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Recurrent Extraskeletal Ewing Sarcoma

MedGen UID:
208944
•Concept ID:
C0855045
•
Neoplastic Process
Synonyms: Extra-Osseous Ewing's Sarcoma, Recurrent; Recurrent Extra-Osseous Ewing's Sarcoma; Recurrent Extraosseous Ewing Sarcoma; Recurrent Extraosseous Ewing's Sarcoma; Recurrent Extraskeletal Ewing's Sarcoma; Relapsed Extra-Osseous Ewing's Sarcoma

Definition

Reemergence of extraskeletal Ewing sarcoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Extraskeletal Ewing Sarcoma

Professional guidelines

PubMed

Treatment outcomes of extraskeletal Ewing sarcoma.
Houdek MT, Heidenreich MJ, Ahmed SK, Allen-Rhoades W, Siontis BL, Robinson SI, Petersen IA, Rose PS
J Surg Oncol 2023 Jul;128(1):105-110. Epub 2023 Mar 31 doi: 10.1002/jso.27250. PMID: 36999583
Evaluating the Soft Tissue Sarcoma Paradigm for the Local Management of Extraskeletal Ewing Sarcoma.
Boyce-Fappiano D, Guadagnolo BA, Ratan R, Wang WL, Wagner MJ, Patel S, Livingston JA, Lin PP, Diao K, Mitra D, Farooqi A, Lazar AJ, Roland CL, Bishop AJ
Oncologist 2021 Mar;26(3):250-260. Epub 2020 Dec 14 doi: 10.1002/onco.13616. PMID: 33289298Free PMC Article

Recent clinical studies

Etiology

Treatment outcomes of extraskeletal Ewing sarcoma.
Houdek MT, Heidenreich MJ, Ahmed SK, Allen-Rhoades W, Siontis BL, Robinson SI, Petersen IA, Rose PS
J Surg Oncol 2023 Jul;128(1):105-110. Epub 2023 Mar 31 doi: 10.1002/jso.27250. PMID: 36999583
Intramedullary, periosteal, and extraskeletal Ewing sarcomas: retrospective study of a series of 126 cases in a reference center.
Violon F, Burns R, Mihoubi F, Audard V, Biau D, Feydy A, Larousserie F
Skeletal Radiol 2022 Aug;51(8):1659-1670. Epub 2022 Feb 18 doi: 10.1007/s00256-021-03983-6. PMID: 35179621
Evaluating the Soft Tissue Sarcoma Paradigm for the Local Management of Extraskeletal Ewing Sarcoma.
Boyce-Fappiano D, Guadagnolo BA, Ratan R, Wang WL, Wagner MJ, Patel S, Livingston JA, Lin PP, Diao K, Mitra D, Farooqi A, Lazar AJ, Roland CL, Bishop AJ
Oncologist 2021 Mar;26(3):250-260. Epub 2020 Dec 14 doi: 10.1002/onco.13616. PMID: 33289298Free PMC Article
Outcomes of extraskeletal vs. skeletal Ewing sarcoma patients treated with standard chemotherapy protocol.
Salah S, Abuhijla F, Ismail T, Yaser S, Sultan I, Halalsheh H, Shehadeh A, Abdelal S, Almousa A, Jaber O, Abu-Hijlih R
Clin Transl Oncol 2020 Jun;22(6):878-883. Epub 2019 Aug 19 doi: 10.1007/s12094-019-02202-y. PMID: 31429039
DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma.
Koelsche C, Kriegsmann M, Kommoss FKF, Stichel D, Kriegsmann K, Vokuhl C, Grünewald TGP, Romero-Pérez L, Kirchner T, de Alava E, Diaz-Martin J, Hartmann W, Baumhoer D, Antonescu CR, Szuhai K, Flucke U, Dirksen U, Pfister SM, Jones DTW, Mechtersheimer G, von Deimling A
J Cancer Res Clin Oncol 2019 May;145(5):1273-1281. Epub 2019 Mar 20 doi: 10.1007/s00432-019-02895-2. PMID: 30895378Free PMC Article

Diagnosis

Intramedullary, periosteal, and extraskeletal Ewing sarcomas: retrospective study of a series of 126 cases in a reference center.
Violon F, Burns R, Mihoubi F, Audard V, Biau D, Feydy A, Larousserie F
Skeletal Radiol 2022 Aug;51(8):1659-1670. Epub 2022 Feb 18 doi: 10.1007/s00256-021-03983-6. PMID: 35179621
Extraskeletal Ewing's Sarcoma with CD7 Positivity and T-cell Receptor/Immunoglobulin Rearrangement Masquerading as T-lymphoblastic Lymphoma.
Cheng Y, Yang L, Zhang N, Chen GS, Li J, Liu YF, Zhou CJ
Fetal Pediatr Pathol 2022 Jun;41(3):499-504. Epub 2020 Nov 19 doi: 10.1080/15513815.2020.1845885. PMID: 33213248
Extraskeletal Ewing sarcoma of thyroid gland: A case report.
Zhu W, Yang X, Zeng J, Wei M, Wang S, Li W
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 May 28;46(5):558-564. doi: 10.11817/j.issn.1672-7347.2021.200161. PMID: 34148894Free PMC Article
Extraskeletal presentation of Ewing's Sarcoma.
Mangual D, Bisbal-Matos LA, Jiménez-Lee R, Vélez R, Noy M
P R Health Sci J 2018 Mar;37(1):55-57. PMID: 29547686
Extraskeletal Ewing's sarcoma: a report of 18 cases and literature review.
Xie CF, Liu MZ, Xi M
Chin J Cancer 2010 Apr;29(4):420-4. doi: 10.5732/cjc.009.10402. PMID: 20346219

