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Penile carcinoma

MedGen UID:
208877
•Concept ID:
C0853105
•
Neoplastic Process
Synonyms: Cancer of Penis; Cancer of the Penis; Carcinoma of penis; Carcinoma of Penis; carcinoma of penis; Carcinoma of the Penis; carcinoma of the penis; Penile Cancer; Penile Carcinoma; penile carcinoma; penis carcinoma
SNOMED CT: Carcinoma of penis (372106005)
 
Monarch Initiative: MONDO:0006360

Definition

A carcinoma that arises from the penis. Risk factors include phimosis and human papillomavirus infection. The majority of penile carcinomas are squamous cell carcinomas. The most frequent clinical presentation is an irregular mass in the glans of the penis. Treatment includes surgical management and radiation therapy. [from NCI]

Professional guidelines

PubMed

A Prospective Study of Chemoradiotherapy as Primary Treatment in Patients With Locoregionally Advanced Penile Carcinoma.
Ottenhof SR, de Vries HM, Doodeman B, Vrijenhoek GL, van der Noort V, Donswijk ML, de Feijter JM, Schaake EE, Horenblas S, Brouwer OR, van der Heijden MS, Pos FJ
Int J Radiat Oncol Biol Phys 2023 Sep 1;117(1):139-147. Epub 2023 Apr 6 doi: 10.1016/j.ijrobp.2023.03.066. PMID: 37030606
Management of Penile Cancer.
Diorio GJ, Leone AR, Spiess PE
Urology 2016 Oct;96:15-21. Epub 2016 Jan 20 doi: 10.1016/j.urology.2015.12.041. PMID: 26802797
Organ-sparing treatment for penile cancer.
Antunes AA, Dall'Oglio MF, Srougi M
Nat Clin Pract Urol 2007 Nov;4(11):596-604. doi: 10.1038/ncpuro0918. PMID: 17982436

Recent clinical studies

Etiology

Epigenetic mechanisms in penile carcinoma.
Kuasne H, Marchi FA, Rogatto SR, de Syllos Cólus IM
Int J Mol Sci 2013 May 23;14(6):10791-808. doi: 10.3390/ijms140610791. PMID: 23702847Free PMC Article
Penile carcinoma: lessons learned from vulvar carcinoma.
Longpre MJ, Lange PH, Kwon JS, Black PC
J Urol 2013 Jan;189(1):17-24. Epub 2012 Nov 16 doi: 10.1016/j.juro.2012.08.082. PMID: 23158472
Lymphadenectomy in penile cancer.
Horenblas S
Urol Clin North Am 2011 Nov;38(4):459-69, vi-vii. Epub 2011 Sep 21 doi: 10.1016/j.ucl.2011.07.004. PMID: 22045177
Genital HPV infection and related lesions in men.
Anic GM, Giuliano AR
Prev Med 2011 Oct;53 Suppl 1(Suppl 1):S36-41. doi: 10.1016/j.ypmed.2011.08.002. PMID: 21962470Free PMC Article
Penile cancer.
Micali G, Nasca MR, Innocenzi D, Schwartz RA
J Am Acad Dermatol 2006 Mar;54(3):369-91; quiz 391-4. doi: 10.1016/j.jaad.2005.05.007. PMID: 16488287

Diagnosis

Epigenetics of Urological Cancers.
Schulz WA, Sørensen KD
Int J Mol Sci 2019 Sep 26;20(19) doi: 10.3390/ijms20194775. PMID: 31561442Free PMC Article
Epigenetic mechanisms in penile carcinoma.
Kuasne H, Marchi FA, Rogatto SR, de Syllos Cólus IM
Int J Mol Sci 2013 May 23;14(6):10791-808. doi: 10.3390/ijms140610791. PMID: 23702847Free PMC Article
Penile carcinoma: lessons learned from vulvar carcinoma.
Longpre MJ, Lange PH, Kwon JS, Black PC
J Urol 2013 Jan;189(1):17-24. Epub 2012 Nov 16 doi: 10.1016/j.juro.2012.08.082. PMID: 23158472
Lymphadenectomy in penile cancer.
Horenblas S
Urol Clin North Am 2011 Nov;38(4):459-69, vi-vii. Epub 2011 Sep 21 doi: 10.1016/j.ucl.2011.07.004. PMID: 22045177
Penile cancer.
Micali G, Nasca MR, Innocenzi D, Schwartz RA
J Am Acad Dermatol 2006 Mar;54(3):369-91; quiz 391-4. doi: 10.1016/j.jaad.2005.05.007. PMID: 16488287

