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Trigeminal neuralgia

MedGen UID:
21683
•Concept ID:
C0040997
•
Disease or Syndrome
Synonyms: Disease, Fothergill; Epileptiform Neuralgia; Epileptiform Neuralgias; Fothergill Disease; Neuralgia, Epileptiform; Neuralgia, Trifacial; Neuralgia, Trigeminal; Tic Doloureux; Tic Douloureux; Trifacial Neuralgia; Trifacial Neuralgias; Trigeminal Neuralgia; Trigeminal Neuralgias
SNOMED CT: TN - Trigeminal neuralgia (31681005); Trigeminal neuralgia (31681005); Tic douloureux (31681005); Trifacial neuralgia (31681005); Fothergill's neuralgia (31681005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0100661
Monarch Initiative: MONDO:0008599
OMIM®: 190400
Orphanet: ORPHA221091

Definition

A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected. [from HPO]

Clinical features

From HPO
Trigeminal neuralgia
MedGen UID:
21683
•Concept ID:
C0040997
•
Disease or Syndrome
A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrigeminal neuralgia
Follow this link to review classifications for Trigeminal neuralgia in Orphanet.

Conditions with this feature

Hemifacial atrophy
MedGen UID:
8761
•Concept ID:
C0015458
•
Disease or Syndrome
Unilateral atrophy of facial tissues, including muscles, bones and skin.
See: Condition Record
Trigeminal neuralgia
MedGen UID:
21683
•Concept ID:
C0040997
•
Disease or Syndrome
A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected.
See: Condition Record
Hemifacial atrophy
Trigeminal neuralgia

Professional guidelines

PubMed

Neuropathic Pain: From Mechanisms to Treatment.
Finnerup NB, Kuner R, Jensen TS
Physiol Rev 2021 Jan 1;101(1):259-301. Epub 2020 Jun 25 doi: 10.1152/physrev.00045.2019. PMID: 32584191
Trigeminal neuralgia - diagnosis and treatment.
Maarbjerg S, Di Stefano G, Bendtsen L, Cruccu G
Cephalalgia 2017 Jun;37(7):648-657. Epub 2017 Jan 11 doi: 10.1177/0333102416687280. PMID: 28076964
Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment.
Baron R, Binder A, Wasner G
Lancet Neurol 2010 Aug;9(8):807-19. doi: 10.1016/S1474-4422(10)70143-5. PMID: 20650402

Curated

UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

Recent clinical studies

Etiology

Trigeminal Neuralgia.
Khawaja SN, Scrivani SJ
Dent Clin North Am 2023 Jan;67(1):99-115. Epub 2022 Oct 27 doi: 10.1016/j.cden.2022.07.008. PMID: 36404084
Clinical outcome after microvascular decompression for trigeminal neuralgia: a systematic review and meta-analysis.
Di Carlo DT, Benedetto N, Perrini P
Neurosurg Rev 2022 Dec 8;46(1):8. doi: 10.1007/s10143-022-01922-0. PMID: 36481917
Trigeminal neuralgia: a practical guide.
Lambru G, Zakrzewska J, Matharu M
Pract Neurol 2021 Oct;21(5):392-402. Epub 2021 Jun 9 doi: 10.1136/practneurol-2020-002782. PMID: 34108244Free PMC Article
Trigeminal Neuralgia and Other Facial Neuralgias.
Wolf A, Kondziolka D
Prog Neurol Surg 2019;34:273-278. Epub 2019 May 16 doi: 10.1159/000493074. PMID: 31096245
Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options.
Di Stefano G, Maarbjerg S, Truini A
J Headache Pain 2019 Feb 19;20(1):20. doi: 10.1186/s10194-019-0969-0. PMID: 30782116Free PMC Article

Diagnosis

Trigeminal Neuralgia.
Khawaja SN, Scrivani SJ
Dent Clin North Am 2023 Jan;67(1):99-115. Epub 2022 Oct 27 doi: 10.1016/j.cden.2022.07.008. PMID: 36404084
Trigeminal Neuralgia: Diagnosis and Treatment.
Allam AK, Sharma H, Larkin MB, Viswanathan A
Neurol Clin 2023 Feb;41(1):107-121. doi: 10.1016/j.ncl.2022.09.001. PMID: 36400550
Advances in diagnosis, classification, pathophysiology, and management of trigeminal neuralgia.
Bendtsen L, Zakrzewska JM, Heinskou TB, Hodaie M, Leal PRL, Nurmikko T, Obermann M, Cruccu G, Maarbjerg S
Lancet Neurol 2020 Sep;19(9):784-796. doi: 10.1016/S1474-4422(20)30233-7. PMID: 32822636
Trigeminal neuralgia - diagnosis and treatment.
Maarbjerg S, Di Stefano G, Bendtsen L, Cruccu G
Cephalalgia 2017 Jun;37(7):648-657. Epub 2017 Jan 11 doi: 10.1177/0333102416687280. PMID: 28076964
Trigeminal neuralgia.
Zakrzewska JM, Linskey ME
BMJ 2015 Mar 12;350:h1238. doi: 10.1136/bmj.h1238. PMID: 25767102

