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Corneal disorder

MedGen UID:
3617
•Concept ID:
C0010034
•
Disease or Syndrome
Synonym: Corneal disease
SNOMED CT: Corneal disorder (15250008); Disorder of cornea (15250008)
 
Monarch Initiative: MONDO:0000942

Definition

A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCorneal disorder

Professional guidelines

PubMed

Refractive surgical correction and treatment of keratoconus.
D'Oria F, Bagaglia SA, Alio Del Barrio JL, Alessio G, Alio JL, Mazzotta C
Surv Ophthalmol 2024 Jan-Feb;69(1):122-139. Epub 2023 Sep 27 doi: 10.1016/j.survophthal.2023.09.005. PMID: 37774800
Optometric practices and attitudes in keratoconus patient management in Latin America.
Braga Vieira S, Rivadeneira-Bueno D, Ortiz-Toquero S, Martin R
Clin Exp Optom 2023 May;106(4):386-394. Epub 2022 Mar 17 doi: 10.1080/08164622.2022.2048997. PMID: 35298892
Neurotrophic keratopathy; its pathophysiology and treatment.
Okada Y, Reinach PS, Kitano A, Shirai K, Kao WW, Saika S
Histol Histopathol 2010 Jun;25(6):771-80. doi: 10.14670/HH-25.771. PMID: 20376784

Recent clinical studies

Therapy

Refractive surgical correction and treatment of keratoconus.
D'Oria F, Bagaglia SA, Alio Del Barrio JL, Alessio G, Alio JL, Mazzotta C
Surv Ophthalmol 2024 Jan-Feb;69(1):122-139. Epub 2023 Sep 27 doi: 10.1016/j.survophthal.2023.09.005. PMID: 37774800
Anterior pituitary, sex hormones, and keratoconus: Beyond traditional targets.
Karamichos D, Escandon P, Vasini B, Nicholas SE, Van L, Dang DH, Cunningham RL, Riaz KM
Prog Retin Eye Res 2022 May;88:101016. Epub 2021 Nov 2 doi: 10.1016/j.preteyeres.2021.101016. PMID: 34740824Free PMC Article
Review on the Use of Topical Ocular Hypertonic Saline in Corneal Edema.
Chow SC, Chan JC
Cornea 2021 Apr;40(4):533-539. doi: 10.1097/ICO.0000000000002652. PMID: 33470681
Autologous Serum and Serum Components.
Higuchi A
Invest Ophthalmol Vis Sci 2018 Nov 1;59(14):DES121-DES129. doi: 10.1167/iovs.17-23760. PMID: 30481816
Neurotrophic keratopathy; its pathophysiology and treatment.
Okada Y, Reinach PS, Kitano A, Shirai K, Kao WW, Saika S
Histol Histopathol 2010 Jun;25(6):771-80. doi: 10.14670/HH-25.771. PMID: 20376784

Prognosis

Whole mitochondrial genome analysis in Chinese patients with keratoconus.
Xu L, Yang K, Fan Q, Zhao D, Pang C, Ren S
Mol Vis 2021;27:270-282. Epub 2021 May 8 PMID: 34012229Free PMC Article
Corneal and conjunctival injury seen in urgent care centres in Israel.
Zimmerman DR, Shneor E, Millodot M, Gordon-Shaag A
Ophthalmic Physiol Opt 2019 Jan;39(1):46-52. doi: 10.1111/opo.12600. PMID: 30628742Free PMC Article
The Association of Refractive Error with Glaucoma in a Multiethnic Population.
Shen L, Melles RB, Metlapally R, Barcellos L, Schaefer C, Risch N, Herrinton LJ, Wildsoet C, Jorgenson E
Ophthalmology 2016 Jan;123(1):92-101. Epub 2015 Aug 8 doi: 10.1016/j.ophtha.2015.07.002. PMID: 26260281Free PMC Article
Fuchs endothelial corneal dystrophy.
Elhalis H, Azizi B, Jurkunas UV
Ocul Surf 2010 Oct;8(4):173-84. doi: 10.1016/s1542-0124(12)70232-x. PMID: 20964980Free PMC Article
Congenital hereditary endothelial dystrophy with progressive sensorineural deafness (Harboyan syndrome).
Desir J, Abramowicz M
Orphanet J Rare Dis 2008 Oct 15;3:28. doi: 10.1186/1750-1172-3-28. PMID: 18922146Free PMC Article

Clinical prediction guides

Safety and activity of anti-mesothelin antibody-drug conjugate anetumab ravtansine in combination with pegylated-liposomal doxorubicin in platinum-resistant ovarian cancer: multicenter, phase Ib dose escalation and expansion study.
Santin AD, Vergote I, González-Martín A, Moore K, Oaknin A, Romero I, Diab S, Copeland LJ, Monk BJ, Coleman RL, Herzog TJ, Siegel J, Kasten L, Schlicker A, Schulz A, Köchert K, Walter AO, Childs BH, Elbi C, Bulat I
Int J Gynecol Cancer 2023 Apr 3;33(4):562-570. doi: 10.1136/ijgc-2022-003927. PMID: 36564099Free PMC Article
Effect of Thyroxine on Transforming Growth Factor β1, Collagen I, and V Expression in Keratoconus Corneal Fibroblasts and Keratocytes, in Vitro.
Stachon T, Omar Ali M, Latta L, Huessein GH, Mohamed TA, Soliman W, Seitz B, Szentmáry N
Curr Eye Res 2022 Feb;47(2):206-213. Epub 2021 Aug 18 doi: 10.1080/02713683.2021.1967403. PMID: 34407700
Whole mitochondrial genome analysis in Chinese patients with keratoconus.
Xu L, Yang K, Fan Q, Zhao D, Pang C, Ren S
Mol Vis 2021;27:270-282. Epub 2021 May 8 PMID: 34012229Free PMC Article
Autologous Serum and Serum Components.
Higuchi A
Invest Ophthalmol Vis Sci 2018 Nov 1;59(14):DES121-DES129. doi: 10.1167/iovs.17-23760. PMID: 30481816
The Association of Refractive Error with Glaucoma in a Multiethnic Population.
Shen L, Melles RB, Metlapally R, Barcellos L, Schaefer C, Risch N, Herrinton LJ, Wildsoet C, Jorgenson E
Ophthalmology 2016 Jan;123(1):92-101. Epub 2015 Aug 8 doi: 10.1016/j.ophtha.2015.07.002. PMID: 26260281Free PMC Article

Recent systematic reviews

Lenticule addition keratoplasty for the treatment of keratoconus: A systematic review and critical considerations.
Liu Y, He Y, Deng Y, Wang L
Indian J Ophthalmol 2024 Feb 1;72(Suppl 2):S167-S175. Epub 2024 Jan 25 doi: 10.4103/IJO.IJO_695_23. PMID: 38271413

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