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Recurrent Extraskeletal Ewing Sarcoma

MedGen UID:
208944
•Concept ID:
C0855045
•
Neoplastic Process
Synonyms: Extra-Osseous Ewing's Sarcoma, Recurrent; Recurrent Extra-Osseous Ewing's Sarcoma; Recurrent Extraosseous Ewing Sarcoma; Recurrent Extraosseous Ewing's Sarcoma; Recurrent Extraskeletal Ewing's Sarcoma; Relapsed Extra-Osseous Ewing's Sarcoma

Definition

Reemergence of extraskeletal Ewing sarcoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Extraskeletal Ewing Sarcoma

Professional guidelines

PubMed

Treatment outcomes of extraskeletal Ewing sarcoma.
Houdek MT, Heidenreich MJ, Ahmed SK, Allen-Rhoades W, Siontis BL, Robinson SI, Petersen IA, Rose PS
J Surg Oncol 2023 Jul;128(1):105-110. Epub 2023 Mar 31 doi: 10.1002/jso.27250. PMID: 36999583
Evaluating the Soft Tissue Sarcoma Paradigm for the Local Management of Extraskeletal Ewing Sarcoma.
Boyce-Fappiano D, Guadagnolo BA, Ratan R, Wang WL, Wagner MJ, Patel S, Livingston JA, Lin PP, Diao K, Mitra D, Farooqi A, Lazar AJ, Roland CL, Bishop AJ
Oncologist 2021 Mar;26(3):250-260. Epub 2020 Dec 14 doi: 10.1002/onco.13616. PMID: 33289298Free PMC Article

Recent clinical studies

Etiology

Extraskeletal Ewing Sarcoma of the Extremities and Trunk: A Retrospective Analysis of a Mono-Institutional Series.
Bianchi G, Laginestra MA, Simonetti E, Ibrahim T, Macrì F, Ostetto F, Tuzzato G, Paioli A, Gambarotti M, Cocchi S, Donati DM, Scotlandi K, Laranga R
Oncol Res Treat 2024;47(10):496-508. Epub 2024 Jul 31 doi: 10.1159/000540613. PMID: 39084202
Treatment outcomes of extraskeletal Ewing sarcoma.
Houdek MT, Heidenreich MJ, Ahmed SK, Allen-Rhoades W, Siontis BL, Robinson SI, Petersen IA, Rose PS
J Surg Oncol 2023 Jul;128(1):105-110. Epub 2023 Mar 31 doi: 10.1002/jso.27250. PMID: 36999583
Intramedullary, periosteal, and extraskeletal Ewing sarcomas: retrospective study of a series of 126 cases in a reference center.
Violon F, Burns R, Mihoubi F, Audard V, Biau D, Feydy A, Larousserie F
Skeletal Radiol 2022 Aug;51(8):1659-1670. Epub 2022 Feb 18 doi: 10.1007/s00256-021-03983-6. PMID: 35179621
Outcomes of extraskeletal vs. skeletal Ewing sarcoma patients treated with standard chemotherapy protocol.
Salah S, Abuhijla F, Ismail T, Yaser S, Sultan I, Halalsheh H, Shehadeh A, Abdelal S, Almousa A, Jaber O, Abu-Hijlih R
Clin Transl Oncol 2020 Jun;22(6):878-883. Epub 2019 Aug 19 doi: 10.1007/s12094-019-02202-y. PMID: 31429039
Ewing's sarcoma of the thumb.
Yamaguchi T, Tamai K, Saotome K, Hoshino T, Masawa N
Skeletal Radiol 1997 Dec;26(12):725-8. doi: 10.1007/s002560050319. PMID: 9453107

Diagnosis

Intramedullary, periosteal, and extraskeletal Ewing sarcomas: retrospective study of a series of 126 cases in a reference center.
Violon F, Burns R, Mihoubi F, Audard V, Biau D, Feydy A, Larousserie F
Skeletal Radiol 2022 Aug;51(8):1659-1670. Epub 2022 Feb 18 doi: 10.1007/s00256-021-03983-6. PMID: 35179621
Extraskeletal Ewing sarcoma of thyroid gland: A case report.
Zhu W, Yang X, Zeng J, Wei M, Wang S, Li W
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 May 28;46(5):558-564. doi: 10.11817/j.issn.1672-7347.2021.200161. PMID: 34148894Free PMC Article
Intradural extramedullary Ewing's sarcoma: A case report and review of the literature.
Paterakis K, Brotis A, Tasiou A, Kotoula V, Kapsalaki E, Vlychou M
Neurol Neurochir Pol 2017 Jan-Feb;51(1):106-110. Epub 2016 Nov 30 doi: 10.1016/j.pjnns.2016.11.006. PMID: 27939398
Extraskeletal Ewing's sarcoma: a report of 18 cases and literature review.
Xie CF, Liu MZ, Xi M
Chin J Cancer 2010 Apr;29(4):420-4. doi: 10.5732/cjc.009.10402. PMID: 20346219
Retroperitoneal Ewing's sarcoma.
Oya M, Nakashima J, Ishii T, Nakamura K, Hata J, Tazaki H
Urol Int 1995;54(2):104-6. doi: 10.1159/000282699. PMID: 7747355

