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Ascariasis

MedGen UID:
2087
•Concept ID:
C0003950
•
Disease or Syndrome
Synonyms: Ascariases; Ascaris Infection; Ascaris Infections; Infection, Ascaris; Infections, Ascaris
SNOMED CT: Ascariasis - roundworms (2435008); Ascariasis (2435008); Ascariosis (2435008)
 
Monarch Initiative: MONDO:0005654

Definition

An infection that is caused by the roundworm Ascaris lumbricoides, many cases of which remain asymptomatic. During the transient larval migratory phase, shortness of breath, fever, and eosinophilia can occur. Depending on the intestinal worm burden, a spectrum of gastrointestinal tract symptoms can occur. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAscariasis

Professional guidelines

PubMed

Treatment response and long-term outcomes in biliary ascariasis: A prospective study.
Patra PS, Das A, Ahmed SKM, Mitra S, Dhali GK
Arab J Gastroenterol 2021 Jun;22(2):164-169. Epub 2021 Mar 19 doi: 10.1016/j.ajg.2020.11.002. PMID: 33752976
Parasites of the liver - epidemiology, diagnosis and clinical management in the European context.
Peters L, Burkert S, Grüner B
J Hepatol 2021 Jul;75(1):202-218. Epub 2021 Feb 24 doi: 10.1016/j.jhep.2021.02.015. PMID: 33636243
Worm Infestation: Diagnosis, Treatment and Prevention.
Bharti B, Bharti S, Khurana S
Indian J Pediatr 2018 Nov;85(11):1017-1024. Epub 2017 Nov 11 doi: 10.1007/s12098-017-2505-z. PMID: 29127616

Recent clinical studies

Etiology

Whipworm and roundworm infections.
Else KJ, Keiser J, Holland CV, Grencis RK, Sattelle DB, Fujiwara RT, Bueno LL, Asaolu SO, Sowemimo OA, Cooper PJ
Nat Rev Dis Primers 2020 May 28;6(1):44. doi: 10.1038/s41572-020-0171-3. PMID: 32467581
Parasite allergens.
Caraballo L, Coronado S
Mol Immunol 2018 Aug;100:113-119. Epub 2018 Mar 24 doi: 10.1016/j.molimm.2018.03.014. PMID: 29588070
Worm Infestation: Diagnosis, Treatment and Prevention.
Bharti B, Bharti S, Khurana S
Indian J Pediatr 2018 Nov;85(11):1017-1024. Epub 2017 Nov 11 doi: 10.1007/s12098-017-2505-z. PMID: 29127616
Parasitic pneumonia.
Berk SL, Verghese A
Semin Respir Infect 1988 Jun;3(2):172-8. PMID: 3041517
Ascariasis: nutritional implications.
Schultz MG
Rev Infect Dis 1982 Jul-Aug;4(4):815-9. doi: 10.1093/4.4.815. PMID: 6750746

Diagnosis

Ascariasis, a review.
Schindler-Piontek M, Chaubal N, Dehmani S, Cui XW, Dong Y, Sharma M, Dietrich CF
Med Ultrason 2022 Aug 31;24(3):329-338. Epub 2021 Aug 3 doi: 10.11152/mu-3343. PMID: 34379712
Human Ascariasis: An Updated Review.
Leung AKC, Leung AAM, Wong AHC, Hon KL
Recent Pat Inflamm Allergy Drug Discov 2020;14(2):133-145. doi: 10.2174/1872213X14666200705235757. PMID: 32628606
Whipworm and roundworm infections.
Else KJ, Keiser J, Holland CV, Grencis RK, Sattelle DB, Fujiwara RT, Bueno LL, Asaolu SO, Sowemimo OA, Cooper PJ
Nat Rev Dis Primers 2020 May 28;6(1):44. doi: 10.1038/s41572-020-0171-3. PMID: 32467581
Parasite allergens.
Caraballo L, Coronado S
Mol Immunol 2018 Aug;100:113-119. Epub 2018 Mar 24 doi: 10.1016/j.molimm.2018.03.014. PMID: 29588070
Ascariasis.
Khuroo MS
Gastroenterol Clin North Am 1996 Sep;25(3):553-77. doi: 10.1016/s0889-8553(05)70263-6. PMID: 8863040

Therapy

Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update.
Chai JY, Jung BK, Hong SJ
Korean J Parasitol 2021 Jun;59(3):189-225. Epub 2021 Jun 21 doi: 10.3347/kjp.2021.59.3.189. PMID: 34218593Free PMC Article
Human Ascariasis: An Updated Review.
Leung AKC, Leung AAM, Wong AHC, Hon KL
Recent Pat Inflamm Allergy Drug Discov 2020;14(2):133-145. doi: 10.2174/1872213X14666200705235757. PMID: 32628606
Ascaris.
Burnett MW
J Spec Oper Med 2018 Summer;18(2):115-116. doi: 10.55460/FFEM-COO8. PMID: 29889967
Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm.
Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, Diemert D, Hotez PJ
Lancet 2006 May 6;367(9521):1521-32. doi: 10.1016/S0140-6736(06)68653-4. PMID: 16679166
Ascariasis.
Khuroo MS
Gastroenterol Clin North Am 1996 Sep;25(3):553-77. doi: 10.1016/s0889-8553(05)70263-6. PMID: 8863040

