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Benign Skin Fibrohistiocytic Neoplasm

MedGen UID:
224806
•Concept ID:
C1274305
•
Neoplastic Process
Synonyms: Benign Cutaneous Fibrohistiocytic Neoplasm; Benign fibrohistiocytic neoplasm of skin
SNOMED CT: Benign fibrohistiocytic neoplasm of skin (402872002)

Definition

A benign neoplasm arising from the skin. It is composed of fibrohistiocytic cells, spindle fibroblastic cells, and histiocytes arranged in a storiform pattern. [from NCI]

Professional guidelines

PubMed

Treatment Options for Multinucleate Cell Angiohistiocytoma: A Case Series and Review of the Literature.
Taibo A, Padin CP, Losada JDP, Fonseca E
J Cutan Med Surg 2023 May-Jun;27(3):219-225. Epub 2023 Mar 16 doi: 10.1177/12034754231163539. PMID: 36927096
Multinucleate cell angiohistiocytoma: A clinicopathologic study of 62 cases and proposed diagnostic criteria.
Roy SF, Dong D, Myung P, McNiff JM
J Cutan Pathol 2019 Aug;46(8):563-569. Epub 2019 Apr 23 doi: 10.1111/cup.13463. PMID: 30927287
Soft tissue sarcomas of childhood: the differential diagnostic dilemma of the small blue cell.
Dehner LP
Natl Cancer Inst Monogr 1981 Apr;(56):43-59. PMID: 6272117

Recent clinical studies

Etiology

Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances?
Hornick JL
Mod Pathol 2020 Jan;33(Suppl 1):56-65. Epub 2019 Oct 25 doi: 10.1038/s41379-019-0388-4. PMID: 31653978
Multinucleate cell angiohistiocytoma: Case report and literature review.
Grgurich E, Quinn K, Oram C, McClain R, Lountzis N
J Cutan Pathol 2019 Jan;46(1):59-61. Epub 2018 Nov 19 doi: 10.1111/cup.13361. PMID: 30251282
Fibrohistiocytic Tumors.
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503
Collapsing angiokeloidal dermatofibroma.
Schnebelen AM, Brown JA, Cheung WL, Hiatt KM, Smoller BR
Am J Dermatopathol 2012 Oct;34(7):e103-5. doi: 10.1097/DAD.0b013e31825625d5. PMID: 22576077
Plexiform fibrohistiocytic tumor in three children.
Jafarian F, McCuaig C, Kokta V, Hatami A, Savard P
Pediatr Dermatol 2006 Jan-Feb;23(1):7-12. doi: 10.1111/j.1525-1470.2006.00160.x. PMID: 16445402

Diagnosis

Fibrohistiocytic Tumors.
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503
Atrophic dermatofibroma.
Mota AN, Tortelly VD, Obadia DL, Silva RS
An Bras Dermatol 2013 Sep-Oct;88(5):793-5. doi: 10.1590/abd1806-4841.20132234. PMID: 24173186Free PMC Article
Atrophic dermatofibroma.
Ohnishi T, Sasaki M, Nakai K, Watanabe S
J Eur Acad Dermatol Venereol 2004 Sep;18(5):580-3. doi: 10.1111/j.1468-3083.2004.00975.x. PMID: 15324399
Histopathologic and immunohistochemical diagnosis of benign and malignant fibrous and fibrohistiocytic tumors of the skin.
Kamino H, Salcedo E
Dermatol Clin 1999 Jul;17(3):487-505, vii. doi: 10.1016/s0733-8635(05)70103-0. PMID: 10410854
Myxoid dermatofibroma.
Zelger BG, Calonje E, Zelger B
Histopathology 1999 Apr;34(4):357-64. doi: 10.1046/j.1365-2559.1999.00633.x. PMID: 10231403

