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Togaviridae infectious disease

MedGen UID:
21575
•Concept ID:
C0040361
•
Disease or Syndrome
Synonyms: Togaviridae disease; Togaviridae infection; Togavirus infections
SNOMED CT: Disease caused by Togaviridae (33947007)
 
Monarch Initiative: MONDO:0005985

Definition

A viral infection caused by any of the arboviruses of the Togaviridae family. It is transmitted by arthropods. Signs and symptoms include fever, headache, nausea, vomiting, rash, confusion, and seizures. [from NCI]

Professional guidelines

PubMed

Chikungunya: Epidemiology, Pathogenesis, Clinical Features, Management, and Prevention.
Vairo F, Haider N, Kock R, Ntoumi F, Ippolito G, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1003-1025. doi: 10.1016/j.idc.2019.08.006. PMID: 31668189
Emergence and treatment of chikungunya arthritis.
Sutaria RB, Amaral JK, Schoen RT
Curr Opin Rheumatol 2018 May;30(3):256-263. doi: 10.1097/BOR.0000000000000486. PMID: 29389830
Chikungunya Arthritis: Implications of Acute and Chronic Inflammation Mechanisms on Disease Management.
Zaid A, Gérardin P, Taylor A, Mostafavi H, Malvy D, Mahalingam S
Arthritis Rheumatol 2018 Apr;70(4):484-495. Epub 2018 Mar 23 doi: 10.1002/art.40403. PMID: 29287308

Recent clinical studies

Etiology

Shifts in receptors during submergence of an encephalitic arbovirus.
Li W, Plante JA, Lin C, Basu H, Plung JS, Fan X, Boeckers JM, Oros J, Buck TK, Anekal PV, Hanson WA, Varnum H, Wells A, Mann CJ, Tjang LV, Yang P, Reyna RA, Mitchell BM, Shinde DP, Walker JL, Choi SY, Brusic V, Llopis PM, Weaver SC, Umemori H, Chiu IM, Plante KS, Abraham J
Nature 2024 Aug;632(8025):614-621. Epub 2024 Jul 24 doi: 10.1038/s41586-024-07740-2. PMID: 39048821Free PMC Article
Chikungunya fever.
Bartholomeeusen K, Daniel M, LaBeaud DA, Gasque P, Peeling RW, Stephenson KE, Ng LFP, Ariën KK
Nat Rev Dis Primers 2023 Apr 6;9(1):17. doi: 10.1038/s41572-023-00429-2. PMID: 37024497Free PMC Article
Chikungunya: risks for travellers.
Simon F, Caumes E, Jelinek T, Lopez-Velez R, Steffen R, Chen LH
J Travel Med 2023 Apr 5;30(2) doi: 10.1093/jtm/taad008. PMID: 36648431Free PMC Article
Arboviral central nervous system infections.
Schultz JS, Sparks H, Beckham JD
Curr Opin Infect Dis 2021 Jun 1;34(3):264-271. doi: 10.1097/QCO.0000000000000729. PMID: 33899755
Chikungunya virus and autoimmunity.
Tanay A
Curr Opin Rheumatol 2017 Jul;29(4):389-393. doi: 10.1097/BOR.0000000000000396. PMID: 28376065

Diagnosis

Metagenomic sequencing with spiked primer enrichment for viral diagnostics and genomic surveillance.
Deng X, Achari A, Federman S, Yu G, Somasekar S, Bártolo I, Yagi S, Mbala-Kingebeni P, Kapetshi J, Ahuka-Mundeke S, Muyembe-Tamfum JJ, Ahmed AA, Ganesh V, Tamhankar M, Patterson JL, Ndembi N, Mbanya D, Kaptue L, McArthur C, Muñoz-Medina JE, Gonzalez-Bonilla CR, López S, Arias CF, Arevalo S, Miller S, Stone M, Busch M, Hsieh K, Messenger S, Wadford DA, Rodgers M, Cloherty G, Faria NR, Thézé J, Pybus OG, Neto Z, Morais J, Taveira N, R Hackett J Jr, Chiu CY
Nat Microbiol 2020 Mar;5(3):443-454. Epub 2020 Jan 13 doi: 10.1038/s41564-019-0637-9. PMID: 31932713Free PMC Article
Chikungunya: Epidemiology, Pathogenesis, Clinical Features, Management, and Prevention.
Vairo F, Haider N, Kock R, Ntoumi F, Ippolito G, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1003-1025. doi: 10.1016/j.idc.2019.08.006. PMID: 31668189
Chikungunya.
MacFadden DR, Bogoch II
CMAJ 2014 Jul 8;186(10):775. Epub 2014 Jun 9 doi: 10.1503/cmaj.140031. PMID: 24914111Free PMC Article
Chikungunya virus infection: an overview.
Caglioti C, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L
New Microbiol 2013 Jul;36(3):211-27. Epub 2013 Jun 30 PMID: 23912863
Rubella.
Banatvala JE, Brown DW
Lancet 2004 Apr 3;363(9415):1127-37. doi: 10.1016/S0140-6736(04)15897-2. PMID: 15064032

