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Experimental Tumor

MedGen UID:
10216
•Concept ID:
C0027659
•
Experimental Model of Disease; Neoplastic Process
Synonyms: Experimental Neoplasm; Experimental Neoplasms; Neoplasm, Experimental; Neoplasms, Experimental

Definition

Laboratory tumor models used to study tumor development and treatment. [from NCI]

Professional guidelines

PubMed

Criteria to make animal studies more relevant to treating human cancer.
Wolf SP, Wen FT, Schreiber H
Curr Opin Immunol 2022 Feb;74:25-31. Epub 2021 Oct 4 doi: 10.1016/j.coi.2021.09.002. PMID: 34619458Free PMC Article
MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer.
Tisato V, Voltan R, Gonelli A, Secchiero P, Zauli G
J Hematol Oncol 2017 Jul 3;10(1):133. doi: 10.1186/s13045-017-0500-5. PMID: 28673313Free PMC Article
Somatostatin and analogues in the treatment of cancer. A review.
Evers BM, Parekh D, Townsend CM Jr, Thompson JC
Ann Surg 1991 Mar;213(3):190-8. doi: 10.1097/00000658-199103000-00002. PMID: 1671812Free PMC Article

Recent clinical studies

Etiology

Practical guidelines for the management of adverse events of the T cell engager bispecific tebentafusp.
Hassel JC, Berking C, Forschner A, Gebhardt C, Heinzerling L, Meier F, Ochsenreither S, Siveke J, Hauschild A, Schadendorf D
Eur J Cancer 2023 Sep;191:112986. Epub 2023 Jul 11 doi: 10.1016/j.ejca.2023.112986. PMID: 37595494
Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells.
Patnana PK, Liu L, Frank D, Nimmagadda SC, Behrens M, Ahmed H, Xie X, Liebmann M, Wei L, Gerdemann A, Thivakaran A, Humpf HU, Klotz L, Dugas M, Varghese J, Trajkovic-Arsic M, Siveke JT, Hanenberg H, Opalka B, Dührsen U, Reinhardt HC, Guenther U, von Bubnoff N, Khandanpour C
Br J Haematol 2023 Sep;202(5):1033-1048. Epub 2023 Jul 9 doi: 10.1111/bjh.18939. PMID: 37423893
Fibroblast Activation Protein Inhibitor Theranostics: The Case for Use in Sarcoma.
Hamacher R, Lanzafame H, Mavroeidi IA, Pabst KM, Kessler L, Cheung PF, Bauer S, Herrmann K, Schildhaus HU, Siveke JT, Fendler WP
PET Clin 2023 Jul;18(3):361-367. Epub 2023 Mar 28 doi: 10.1016/j.cpet.2023.02.008. PMID: 36997366
Novel (68)Ga-FAPI PET/CT Offers Oncologic Staging Without COVID-19 Vaccine-Related Pitfalls.
Demmert TT, Maric I, Pomykala KL, Lueckerath K, Siveke J, Schaarschmidt BM, Hamacher R, Herrmann K, Fendler WP
J Nucl Med 2023 Mar;64(3):368-371. Epub 2022 Nov 17 doi: 10.2967/jnumed.122.264872. PMID: 36396454Free PMC Article
Synthesis and biological activity of 21,22-cyclosteroids and their derivatives.
Barysevich MV, Laktsevich-Iskryk MV, Scherbakov AM, Salnikova DI, Andreeva OE, Sorokin DV, Shchegolev YY, Hurski AL, Zhabinskii VN, Khripach VA
Steroids 2022 Dec;188:109135. Epub 2022 Nov 3 doi: 10.1016/j.steroids.2022.109135. PMID: 36336105

