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Hepatoid adenocarcinoma

MedGen UID:
220413
•Concept ID:
C1266090
•
Neoplastic Process
Synonyms: Hepatoid Adenocarcinoma; hepatoid adenocarcinoma; Hepatoid Carcinoma; Hepatoid carcinoma; hepatoid carcinoma
SNOMED CT: Hepatoid carcinoma (128706007); Hepatoid adenocarcinoma (128706007)
 
Monarch Initiative: MONDO:0006243

Definition

An adenocarcinoma with morphologic characteristics similar to hepatocellular carcinoma, arising from an anatomic site other than the liver. [from NCI]

Professional guidelines

PubMed

Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma: a literature review.
Su JS, Chen YT, Wang RC, Wu CY, Lee SW, Lee TY
World J Gastroenterol 2013 Jan 21;19(3):321-7. doi: 10.3748/wjg.v19.i3.321. PMID: 23372352Free PMC Article
Clinicopathologic characteristics and treatment outcomes of hepatoid adenocarcinoma of the stomach, a rare but unique subtype of gastric cancer.
Baek SK, Han SW, Oh DY, Im SA, Kim TY, Bang YJ
BMC Gastroenterol 2011 May 19;11:56. doi: 10.1186/1471-230X-11-56. PMID: 21592404Free PMC Article

Recent clinical studies

Etiology

Assessment of Clinicopathological Characteristics and Development of an Individualized Prognostic Model for Patients With Hepatoid Adenocarcinoma of the Stomach.
Lin JX, Wang ZK, Hong QQ, Zhang P, Zhang ZZ, He L, Wang Q, Shang L, Wang LJ, Sun YF, Li ZX, Liu JJ, Ding FH, Lin ED, Fu YA, Lin SM, Xie JW, Li P, Zheng CH, Huang CM
JAMA Netw Open 2021 Oct 1;4(10):e2128217. doi: 10.1001/jamanetworkopen.2021.28217. PMID: 34609494Free PMC Article
SMARCA4/BRG1-Deficient Non-Small Cell Lung Carcinomas: A Case Series and Review of the Literature.
Nambirajan A, Singh V, Bhardwaj N, Mittal S, Kumar S, Jain D
Arch Pathol Lab Med 2021 Jan 1;145(1):90-98. doi: 10.5858/arpa.2019-0633-OA. PMID: 33367658
The prognosis of hepatoid adenocarcinoma of the stomach: a propensity score-based analysis.
Zhou K, Wang A, Ao S, Chen J, Ji K, He Q, Ji X, Wu X, Zhang J, Li Z, Bu Z, Ji J
BMC Cancer 2020 Jul 17;20(1):671. doi: 10.1186/s12885-020-07031-9. PMID: 32680468Free PMC Article
Gastric Hepatoid Adenocarcinoma: Differentiation From Gastric Adenocarcinoma With Dynamic Contrast-Enhanced Computed Tomographic Findings.
Fu Y, Zhu H, Peng WJ
J Comput Assist Tomogr 2019 Nov/Dec;43(6):887-891. doi: 10.1097/RCT.0000000000000924. PMID: 31490893
Clinicopathological and prognostic features of hepatoid adenocarcinoma of the stomach.
Zhang JF, Shi SS, Shao YF, Zhang HZ
Chin Med J (Engl) 2011 May;124(10):1470-6. PMID: 21740800

Diagnosis

Metastatic mediastinal hepatoid adenocarcinoma.
Caruana G, Cachia R, Micallef S, Sammut M, Psaila J
BMJ Case Rep 2024 Apr 9;17(4) doi: 10.1136/bcr-2022-253747. PMID: 38594200Free PMC Article
Hepatoid adenocarcinoma-Clinicopathological features and molecular characteristics.
Li M, Mei YX, Wen JH, Jiao YR, Pan QR, Kong XX, Li J
Cancer Lett 2023 Apr 10;559:216104. Epub 2023 Mar 1 doi: 10.1016/j.canlet.2023.216104. PMID: 36863507
Hepatoid Adenocarcinoma of the Lung.
Li M, Fan Y, Lu H
Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211057983. doi: 10.1177/15330338211057983. PMID: 34816785Free PMC Article
Genomic and transcriptomic profiling of hepatoid adenocarcinoma of the stomach.
Liu Z, Wang A, Pu Y, Li Z, Xue R, Zhang C, Xiang X, E JY, Bu Z, Bai F, Ji J
Oncogene 2021 Sep;40(38):5705-5717. Epub 2021 Jul 30 doi: 10.1038/s41388-021-01976-2. PMID: 34326469
SMARCA4/BRG1-Deficient Non-Small Cell Lung Carcinomas: A Case Series and Review of the Literature.
Nambirajan A, Singh V, Bhardwaj N, Mittal S, Kumar S, Jain D
Arch Pathol Lab Med 2021 Jan 1;145(1):90-98. doi: 10.5858/arpa.2019-0633-OA. PMID: 33367658

