U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cogan-Reese syndrome

MedGen UID:
218910
•Concept ID:
C1168173
•
Disease or Syndrome
Synonyms: Cogan-Reese Syndrome; Iris nevus syndrome; Nodular unilateral glaucoma
SNOMED CT: Cogan-Reese syndrome (404633004); Iris nevus syndrome (404633004); Nodular unilateral glaucoma (404633004)
 
Monarch Initiative: MONDO:0020370
Orphanet: ORPHA98980

Definition

A clinical variant of iridocorneal endothelial (ICE) syndrome, characterized by variable iris atrophy, pigmented and pedunculated nodules on the iris and corneal abonormalities. Secondary glaucoma is also a common complication of the disease. [from ORDO]

Professional guidelines

PubMed

Diagnosis and Management of Iridocorneal Endothelial Syndrome.
Sacchetti M, Mantelli F, Marenco M, Macchi I, Ambrosio O, Rama P
Biomed Res Int 2015;2015:763093. Epub 2015 Sep 16 doi: 10.1155/2015/763093. PMID: 26451377Free PMC Article

Recent clinical studies

Etiology

Our experience with micropulse cyclophotocoagulation in the therapy of glaucoma.
Nutterová E, Pitrová Š, Lešták J
Cesk Slov Oftalmol 2020 Winter;76(1):29-36. doi: 10.31348/2020/4. PMID: 32917092
The iridocorneal endothelial syndrome.
Silva L, Najafi A, Suwan Y, Teekhasaenee C, Ritch R
Surv Ophthalmol 2018 Sep-Oct;63(5):665-676. Epub 2018 Jan 11 doi: 10.1016/j.survophthal.2018.01.001. PMID: 29331589
Glaucoma associated with iridocorneal endothelial syndrome in 203 Indian subjects.
Chandran P, Rao HL, Mandal AK, Choudhari NS, Garudadri CS, Senthil S
PLoS One 2017;12(3):e0171884. Epub 2017 Mar 10 doi: 10.1371/journal.pone.0171884. PMID: 28282413Free PMC Article
ICE SYNDROME--CASE REPORT.
Coviltir V, Valentin D
Rom J Ophthalmol 2015 Apr-Jun;59(2):119-22. PMID: 26978875Free PMC Article
Diagnosis and Management of Iridocorneal Endothelial Syndrome.
Sacchetti M, Mantelli F, Marenco M, Macchi I, Ambrosio O, Rama P
Biomed Res Int 2015;2015:763093. Epub 2015 Sep 16 doi: 10.1155/2015/763093. PMID: 26451377Free PMC Article

Diagnosis

Cogan-Reese syndrome with Iris cyst: A novel presentation.
Selvan H, Brar AS, Angmo D
Cont Lens Anterior Eye 2019 Aug;42(4):467-469. Epub 2019 May 17 doi: 10.1016/j.clae.2019.04.014. PMID: 31104851
The iridocorneal endothelial syndrome.
Silva L, Najafi A, Suwan Y, Teekhasaenee C, Ritch R
Surv Ophthalmol 2018 Sep-Oct;63(5):665-676. Epub 2018 Jan 11 doi: 10.1016/j.survophthal.2018.01.001. PMID: 29331589
A unique case of keratoconus with Cogan-Reese syndrome and secondary glaucoma.
Chakrabarty L
Indian J Ophthalmol 2017 Jan;65(1):64-66. doi: 10.4103/ijo.IJO_986_15. PMID: 28300746Free PMC Article
Diagnosis and Management of Iridocorneal Endothelial Syndrome.
Sacchetti M, Mantelli F, Marenco M, Macchi I, Ambrosio O, Rama P
Biomed Res Int 2015;2015:763093. Epub 2015 Sep 16 doi: 10.1155/2015/763093. PMID: 26451377Free PMC Article
Association of Cogan-Reese syndrome, exfoliation syndrome, and secondary open-angle glaucoma.
Holló G, Kóthy P, Konstas AG
Eur J Ophthalmol 2012 Jan-Feb;22(1):117-20. doi: 10.5301/ejo.5000047. PMID: 22167551

