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Ascariasis

MedGen UID:
2087
•Concept ID:
C0003950
•
Disease or Syndrome
Synonyms: Ascariases; Ascaris Infection; Ascaris Infections; Infection, Ascaris; Infections, Ascaris
SNOMED CT: Ascariasis - roundworms (2435008); Ascariasis (2435008); Ascariosis (2435008)
 
Monarch Initiative: MONDO:0005654

Definition

An infection that is caused by the roundworm Ascaris lumbricoides, many cases of which remain asymptomatic. During the transient larval migratory phase, shortness of breath, fever, and eosinophilia can occur. Depending on the intestinal worm burden, a spectrum of gastrointestinal tract symptoms can occur. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAscariasis

Professional guidelines

PubMed

Efficacy of triple dose albendazole treatment for soil-transmitted helminth infections.
Tee MZ, Lee SC, Er YX, Yap NJ, Ngui R, Easton AV, Siow VWY, Ng KS, Boey CCM, Chua KH, Cadwell K, Loke P, Lim YAL
PLoS One 2022;17(8):e0272821. Epub 2022 Aug 12 doi: 10.1371/journal.pone.0272821. PMID: 35960935Free PMC Article
Treatment response and long-term outcomes in biliary ascariasis: A prospective study.
Patra PS, Das A, Ahmed SKM, Mitra S, Dhali GK
Arab J Gastroenterol 2021 Jun;22(2):164-169. Epub 2021 Mar 19 doi: 10.1016/j.ajg.2020.11.002. PMID: 33752976
Worm Infestation: Diagnosis, Treatment and Prevention.
Bharti B, Bharti S, Khurana S
Indian J Pediatr 2018 Nov;85(11):1017-1024. Epub 2017 Nov 11 doi: 10.1007/s12098-017-2505-z. PMID: 29127616

Recent clinical studies

Etiology

SHOULD ASCARIASIS BE CONSIDERED AS A REPRODUCTOLOGY PROBLEM?
Sklyarova V, Shatylovich K, Sklyarov P, Filipyuk A
Wiad Lek 2021;74(9 cz 1):2138-2146. PMID: 34725290
Soil-Transmitted Helminth Vaccines: Are We Getting Closer?
Zawawi A, Else KJ
Front Immunol 2020;11:576748. Epub 2020 Sep 30 doi: 10.3389/fimmu.2020.576748. PMID: 33133094Free PMC Article
Whipworm and roundworm infections.
Else KJ, Keiser J, Holland CV, Grencis RK, Sattelle DB, Fujiwara RT, Bueno LL, Asaolu SO, Sowemimo OA, Cooper PJ
Nat Rev Dis Primers 2020 May 28;6(1):44. doi: 10.1038/s41572-020-0171-3. PMID: 32467581
Parasite allergens.
Caraballo L, Coronado S
Mol Immunol 2018 Aug;100:113-119. Epub 2018 Mar 24 doi: 10.1016/j.molimm.2018.03.014. PMID: 29588070
Parasitic pneumonia.
Berk SL, Verghese A
Semin Respir Infect 1988 Jun;3(2):172-8. PMID: 3041517

Diagnosis

Biliary Ascariasis.
Chaves JJ, Chaves-Chamorro JO
N Engl J Med 2023 Aug 31;389(9):839. Epub 2023 Aug 26 doi: 10.1056/NEJMicm2301930. PMID: 37632462
Ascariasis, a review.
Schindler-Piontek M, Chaubal N, Dehmani S, Cui XW, Dong Y, Sharma M, Dietrich CF
Med Ultrason 2022 Aug 31;24(3):329-338. Epub 2021 Aug 3 doi: 10.11152/mu-3343. PMID: 34379712
Human Ascariasis: An Updated Review.
Leung AKC, Leung AAM, Wong AHC, Hon KL
Recent Pat Inflamm Allergy Drug Discov 2020;14(2):133-145. doi: 10.2174/1872213X14666200705235757. PMID: 32628606
Whipworm and roundworm infections.
Else KJ, Keiser J, Holland CV, Grencis RK, Sattelle DB, Fujiwara RT, Bueno LL, Asaolu SO, Sowemimo OA, Cooper PJ
Nat Rev Dis Primers 2020 May 28;6(1):44. doi: 10.1038/s41572-020-0171-3. PMID: 32467581
Ascaris.
Burnett MW
J Spec Oper Med 2018 Summer;18(2):115-116. doi: 10.55460/FFEM-COO8. PMID: 29889967

Therapy

Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update.
Chai JY, Jung BK, Hong SJ
Korean J Parasitol 2021 Jun;59(3):189-225. Epub 2021 Jun 21 doi: 10.3347/kjp.2021.59.3.189. PMID: 34218593Free PMC Article
Human Ascariasis: An Updated Review.
Leung AKC, Leung AAM, Wong AHC, Hon KL
Recent Pat Inflamm Allergy Drug Discov 2020;14(2):133-145. doi: 10.2174/1872213X14666200705235757. PMID: 32628606
Ascaris.
Burnett MW
J Spec Oper Med 2018 Summer;18(2):115-116. doi: 10.55460/FFEM-COO8. PMID: 29889967
Ascariasis and hookworm.
Sarinas PS, Chitkara RK
Semin Respir Infect 1997 Jun;12(2):130-7. PMID: 9195678
Ascariasis.
Khuroo MS
Gastroenterol Clin North Am 1996 Sep;25(3):553-77. doi: 10.1016/s0889-8553(05)70263-6. PMID: 8863040

