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Hemifacial atrophy(HFA)

MedGen UID:
8761
Concept ID:
C0015458
Disease or Syndrome
Synonyms: Facial hemiatrophy; PARRY-ROMBERG SYNDROME; Progressive hemifacial atrophy; Romberg hemi-facial atrophy
SNOMED CT: Hemifacial atrophy (95834000); Facial hemiatrophy (95834000); Facial trophoneurosis (95834000); Progressive hemifacial atrophy (718224004); Parry Romberg syndrome (718224004); Romberg syndrome (718224004)
Modes of inheritance:
 
HPO: HP:0011331
Monarch Initiative: MONDO:0007710
OMIM®: 141300
Orphanet: ORPHA1214

Definition

Unilateral atrophy of facial tissues, including muscles, bones and skin. [from HPO]

Clinical features

From HPO

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemifacial atrophy

Conditions with this feature

Professional guidelines

PubMed

He L, Liu X, Khatter NJ, Yu X, Washington KM, Shu M
Plast Reconstr Surg 2024 Mar 1;153(3):679-688. Epub 2023 Apr 25 doi: 10.1097/PRS.0000000000010585. PMID: 37092964
Ullman S, Danielsen PL, Fledelius HC, Daugaard-Jensen J, Serup J
Dermatology 2021;237(2):204-212. Epub 2020 Oct 5 doi: 10.1159/000507925. PMID: 33017821

Recent clinical studies

Etiology

AboShaban MS, Ghareeb FM
Oral Maxillofac Surg 2024 Mar;28(1):195-203. Epub 2022 Nov 14 doi: 10.1007/s10006-022-01115-5. PMID: 36376747
Kuu-Karkku L, Suominen A, Svedström-Oristo AL
Orthod Craniofac Res 2023 Feb;26(1):117-122. Epub 2022 Jun 20 doi: 10.1111/ocr.12592. PMID: 35689427Free PMC Article
De la Garza-Ramos C, Jain A, Montazeri SA, Okromelidze L, McGeary R, Bhatt AA, Sandhu SJS, Grewal SS, Feyissa A, Sirven JI, Ritaccio AL, Tatum WO, Gupta V, Middlebrooks EH
AJNR Am J Neuroradiol 2022 Jun;43(6):850-856. doi: 10.3174/ajnr.A7517. PMID: 35672084Free PMC Article
Agostini T, Spinelli G, Marino G, Perello R
J Craniofac Surg 2014 May;25(3):783-7. doi: 10.1097/SCS.0000000000000831. PMID: 24769615
Rees TD
Clin Plast Surg 1976 Oct;3(4):637-46. PMID: 788999

Diagnosis

Schultz KP, Dong E, Truong TA, Maricevich RS
Clin Plast Surg 2019 Apr;46(2):231-237. Epub 2019 Jan 9 doi: 10.1016/j.cps.2018.11.007. PMID: 30851754
Bucher F, Fricke J, Neugebauer A, Cursiefen C, Heindl LM
Surv Ophthalmol 2016 Nov-Dec;61(6):693-701. Epub 2016 Apr 1 doi: 10.1016/j.survophthal.2016.03.009. PMID: 27045226
Tolkachjov SN, Patel NG, Tollefson MM
Orphanet J Rare Dis 2015 Apr 1;10:39. doi: 10.1186/s13023-015-0250-9. PMID: 25881068Free PMC Article
Vedvyas C, Urbanek RW
Dermatol Online J 2013 Dec 16;19(12):20717. PMID: 24365008
El-Kehdy J, Abbas O, Rubeiz N
J Am Acad Dermatol 2012 Oct;67(4):769-84. Epub 2012 Mar 7 doi: 10.1016/j.jaad.2012.01.019. PMID: 22405645

