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Squamous cell bile duct carcinoma

MedGen UID:
209017
•Concept ID:
C0861861
•
Neoplastic Process
Synonyms: Bile Duct Squamous Cell Carcinoma; bile duct squamous cell carcinoma; Extrahepatic Bile Duct Squamous Cell Carcinoma; Squamous Cell Bile Duct Carcinoma; squamous cell bile duct carcinoma; Squamous Cell Carcinoma of Bile Duct; Squamous Cell Carcinoma of the Bile Duct
 
Monarch Initiative: MONDO:0003500

Definition

A carcinoma that arises from the extrahepatic bile ducts. It is composed entirely by malignant squamous epithelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous cell bile duct carcinoma

Professional guidelines

PubMed

An Insight into Cholangiocarcinoma and Recent Advances in its Treatment.
Sahu R, Sharma P, Kumar A
J Gastrointest Cancer 2023 Mar;54(1):213-226. Epub 2022 Jan 13 doi: 10.1007/s12029-021-00728-5. PMID: 35023010
Surgical Treatment of Distal Cholangiocarcinoma.
Gorji L, Beal EW
Curr Oncol 2022 Sep 17;29(9):6674-6687. doi: 10.3390/curroncol29090524. PMID: 36135093Free PMC Article
Management of Simple Hepatic Cyst.
Shimizu T, Yoshioka M, Kaneya Y, Kanda T, Aoki Y, Kondo R, Takata H, Ueda J, Kawano Y, Hirakata A, Matsushita A, Taniai N, Mamada Y, Yoshida H
J Nippon Med Sch 2022 Mar 11;89(1):2-8. Epub 2021 Sep 14 doi: 10.1272/jnms.JNMS.2022_89-115. PMID: 34526451

Recent clinical studies

Etiology

Pathology of Cholangiocarcinomas.
Guedj N
Curr Oncol 2022 Dec 26;30(1):370-380. doi: 10.3390/curroncol30010030. PMID: 36661679Free PMC Article
NOTCH-YAP1/TEAD-DNMT1 Axis Drives Hepatocyte Reprogramming Into Intrahepatic Cholangiocarcinoma.
Hu S, Molina L, Tao J, Liu S, Hassan M, Singh S, Poddar M, Bell A, Sia D, Oertel M, Raeman R, Nejak-Bowen K, Singhi A, Luo J, Monga SP, Ko S
Gastroenterology 2022 Aug;163(2):449-465. Epub 2022 May 10 doi: 10.1053/j.gastro.2022.05.007. PMID: 35550144Free PMC Article
Intrahepatic Cholangiocarcinoma.
El-Diwany R, Pawlik TM, Ejaz A
Surg Oncol Clin N Am 2019 Oct;28(4):587-599. doi: 10.1016/j.soc.2019.06.002. PMID: 31472907
Targeting cholangiocarcinoma.
Mertens JC, Rizvi S, Gores GJ
Biochim Biophys Acta Mol Basis Dis 2018 Apr;1864(4 Pt B):1454-1460. Epub 2017 Aug 24 doi: 10.1016/j.bbadis.2017.08.027. PMID: 28844952Free PMC Article
Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis.
Sia D, Villanueva A, Friedman SL, Llovet JM
Gastroenterology 2017 Mar;152(4):745-761. Epub 2016 Dec 30 doi: 10.1053/j.gastro.2016.11.048. PMID: 28043904

