093/eurheartj/5.suppl_a.83. PMID: 6373289
Chronic right bundle branch block and left posterior hemiblock. Clinical, electrophysiologic and prognostic observations.
Dhingra RC, Denes P, Wu D, Chuquimia R, Amat-Y-Leon F, Wyndham C, Rosen KM
Am J Cardiol 1975 Dec;36(7):867-79. doi: 10.1016/0002-9149(75)90075-2. PMID: 1199943

Diagnosis

Sick Sinus Syndrome.
De Ponti R, Marazzato J, Bagliani G, Leonelli FM, Padeletti L
Card Electrophysiol Clin 2018 Jun;10(2):183-195. doi: 10.1016/j.ccep.2018.02.002. PMID: 29784479
Bradydysrhythmias and atrioventricular conduction blocks.
Ufberg JW, Clark JS
Emerg Med Clin North Am 2006 Feb;24(1):1-9, v. doi: 10.1016/j.emc.2005.08.006. PMID: 16308110
Sick sinus syndrome.
Brignole M
Clin Geriatr Med 2002 May;18(2):211-27. doi: 10.1016/s0749-0690(02)00006-x. PMID: 12180244
Fetal cardiac arrhythmias.
Shenker L
Obstet Gynecol Surv 1979 Aug;34(8):561-72. doi: 10.1097/00006254-197908000-00001. PMID: 384305
The tachycardia-bradycardia syndrome.
Kaplan BM
Med Clin North Am 1976 Jan;60(1):81-99. doi: 10.1016/s0025-7125(16)31921-6. PMID: 1107695

Therapy

Sick sinus syndrome.
Brignole M
Clin Geriatr Med 2002 May;18(2):211-27. doi: 10.1016/s0749-0690(02)00006-x. PMID: 12180244
Cardiac electrophysiologic effects of moricizine hydrochloride.
Bigger JT Jr
Am J Cardiol 1990 Feb 20;65(8):15D-20D; discussion 68D-71D. doi: 10.1016/0002-9149(90)91412-y. PMID: 2407089
Circulatory and metabolic aspects of beta-adrenoceptor blockade.
Frishman WH
Am Heart J 1988 Nov;116(5 Pt 2):1393-400. doi: 10.1016/0002-8703(88)90129-9. PMID: 2903649
Amiodarone-induced sinoatrial block.
Strasberg B, Davidson E, Berand M
Int J Cardiol 1985 Jun;8(2):214-6. doi: 10.1016/0167-5273(85)90291-8. PMID: 4008111
The tachycardia-bradycardia syndrome.
Kaplan BM
Med Clin North Am 1976 Jan;60(1):81-99. doi: 10.1016/s0025-7125(16)31921-6. PMID: 1107695

Prognosis

Genetic predictors of sick sinus syndrome.
Timasheva Y, Badykov M, Akhmadishina L, Nasibullin T, Badykova E, Pushkareva A, Plechev V, Sagitov I, Zagidullin N
Mol Biol Rep 2021 Jun;48(6):5355-5362. Epub 2021 Jun 30 doi: 10.1007/s11033-021-06517-4. PMID: 34195885
Diagnosis and treatment of sick sinus syndrome.
Adán V, Crown LA
Am Fam Physician 2003 Apr 15;67(8):1725-32. PMID: 12725451
Sinus node arrest and sino--atrial block.
Shaw DB, Southall DP
Eur Heart J 1984 Mar;5 Suppl A:83-7. doi: 10.1093/eurheartj/5.suppl_a.83. PMID: 6373289
The tachycardia-bradycardia syndrome.
Kaplan BM
Med Clin North Am 1976 Jan;60(1):81-99. doi: 10.1016/s0025-7125(16)31921-6. PMID: 1107695
Chronic right bundle branch block and left posterior hemiblock. Clinical, electrophysiologic and prognostic observations.
Dhingra RC, Denes P, Wu D, Chuquimia R, Amat-Y-Leon F, Wyndham C, Rosen KM
Am J Cardiol 1975 Dec;36(7):867-79. doi: 10.1016/0002-9149(75)90075-2. PMID: 1199943

Clinical prediction guides

Genetic predictors of sick sinus syndrome.
Timasheva Y, Badykov M, Akhmadishina L, Nasibullin T, Badykova E, Pushkareva A, Plechev V, Sagitov I, Zagidullin N
Mol Biol Rep 2021 Jun;48(6):5355-5362. Epub 2021 Jun 30 doi: 10.1007/s11033-021-06517-4. PMID: 34195885
Ventricular arrhythmias and sudden cardiac arrest in Takotsubo cardiomyopathy: Incidence, predictive factors, and clinical implications.
Jesel L, Berthon C, Messas N, Lim HS, Girardey M, Marzak H, Marchandot B, Trinh A, Ohlmann P, Morel O
Heart Rhythm 2018 Aug;15(8):1171-1178. Epub 2018 Apr 6 doi: 10.1016/j.hrthm.2018.04.002. PMID: 29627435
Clinical significance of second degree Wenckebach type sinoatrial block identified during Holter monitoring in patients with symptoms suggestive of arrhythmia.
Kramarz E, Makowski K
Europace 2015 Jan;17(1):123-30. Epub 2014 Aug 2 doi: 10.1093/europace/euu158. PMID: 25087152
Sick sinus syndrome.
Brignole M
Clin Geriatr Med 2002 May;18(2):211-27. doi: 10.1016/s0749-0690(02)00006-x. PMID: 12180244
Wenckebach periods in sinoatrial block: experimental and clinical evidence.
Le Heuzey JY, Caron J, Guize L, Libersa C, Kacet S, Boutjdir M, Lavergne T, Lekieffre J
Pacing Clin Electrophysiol 1991 Jun;14(6):1032-9. doi: 10.1111/j.1540-8159.1991.tb04154.x. PMID: 1715064

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