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Squamous Cell Carcinoma with Horn Formation

MedGen UID:
220405
Concept ID:
C1266004
Neoplastic Process
Synonym: Squamous cell carcinoma with horn formation
SNOMED CT: Squamous cell carcinoma with horn formation (128633003)

Definition

A keratinizing squamous cell carcinoma characterized by the presence of horn pearls. Representative examples include squamous cell carcinomas of the face presenting as a cutaneous horn. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous Cell Carcinoma with Horn Formation

Recent clinical studies

Etiology

Radermacher A, Fehrenz M, Bellin T, Claßen C, Möller L, Struckmeier AK, Wagner M, Wartenberg P, Moratin J, Freudlsperger C, Freier K, Horn D
Int J Mol Sci 2023 Nov 24;24(23) doi: 10.3390/ijms242316699. PMID: 38069020Free PMC Article
Steen S, Semmelmayer K, Flechtenmacher C, Hoffmann J, Freier K, Horn D, Hess J, Freudlsperger C, Moratin J
Int J Mol Sci 2023 Nov 16;24(22) doi: 10.3390/ijms242216386. PMID: 38003576Free PMC Article
Thompson EF, Hoang L, Höhn AK, Palicelli A, Talia KL, Tchrakian N, Senz J, Rusike R, Jordan S, Jamieson A, Huvila J, McAlpine JN, Gilks CB, Höckel M, Singh N, Horn LC
Int J Gynecol Cancer 2022 Aug 1;32(8):977-985. doi: 10.1136/ijgc-2021-003251. PMID: 35764349
Moratin J, Hartmann S, Brands RC, Horn D, Fuchs A, Mutzbauer G, Seher A, Scholz C, Müller-Richter UDA, Linz C
J Craniomaxillofac Surg 2019 Mar;47(3):523-529. Epub 2019 Jan 17 doi: 10.1016/j.jcms.2019.01.015. PMID: 30709758
Horn D, Gross M, Dyckhoff G, Fuchs J, Grabe N, Weichert W, Herpel E, Herold-Mende C, Lichter P, Hoffmann J, Hess J, Freier K
Head Neck 2018 Dec;40(12):2685-2694. Epub 2018 Nov 20 doi: 10.1002/hed.25515. PMID: 30456890

Diagnosis

Morais PM, Schettini APM, Rocha JA, Silva Júnior RCD
An Bras Dermatol 2018 Jan-Feb;93(1):96-98. doi: 10.1590/abd1806-4841.20186757. PMID: 29641705Free PMC Article
Wichmann G, Rosolowski M, Krohn K, Kreuz M, Boehm A, Reiche A, Scharrer U, Halama D, Bertolini J, Bauer U, Holzinger D, Pawlita M, Hess J, Engel C, Hasenclever D, Scholz M, Ahnert P, Kirsten H, Hemprich A, Wittekind C, Herbarth O, Horn F, Dietz A, Loeffler M; Leipzig Head and Neck Group (LHNG)
Int J Cancer 2015 Dec 15;137(12):2846-57. Epub 2015 Jul 6 doi: 10.1002/ijc.29649. PMID: 26095926
Brustmann H, Hinterholzer S, Brunner A
Int J Gynecol Pathol 2011 Nov;30(6):583-90. doi: 10.1097/PGP.0b013e31821e18fd. PMID: 21979596
Terada T, Yamagami J, Fugimoto A, Tanaka K, Sugiura M
Pathol Int 2003 Jul;53(7):468-72. doi: 10.1046/j.1440-1827.2003.01495.x. PMID: 12828613
Said JW, Sassoon AF, Shintaku IP, Banks-Schlegel S
J Invest Dermatol 1984 May;82(5):449-52. doi: 10.1111/1523-1747.ep12260937. PMID: 6210326