Prognosis

The Scabies Epidemic During the Covid-19 Pandemic.
Etiz P, Altunsu AT
Turkiye Parazitol Derg 2023 Dec 27;47(4):235-239. doi: 10.4274/tpd.galenos.2023.44154. PMID: 38149445
Mucocutaneous manifestations of helminth infections: Nematodes.
Lupi O, Downing C, Lee M, Pino L, Bravo F, Giglio P, Sethi A, Klaus S, Sangueza OP, Fuller C, Mendoza N, Ladizinski B, Woc-Colburn L, Tyring SK
J Am Acad Dermatol 2015 Dec;73(6):929-44; quiz 945-6. doi: 10.1016/j.jaad.2014.11.034. PMID: 26568337
Europe's neglected infections of poverty.
Hotez PJ, Gurwith M
Int J Infect Dis 2011 Sep;15(9):e611-9. Epub 2011 Jul 16 doi: 10.1016/j.ijid.2011.05.006. PMID: 21763173
Biliary ascariasis: a review.
Shah OJ, Zargar SA, Robbani I
World J Surg 2006 Aug;30(8):1500-6. doi: 10.1007/s00268-005-0309-1. PMID: 16874446
Biliary parasites.
Osman M, Lausten SB, El-Sefi T, Boghdadi I, Rashed MY, Jensen SL
Dig Surg 1998;15(4):287-96. doi: 10.1159/000018640. PMID: 9845601

Clinical prediction guides

Resurgence of intestinal ascariasis among adults: radiological diagnosis and clinical implications.
Ghahremani GG, Hahn ME
Abdom Radiol (NY) 2022 Mar;47(3):915-922. Epub 2022 Jan 11 doi: 10.1007/s00261-022-03407-6. PMID: 35015117
Human Ascariasis: An Updated Review.
Leung AKC, Leung AAM, Wong AHC, Hon KL
Recent Pat Inflamm Allergy Drug Discov 2020;14(2):133-145. doi: 10.2174/1872213X14666200705235757. PMID: 32628606
Parasite allergens.
Caraballo L, Coronado S
Mol Immunol 2018 Aug;100:113-119. Epub 2018 Mar 24 doi: 10.1016/j.molimm.2018.03.014. PMID: 29588070
Ascaris and ascariasis.
Crompton DW
Adv Parasitol 2001;48:285-375. doi: 10.1016/s0065-308x(01)48008-0. PMID: 11013758
Ascariasis and childhood malnutrition.
Hlaing T
Parasitology 1993;107 Suppl:S125-36. doi: 10.1017/s0031182000075557. PMID: 8115177

Recent systematic reviews

A systematic review of neglected tropical diseases (NTDs) in Myanmar.
Swe MMM, Phyo AP, Cooper BS, White NJ, Smithuis F, Ashley EA
PLoS Negl Trop Dis 2023 Nov;17(11):e0011706. Epub 2023 Nov 1 doi: 10.1371/journal.pntd.0011706. PMID: 37910592Free PMC Article
Global prevalence of Ascaris infection in humans (2010-2021): a systematic review and meta-analysis.
Holland C, Sepidarkish M, Deslyper G, Abdollahi A, Valizadeh S, Mollalo A, Mahjour S, Ghodsian S, Ardekani A, Behniafar H, Gasser RB, Rostami A
Infect Dis Poverty 2022 Nov 18;11(1):113. doi: 10.1186/s40249-022-01038-z. PMID: 36401308Free PMC Article
The prevalence of human trichuriasis in Asia: a systematic review and meta-analysis.
Badri M, Olfatifar M, Wandra T, Budke CM, Mahmoudi R, Abdoli A, Hajialilo E, Pestehchian N, Ghaffarifar F, Foroutan M, Hashemipour S, Sotoodeh S, Samimi R, Eslahi AV
Parasitol Res 2022 Jan;121(1):1-10. Epub 2022 Jan 6 doi: 10.1007/s00436-021-07365-8. PMID: 34993634
A historical and systematic overview of Ascaris vaccine development.
Gazzinelli-Guimarães AC, Gazzinelli-Guimarães P, Weatherhead JE
Parasitology 2021 Dec;148(14):1795-1805. Epub 2021 Aug 9 doi: 10.1017/s0031182021001347. PMID: 35586777Free PMC Article
Systematic review of evidence on the effectiveness of safe child faeces disposal interventions.
Morita T, Godfrey S, George CM
Trop Med Int Health 2016 Nov;21(11):1403-1419. Epub 2016 Sep 16 doi: 10.1111/tmi.12773. PMID: 27546207

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