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Togaviridae infectious disease

MedGen UID:
21575
Concept ID:
C0040361
Disease or Syndrome
Synonyms: Togaviridae disease; Togaviridae infection; Togavirus infections
SNOMED CT: Disease caused by Togaviridae (33947007)
 
Monarch Initiative: MONDO:0005985

Definition

A viral infection caused by any of the arboviruses of the Togaviridae family. It is transmitted by arthropods. Signs and symptoms include fever, headache, nausea, vomiting, rash, confusion, and seizures. [from NCI]

Professional guidelines

PubMed

Vairo F, Haider N, Kock R, Ntoumi F, Ippolito G, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1003-1025. doi: 10.1016/j.idc.2019.08.006. PMID: 31668189
Sutaria RB, Amaral JK, Schoen RT
Curr Opin Rheumatol 2018 May;30(3):256-263. doi: 10.1097/BOR.0000000000000486. PMID: 29389830
Abraham R, Manakkadan A, Mudaliar P, Joseph I, Sivakumar KC, Nair RR, Sreekumar E
Infect Genet Evol 2016 Jan;37:174-84. Epub 2015 Nov 27 doi: 10.1016/j.meegid.2015.11.019. PMID: 26611825

Recent clinical studies

Etiology

Bartholomeeusen K, Daniel M, LaBeaud DA, Gasque P, Peeling RW, Stephenson KE, Ng LFP, Ariën KK
Nat Rev Dis Primers 2023 Apr 6;9(1):17. doi: 10.1038/s41572-023-00429-2. PMID: 37024497Free PMC Article
Simon F, Caumes E, Jelinek T, Lopez-Velez R, Steffen R, Chen LH
J Travel Med 2023 Apr 5;30(2) doi: 10.1093/jtm/taad008. PMID: 36648431Free PMC Article
Tanay A
Curr Opin Rheumatol 2017 Jul;29(4):389-393. doi: 10.1097/BOR.0000000000000396. PMID: 28376065
Martínez-Pulgarín DF, Chowdhury FR, Villamil-Gomez WE, Rodriguez-Morales AJ, Blohm GM, Paniz-Mondolfi AE
Travel Med Infect Dis 2016 Sep-Oct;14(5):451-457. Epub 2016 May 26 doi: 10.1016/j.tmaid.2016.05.008. PMID: 27238905
Powers AM, Roehrig JT
Methods Mol Biol 2011;665:17-38. doi: 10.1007/978-1-60761-817-1_2. PMID: 21116793

Diagnosis

Deng X, Achari A, Federman S, Yu G, Somasekar S, Bártolo I, Yagi S, Mbala-Kingebeni P, Kapetshi J, Ahuka-Mundeke S, Muyembe-Tamfum JJ, Ahmed AA, Ganesh V, Tamhankar M, Patterson JL, Ndembi N, Mbanya D, Kaptue L, McArthur C, Muñoz-Medina JE, Gonzalez-Bonilla CR, López S, Arias CF, Arevalo S, Miller S, Stone M, Busch M, Hsieh K, Messenger S, Wadford DA, Rodgers M, Cloherty G, Faria NR, Thézé J, Pybus OG, Neto Z, Morais J, Taveira N, R Hackett J Jr, Chiu CY
Nat Microbiol 2020 Mar;5(3):443-454. Epub 2020 Jan 13 doi: 10.1038/s41564-019-0637-9. PMID: 31932713Free PMC Article
Vairo F, Haider N, Kock R, Ntoumi F, Ippolito G, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1003-1025. doi: 10.1016/j.idc.2019.08.006. PMID: 31668189
Caglioti C, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L
New Microbiol 2013 Jul;36(3):211-27. Epub 2013 Jun 30 PMID: 23912863
Powers AM, Roehrig JT
Methods Mol Biol 2011;665:17-38. doi: 10.1007/978-1-60761-817-1_2. PMID: 21116793
Banatvala JE, Brown DW
Lancet 2004 Apr 3;363(9415):1127-37. doi: 10.1016/S0140-6736(04)15897-2. PMID: 15064032

