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Sarcoma, Experimental

MedGen UID:
20652
•Concept ID:
C0036216
•
Experimental Model of Disease; Neoplastic Process
Synonyms: Experimental Sarcoma; Experimental Sarcomas; Sarcomas, Experimental

Definition

Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSarcoma, Experimental

Professional guidelines

PubMed

4-amino-2-phenyl-6-(p-fluorophenyl)-5-carbonitrile-pyrimidine-bis-substituted-loaded liposomes as promising system for cancer treatment.
Oliveira JV, Almeida GC, Nogueira MCBL, Aguiar Júnior FCA, Melo AO, Silva TDS, Santos NPS, Magalhães NSS, Melo SJ, Falcão EPS
An Acad Bras Cienc 2023;95(suppl 1):e20211078. Epub 2023 Jul 10 doi: 10.1590/0001-3765202320211078. PMID: 37436228
Survival impact of centralization and clinical guidelines for soft tissue sarcoma (A prospective and exhaustive population-based cohort).
Derbel O, Heudel PE, Cropet C, Meeus P, Vaz G, Biron P, Cassier P, Decouvelaere AV, Ranchere-Vince D, Collard O, De Laroche E, Thiesse P, Farsi F, Cellier D, Gilly FN, Blay JY, Ray-Coquard I
PLoS One 2017;12(2):e0158406. Epub 2017 Feb 3 doi: 10.1371/journal.pone.0158406. PMID: 28158190Free PMC Article

Recent clinical studies

Etiology

The anticancer peptide RT53 induces immunogenic cell death.
Pasquereau-Kotula E, Habault J, Kroemer G, Poyet JL
PLoS One 2018;13(8):e0201220. Epub 2018 Aug 6 doi: 10.1371/journal.pone.0201220. PMID: 30080874Free PMC Article
Present at the beginning: a personal reminiscence on the history of teriparatide.
Marcus R
Osteoporos Int 2011 Aug;22(8):2241-8. Epub 2011 Mar 31 doi: 10.1007/s00198-011-1598-x. PMID: 21452026
The high mobility group protein, HMGI-C.
Goodwin G
Int J Biochem Cell Biol 1998 Jul;30(7):761-6. doi: 10.1016/s1357-2725(98)00016-8. PMID: 9722980
Tumour pH in human mammary carcinoma.
van den Berg AP, Wike-Hooley JL, van den Berg-Blok AE, van der Zee J, Reinhold HS
Eur J Cancer Clin Oncol 1982 May;18(5):457-62. doi: 10.1016/0277-5379(82)90114-6. PMID: 6889524
Microwave absorption by normal and tumor cells.
Webb SJ, Booth AD
Science 1971 Oct 1;174(4004):72-4. doi: 10.1126/science.174.4004.72. PMID: 5120873

Diagnosis

Type 1 Innate Lymphoid Cells Limit the Antitumoral Immune Response.
Vienne M, Etiennot M, Escalière B, Galluso J, Spinelli L, Guia S, Fenis A, Vivier E, Kerdiles YM
Front Immunol 2021;12:768989. Epub 2021 Nov 16 doi: 10.3389/fimmu.2021.768989. PMID: 34868026Free PMC Article
PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α.
Klotzsche-von Ameln A, Prade I, Grosser M, Kettelhake A, Rezaei M, Chavakis T, Flamme I, Wielockx B, Breier G
Mol Cancer Res 2013 Nov;11(11):1337-48. Epub 2013 Sep 18 doi: 10.1158/1541-7786.MCR-13-0201. PMID: 24048703
Osteosarcoma and other tumors of bone.
Mertens WC, Bramwell V
Curr Opin Oncol 1994 Jul;6(4):384-90. doi: 10.1097/00001622-199407000-00010. PMID: 7803539
Cytogenetic and experimental models.
Fletcher J
Curr Opin Oncol 1992 Aug;4(4):659-66. doi: 10.1097/00001622-199208000-00010. PMID: 1511022
Cell cycle analysis using flow cytometry.
Gray JW, Dolbeare F, Pallavicini MG, Beisker W, Waldman F
Int J Radiat Biol Relat Stud Phys Chem Med 1986 Feb;49(2):237-55. doi: 10.1080/09553008514552531. PMID: 3510993