Therapy

Assessment of Clinicopathological Characteristics and Development of an Individualized Prognostic Model for Patients With Hepatoid Adenocarcinoma of the Stomach.
Lin JX, Wang ZK, Hong QQ, Zhang P, Zhang ZZ, He L, Wang Q, Shang L, Wang LJ, Sun YF, Li ZX, Liu JJ, Ding FH, Lin ED, Fu YA, Lin SM, Xie JW, Li P, Zheng CH, Huang CM
JAMA Netw Open 2021 Oct 1;4(10):e2128217. doi: 10.1001/jamanetworkopen.2021.28217. PMID: 34609494Free PMC Article
Non-α-fetoprotein-producing adrenal hepatoid adenocarcinoma: A case report and literature review.
Lin J, Cao Y, Yu L, Lin L
Medicine (Baltimore) 2018 Sep;97(39):e12336. doi: 10.1097/MD.0000000000012336. PMID: 30278510Free PMC Article
Next-generation sequencing analysis for gastric adenocarcinoma with enteroblastic differentiation: emphasis on the relationship with hepatoid adenocarcinoma.
Akazawa Y, Saito T, Hayashi T, Yanai Y, Tsuyama S, Akaike K, Suehara Y, Takahashi F, Takamochi K, Ueyama H, Murakami T, Watanabe S, Nagahara A, Yao T
Hum Pathol 2018 Aug;78:79-88. Epub 2018 May 8 doi: 10.1016/j.humpath.2018.04.022. PMID: 29751042
Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature.
Yoshizawa J, Ishizone S, Ikeyama M, Nakayama J
BMC Cancer 2017 May 25;17(1):368. doi: 10.1186/s12885-017-3357-7. PMID: 28545511Free PMC Article
Hepatoid adenocarcinoma of the lung: Review of a rare form of lung cancer.
Grossman K, Beasley MB, Braman SS
Respir Med 2016 Oct;119:175-179. Epub 2016 Sep 3 doi: 10.1016/j.rmed.2016.09.003. PMID: 27692141

Prognosis

Hepatoid adenocarcinoma-Clinicopathological features and molecular characteristics.
Li M, Mei YX, Wen JH, Jiao YR, Pan QR, Kong XX, Li J
Cancer Lett 2023 Apr 10;559:216104. Epub 2023 Mar 1 doi: 10.1016/j.canlet.2023.216104. PMID: 36863507
Hepatoid Adenocarcinoma of the Lung.
Li M, Fan Y, Lu H
Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211057983. doi: 10.1177/15330338211057983. PMID: 34816785Free PMC Article
Genomic and transcriptomic profiling of hepatoid adenocarcinoma of the stomach.
Liu Z, Wang A, Pu Y, Li Z, Xue R, Zhang C, Xiang X, E JY, Bu Z, Bai F, Ji J
Oncogene 2021 Sep;40(38):5705-5717. Epub 2021 Jul 30 doi: 10.1038/s41388-021-01976-2. PMID: 34326469
SMARCA4/BRG1-Deficient Non-Small Cell Lung Carcinomas: A Case Series and Review of the Literature.
Nambirajan A, Singh V, Bhardwaj N, Mittal S, Kumar S, Jain D
Arch Pathol Lab Med 2021 Jan 1;145(1):90-98. doi: 10.5858/arpa.2019-0633-OA. PMID: 33367658
Pulmonary hepatoid adenocarcinoma.
Ayub A, Nunez Lopez O, Booth A, Okereke I
J Thorac Cardiovasc Surg 2019 Oct;158(4):e139-e140. Epub 2019 Jun 20 doi: 10.1016/j.jtcvs.2019.06.023. PMID: 31358339

Clinical prediction guides

Hepatoid adenocarcinoma of lung: A diagnostic challenge - Series of six cases with histopathological, predictive molecular and PD.L1 assessment.
Pasricha S, Grover S, Kamboj M, Bansal D, Batra U, Gupta G, Sharma A, Durga G, Jajodia A, B Koyyala VP, Mehta A
Indian J Pathol Microbiol 2021 Jan-Mar;64(1):128-131. doi: 10.4103/IJPM.IJPM_334_20. PMID: 33433422
SMARCA4/BRG1-Deficient Non-Small Cell Lung Carcinomas: A Case Series and Review of the Literature.
Nambirajan A, Singh V, Bhardwaj N, Mittal S, Kumar S, Jain D
Arch Pathol Lab Med 2021 Jan 1;145(1):90-98. doi: 10.5858/arpa.2019-0633-OA. PMID: 33367658
Aberrant β-catenin Activity in Hepatoid Adenocarcinoma of the Stomach.
Wang N, Kong R, Han W, Lu J
Curr Mol Med 2021;21(8):655-664. doi: 10.2174/0929867327666200522215607. PMID: 32442081
The prognosis of hepatoid adenocarcinoma of the stomach: a propensity score-based analysis.
Zhou K, Wang A, Ao S, Chen J, Ji K, He Q, Ji X, Wu X, Zhang J, Li Z, Bu Z, Ji J
BMC Cancer 2020 Jul 17;20(1):671. doi: 10.1186/s12885-020-07031-9. PMID: 32680468Free PMC Article
Hepatoid adenocarcinoma of the stomach--proper identification and treatment remain a challenge.
Søreide JA, Greve OJ, Gudlaugsson E, Størset S
Scand J Gastroenterol 2016;51(6):646-53. Epub 2016 Jan 5 doi: 10.3109/00365521.2015.1124286. PMID: 26728165Free PMC Article

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