Therapy

Trigeminal Neuralgia.
Cruccu G, Di Stefano G, Truini A
N Engl J Med 2020 Aug 20;383(8):754-762. doi: 10.1056/NEJMra1914484. PMID: 32813951
Use of Botulinum Toxin in Orofacial Clinical Practice.
Serrera-Figallo MA, Ruiz-de-León-Hernández G, Torres-Lagares D, Castro-Araya A, Torres-Ferrerosa O, Hernández-Pacheco E, Gutierrez-Perez JL
Toxins (Basel) 2020 Feb 11;12(2) doi: 10.3390/toxins12020112. PMID: 32053883Free PMC Article
Trigeminal neuralgia.
Zakrzewska JM, Linskey ME
BMJ Clin Evid 2014 Oct 6;2014 PMID: 25299564Free PMC Article
Interventional management of neuropathic pain: NeuPSIG recommendations.
Dworkin RH, O'Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, Levy RM, Backonja M, Baron R, Harke H, Loeser JD, Treede RD, Turk DC, Wells CD
Pain 2013 Nov;154(11):2249-2261. Epub 2013 Jun 6 doi: 10.1016/j.pain.2013.06.004. PMID: 23748119Free PMC Article
EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision.
Attal N, Cruccu G, Baron R, Haanpää M, Hansson P, Jensen TS, Nurmikko T
Eur J Neurol 2010 Sep;17(9):1113-e88. Epub 2010 Apr 9 doi: 10.1111/j.1468-1331.2010.02999.x. PMID: 20402746

Prognosis

A glance at the past.
Ganz JC
Prog Brain Res 2022;268(1):1-8. Epub 2021 Dec 14 doi: 10.1016/bs.pbr.2021.10.022. PMID: 35074076
Tumor control and trigeminal dysfunction improvement after stereotactic radiosurgery for trigeminal schwannomas: a systematic review and meta-analysis.
Peciu-Florianu I, Régis J, Levivier M, Dedeciusova M, Reyns N, Tuleasca C
Neurosurg Rev 2021 Oct;44(5):2391-2403. Epub 2020 Nov 13 doi: 10.1007/s10143-020-01433-w. PMID: 33185756Free PMC Article
Fully endoscopic microvascular decompression for trigeminal neuralgia: technique review and early outcomes.
Bohman LE, Pierce J, Stephen JH, Sandhu S, Lee JY
Neurosurg Focus 2014;37(4):E18. doi: 10.3171/2014.7.FOCUS14318. PMID: 25270137
Neuropathic pain in the general population: a systematic review of epidemiological studies.
van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N
Pain 2014 Apr;155(4):654-662. Epub 2013 Nov 26 doi: 10.1016/j.pain.2013.11.013. PMID: 24291734
Trigeminal neuralgia.
Hayashi M
Prog Neurol Surg 2009;22:182-190. doi: 10.1159/000163431. PMID: 18948729

Clinical prediction guides

Acupuncture for the treatment of trigeminal neuralgia: A systematic review and meta-analysis.
Ang L, Kim HJ, Heo JW, Choi TY, Lee HW, Kim JI, Lee MS
Complement Ther Clin Pract 2023 Aug;52:101763. Epub 2023 May 2 doi: 10.1016/j.ctcp.2023.101763. PMID: 37159979
Cervical Spinal Cord Stimulation for Trigeminal Neuralgia: a Narrative Review.
Gupta M, Chitneni A, Ghorayeb J, Schnetzer B, Klusek M
Curr Pain Headache Rep 2022 Aug;26(8):639-645. Epub 2022 Jun 18 doi: 10.1007/s11916-022-01066-2. PMID: 35716273
Differential expression of a brain aging biomarker across discrete chronic pain disorders.
Hung PS, Zhang JY, Noorani A, Walker MR, Huang M, Zhang JW, Laperriere N, Rudzicz F, Hodaie M
Pain 2022 Aug 1;163(8):1468-1478. Epub 2022 Feb 23 doi: 10.1097/j.pain.0000000000002613. PMID: 35202044
Recent advances in understanding/managing trigeminal neuralgia.
Obermann M
F1000Res 2019;8 Epub 2019 Apr 17 doi: 10.12688/f1000research.16092.1. PMID: 31069052Free PMC Article
Trigeminal neuralgia.
Hayashi M
Prog Neurol Surg 2009;22:182-190. doi: 10.1159/000163431. PMID: 18948729

Recent systematic reviews

Clinical outcome after microvascular decompression for trigeminal neuralgia: a systematic review and meta-analysis.
Di Carlo DT, Benedetto N, Perrini P
Neurosurg Rev 2022 Dec 8;46(1):8. doi: 10.1007/s10143-022-01922-0. PMID: 36481917
Prevalence of trigeminal neuralgia in multiple sclerosis: A systematic review and meta-analysis.
Houshi S, Tavallaei MJ, Barzegar M, Afshari-Safavi A, Vaheb S, Mirmosayyeb O, Shaygannejad V
Mult Scler Relat Disord 2022 Jan;57:103472. Epub 2021 Dec 29 doi: 10.1016/j.msard.2021.103472. PMID: 34986455
Trigeminal neuralgia.
Zakrzewska JM, Linskey ME
BMJ Clin Evid 2014 Oct 6;2014 PMID: 25299564Free PMC Article
Neuropathic pain in the general population: a systematic review of epidemiological studies.
van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N
Pain 2014 Apr;155(4):654-662. Epub 2013 Nov 26 doi: 10.1016/j.pain.2013.11.013. PMID: 24291734
Trigeminal neuralgia.
Zakrzewska JM, Linskey ME
BMJ Clin Evid 2009 Mar 12;2009 PMID: 19445753Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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