Therapy

de Alwis R, Gan ES, Chen S, Leong YS, Tan HC, Zhang SL, Yau C, Low JGH, Kalimuddin S, Matsuda D, Allen EC, Hartman P, Park KJ, Alayyoubi M, Bhaskaran H, Dukanovic A, Bao Y, Clemente B, Vega J, Roberts S, Gonzalez JA, Sablad M, Yelin R, Taylor W, Tachikawa K, Parker S, Karmali P, Davis J, Sullivan BM, Sullivan SM, Hughes SG, Chivukula P, Ooi EE
Mol Ther 2021 Jun 2;29(6):1970-1983. Epub 2021 Apr 5 doi: 10.1016/j.ymthe.2021.04.001. PMID: 33823303Free PMC Article
Blakney AK, McKay PF, Bouton CR, Hu K, Samnuan K, Shattock RJ
Mol Ther 2021 Mar 3;29(3):1174-1185. Epub 2020 Dec 21 doi: 10.1016/j.ymthe.2020.11.011. PMID: 33352107Free PMC Article
Pathak H, Mohan MC, Ravindran V
Clin Med (Lond) 2019 Sep;19(5):381-385. doi: 10.7861/clinmed.2019-0035. PMID: 31530685Free PMC Article
Vauloup-Fellous C
J Clin Virol 2018 May;102:34-38. Epub 2018 Feb 15 doi: 10.1016/j.jcv.2018.02.006. PMID: 29486385
Banatvala JE, Brown DW
Lancet 2004 Apr 3;363(9415):1127-37. doi: 10.1016/S0140-6736(04)15897-2. PMID: 15064032

Prognosis

Humphrey JM, Cleton NB, Reusken CBEM, Glesby MJ, Koopmans MPG, Abu-Raddad LJ
PLoS Negl Trop Dis 2017 Jun;11(6):e0005707. Epub 2017 Jun 26 doi: 10.1371/journal.pntd.0005707. PMID: 28651007Free PMC Article
Tanay A
Curr Opin Rheumatol 2017 Jul;29(4):389-393. doi: 10.1097/BOR.0000000000000396. PMID: 28376065
Martínez-Pulgarín DF, Chowdhury FR, Villamil-Gomez WE, Rodriguez-Morales AJ, Blohm GM, Paniz-Mondolfi AE
Travel Med Infect Dis 2016 Sep-Oct;14(5):451-457. Epub 2016 May 26 doi: 10.1016/j.tmaid.2016.05.008. PMID: 27238905
Adışen E, Önder M
Clin Dermatol 2015 Jul-Aug;33(4):429-36. Epub 2015 Apr 8 doi: 10.1016/j.clindermatol.2015.04.004. PMID: 26051057
MacFadden DR, Bogoch II
CMAJ 2014 Jul 8;186(10):775. Epub 2014 Jun 9 doi: 10.1503/cmaj.140031. PMID: 24914111Free PMC Article

Clinical prediction guides

Yakob L
Viruses 2022 Aug 26;14(9) doi: 10.3390/v14091889. PMID: 36146696Free PMC Article
Blakney AK, McKay PF, Bouton CR, Hu K, Samnuan K, Shattock RJ
Mol Ther 2021 Mar 3;29(3):1174-1185. Epub 2020 Dec 21 doi: 10.1016/j.ymthe.2020.11.011. PMID: 33352107Free PMC Article
Broeckel RM, Haese N, Ando T, Dmitriev I, Kreklywich CN, Powers J, Denton M, Smith P, Morrison TE, Heise M, DeFilippis V, Messaoudi I, Curiel DT, Streblow DN
Front Immunol 2019;10:2563. Epub 2019 Oct 31 doi: 10.3389/fimmu.2019.02563. PMID: 31736977Free PMC Article
Caglioti C, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L
New Microbiol 2013 Jul;36(3):211-27. Epub 2013 Jun 30 PMID: 23912863
Weaver SC
Curr Top Microbiol Immunol 2006;299:285-314. doi: 10.1007/3-540-26397-7_10. PMID: 16568903Free PMC Article

Recent systematic reviews

Damtew YT, Tong M, Varghese BM, Hansen A, Liu J, Dear K, Zhang Y, Morgan G, Driscoll T, Capon T, Bi P
Acta Trop 2022 Jul;231:106454. Epub 2022 Apr 9 doi: 10.1016/j.actatropica.2022.106454. PMID: 35405101
Contopoulos-Ioannidis D, Newman-Lindsay S, Chow C, LaBeaud AD
PLoS Negl Trop Dis 2018 Jun;12(6):e0006510. Epub 2018 Jun 13 doi: 10.1371/journal.pntd.0006510. PMID: 29897898Free PMC Article
Mehta R, Gerardin P, de Brito CAA, Soares CN, Ferreira MLB, Solomon T
Rev Med Virol 2018 May;28(3):e1978. Epub 2018 Apr 19 doi: 10.1002/rmv.1978. PMID: 29671914Free PMC Article
Humphrey JM, Cleton NB, Reusken CBEM, Glesby MJ, Koopmans MPG, Abu-Raddad LJ
PLoS Negl Trop Dis 2017 Jun;11(6):e0005707. Epub 2017 Jun 26 doi: 10.1371/journal.pntd.0005707. PMID: 28651007Free PMC Article
Rudolph KE, Lessler J, Moloney RM, Kmush B, Cummings DA
Am J Trop Med Hyg 2014 May;90(5):882-91. Epub 2014 Mar 17 doi: 10.4269/ajtmh.13-0403. PMID: 24639305Free PMC Article

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