Therapy

A global approach to improving penile cancer care.
Bandini M, Ahmed M, Basile G, Watkin N, Master V, Zhu Y, Prakash G, Rodriguez A, Ssebakumba MK, Leni R, Cirulli GO, Ayres B, Compitello R, Pederzoli F, Joshi PM, Kulkarni SB, Montorsi F, Sonpavde G, Necchi A, Spiess PE
Nat Rev Urol 2022 Apr;19(4):231-239. Epub 2021 Dec 22 doi: 10.1038/s41585-021-00557-y. PMID: 34937881Free PMC Article
Topical chemotherapy for penile carcinoma in situ: Contemporary outcomes and reported toxicity.
Hajiran A, Zemp L, Aydin AM, Cheryian SK, Pow-Sang JM, Chahoud J, Spiess PE
Urol Oncol 2021 Jan;39(1):72.e1-72.e5. Epub 2020 Oct 6 doi: 10.1016/j.urolonc.2020.09.021. PMID: 33036902
Immune checkpoint inhibitors in genitourinary malignancies.
Thana M, Wood L
Curr Oncol 2020 Apr;27(Suppl 2):S69-S77. Epub 2020 Apr 1 doi: 10.3747/co.27.5121. PMID: 32368176Free PMC Article
Erythroplasia of Queyrat treated by laser and light modalities: a systematic review.
Maranda EL, Nguyen AH, Lim VM, Shah VV, Jimenez JJ
Lasers Med Sci 2016 Dec;31(9):1971-1976. Epub 2016 Jun 21 doi: 10.1007/s10103-016-2005-9. PMID: 27324019
Genital HPV infection and related lesions in men.
Anic GM, Giuliano AR
Prev Med 2011 Oct;53 Suppl 1(Suppl 1):S36-41. doi: 10.1016/j.ypmed.2011.08.002. PMID: 21962470Free PMC Article

Prognosis

Epigenetics of Urological Cancers.
Schulz WA, Sørensen KD
Int J Mol Sci 2019 Sep 26;20(19) doi: 10.3390/ijms20194775. PMID: 31561442Free PMC Article
The molecular pathogenesis of penile carcinoma-current developments and understanding.
Emmanuel A, Nettleton J, Watkin N, Berney DM
Virchows Arch 2019 Oct;475(4):397-405. Epub 2019 Jun 26 doi: 10.1007/s00428-019-02607-8. PMID: 31243533
Pathologic Evaluation and Reporting of Carcinoma of the Penis.
Erbersdobler A
Clin Genitourin Cancer 2017 Apr;15(2):192-195. Epub 2016 Aug 10 doi: 10.1016/j.clgc.2016.08.003. PMID: 27594553
Epigenetic mechanisms in penile carcinoma.
Kuasne H, Marchi FA, Rogatto SR, de Syllos Cólus IM
Int J Mol Sci 2013 May 23;14(6):10791-808. doi: 10.3390/ijms140610791. PMID: 23702847Free PMC Article
Lymphadenectomy in penile cancer.
Horenblas S
Urol Clin North Am 2011 Nov;38(4):459-69, vi-vii. Epub 2011 Sep 21 doi: 10.1016/j.ucl.2011.07.004. PMID: 22045177

Clinical prediction guides

The association between penile cancer and HIV infection: A literature review.
Amini AP, Brookes TS, Shah H, Bhate K, Alnajjar H, Muneer A, Kravvas G, Bunker CB
Int J STD AIDS 2023 Mar;34(4):214-228. Epub 2023 Jan 11 doi: 10.1177/09564624221148622. PMID: 36630307
Topical chemotherapy for penile carcinoma in situ: Contemporary outcomes and reported toxicity.
Hajiran A, Zemp L, Aydin AM, Cheryian SK, Pow-Sang JM, Chahoud J, Spiess PE
Urol Oncol 2021 Jan;39(1):72.e1-72.e5. Epub 2020 Oct 6 doi: 10.1016/j.urolonc.2020.09.021. PMID: 33036902
Review of in situ and invasive penile squamous cell carcinoma and associated non-neoplastic dermatological conditions.
Downes MR
J Clin Pathol 2015 May;68(5):333-40. doi: 10.1136/jclinpath-2015-202911. PMID: 25883161
Photodynamic diagnosis in urology: state-of-the-art.
Jocham D, Stepp H, Waidelich R
Eur Urol 2008 Jun;53(6):1138-48. Epub 2007 Dec 10 doi: 10.1016/j.eururo.2007.11.048. PMID: 18096307
Penile cancer.
Micali G, Nasca MR, Innocenzi D, Schwartz RA
J Am Acad Dermatol 2006 Mar;54(3):369-91; quiz 391-4. doi: 10.1016/j.jaad.2005.05.007. PMID: 16488287

Recent systematic reviews

The Acute Complications After Surgery for Penile Carcinoma and Strategies for Their Management: A Systematic Review of the Literature.
Sood A, Rudzinski JK, Spiess PE, Pettaway CA
Semin Oncol Nurs 2022 Jun;38(3):151285. Epub 2022 May 18 doi: 10.1016/j.soncn.2022.151285. PMID: 35597731
Erythroplasia of Queyrat treated by laser and light modalities: a systematic review.
Maranda EL, Nguyen AH, Lim VM, Shah VV, Jimenez JJ
Lasers Med Sci 2016 Dec;31(9):1971-1976. Epub 2016 Jun 21 doi: 10.1007/s10103-016-2005-9. PMID: 27324019
Dynamic sentinel node biopsy for inguinal lymph node staging in patients with penile cancer: a systematic review and cumulative analysis of the literature.
Neto AS, Tobias-Machado M, Ficarra V, Wroclawski ML, Amarante RD, Pompeo AC, Del Giglio A
Ann Surg Oncol 2011 Jul;18(7):2026-34. Epub 2011 Feb 10 doi: 10.1245/s10434-010-1546-6. PMID: 21308487
Systematic review of human papillomavirus prevalence in invasive penile cancer.
Backes DM, Kurman RJ, Pimenta JM, Smith JS
Cancer Causes Control 2009 May;20(4):449-57. Epub 2008 Dec 11 doi: 10.1007/s10552-008-9276-9. PMID: 19082746

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