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Trigeminal neuralgia

MedGen UID:
21683
Concept ID:
C0040997
Disease or Syndrome
Synonyms: Disease, Fothergill; Epileptiform Neuralgia; Epileptiform Neuralgias; Fothergill Disease; Neuralgia, Epileptiform; Neuralgia, Trifacial; Neuralgia, Trigeminal; Tic Doloureux; Tic Douloureux; Trifacial Neuralgia; Trifacial Neuralgias; Trigeminal Neuralgia; Trigeminal Neuralgias
SNOMED CT: TN - Trigeminal neuralgia (31681005); Trigeminal neuralgia (31681005); Tic douloureux (31681005); Trifacial neuralgia (31681005); Fothergill's neuralgia (31681005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0100661
Monarch Initiative: MONDO:0008599
OMIM®: 190400
Orphanet: ORPHA221091

Definition

A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected. [from HPO]

Clinical features

From HPO
Trigeminal neuralgia
MedGen UID:
21683
Concept ID:
C0040997
Disease or Syndrome
A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrigeminal neuralgia
Follow this link to review classifications for Trigeminal neuralgia in Orphanet.

Conditions with this feature

Facial hemiatrophy
MedGen UID:
8761
Concept ID:
C0015458
Disease or Syndrome
Unilateral atrophy of facial tissues, including muscles, bones and skin.
Trigeminal neuralgia
MedGen UID:
21683
Concept ID:
C0040997
Disease or Syndrome
A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected.

Professional guidelines

PubMed

Allam AK, Sharma H, Larkin MB, Viswanathan A
Neurol Clin 2023 Feb;41(1):107-121. doi: 10.1016/j.ncl.2022.09.001. PMID: 36400550
Finnerup NB, Kuner R, Jensen TS
Physiol Rev 2021 Jan 1;101(1):259-301. Epub 2020 Jun 25 doi: 10.1152/physrev.00045.2019. PMID: 32584191
Baron R, Binder A, Wasner G
Lancet Neurol 2010 Aug;9(8):807-19. doi: 10.1016/S1474-4422(10)70143-5. PMID: 20650402

Curated

UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

Recent clinical studies

Etiology

Ang L, Kim HJ, Heo JW, Choi TY, Lee HW, Kim JI, Lee MS
Complement Ther Clin Pract 2023 Aug;52:101763. Epub 2023 May 2 doi: 10.1016/j.ctcp.2023.101763. PMID: 37159979
Khawaja SN, Scrivani SJ
Dent Clin North Am 2023 Jan;67(1):99-115. Epub 2022 Oct 27 doi: 10.1016/j.cden.2022.07.008. PMID: 36404084
Maarbjerg S, Benoliel R
Headache 2021 Jun;61(6):817-837. doi: 10.1111/head.14144. PMID: 34214179
Lambru G, Zakrzewska J, Matharu M
Pract Neurol 2021 Oct;21(5):392-402. Epub 2021 Jun 9 doi: 10.1136/practneurol-2020-002782. PMID: 34108244Free PMC Article
Di Stefano G, Maarbjerg S, Truini A
J Headache Pain 2019 Feb 19;20(1):20. doi: 10.1186/s10194-019-0969-0. PMID: 30782116Free PMC Article

Diagnosis

Khawaja SN, Scrivani SJ
Dent Clin North Am 2023 Jan;67(1):99-115. Epub 2022 Oct 27 doi: 10.1016/j.cden.2022.07.008. PMID: 36404084
Allam AK, Sharma H, Larkin MB, Viswanathan A
Neurol Clin 2023 Feb;41(1):107-121. doi: 10.1016/j.ncl.2022.09.001. PMID: 36400550
Radoš I
Acta Clin Croat 2022 Sep;61(Suppl 2):96-102. doi: 10.20471/acc.2022.61.s2.12. PMID: 36824641Free PMC Article
Bendtsen L, Zakrzewska JM, Heinskou TB, Hodaie M, Leal PRL, Nurmikko T, Obermann M, Cruccu G, Maarbjerg S
Lancet Neurol 2020 Sep;19(9):784-796. doi: 10.1016/S1474-4422(20)30233-7. PMID: 32822636
Maarbjerg S, Di Stefano G, Bendtsen L, Cruccu G
Cephalalgia 2017 Jun;37(7):648-657. Epub 2017 Jan 11 doi: 10.1177/0333102416687280. PMID: 28076964