Therapy

Chen GC, Chen MJ, Wei WB, Hao YB
J Craniofac Surg 2020 Mar/Apr;31(2):e205-e208. doi: 10.1097/SCS.0000000000006228. PMID: 31977713
Yang X, Wu R, Bi H, Lu H, Jia Z, Jin X, Qi Z
Ann Plast Surg 2016 Sep;77(3):308-13. doi: 10.1097/SAP.0000000000000641. PMID: 26418803
Grimaldi M, Gentile P, Labardi L, Silvi E, Trimarco A, Cervelli V
J Craniofac Surg 2008 Jul;19(4):1089-91. doi: 10.1097/SCS.0b013e318176354a. PMID: 18650738
Losken A, Carlson GW, Culbertson JH, Scott Hultman C, Kumar AV, Jones GE, Bostwick J 3rd, Jurkiewicz MJ
Head Neck 2002 Apr;24(4):326-31. doi: 10.1002/hed.10082. PMID: 11933173
Bart RS, Kopf AW
J Dermatol Surg Oncol 1978 Dec;4(12):908-9. doi: 10.1111/j.1524-4725.1978.tb00579.x. PMID: 730934

Prognosis

Chen JT, Schmid DB, Israel JS, Siebert JW
Plast Reconstr Surg 2018 Nov;142(5):1275-1283. doi: 10.1097/PRS.0000000000004922. PMID: 30511981
Yang X, Wu R, Bi H, Lu H, Jia Z, Jin X, Qi Z
Ann Plast Surg 2016 Sep;77(3):308-13. doi: 10.1097/SAP.0000000000000641. PMID: 26418803
Tolkachjov SN, Patel NG, Tollefson MM
Orphanet J Rare Dis 2015 Apr 1;10:39. doi: 10.1186/s13023-015-0250-9. PMID: 25881068Free PMC Article
Kini TA, Prakash VS, Puthalath S, Bhandari PL
Indian J Ophthalmol 2015 Jan;63(1):61-3. doi: 10.4103/0301-4738.151474. PMID: 25686066Free PMC Article
Rees TD
Clin Plast Surg 1976 Oct;3(4):637-46. PMID: 788999

Clinical prediction guides

Xiang X, Jiang Z, Che D, Chen G, Shen S, Ding W, Zhang Y, Xiang M, Zhu B, Xie J, Cao D
Asian J Surg 2024 Feb;47(2):973-981. Epub 2023 Nov 30 doi: 10.1016/j.asjsur.2023.11.044. PMID: 38036368
AboShaban MS, Ghareeb FM
Oral Maxillofac Surg 2024 Mar;28(1):195-203. Epub 2022 Nov 14 doi: 10.1007/s10006-022-01115-5. PMID: 36376747
Dermarkarian CR, Sweeney AR, Chambers CB, Chang SH
Int Ophthalmol 2021 Feb;41(2):599-604. Epub 2020 Oct 13 doi: 10.1007/s10792-020-01614-y. PMID: 33051768
Yang X, Wu R, Bi H, Lu H, Jia Z, Jin X, Qi Z
Ann Plast Surg 2016 Sep;77(3):308-13. doi: 10.1097/SAP.0000000000000641. PMID: 26418803
Song B, Li Y, Wang B, Han Y, Hu Y, Zhang J, Liu C, Hao D, Guo S
J Craniofac Surg 2015 Mar;26(2):e162-6. doi: 10.1097/SCS.0000000000001388. PMID: 25710747

Recent systematic reviews

Foiadelli T, Rossi A, Trabatti C, Spreafico E, Santi V, Orsini A, Verrotti A, Savasta S
Cephalalgia 2022 Apr;42(4-5):409-425. Epub 2021 Sep 26 doi: 10.1177/03331024211043452. PMID: 34569314
Hixon AM, Christensen E, Hamilton R, Drees C
Epilepsy Behav 2021 Aug;121(Pt A):108068. Epub 2021 May 28 doi: 10.1016/j.yebeh.2021.108068. PMID: 34052630Free PMC Article
Rodby KA, Kaptein YE, Roring J, Jacobs RJ, Kang V, Quinn KP, Antony AK
Cleft Palate Craniofac J 2016 May;53(3):339-50. Epub 2015 Aug 21 doi: 10.1597/14-232. PMID: 26295800
Agostini T, Spinelli G, Marino G, Perello R
J Craniofac Surg 2014 May;25(3):783-7. doi: 10.1097/SCS.0000000000000831. PMID: 24769615

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

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