Therapy

Cystoid macular edema associated with iridocorneal endothelial syndrome: a case report.
Suzuki K, Mizuguchi T, Seno Y, Tanikawa A, Horiguchi M
BMC Ophthalmol 2016 Sep 1;16(1):155. doi: 10.1186/s12886-016-0333-y. PMID: 27585567Free PMC Article
Association of Cogan-Reese syndrome, exfoliation syndrome, and secondary open-angle glaucoma.
Holló G, Kóthy P, Konstas AG
Eur J Ophthalmol 2012 Jan-Feb;22(1):117-20. doi: 10.5301/ejo.5000047. PMID: 22167551
Clinical and histopathologic findings of iris nevus (Cogan-Reese) syndrome.
Ozdemir Y, Onder F, Coşar CB, Usubütün A, Kural G
Acta Ophthalmol Scand 1999 Apr;77(2):234-7. doi: 10.1034/j.1600-0420.1999.770226.x. PMID: 10321548

Prognosis

Our experience with micropulse cyclophotocoagulation in the therapy of glaucoma.
Nutterová E, Pitrová Š, Lešták J
Cesk Slov Oftalmol 2020 Winter;76(1):29-36. doi: 10.31348/2020/4. PMID: 32917092
Cogan-Reese syndrome with Iris cyst: A novel presentation.
Selvan H, Brar AS, Angmo D
Cont Lens Anterior Eye 2019 Aug;42(4):467-469. Epub 2019 May 17 doi: 10.1016/j.clae.2019.04.014. PMID: 31104851
Unique variations and characteristics of iridocorneal endothelial syndrome in China: a case series of 58 patients.
Feng B, Tang X, Chen H, Sun X, Wang N
Int Ophthalmol 2018 Oct;38(5):2117-2126. Epub 2017 Oct 10 doi: 10.1007/s10792-017-0712-2. PMID: 28993974
Glaucoma associated with iridocorneal endothelial syndrome in 203 Indian subjects.
Chandran P, Rao HL, Mandal AK, Choudhari NS, Garudadri CS, Senthil S
PLoS One 2017;12(3):e0171884. Epub 2017 Mar 10 doi: 10.1371/journal.pone.0171884. PMID: 28282413Free PMC Article
Bilateral iridocorneal endothelial syndrome presented as Cogan-Reese and Chandler's syndrome.
Huna R, Barak A, Melamed S
J Glaucoma 1996 Feb;5(1):60-2. PMID: 8795735

Clinical prediction guides

Iridocorneal Endothelial Syndrome: Case Report of Essential Progressive Iris Atrophy.
Beganovic AP, Vodencarevic AN, Halilbasic M, Medjedovic A
Med Arch 2022 Jun;76(3):224-228. doi: 10.5455/medarh.2022.76.224-228. PMID: 36200117Free PMC Article
Our experience with micropulse cyclophotocoagulation in the therapy of glaucoma.
Nutterová E, Pitrová Š, Lešták J
Cesk Slov Oftalmol 2020 Winter;76(1):29-36. doi: 10.31348/2020/4. PMID: 32917092
A unique case of keratoconus with Cogan-Reese syndrome and secondary glaucoma.
Chakrabarty L
Indian J Ophthalmol 2017 Jan;65(1):64-66. doi: 10.4103/ijo.IJO_986_15. PMID: 28300746Free PMC Article
Clinical and specular microscopic manifestations of iridocorneal endothelial syndrome.
Liu YK, Wang IJ, Hu FR, Hung PT, Chang HW
Jpn J Ophthalmol 2001 May-Jun;45(3):281-7. doi: 10.1016/s0021-5155(00)00383-x. PMID: 11369379
The iris naevus (Cogan-Reese) syndrome: light and electron microscopic observations.
Eagle RC Jr, Font RL, Yanoff M, Fine BS
Br J Ophthalmol 1980 Jun;64(6):446-52. doi: 10.1136/bjo.64.6.446. PMID: 7387971Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...