Therapy

Waterhouse D, Horn L, Reynolds C, Spigel D, Chandler J, Mekhail T, Mohamed M, Creelan B, Blankstein KB, Nikolinakos P, McCleod MJ, Li A, Oukessou A, Agrawal S, Aanur N
Cancer Chemother Pharmacol 2018 Apr;81(4):679-686. Epub 2018 Feb 13 doi: 10.1007/s00280-018-3527-6. PMID: 29442139
Gettinger SN, Horn L, Gandhi L, Spigel DR, Antonia SJ, Rizvi NA, Powderly JD, Heist RS, Carvajal RD, Jackman DM, Sequist LV, Smith DC, Leming P, Carbone DP, Pinder-Schenck MC, Topalian SL, Hodi FS, Sosman JA, Sznol M, McDermott DF, Pardoll DM, Sankar V, Ahlers CM, Salvati M, Wigginton JM, Hellmann MD, Kollia GD, Gupta AK, Brahmer JR
J Clin Oncol 2015 Jun 20;33(18):2004-12. Epub 2015 Apr 20 doi: 10.1200/JCO.2014.58.3708. PMID: 25897158Free PMC Article
Rizvi NA, Mazières J, Planchard D, Stinchcombe TE, Dy GK, Antonia SJ, Horn L, Lena H, Minenza E, Mennecier B, Otterson GA, Campos LT, Gandara DR, Levy BP, Nair SG, Zalcman G, Wolf J, Souquet PJ, Baldini E, Cappuzzo F, Chouaid C, Dowlati A, Sanborn R, Lopez-Chavez A, Grohe C, Huber RM, Harbison CT, Baudelet C, Lestini BJ, Ramalingam SS
Lancet Oncol 2015 Mar;16(3):257-65. Epub 2015 Feb 20 doi: 10.1016/S1470-2045(15)70054-9. PMID: 25704439Free PMC Article
Koringa PG, Jakhesara SJ, Bhatt VD, Patel AB, Dash D, Joshi CG
Gene 2013 Nov 1;530(1):119-26. Epub 2013 Aug 24 doi: 10.1016/j.gene.2013.07.061. PMID: 23978612
Johnson B, Horn T, Sander C, Kohler S, R Smoller B
J Cutan Pathol 2003 Jul;30(6):358-62. doi: 10.1034/j.1600-0560.2003.00070.x. PMID: 12834483

Prognosis

Steen S, Semmelmayer K, Flechtenmacher C, Hoffmann J, Freier K, Horn D, Hess J, Freudlsperger C, Moratin J
Int J Mol Sci 2023 Nov 16;24(22) doi: 10.3390/ijms242216386. PMID: 38003576Free PMC Article
Thompson EF, Hoang L, Höhn AK, Palicelli A, Talia KL, Tchrakian N, Senz J, Rusike R, Jordan S, Jamieson A, Huvila J, McAlpine JN, Gilks CB, Höckel M, Singh N, Horn LC
Int J Gynecol Cancer 2022 Aug 1;32(8):977-985. doi: 10.1136/ijgc-2021-003251. PMID: 35764349
Moratin J, Hartmann S, Brands RC, Horn D, Fuchs A, Mutzbauer G, Seher A, Scholz C, Müller-Richter UDA, Linz C
J Craniomaxillofac Surg 2019 Mar;47(3):523-529. Epub 2019 Jan 17 doi: 10.1016/j.jcms.2019.01.015. PMID: 30709758
Horn D, Gross M, Dyckhoff G, Fuchs J, Grabe N, Weichert W, Herpel E, Herold-Mende C, Lichter P, Hoffmann J, Hess J, Freier K
Head Neck 2018 Dec;40(12):2685-2694. Epub 2018 Nov 20 doi: 10.1002/hed.25515. PMID: 30456890
Morais PM, Schettini APM, Rocha JA, Silva Júnior RCD
An Bras Dermatol 2018 Jan-Feb;93(1):96-98. doi: 10.1590/abd1806-4841.20186757. PMID: 29641705Free PMC Article

Clinical prediction guides

Höhn AK, Forberger M, Alfaraidi M, Gilks CB, Brambs CE, Höckel M, Hoang L, Singh N, Horn LC
Gynecol Oncol 2024 Jun;185:17-24. Epub 2024 Feb 10 doi: 10.1016/j.ygyno.2024.02.001. PMID: 38342005
Steen S, Semmelmayer K, Flechtenmacher C, Hoffmann J, Freier K, Horn D, Hess J, Freudlsperger C, Moratin J
Int J Mol Sci 2023 Nov 16;24(22) doi: 10.3390/ijms242216386. PMID: 38003576Free PMC Article
Thompson EF, Hoang L, Höhn AK, Palicelli A, Talia KL, Tchrakian N, Senz J, Rusike R, Jordan S, Jamieson A, Huvila J, McAlpine JN, Gilks CB, Höckel M, Singh N, Horn LC
Int J Gynecol Cancer 2022 Aug 1;32(8):977-985. doi: 10.1136/ijgc-2021-003251. PMID: 35764349
Moratin J, Metzger K, Safaltin A, Herpel E, Hoffmann J, Freier K, Hess J, Horn D
Head Neck 2019 Aug;41(8):2484-2491. Epub 2019 Mar 1 doi: 10.1002/hed.25713. PMID: 30821864
Mouawad F, Gros A, Rysman B, Bal-Mahieu C, Bertheau C, Horn S, Sarrazin T, Lartigau E, Chevalier D, Bailly C, Lansiaux A, Meignan S
Oral Oncol 2014 Feb;50(2):113-9. Epub 2013 Nov 26 doi: 10.1016/j.oraloncology.2013.11.003. PMID: 24290982

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