Diagnosis

Early Metabolic Response by PET Predicts Sensitivity to Next-Line Targeted Therapy in EGFR-Mutated Lung Cancer with Unknown Mechanism of Acquired Resistance.
Schuler M, Hense J, Darwiche K, Michels S, Hautzel H, Kobe C, Lueong S, Metzenmacher M, Herold T, Zaun G, Laue K, Drzezga A, Theegarten D, Nensa F, Wolf J, Herrmann K, Wiesweg M
J Nucl Med 2024 Jun 3;65(6):851-855. doi: 10.2967/jnumed.123.266979. PMID: 38575188
Oncologic Staging with (68)Ga-FAPI PET/CT Demonstrates a Lower Rate of Nonspecific Lymph Node Findings Than (18)F-FDG PET/CT.
Demmert TT, Pomykala KL, Lanzafame H, Pabst KM, Lueckerath K, Siveke J, Umutlu L, Hautzel H, Hamacher R, Herrmann K, Fendler WP
J Nucl Med 2023 Dec 1;64(12):1906-1909. doi: 10.2967/jnumed.123.265751. PMID: 37734836
Practical guidelines for the management of adverse events of the T cell engager bispecific tebentafusp.
Hassel JC, Berking C, Forschner A, Gebhardt C, Heinzerling L, Meier F, Ochsenreither S, Siveke J, Hauschild A, Schadendorf D
Eur J Cancer 2023 Sep;191:112986. Epub 2023 Jul 11 doi: 10.1016/j.ejca.2023.112986. PMID: 37595494
When cytoprotective autophagy isn't… and even when it is.
Gewirtz DA
Autophagy 2014 Mar;10(3):391-2. Epub 2014 Jan 6 doi: 10.4161/auto.27719. PMID: 24419177Free PMC Article
Brain tumors.
Black KL, Mazziotta JC, Becker DP
West J Med 1991 Feb;154(2):186-97. PMID: 1848735Free PMC Article

Therapy

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer.
Tintelnot J, Xu Y, Lesker TR, Schönlein M, Konczalla L, Giannou AD, Pelczar P, Kylies D, Puelles VG, Bielecka AA, Peschka M, Cortesi F, Riecken K, Jung M, Amend L, Bröring TS, Trajkovic-Arsic M, Siveke JT, Renné T, Zhang D, Boeck S, Strowig T, Uzunoglu FG, Güngör C, Stein A, Izbicki JR, Bokemeyer C, Sinn M, Kimmelman AC, Huber S, Gagliani N
Nature 2023 Mar;615(7950):168-174. Epub 2023 Feb 22 doi: 10.1038/s41586-023-05728-y. PMID: 36813961Free PMC Article
Biomimetic Immunosuppressive Exosomes that Inhibit Cytokine Storms Contribute to the Alleviation of Sepsis.
Li Y, Zhang H, Chen C, Qiao K, Li Z, Han J, Han X, Li K, Lai K, Liu N, Li A, Xiao N, Zhang Y, Zhao X, Gao W, Zhang Y, Liu H, Sun T
Adv Mater 2022 May;34(19):e2108476. Epub 2022 Apr 3 doi: 10.1002/adma.202108476. PMID: 35267211
Rituximab biosimilars for lymphoma in Europe.
Jurczak W, Długosz Danecka M, Buske C
Expert Opin Biol Ther 2019 Oct;19(10):1045-1056. doi: 10.1080/14712598.2019.1665017. PMID: 31512535
Future of cancer vaccines.
Winter H, Fox BA, Rüttinger D
Methods Mol Biol 2014;1139:555-64. doi: 10.1007/978-1-4939-0345-0_40. PMID: 24619704
Protection against cancer by dietary IP6 and inositol.
Vucenik I, Shamsuddin AM
Nutr Cancer 2006;55(2):109-25. doi: 10.1207/s15327914nc5502_1. PMID: 17044765