Therapy

Morphometric analyses of elastic tissue fibers in dermatofibroma: clues to etiopathogenesis?
Pongpudpunth M, Keady M, Mahalingam M
J Cutan Pathol 2009 Oct;36(10):1083-8. Epub 2009 Jul 10 doi: 10.1111/j.1600-0560.2009.01237.x. PMID: 19615002
Giant dermatofibroma with granular cell changes: side-effect of bee-venom acupuncture?
Rhee DY, Lee HW, Chung WK, Chang SE, Lee MW, Choi JH, Moon KC, Koh JK
Clin Exp Dermatol 2009 Jul;34(5):e18-20. Epub 2009 May 26 doi: 10.1111/j.1365-2230.2008.03149.x. PMID: 19486038
Multiple eruptive dermatofibromas and immunosuppression: report of two cases and review of the literature.
Zaccaria E, Rebora A, Rongioletti F
Int J Dermatol 2008 Jul;47(7):723-7. doi: 10.1111/j.1365-4632.2008.03575.x. PMID: 18613883
Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma).
Hui P, Glusac EJ, Sinard JH, Perkins AS
J Cutan Pathol 2002 Aug;29(7):385-9. doi: 10.1034/j.1600-0560.2002.290701.x. PMID: 12139632

Prognosis

Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances?
Hornick JL
Mod Pathol 2020 Jan;33(Suppl 1):56-65. Epub 2019 Oct 25 doi: 10.1038/s41379-019-0388-4. PMID: 31653978
Multinucleate cell angiohistiocytoma: Case report and literature review.
Grgurich E, Quinn K, Oram C, McClain R, Lountzis N
J Cutan Pathol 2019 Jan;46(1):59-61. Epub 2018 Nov 19 doi: 10.1111/cup.13361. PMID: 30251282
The Role of CD34 and D2-40 in the Differentiation of Dermatofibroma and Dermatofibrosarcoma Protuberans.
Sadullahoğlu C, Dere Y, Atasever TR, Öztop MT, Karaaslan Ö
Turk Patoloji Derg 2017;1(1):223-227. doi: 10.5146/tjpath.2017.01402. PMID: 28832078
Plexiform fibrohistiocytic tumor in three children.
Jafarian F, McCuaig C, Kokta V, Hatami A, Savard P
Pediatr Dermatol 2006 Jan-Feb;23(1):7-12. doi: 10.1111/j.1525-1470.2006.00160.x. PMID: 16445402
New entities in cutaneous soft tissue tumours.
Calonje E, Fletcher CD
Pathologica 1993 Jan-Feb;85(1095):1-15. PMID: 8390634

Clinical prediction guides

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review.
Seifi G, Kalantari Y, Etesami I
J Dtsch Dermatol Ges 2022 Dec;20(12):1569-1579. Epub 2022 Dec 4 doi: 10.1111/ddg.14888. PMID: 36464809
Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances?
Hornick JL
Mod Pathol 2020 Jan;33(Suppl 1):56-65. Epub 2019 Oct 25 doi: 10.1038/s41379-019-0388-4. PMID: 31653978
The Role of CD34 and D2-40 in the Differentiation of Dermatofibroma and Dermatofibrosarcoma Protuberans.
Sadullahoğlu C, Dere Y, Atasever TR, Öztop MT, Karaaslan Ö
Turk Patoloji Derg 2017;1(1):223-227. doi: 10.5146/tjpath.2017.01402. PMID: 28832078
Atrophic dermatofibroma.
Ohnishi T, Sasaki M, Nakai K, Watanabe S
J Eur Acad Dermatol Venereol 2004 Sep;18(5):580-3. doi: 10.1111/j.1468-3083.2004.00975.x. PMID: 15324399
Granular cell dermatofibroma.
Soyer HP, Metze D, Kerl H
Am J Dermatopathol 1997 Apr;19(2):168-73. doi: 10.1097/00000372-199704000-00011. PMID: 9129702

Recent systematic reviews

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review.
Seifi G, Kalantari Y, Etesami I
J Dtsch Dermatol Ges 2022 Dec;20(12):1569-1579. Epub 2022 Dec 4 doi: 10.1111/ddg.14888. PMID: 36464809
Generalized multinucleate cell angiohistiocytoma: case report and literature review.
Wang M, Abdul-Fattah B, Wang C, Zhao Y, Qu X, Al-Muriesh M, Wang X, Zhu L, Qian Y, Huang C, Chen S
J Cutan Pathol 2017 Feb;44(2):125-134. Epub 2016 Nov 28 doi: 10.1111/cup.12853. PMID: 27813137

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