Therapy

A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice.
de Alwis R, Gan ES, Chen S, Leong YS, Tan HC, Zhang SL, Yau C, Low JGH, Kalimuddin S, Matsuda D, Allen EC, Hartman P, Park KJ, Alayyoubi M, Bhaskaran H, Dukanovic A, Bao Y, Clemente B, Vega J, Roberts S, Gonzalez JA, Sablad M, Yelin R, Taylor W, Tachikawa K, Parker S, Karmali P, Davis J, Sullivan BM, Sullivan SM, Hughes SG, Chivukula P, Ooi EE
Mol Ther 2021 Jun 2;29(6):1970-1983. Epub 2021 Apr 5 doi: 10.1016/j.ymthe.2021.04.001. PMID: 33823303Free PMC Article
Innate Inhibiting Proteins Enhance Expression and Immunogenicity of Self-Amplifying RNA.
Blakney AK, McKay PF, Bouton CR, Hu K, Samnuan K, Shattock RJ
Mol Ther 2021 Mar 3;29(3):1174-1185. Epub 2020 Dec 21 doi: 10.1016/j.ymthe.2020.11.011. PMID: 33352107Free PMC Article
Chikungunya arthritis.
Pathak H, Mohan MC, Ravindran V
Clin Med (Lond) 2019 Sep;19(5):381-385. doi: 10.7861/clinmed.2019-0035. PMID: 31530685Free PMC Article
Standardization of rubella immunoassays.
Vauloup-Fellous C
J Clin Virol 2018 May;102:34-38. Epub 2018 Feb 15 doi: 10.1016/j.jcv.2018.02.006. PMID: 29486385
Rubella.
Banatvala JE, Brown DW
Lancet 2004 Apr 3;363(9415):1127-37. doi: 10.1016/S0140-6736(04)15897-2. PMID: 15064032

Prognosis

Genetic control of alphavirus pathogenesis.
Baxter VK, Heise MT
Mamm Genome 2018 Aug;29(7-8):408-424. Epub 2018 Aug 27 doi: 10.1007/s00335-018-9776-1. PMID: 30151711Free PMC Article
Chikungunya virus and autoimmunity.
Tanay A
Curr Opin Rheumatol 2017 Jul;29(4):389-393. doi: 10.1097/BOR.0000000000000396. PMID: 28376065
How great is the threat of chikungunya virus?
Waggoner JJ, Pinsky BA
Expert Rev Anti Infect Ther 2015 Mar;13(3):291-3. Epub 2014 Dec 24 doi: 10.1586/14787210.2015.995634. PMID: 25537007Free PMC Article
Chikungunya.
MacFadden DR, Bogoch II
CMAJ 2014 Jul 8;186(10):775. Epub 2014 Jun 9 doi: 10.1503/cmaj.140031. PMID: 24914111Free PMC Article
Arthritogenic alphaviruses--an overview.
Suhrbier A, Jaffar-Bandjee MC, Gasque P
Nat Rev Rheumatol 2012 May 8;8(7):420-9. doi: 10.1038/nrrheum.2012.64. PMID: 22565316

Clinical prediction guides

Innate Inhibiting Proteins Enhance Expression and Immunogenicity of Self-Amplifying RNA.
Blakney AK, McKay PF, Bouton CR, Hu K, Samnuan K, Shattock RJ
Mol Ther 2021 Mar 3;29(3):1174-1185. Epub 2020 Dec 21 doi: 10.1016/j.ymthe.2020.11.011. PMID: 33352107Free PMC Article
How great is the threat of chikungunya virus?
Waggoner JJ, Pinsky BA
Expert Rev Anti Infect Ther 2015 Mar;13(3):291-3. Epub 2014 Dec 24 doi: 10.1586/14787210.2015.995634. PMID: 25537007Free PMC Article
Incubation periods of mosquito-borne viral infections: a systematic review.
Rudolph KE, Lessler J, Moloney RM, Kmush B, Cummings DA
Am J Trop Med Hyg 2014 May;90(5):882-91. Epub 2014 Mar 17 doi: 10.4269/ajtmh.13-0403. PMID: 24639305Free PMC Article
Chikungunya virus infection: an overview.
Caglioti C, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L
New Microbiol 2013 Jul;36(3):211-27. Epub 2013 Jun 30 PMID: 23912863
Chikungunya virus: host pathogen interaction.
Singh SK, Unni SK
Rev Med Virol 2011 Mar;21(2):78-88. Epub 2011 Mar 15 doi: 10.1002/rmv.681. PMID: 21412934

Recent systematic reviews

Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis.
Contopoulos-Ioannidis D, Newman-Lindsay S, Chow C, LaBeaud AD
PLoS Negl Trop Dis 2018 Jun;12(6):e0006510. Epub 2018 Jun 13 doi: 10.1371/journal.pntd.0006510. PMID: 29897898Free PMC Article
The neurological complications of chikungunya virus: A systematic review.
Mehta R, Gerardin P, de Brito CAA, Soares CN, Ferreira MLB, Solomon T
Rev Med Virol 2018 May;28(3):e1978. Epub 2018 Apr 19 doi: 10.1002/rmv.1978. PMID: 29671914Free PMC Article
Prevalence of chronic comorbidities in chikungunya: A systematic review and meta-analysis.
Badawi A, Ryoo SG, Vasileva D, Yaghoubi S
Int J Infect Dis 2018 Feb;67:107-113. Epub 2017 Dec 20 doi: 10.1016/j.ijid.2017.12.018. PMID: 29277382Free PMC Article
Urban Chikungunya in the Middle East and North Africa: A systematic review.
Humphrey JM, Cleton NB, Reusken CBEM, Glesby MJ, Koopmans MPG, Abu-Raddad LJ
PLoS Negl Trop Dis 2017 Jun;11(6):e0005707. Epub 2017 Jun 26 doi: 10.1371/journal.pntd.0005707. PMID: 28651007Free PMC Article
Incubation periods of mosquito-borne viral infections: a systematic review.
Rudolph KE, Lessler J, Moloney RM, Kmush B, Cummings DA
Am J Trop Med Hyg 2014 May;90(5):882-91. Epub 2014 Mar 17 doi: 10.4269/ajtmh.13-0403. PMID: 24639305Free PMC Article

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