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Hepatobiliary disorder

MedGen UID:
82758
•Concept ID:
C0267792
•
Disease or Syndrome
Synonym: Hepatobiliary disease
 
Monarch Initiative: MONDO:0002515

Definition

A non-neoplastic or neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples of non-neoplastic disorders include hepatitis, cirrhosis, cholangitis, and cholecystitis. Representative examples of neoplastic disorders include hepatocellular adenoma, hepatocellular carcinoma, and cholangiocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatobiliary disorder

Professional guidelines

PubMed

Pruritus secondary to primary biliary cholangitis: a review of the pathophysiology and management with phototherapy.
Hussain AB, Samuel R, Hegade VS, Jones DE, Reynolds NJ
Br J Dermatol 2019 Dec;181(6):1138-1145. Epub 2019 Jul 28 doi: 10.1111/bjd.17933. PMID: 30920648
Cholestatic pruritus: a retrospective analysis on clinical characteristics and treatment response.
Huesmann M, Huesmann T, Osada N, Phan NQ, Kremer AE, Ständer S
J Dtsch Dermatol Ges 2013 Feb;11(2):158-68. Epub 2012 Nov 29 doi: 10.1111/j.1610-0387.2012.08028.x. PMID: 23190476
Diagnosis and treatment of primary sclerosing cholangitis.
Wiesner RH, Ludwig J, LaRusso NF, MacCarty RL
Semin Liver Dis 1985 Aug;5(3):241-53. doi: 10.1055/s-2008-1040621. PMID: 3901273

Recent clinical studies

Etiology

Acupuncture on GB34 for immediate analgesia and regulating pain-related anxiety for patients with biliary colic: a protocol of randomized controlled trial.
Zhou Y, Shen Y, Ye X, He D, Sun N, Zhang Y, Zhang Y, Long C, Ding S, Deng L, Deng Y, Liang F, Gong X, Sun R
BMC Complement Med Ther 2023 Jul 7;23(1):224. doi: 10.1186/s12906-023-04030-8. PMID: 37420212Free PMC Article
Pharmacogenomics of Alzheimer's Disease: Novel Strategies for Drug Utilization and Development.
Cacabelos R, Naidoo V, Martínez-Iglesias O, Corzo L, Cacabelos N, Pego R, Carril JC
Methods Mol Biol 2022;2547:275-387. doi: 10.1007/978-1-0716-2573-6_13. PMID: 36068470
SYMPTOMATIC CHOLELITHIASIS AS THE PRESENTATION OF PEDIATRIC PRIMARY SCLEROSING CHOLANGITIS - CASE SERIES AND LITERATURE REVIEW.
Alvarenga LR, Sandy NS, Gomez GS, Hessel G, DE Tommaso AMA, Bellomo-Brandão MÂ
Arq Gastroenterol 2021 Apr-Jun;58(2):227-233. doi: 10.1590/S0004-2803.202100000-41. PMID: 34287532
The Fifth Carlos E. Rubio Memorial Lecture. Sclerosing cholangitis: pathogenesis, pathology, and practice.
Larusso NF
P R Health Sci J 1999 Mar;18(1):11-7. PMID: 10343981
Diagnosis and treatment of primary sclerosing cholangitis.
Wiesner RH, Ludwig J, LaRusso NF, MacCarty RL
Semin Liver Dis 1985 Aug;5(3):241-53. doi: 10.1055/s-2008-1040621. PMID: 3901273