Therapy

Treatment outcomes of extraskeletal Ewing sarcoma.
Houdek MT, Heidenreich MJ, Ahmed SK, Allen-Rhoades W, Siontis BL, Robinson SI, Petersen IA, Rose PS
J Surg Oncol 2023 Jul;128(1):105-110. Epub 2023 Mar 31 doi: 10.1002/jso.27250. PMID: 36999583
Outcomes of extraskeletal vs. skeletal Ewing sarcoma patients treated with standard chemotherapy protocol.
Salah S, Abuhijla F, Ismail T, Yaser S, Sultan I, Halalsheh H, Shehadeh A, Abdelal S, Almousa A, Jaber O, Abu-Hijlih R
Clin Transl Oncol 2020 Jun;22(6):878-883. Epub 2019 Aug 19 doi: 10.1007/s12094-019-02202-y. PMID: 31429039
Extraskeletal Ewing's sarcoma family of tumors in adults: prognostic factors and clinical outcome.
Tural D, Molinas Mandel N, Dervisoglu S, Oner Dincbas F, Koca S, Colpan Oksuz D, Kantarci F, Turna H, Selcukbiricik F, Hiz M
Jpn J Clin Oncol 2012 May;42(5):420-6. Epub 2012 Mar 12 doi: 10.1093/jjco/hys027. PMID: 22416252
Extraskeletal Ewing's sarcoma of the thoracic epidural space: case report and review of the literature.
Yasuda T, Suzuki K, Kanamori M, Hori T, Huang D, Bridge JA, Kimura T
Oncol Rep 2011 Sep;26(3):711-5. Epub 2011 May 26 doi: 10.3892/or.2011.1326. PMID: 21617880
Extraskeletal Ewing's sarcoma: a report of 18 cases and literature review.
Xie CF, Liu MZ, Xi M
Chin J Cancer 2010 Apr;29(4):420-4. doi: 10.5732/cjc.009.10402. PMID: 20346219

Prognosis

Intramedullary, periosteal, and extraskeletal Ewing sarcomas: retrospective study of a series of 126 cases in a reference center.
Violon F, Burns R, Mihoubi F, Audard V, Biau D, Feydy A, Larousserie F
Skeletal Radiol 2022 Aug;51(8):1659-1670. Epub 2022 Feb 18 doi: 10.1007/s00256-021-03983-6. PMID: 35179621
Evaluating the Soft Tissue Sarcoma Paradigm for the Local Management of Extraskeletal Ewing Sarcoma.
Boyce-Fappiano D, Guadagnolo BA, Ratan R, Wang WL, Wagner MJ, Patel S, Livingston JA, Lin PP, Diao K, Mitra D, Farooqi A, Lazar AJ, Roland CL, Bishop AJ
Oncologist 2021 Mar;26(3):250-260. Epub 2020 Dec 14 doi: 10.1002/onco.13616. PMID: 33289298Free PMC Article
Extraskeletal Ewing's sarcoma family of tumors in adults: prognostic factors and clinical outcome.
Tural D, Molinas Mandel N, Dervisoglu S, Oner Dincbas F, Koca S, Colpan Oksuz D, Kantarci F, Turna H, Selcukbiricik F, Hiz M
Jpn J Clin Oncol 2012 May;42(5):420-6. Epub 2012 Mar 12 doi: 10.1093/jjco/hys027. PMID: 22416252
Extraskeletal Ewing's sarcoma of the thoracic epidural space: case report and review of the literature.
Yasuda T, Suzuki K, Kanamori M, Hori T, Huang D, Bridge JA, Kimura T
Oncol Rep 2011 Sep;26(3):711-5. Epub 2011 May 26 doi: 10.3892/or.2011.1326. PMID: 21617880
Extraskeletal Ewing's sarcoma: a report of 18 cases and literature review.
Xie CF, Liu MZ, Xi M
Chin J Cancer 2010 Apr;29(4):420-4. doi: 10.5732/cjc.009.10402. PMID: 20346219

Clinical prediction guides

Extraskeletal Ewing's sarcoma family of tumors in adults: prognostic factors and clinical outcome.
Tural D, Molinas Mandel N, Dervisoglu S, Oner Dincbas F, Koca S, Colpan Oksuz D, Kantarci F, Turna H, Selcukbiricik F, Hiz M
Jpn J Clin Oncol 2012 May;42(5):420-6. Epub 2012 Mar 12 doi: 10.1093/jjco/hys027. PMID: 22416252
R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study.
Pappo AS, Patel SR, Crowley J, Reinke DK, Kuenkele KP, Chawla SP, Toner GC, Maki RG, Meyers PA, Chugh R, Ganjoo KN, Schuetze SM, Juergens H, Leahy MG, Geoerger B, Benjamin RS, Helman LJ, Baker LH
J Clin Oncol 2011 Dec 1;29(34):4541-7. Epub 2011 Oct 24 doi: 10.1200/JCO.2010.34.0000. PMID: 22025149Free PMC Article
Small cell extraskeletal osteosarcoma.
Yang JY, Kim JM
Orthopedics 2009 Mar;32(3):217. PMID: 19309043

Recent systematic reviews

Primary extraskeletal intradural Ewing sarcoma with acute hemorrhage: a case report and review of the literature.
Salama H, Abu-Hilal LH, Idkedek M, Kharousha A, Abulihya M, Nimer H
J Med Case Rep 2024 Mar 9;18(1):144. doi: 10.1186/s13256-024-04384-8. PMID: 38459600Free PMC Article

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