Diagnosis

Bile exosomal miR-182/183-5p increases cholangiocarcinoma stemness and progression by targeting HPGD and increasing PGE2 generation.
Shu L, Li X, Liu Z, Li K, Shi A, Tang Y, Zhao L, Huang L, Zhang Z, Zhang D, Huang S, Lian S, Sheng G, Yan Z, Zhang Z, Xu Y
Hepatology 2024 Feb 1;79(2):307-322. Epub 2023 May 5 doi: 10.1097/HEP.0000000000000437. PMID: 37140231
Pathology of Cholangiocarcinomas.
Guedj N
Curr Oncol 2022 Dec 26;30(1):370-380. doi: 10.3390/curroncol30010030. PMID: 36661679Free PMC Article
Management of Simple Hepatic Cyst.
Shimizu T, Yoshioka M, Kaneya Y, Kanda T, Aoki Y, Kondo R, Takata H, Ueda J, Kawano Y, Hirakata A, Matsushita A, Taniai N, Mamada Y, Yoshida H
J Nippon Med Sch 2022 Mar 11;89(1):2-8. Epub 2021 Sep 14 doi: 10.1272/jnms.JNMS.2022_89-115. PMID: 34526451
Normal Components and Contaminants.
Dhillon J
Monogr Clin Cytol 2020;26:34-41. Epub 2020 Sep 28 doi: 10.1159/000455733. PMID: 32987395
Extracellular Vesicles in Hepatobiliary Malignancies.
Lapitz A, Arbelaiz A, Olaizola P, Aranburu A, Bujanda L, Perugorria MJ, Banales JM
Front Immunol 2018;9:2270. Epub 2018 Oct 12 doi: 10.3389/fimmu.2018.02270. PMID: 30369925Free PMC Article

Therapy

Dissecting Intra-Tumoral Changes Following Immune Checkpoint Blockades in Intrahepatic Cholangiocarcinoma via Single-Cell Analysis.
Sun BY, Zhou C, Guan RY, Liu G, Yang ZF, Wang ZT, Gan W, Zhou J, Fan J, Yi Y, Qiu SJ
Front Immunol 2022;13:871769. Epub 2022 Apr 26 doi: 10.3389/fimmu.2022.871769. PMID: 35558087Free PMC Article
A PLCB1-PI3K-AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression.
Liang S, Guo H, Ma K, Li X, Wu D, Wang Y, Wang W, Zhang S, Cui Y, Liu Y, Sun L, Zhang B, Xin M, Zhang N, Zhou H, Liu Y, Wang J, Liu L
Cancer Res 2021 Dec 1;81(23):5889-5903. Epub 2021 Sep 27 doi: 10.1158/0008-5472.CAN-21-1538. PMID: 34580062Free PMC Article
Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma.
Raggi C, Taddei ML, Sacco E, Navari N, Correnti M, Piombanti B, Pastore M, Campani C, Pranzini E, Iorio J, Lori G, Lottini T, Peano C, Cibella J, Lewinska M, Andersen JB, di Tommaso L, Viganò L, Di Maira G, Madiai S, Ramazzotti M, Orlandi I, Arcangeli A, Chiarugi P, Marra F
J Hepatol 2021 Jun;74(6):1373-1385. Epub 2021 Jan 21 doi: 10.1016/j.jhep.2020.12.031. PMID: 33484774
Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis.
Qu C, Zheng D, Li S, Liu Y, Lidofsky A, Holmes JA, Chen J, He L, Wei L, Liao Y, Yuan H, Jin Q, Lin Z, Hu Q, Jiang Y, Tu M, Chen X, Li W, Lin W, Fuchs BC, Chung RT, Hong J
Hepatology 2018 Sep;68(3):1125-1139. Epub 2018 May 21 doi: 10.1002/hep.29881. PMID: 29537660Free PMC Article
Targeting cholangiocarcinoma.
Mertens JC, Rizvi S, Gores GJ
Biochim Biophys Acta Mol Basis Dis 2018 Apr;1864(4 Pt B):1454-1460. Epub 2017 Aug 24 doi: 10.1016/j.bbadis.2017.08.027. PMID: 28844952Free PMC Article