Prognosis

Early Metabolic Response by PET Predicts Sensitivity to Next-Line Targeted Therapy in EGFR-Mutated Lung Cancer with Unknown Mechanism of Acquired Resistance.
Schuler M, Hense J, Darwiche K, Michels S, Hautzel H, Kobe C, Lueong S, Metzenmacher M, Herold T, Zaun G, Laue K, Drzezga A, Theegarten D, Nensa F, Wolf J, Herrmann K, Wiesweg M
J Nucl Med 2024 Jun 3;65(6):851-855. doi: 10.2967/jnumed.123.266979. PMID: 38575188
Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells.
Patnana PK, Liu L, Frank D, Nimmagadda SC, Behrens M, Ahmed H, Xie X, Liebmann M, Wei L, Gerdemann A, Thivakaran A, Humpf HU, Klotz L, Dugas M, Varghese J, Trajkovic-Arsic M, Siveke JT, Hanenberg H, Opalka B, Dührsen U, Reinhardt HC, Guenther U, von Bubnoff N, Khandanpour C
Br J Haematol 2023 Sep;202(5):1033-1048. Epub 2023 Jul 9 doi: 10.1111/bjh.18939. PMID: 37423893
Fibroblast Activation Protein Inhibitor Theranostics: The Case for Use in Sarcoma.
Hamacher R, Lanzafame H, Mavroeidi IA, Pabst KM, Kessler L, Cheung PF, Bauer S, Herrmann K, Schildhaus HU, Siveke JT, Fendler WP
PET Clin 2023 Jul;18(3):361-367. Epub 2023 Mar 28 doi: 10.1016/j.cpet.2023.02.008. PMID: 36997366
Lymphangiogenesis and colorectal cancer.
Huang C, Chen Y
Saudi Med J 2017 Mar;38(3):237-244. doi: 10.15537/smj.2017.3.16245. PMID: 28251217Free PMC Article
Future of cancer vaccines.
Winter H, Fox BA, Rüttinger D
Methods Mol Biol 2014;1139:555-64. doi: 10.1007/978-1-4939-0345-0_40. PMID: 24619704

Clinical prediction guides

Oncologic Staging with (68)Ga-FAPI PET/CT Demonstrates a Lower Rate of Nonspecific Lymph Node Findings Than (18)F-FDG PET/CT.
Demmert TT, Pomykala KL, Lanzafame H, Pabst KM, Lueckerath K, Siveke J, Umutlu L, Hautzel H, Hamacher R, Herrmann K, Fendler WP
J Nucl Med 2023 Dec 1;64(12):1906-1909. doi: 10.2967/jnumed.123.265751. PMID: 37734836
Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer.
Tintelnot J, Xu Y, Lesker TR, Schönlein M, Konczalla L, Giannou AD, Pelczar P, Kylies D, Puelles VG, Bielecka AA, Peschka M, Cortesi F, Riecken K, Jung M, Amend L, Bröring TS, Trajkovic-Arsic M, Siveke JT, Renné T, Zhang D, Boeck S, Strowig T, Uzunoglu FG, Güngör C, Stein A, Izbicki JR, Bokemeyer C, Sinn M, Kimmelman AC, Huber S, Gagliani N
Nature 2023 Mar;615(7950):168-174. Epub 2023 Feb 22 doi: 10.1038/s41586-023-05728-y. PMID: 36813961Free PMC Article
Biomimetic Immunosuppressive Exosomes that Inhibit Cytokine Storms Contribute to the Alleviation of Sepsis.
Li Y, Zhang H, Chen C, Qiao K, Li Z, Han J, Han X, Li K, Lai K, Liu N, Li A, Xiao N, Zhang Y, Zhao X, Gao W, Zhang Y, Liu H, Sun T
Adv Mater 2022 May;34(19):e2108476. Epub 2022 Apr 3 doi: 10.1002/adma.202108476. PMID: 35267211
Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint.
Wischhusen J, Melero I, Fridman WH
Front Immunol 2020;11:951. Epub 2020 May 19 doi: 10.3389/fimmu.2020.00951. PMID: 32508832Free PMC Article
When cytoprotective autophagy isn't… and even when it is.
Gewirtz DA
Autophagy 2014 Mar;10(3):391-2. Epub 2014 Jan 6 doi: 10.4161/auto.27719. PMID: 24419177Free PMC Article

Recent systematic reviews

Experimental Tumor Induction and Evaluation of Its Treatment in the Chicken Embryo Chorioallantoic Membrane Model: A Systematic Review.
Mesas C, Chico MA, Doello K, Lara P, Moreno J, Melguizo C, Perazzoli G, Prados J
Int J Mol Sci 2024 Jan 9;25(2) doi: 10.3390/ijms25020837. PMID: 38255911Free PMC Article

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