Therapy

Radoš I
Acta Clin Croat 2022 Sep;61(Suppl 2):96-102. doi: 10.20471/acc.2022.61.s2.12. PMID: 36824641Free PMC Article
Cruccu G, Di Stefano G, Truini A
N Engl J Med 2020 Aug 20;383(8):754-762. doi: 10.1056/NEJMra1914484. PMID: 32813951
Serrera-Figallo MA, Ruiz-de-León-Hernández G, Torres-Lagares D, Castro-Araya A, Torres-Ferrerosa O, Hernández-Pacheco E, Gutierrez-Perez JL
Toxins (Basel) 2020 Feb 11;12(2) doi: 10.3390/toxins12020112. PMID: 32053883Free PMC Article
Dworkin RH, O'Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, Levy RM, Backonja M, Baron R, Harke H, Loeser JD, Treede RD, Turk DC, Wells CD
Pain 2013 Nov;154(11):2249-2261. Epub 2013 Jun 6 doi: 10.1016/j.pain.2013.06.004. PMID: 23748119Free PMC Article
Attal N, Cruccu G, Baron R, Haanpää M, Hansson P, Jensen TS, Nurmikko T
Eur J Neurol 2010 Sep;17(9):1113-e88. Epub 2010 Apr 9 doi: 10.1111/j.1468-1331.2010.02999.x. PMID: 20402746

Prognosis

Grewal SS, Kerezoudis P, Garcia O, Quinones-Hinojosa A, Reimer R, Wharen RE
World Neurosurg 2018 Jun;114:e892-e899. Epub 2018 Mar 23 doi: 10.1016/j.wneu.2018.03.111. PMID: 29581020
Tanrikulu L, Hastreiter P, Bassemir T, Bischoff B, Buchfelder M, Dörfler A, Naraghi R
World Neurosurg 2016 Aug;92:189-196. Epub 2016 May 6 doi: 10.1016/j.wneu.2016.04.119. PMID: 27157289
Parikh RR, Goodman RR, Rhome R, Sudentas E, Trichter F, Harrison LB, Choi W
Pract Radiat Oncol 2016 Jan-Feb;6(1):e1-7. Epub 2015 Sep 10 doi: 10.1016/j.prro.2015.09.001. PMID: 26577003
van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N
Pain 2014 Apr;155(4):654-662. Epub 2013 Nov 26 doi: 10.1016/j.pain.2013.11.013. PMID: 24291734
Harrison MS
J Laryngol Otol 1976 Jun;90(6):561-70. doi: 10.1017/s0022215100082451. PMID: 778316

Clinical prediction guides

Kalluri AL, So RJ, Ran KR, Xie ME, Kilgore C, Nair SK, Huang J, Bettegowda C, Xu R
Neurosurgery 2023 Nov 1;93(5):1075-1081. Epub 2023 Jun 12 doi: 10.1227/neu.0000000000002549. PMID: 37306434
Ang L, Kim HJ, Heo JW, Choi TY, Lee HW, Kim JI, Lee MS
Complement Ther Clin Pract 2023 Aug;52:101763. Epub 2023 May 2 doi: 10.1016/j.ctcp.2023.101763. PMID: 37159979
Knezevic NN, Nader A, Pirvulescu I, Pynadath A, Rahavard BB, Candido KD
Pain Pract 2023 Jan;23(1):94-109. Epub 2022 Aug 2 doi: 10.1111/papr.13149. PMID: 35869813Free PMC Article
Zhang X, Peng L, Liu D
Pain Physician 2022 Dec;25(9):E1327-E1337. PMID: 36608005
Gurvits GE, Tan A
World J Gastroenterol 2014 Aug 21;20(31):10845-50. doi: 10.3748/wjg.v20.i31.10845. PMID: 25152586Free PMC Article

Recent systematic reviews

Truini A, Aleksovska K, Anderson CC, Attal N, Baron R, Bennett DL, Bouhassira D, Cruccu G, Eisenberg E, Enax-Krumova E, Davis KD, Di Stefano G, Finnerup NB, Garcia-Larrea L, Hanafi I, Haroutounian S, Karlsson P, Rakusa M, Rice ASC, Sachau J, Smith BH, Sommer C, Tölle T, Valls-Solé J, Veluchamy A
Eur J Neurol 2023 Aug;30(8):2177-2196. Epub 2023 May 30 doi: 10.1111/ene.15831. PMID: 37253688
Ang L, Kim HJ, Heo JW, Choi TY, Lee HW, Kim JI, Lee MS
Complement Ther Clin Pract 2023 Aug;52:101763. Epub 2023 May 2 doi: 10.1016/j.ctcp.2023.101763. PMID: 37159979
Zhang X, Peng L, Liu D
Pain Physician 2022 Dec;25(9):E1327-E1337. PMID: 36608005
Zhang C, Hu H, Das SK, Yang MJ, Li B, Li Y, Xu XX, Yang HF
J Oral Facial Pain Headache 2020 Summer;34(3):222-235. doi: 10.11607/ofph.2626. PMID: 32870951
van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N
Pain 2014 Apr;155(4):654-662. Epub 2013 Nov 26 doi: 10.1016/j.pain.2013.11.013. PMID: 24291734

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

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