Prognosis

Bile exosomal miR-182/183-5p increases cholangiocarcinoma stemness and progression by targeting HPGD and increasing PGE2 generation.
Shu L, Li X, Liu Z, Li K, Shi A, Tang Y, Zhao L, Huang L, Zhang Z, Zhang D, Huang S, Lian S, Sheng G, Yan Z, Zhang Z, Xu Y
Hepatology 2024 Feb 1;79(2):307-322. Epub 2023 May 5 doi: 10.1097/HEP.0000000000000437. PMID: 37140231
Tumor-derived exosomes induce immunosuppressive macrophages to foster intrahepatic cholangiocarcinoma progression.
Luo C, Xin H, Zhou Z, Hu Z, Sun R, Yao N, Sun Q, Borjigin U, Wu X, Fan J, Huang X, Zhou S, Zhou J
Hepatology 2022 Oct;76(4):982-999. Epub 2022 Feb 28 doi: 10.1002/hep.32387. PMID: 35106794
A PLCB1-PI3K-AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression.
Liang S, Guo H, Ma K, Li X, Wu D, Wang Y, Wang W, Zhang S, Cui Y, Liu Y, Sun L, Zhang B, Xin M, Zhang N, Zhou H, Liu Y, Wang J, Liu L
Cancer Res 2021 Dec 1;81(23):5889-5903. Epub 2021 Sep 27 doi: 10.1158/0008-5472.CAN-21-1538. PMID: 34580062Free PMC Article
Intrahepatic Cholangiocarcinoma.
El-Diwany R, Pawlik TM, Ejaz A
Surg Oncol Clin N Am 2019 Oct;28(4):587-599. doi: 10.1016/j.soc.2019.06.002. PMID: 31472907
Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis.
Sia D, Villanueva A, Friedman SL, Llovet JM
Gastroenterology 2017 Mar;152(4):745-761. Epub 2016 Dec 30 doi: 10.1053/j.gastro.2016.11.048. PMID: 28043904

Clinical prediction guides

Single-cell and spatial architecture of primary liver cancer.
Zhou PY, Zhou C, Gan W, Tang Z, Sun BY, Huang JL, Liu G, Liu WR, Tian MX, Jiang XF, Wang H, Tao CY, Fang Y, Qu WF, Huang R, Zhu GQ, Huang C, Fu XT, Ding ZB, Gao Q, Zhou J, Shi YH, Yi Y, Fan J, Qiu SJ
Commun Biol 2023 Nov 20;6(1):1181. doi: 10.1038/s42003-023-05455-0. PMID: 37985711Free PMC Article
Dissecting Intra-Tumoral Changes Following Immune Checkpoint Blockades in Intrahepatic Cholangiocarcinoma via Single-Cell Analysis.
Sun BY, Zhou C, Guan RY, Liu G, Yang ZF, Wang ZT, Gan W, Zhou J, Fan J, Yi Y, Qiu SJ
Front Immunol 2022;13:871769. Epub 2022 Apr 26 doi: 10.3389/fimmu.2022.871769. PMID: 35558087Free PMC Article
Tumor-derived exosomes induce immunosuppressive macrophages to foster intrahepatic cholangiocarcinoma progression.
Luo C, Xin H, Zhou Z, Hu Z, Sun R, Yao N, Sun Q, Borjigin U, Wu X, Fan J, Huang X, Zhou S, Zhou J
Hepatology 2022 Oct;76(4):982-999. Epub 2022 Feb 28 doi: 10.1002/hep.32387. PMID: 35106794
Intrahepatic Cholangiocarcinoma.
El-Diwany R, Pawlik TM, Ejaz A
Surg Oncol Clin N Am 2019 Oct;28(4):587-599. doi: 10.1016/j.soc.2019.06.002. PMID: 31472907
Extracellular Vesicles in Hepatobiliary Malignancies.
Lapitz A, Arbelaiz A, Olaizola P, Aranburu A, Bujanda L, Perugorria MJ, Banales JM
Front Immunol 2018;9:2270. Epub 2018 Oct 12 doi: 10.3389/fimmu.2018.02270. PMID: 30369925Free PMC Article

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