Diagnosis

Hepatic Complications of Inflammatory Bowel Disease.
Mahfouz M, Martin P, Carrion AF
Clin Liver Dis 2019 May;23(2):191-208. Epub 2019 Feb 26 doi: 10.1016/j.cld.2018.12.003. PMID: 30947871
Autoimmune sclerosing cholangitis: Evidence and open questions.
Terziroli Beretta-Piccoli B, Vergani D, Mieli-Vergani G
J Autoimmun 2018 Dec;95:15-25. Epub 2018 Oct 23 doi: 10.1016/j.jaut.2018.10.008. PMID: 30366655
Primary sclerosing cholangitis.
Gordon FD
Surg Clin North Am 2008 Dec;88(6):1385-407, x. doi: 10.1016/j.suc.2008.07.010. PMID: 18992601
Unraveling the pathogenesis and etiology of biliary atresia.
Mack CL, Sokol RJ
Pediatr Res 2005 May;57(5 Pt 2):87R-94R. Epub 2005 Apr 6 doi: 10.1203/01.PDR.0000159569.57354.47. PMID: 15817506
Diagnosis and treatment of primary sclerosing cholangitis.
Wiesner RH, Ludwig J, LaRusso NF, MacCarty RL
Semin Liver Dis 1985 Aug;5(3):241-53. doi: 10.1055/s-2008-1040621. PMID: 3901273

Therapy

Acupuncture on GB34 for immediate analgesia and regulating pain-related anxiety for patients with biliary colic: a protocol of randomized controlled trial.
Zhou Y, Shen Y, Ye X, He D, Sun N, Zhang Y, Zhang Y, Long C, Ding S, Deng L, Deng Y, Liang F, Gong X, Sun R
BMC Complement Med Ther 2023 Jul 7;23(1):224. doi: 10.1186/s12906-023-04030-8. PMID: 37420212Free PMC Article
Pharmacogenomics of Alzheimer's Disease: Novel Strategies for Drug Utilization and Development.
Cacabelos R, Naidoo V, Martínez-Iglesias O, Corzo L, Cacabelos N, Pego R, Carril JC
Methods Mol Biol 2022;2547:275-387. doi: 10.1007/978-1-0716-2573-6_13. PMID: 36068470
Frequency of Hepatobiliary Manifestations and Concomitant Liver Disease in Inflammatory Bowel Disease Patients.
Silva J, Brito BS, Silva INN, Nóbrega VG, da Silva MCSM, Gomes HDN, Fortes FM, Pimentel AM, Mota J, Almeida N, Surlo VC, Lyra A, Rocha R, Santana GO
Biomed Res Int 2019;2019:7604939. Epub 2019 Jan 31 doi: 10.1155/2019/7604939. PMID: 30834274Free PMC Article
Autoimmune sclerosing cholangitis: Evidence and open questions.
Terziroli Beretta-Piccoli B, Vergani D, Mieli-Vergani G
J Autoimmun 2018 Dec;95:15-25. Epub 2018 Oct 23 doi: 10.1016/j.jaut.2018.10.008. PMID: 30366655
Diagnosis and treatment of primary sclerosing cholangitis.
Wiesner RH, Ludwig J, LaRusso NF, MacCarty RL
Semin Liver Dis 1985 Aug;5(3):241-53. doi: 10.1055/s-2008-1040621. PMID: 3901273