Prognosis

Ascariasis and its relationship with selected psycho-neurological symptoms among children and adults in Poland.
Gras-Ozimek J, Ozimek W, Kozińska U, Gras-Graupera M, Kozińska E, Bar A
Pol Merkur Lekarski 2019 Apr 29;46(274):165-171. PMID: 31099762
Mucocutaneous manifestations of helminth infections: Nematodes.
Lupi O, Downing C, Lee M, Pino L, Bravo F, Giglio P, Sethi A, Klaus S, Sangueza OP, Fuller C, Mendoza N, Ladizinski B, Woc-Colburn L, Tyring SK
J Am Acad Dermatol 2015 Dec;73(6):929-44; quiz 945-6. doi: 10.1016/j.jaad.2014.11.034. PMID: 26568337
A review of pig pathology in Tanzania.
Wilson RT, Swai E
Trop Anim Health Prod 2013 Aug;45(6):1269-75. Epub 2013 Jun 5 doi: 10.1007/s11250-013-0426-z. PMID: 23733144
Biliary ascariasis: a review.
Shah OJ, Zargar SA, Robbani I
World J Surg 2006 Aug;30(8):1500-6. doi: 10.1007/s00268-005-0309-1. PMID: 16874446
Biliary parasites.
Osman M, Lausten SB, El-Sefi T, Boghdadi I, Rashed MY, Jensen SL
Dig Surg 1998;15(4):287-96. doi: 10.1159/000018640. PMID: 9845601

Clinical prediction guides

Resurgence of intestinal ascariasis among adults: radiological diagnosis and clinical implications.
Ghahremani GG, Hahn ME
Abdom Radiol (NY) 2022 Mar;47(3):915-922. Epub 2022 Jan 11 doi: 10.1007/s00261-022-03407-6. PMID: 35015117
Human Ascariasis: An Updated Review.
Leung AKC, Leung AAM, Wong AHC, Hon KL
Recent Pat Inflamm Allergy Drug Discov 2020;14(2):133-145. doi: 10.2174/1872213X14666200705235757. PMID: 32628606
Parasite allergens.
Caraballo L, Coronado S
Mol Immunol 2018 Aug;100:113-119. Epub 2018 Mar 24 doi: 10.1016/j.molimm.2018.03.014. PMID: 29588070
Ascaris and ascariasis.
Crompton DW
Adv Parasitol 2001;48:285-375. doi: 10.1016/s0065-308x(01)48008-0. PMID: 11013758
Ascariasis and childhood malnutrition.
Hlaing T
Parasitology 1993;107 Suppl:S125-36. doi: 10.1017/s0031182000075557. PMID: 8115177

Recent systematic reviews

Global prevalence of Ascaris infection in humans (2010-2021): a systematic review and meta-analysis.
Holland C, Sepidarkish M, Deslyper G, Abdollahi A, Valizadeh S, Mollalo A, Mahjour S, Ghodsian S, Ardekani A, Behniafar H, Gasser RB, Rostami A
Infect Dis Poverty 2022 Nov 18;11(1):113. doi: 10.1186/s40249-022-01038-z. PMID: 36401308Free PMC Article
The prevalence of human trichuriasis in Asia: a systematic review and meta-analysis.
Badri M, Olfatifar M, Wandra T, Budke CM, Mahmoudi R, Abdoli A, Hajialilo E, Pestehchian N, Ghaffarifar F, Foroutan M, Hashemipour S, Sotoodeh S, Samimi R, Eslahi AV
Parasitol Res 2022 Jan;121(1):1-10. Epub 2022 Jan 6 doi: 10.1007/s00436-021-07365-8. PMID: 34993634
Complexities and Perplexities: A Critical Appraisal of the Evidence for Soil-Transmitted Helminth Infection-Related Morbidity.
Campbell SJ, Nery SV, Doi SA, Gray DJ, Soares Magalhães RJ, McCarthy JS, Traub RJ, Andrews RM, Clements AC
PLoS Negl Trop Dis 2016 May;10(5):e0004566. Epub 2016 May 19 doi: 10.1371/journal.pntd.0004566. PMID: 27196100Free PMC Article
Epidemiological surveys of, and research on, soil-transmitted helminths in Southeast Asia: a systematic review.
Dunn JC, Turner HC, Tun A, Anderson RM
Parasit Vectors 2016 Jan 27;9:31. doi: 10.1186/s13071-016-1310-2. PMID: 26813007Free PMC Article
Effect of sanitation on soil-transmitted helminth infection: systematic review and meta-analysis.
Ziegelbauer K, Speich B, Mäusezahl D, Bos R, Keiser J, Utzinger J
PLoS Med 2012 Jan;9(1):e1001162. Epub 2012 Jan 24 doi: 10.1371/journal.pmed.1001162. PMID: 22291577Free PMC Article

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