Therapy

Dendritic cell immunotherapy in soft tissue sarcoma.
Indelicato DJ, Finkelstein SE
Immunotherapy 2012 Oct;4(10):1023-9. doi: 10.2217/imt.12.106. PMID: 23148754
Cell cycle analysis using flow cytometry.
Gray JW, Dolbeare F, Pallavicini MG, Beisker W, Waldman F
Int J Radiat Biol Relat Stud Phys Chem Med 1986 Feb;49(2):237-55. doi: 10.1080/09553008514552531. PMID: 3510993
A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes.
Rosenberg SA, Spiess P, Lafreniere R
Science 1986 Sep 19;233(4770):1318-21. doi: 10.1126/science.3489291. PMID: 3489291
Radiation sensitizers.
Cancer 1976 Apr;37(4 Suppl):2062-70. PMID: 130967
Implications of cancer immunity.
Burnet FM
Aust N Z J Med 1973 Feb;3(1):71-7. doi: 10.1111/j.1445-5994.1973.tb03959.x. PMID: 4573195

Prognosis

Chemical sympathectomy suppresses fibrosarcoma development and improves survival of tumor-bearing rats.
Lackovicova L, Banovska L, Bundzikova J, Janega P, Bizik J, Kiss A, Mravec B
Neoplasma 2011;58(5):424-9. doi: 10.4149/neo_2011_05_424. PMID: 21744996
Phosphorus MR spectroscopy in the treatment of human extremity sarcomas.
Sijens PE
NMR Biomed 1998 Nov;11(7):341-53. doi: 10.1002/(sici)1099-1492(1998110)11:7<341::aid-nbm516>3.0.co;2-u. PMID: 9859940
Osteosarcoma and other tumors of bone.
Mertens WC, Bramwell V
Curr Opin Oncol 1994 Jul;6(4):384-90. doi: 10.1097/00001622-199407000-00010. PMID: 7803539
Perioperative blood transfusions and survival in osteosarcoma.
Chesi R, Borghi B, Lari S
Cancer Treat Res 1993;62:25-8. doi: 10.1007/978-1-4615-3518-8_4. PMID: 8096741
Cytogenetic and experimental models.
Fletcher J
Curr Opin Oncol 1992 Aug;4(4):659-66. doi: 10.1097/00001622-199208000-00010. PMID: 1511022

Clinical prediction guides

The anticancer peptide RT53 induces immunogenic cell death.
Pasquereau-Kotula E, Habault J, Kroemer G, Poyet JL
PLoS One 2018;13(8):e0201220. Epub 2018 Aug 6 doi: 10.1371/journal.pone.0201220. PMID: 30080874Free PMC Article
Oxygen microbubbles improve radiotherapy tumor control in a rat fibrosarcoma model - A preliminary study.
Fix SM, Papadopoulou V, Velds H, Kasoji SK, Rivera JN, Borden MA, Chang S, Dayton PA
PLoS One 2018;13(4):e0195667. Epub 2018 Apr 9 doi: 10.1371/journal.pone.0195667. PMID: 29630640Free PMC Article
Antitumor activity of levan polysaccharides from selected microorganisms.
Yoo SH, Yoon EJ, Cha J, Lee HG
Int J Biol Macromol 2004 Apr;34(1-2):37-41. doi: 10.1016/j.ijbiomac.2004.01.002. PMID: 15178007
The high mobility group protein, HMGI-C.
Goodwin G
Int J Biochem Cell Biol 1998 Jul;30(7):761-6. doi: 10.1016/s1357-2725(98)00016-8. PMID: 9722980
Antitumor 2-(aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- hydrazines.
Shyam K, Penketh PG, Loomis RH, Rose WC, Sartorelli AC
J Med Chem 1996 Feb 2;39(3):796-801. doi: 10.1021/jm9505021. PMID: 8576923

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