Prognosis

Gender Characteristics of the Novel Coronavirus Infection (COVID-19) in Middle-Aged Adults.
Nekaeva ES, Bolshakova AE, Malysheva ES, Galova EA, Makarova EV, Nekrasova TA, Polyakova IV, Bedretdinova ZS, Belikina DV, Lavrenyuk AA, Fomin IV
Sovrem Tekhnologii Med 2021;13(4):16-24. Epub 2021 Aug 28 doi: 10.17691/stm2021.13.4.02. PMID: 34603760Free PMC Article
SYMPTOMATIC CHOLELITHIASIS AS THE PRESENTATION OF PEDIATRIC PRIMARY SCLEROSING CHOLANGITIS - CASE SERIES AND LITERATURE REVIEW.
Alvarenga LR, Sandy NS, Gomez GS, Hessel G, DE Tommaso AMA, Bellomo-Brandão MÂ
Arq Gastroenterol 2021 Apr-Jun;58(2):227-233. doi: 10.1590/S0004-2803.202100000-41. PMID: 34287532
Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis.
Weismüller TJ, Trivedi PJ, Bergquist A, Imam M, Lenzen H, Ponsioen CY, Holm K, Gotthardt D, Färkkilä MA, Marschall HU, Thorburn D, Weersma RK, Fevery J, Mueller T, Chazouillères O, Schulze K, Lazaridis KN, Almer S, Pereira SP, Levy C, Mason A, Naess S, Bowlus CL, Floreani A, Halilbasic E, Yimam KK, Milkiewicz P, Beuers U, Huynh DK, Pares A, Manser CN, Dalekos GN, Eksteen B, Invernizzi P, Berg CP, Kirchner GI, Sarrazin C, Zimmer V, Fabris L, Braun F, Marzioni M, Juran BD, Said K, Rupp C, Jokelainen K, Benito de Valle M, Saffioti F, Cheung A, Trauner M, Schramm C, Chapman RW, Karlsen TH, Schrumpf E, Strassburg CP, Manns MP, Lindor KD, Hirschfield GM, Hansen BE, Boberg KM; International PSC Study Group
Gastroenterology 2017 Jun;152(8):1975-1984.e8. Epub 2017 Mar 6 doi: 10.1053/j.gastro.2017.02.038. PMID: 28274849Free PMC Article
Association between serum IgE level and adverse clinical endpoints in primary sclerosing cholangitis.
Tabibian JH, Enders F, Imam MH, Kolar G, Lindor KD, Talwalkar JA
Ann Hepatol 2014 May-Jun;13(3):384-9. PMID: 24756015Free PMC Article
Endoscopic retrograde cholangiopancreatography outcome from a single referral center in Iran.
Mohammad Alizadeh AH, Afzali ES, Mousavi M, Moaddab Y, Zali MR
Hepatobiliary Pancreat Dis Int 2010 Aug;9(4):428-32. PMID: 20688609

Clinical prediction guides

Evaluation of Gastrointestinal System Complaints and Comorbidities in Pediatric Familial Mediterranean Fever Patients.
Karakas HD, Kuloglu Z, Aydin F, Ozdemir S, Avar-Aydin PO, Tuna Kirsaclioglu C, Cakar N, Ozcakar ZB
J Clin Rheumatol 2023 Dec 1;29(8):375-380. Epub 2023 Sep 19 doi: 10.1097/RHU.0000000000002027. PMID: 37723615
Acupuncture on GB34 for immediate analgesia and regulating pain-related anxiety for patients with biliary colic: a protocol of randomized controlled trial.
Zhou Y, Shen Y, Ye X, He D, Sun N, Zhang Y, Zhang Y, Long C, Ding S, Deng L, Deng Y, Liang F, Gong X, Sun R
BMC Complement Med Ther 2023 Jul 7;23(1):224. doi: 10.1186/s12906-023-04030-8. PMID: 37420212Free PMC Article
Frequency of Hepatobiliary Manifestations and Concomitant Liver Disease in Inflammatory Bowel Disease Patients.
Silva J, Brito BS, Silva INN, Nóbrega VG, da Silva MCSM, Gomes HDN, Fortes FM, Pimentel AM, Mota J, Almeida N, Surlo VC, Lyra A, Rocha R, Santana GO
Biomed Res Int 2019;2019:7604939. Epub 2019 Jan 31 doi: 10.1155/2019/7604939. PMID: 30834274Free PMC Article
Association between serum IgE level and adverse clinical endpoints in primary sclerosing cholangitis.
Tabibian JH, Enders F, Imam MH, Kolar G, Lindor KD, Talwalkar JA
Ann Hepatol 2014 May-Jun;13(3):384-9. PMID: 24756015Free PMC Article
The Fifth Carlos E. Rubio Memorial Lecture. Sclerosing cholangitis: pathogenesis, pathology, and practice.
Larusso NF
P R Health Sci J 1999 Mar;18(1):11-7. PMID: 10343981

Recent systematic reviews

Programmed cell death-1 inhibitor-related sclerosing cholangitis: A systematic review.
Onoyama T, Takeda Y, Yamashita T, Hamamoto W, Sakamoto Y, Koda H, Kawata S, Matsumoto K, Isomoto H
World J Gastroenterol 2020 Jan 21;26(3):353-365. doi: 10.3748/wjg.v26.i3.353. PMID: 31988594Free PMC Article

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