Therapy

Treatment outcomes of extraskeletal Ewing sarcoma.
Houdek MT, Heidenreich MJ, Ahmed SK, Allen-Rhoades W, Siontis BL, Robinson SI, Petersen IA, Rose PS
J Surg Oncol 2023 Jul;128(1):105-110. Epub 2023 Mar 31 doi: 10.1002/jso.27250. PMID: 36999583
Outcomes of extraskeletal vs. skeletal Ewing sarcoma patients treated with standard chemotherapy protocol.
Salah S, Abuhijla F, Ismail T, Yaser S, Sultan I, Halalsheh H, Shehadeh A, Abdelal S, Almousa A, Jaber O, Abu-Hijlih R
Clin Transl Oncol 2020 Jun;22(6):878-883. Epub 2019 Aug 19 doi: 10.1007/s12094-019-02202-y. PMID: 31429039
Extraskeletal Ewing sarcomas in late adolescence and adults: a study of 37 patients.
Tao HT, Hu Y, Wang JL, Cheng Y, Zhang X, Wang H, Zhang SJ
Asian Pac J Cancer Prev 2013;14(5):2967-71. doi: 10.7314/apjcp.2013.14.5.2967. PMID: 23803063
Extraskeletal Ewing's sarcoma family of tumors in adults: prognostic factors and clinical outcome.
Tural D, Molinas Mandel N, Dervisoglu S, Oner Dincbas F, Koca S, Colpan Oksuz D, Kantarci F, Turna H, Selcukbiricik F, Hiz M
Jpn J Clin Oncol 2012 May;42(5):420-6. Epub 2012 Mar 12 doi: 10.1093/jjco/hys027. PMID: 22416252
Extraskeletal Ewing's sarcoma: a report of 18 cases and literature review.
Xie CF, Liu MZ, Xi M
Chin J Cancer 2010 Apr;29(4):420-4. doi: 10.5732/cjc.009.10402. PMID: 20346219

Prognosis

Extraskeletal Ewing Sarcoma of the Extremities and Trunk: A Retrospective Analysis of a Mono-Institutional Series.
Bianchi G, Laginestra MA, Simonetti E, Ibrahim T, Macrì F, Ostetto F, Tuzzato G, Paioli A, Gambarotti M, Cocchi S, Donati DM, Scotlandi K, Laranga R
Oncol Res Treat 2024;47(10):496-508. Epub 2024 Jul 31 doi: 10.1159/000540613. PMID: 39084202
Intramedullary, periosteal, and extraskeletal Ewing sarcomas: retrospective study of a series of 126 cases in a reference center.
Violon F, Burns R, Mihoubi F, Audard V, Biau D, Feydy A, Larousserie F
Skeletal Radiol 2022 Aug;51(8):1659-1670. Epub 2022 Feb 18 doi: 10.1007/s00256-021-03983-6. PMID: 35179621
Evaluating the Soft Tissue Sarcoma Paradigm for the Local Management of Extraskeletal Ewing Sarcoma.
Boyce-Fappiano D, Guadagnolo BA, Ratan R, Wang WL, Wagner MJ, Patel S, Livingston JA, Lin PP, Diao K, Mitra D, Farooqi A, Lazar AJ, Roland CL, Bishop AJ
Oncologist 2021 Mar;26(3):250-260. Epub 2020 Dec 14 doi: 10.1002/onco.13616. PMID: 33289298Free PMC Article
Extraskeletal Ewing's sarcoma: a report of 18 cases and literature review.
Xie CF, Liu MZ, Xi M
Chin J Cancer 2010 Apr;29(4):420-4. doi: 10.5732/cjc.009.10402. PMID: 20346219
Ewing's sarcoma of the thumb.
Yamaguchi T, Tamai K, Saotome K, Hoshino T, Masawa N
Skeletal Radiol 1997 Dec;26(12):725-8. doi: 10.1007/s002560050319. PMID: 9453107

Clinical prediction guides

Extraskeletal Ewing's sarcoma family of tumors in adults: prognostic factors and clinical outcome.
Tural D, Molinas Mandel N, Dervisoglu S, Oner Dincbas F, Koca S, Colpan Oksuz D, Kantarci F, Turna H, Selcukbiricik F, Hiz M
Jpn J Clin Oncol 2012 May;42(5):420-6. Epub 2012 Mar 12 doi: 10.1093/jjco/hys027. PMID: 22416252
R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study.
Pappo AS, Patel SR, Crowley J, Reinke DK, Kuenkele KP, Chawla SP, Toner GC, Maki RG, Meyers PA, Chugh R, Ganjoo KN, Schuetze SM, Juergens H, Leahy MG, Geoerger B, Benjamin RS, Helman LJ, Baker LH
J Clin Oncol 2011 Dec 1;29(34):4541-7. Epub 2011 Oct 24 doi: 10.1200/JCO.2010.34.0000. PMID: 22025149Free PMC Article
Small cell extraskeletal osteosarcoma.
Yang JY, Kim JM
Orthopedics 2009 Mar;32(3):217. PMID: 19309043

Recent systematic reviews

Primary extraskeletal intradural Ewing sarcoma with acute hemorrhage: a case report and review of the literature.
Salama H, Abu-Hilal LH, Idkedek M, Kharousha A, Abulihya M, Nimer H
J Med Case Rep 2024 Mar 9;18(1):144. doi: 10.1186/s13256-024-04384-8. PMID: 38459600Free PMC Article

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