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Therapy-Related Myelodysplastic Syndrome

MedGen UID:
224863
•Concept ID:
C1292780
•
Neoplastic Process
Synonyms: Therapy Related Myelodysplastic Syndrome; Therapy-Related MDS; Therapy-related myelodysplastic syndrome
SNOMED CT: Therapy-related myelodysplastic syndrome (702476004)

Definition

A myelodysplastic syndrome caused by chemotherapy and/or radiotherapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTherapy-Related Myelodysplastic Syndrome

Professional guidelines

PubMed

Outcomes following venetoclax-based treatment in therapy-related myeloid neoplasms.
Shah MV, Chhetri R, Dholakia R, Kok CH, Gangat N, Alkhateeb HB, Al-Kali A, Patnaik MM, Baranwal A, Greipp PT, He R, Begna KH, Tiong IS, Wei AH, Hiwase D
Am J Hematol 2022 Aug;97(8):1013-1022. Epub 2022 May 27 doi: 10.1002/ajh.26589. PMID: 35560061Free PMC Article
Clonal selection in therapy-related myelodysplastic syndromes and acute myeloid leukemia under azacitidine treatment.
Calleja A, Yun S, Moreilhon C, Karsenti JM, Gastaud L, Mannone L, Komrokji R, Al Ali N, Dadone-Montaudie B, Robert G, Auberger P, Raynaud S, Sallman DA, Cluzeau T
Eur J Haematol 2020 May;104(5):488-498. Epub 2020 Mar 9 doi: 10.1111/ejh.13390. PMID: 31990086
Therapy-related malignancies following treatment of germ cell cancer.
Kollmannsberger C, Hartmann JT, Kanz L, Bokemeyer C
Int J Cancer 1999 Dec 10;83(6):860-3. doi: 10.1002/(sici)1097-0215(19991210)83:6<860::aid-ijc32>3.0.co;2-l. PMID: 10597212

Recent clinical studies

Etiology

TP53 and therapy-related myeloid neoplasms.
Chung J, Sallman DA, Padron E
Best Pract Res Clin Haematol 2019 Mar;32(1):98-103. Epub 2019 Feb 19 doi: 10.1016/j.beha.2019.02.009. PMID: 30927980
Therapy-related myeloid neoplasms in lymphoma survivors: Reducing risks.
Al-Juhaishi T, Khurana A, Shafer D
Best Pract Res Clin Haematol 2019 Mar;32(1):47-53. Epub 2019 Feb 16 doi: 10.1016/j.beha.2019.02.008. PMID: 30927975
Therapy-related myelodysplastic syndromes, or are they?
Abou Zahr A, Kavi AM, Mukherjee S, Zeidan AM
Blood Rev 2017 May;31(3):119-128. Epub 2016 Nov 24 doi: 10.1016/j.blre.2016.11.002. PMID: 27923516
Therapy-related myelodysplastic syndrome.
Candelaria M, Dueñas-Gonzalez A
Expert Opin Drug Saf 2015 May;14(5):655-65. Epub 2015 Feb 12 doi: 10.1517/14740338.2015.1014340. PMID: 25675961
Therapy-related myeloid leukemia.
Godley LA, Larson RA
Semin Oncol 2008 Aug;35(4):418-29. doi: 10.1053/j.seminoncol.2008.04.012. PMID: 18692692Free PMC Article

Diagnosis

Clinicopathologic Features of Therapy-Related Myeloid Neoplasms in Patients with Myeloma in the Era of Novel Therapies.
Jelloul FZ, Quesada AE, Yang RK, Li S, Wang W, Xu J, Tang G, Yin CC, Fang H, El Hussein S, Khoury J, Bassett RL, Garcia-Manero G, Manasanch EE, Orlowski RZ, Qazilbash MH, Patel KP, Medeiros LJ, Lin P
Mod Pathol 2023 Jun;36(6):100166. Epub 2023 Mar 27 doi: 10.1016/j.modpat.2023.100166. PMID: 36990279
Targeting TP53 Mutations in Myelodysplastic Syndromes.
Hunter AM, Sallman DA
Hematol Oncol Clin North Am 2020 Apr;34(2):421-440. Epub 2019 Dec 12 doi: 10.1016/j.hoc.2019.11.004. PMID: 32089220
Myelodysplastic Syndromes: Updates and Nuances.
Dao KT
Med Clin North Am 2017 Mar;101(2):333-350. doi: 10.1016/j.mcna.2016.09.006. PMID: 28189174Free PMC Article
Therapy-related myelodysplastic syndromes, or are they?
Abou Zahr A, Kavi AM, Mukherjee S, Zeidan AM
Blood Rev 2017 May;31(3):119-128. Epub 2016 Nov 24 doi: 10.1016/j.blre.2016.11.002. PMID: 27923516
Therapy-Related Myeloid Neoplasms.
Bueso-Ramos CE, Kanagal-Shamanna R, Routbort MJ, Hanson CA
Am J Clin Pathol 2015 Aug;144(2):207-18. doi: 10.1309/AJCPU1JO2LYTWUAV. PMID: 26185306

Therapy

Targeting TP53 Mutations in Myelodysplastic Syndromes.
Hunter AM, Sallman DA
Hematol Oncol Clin North Am 2020 Apr;34(2):421-440. Epub 2019 Dec 12 doi: 10.1016/j.hoc.2019.11.004. PMID: 32089220
Myelodysplastic Syndromes: Updates and Nuances.
Dao KT
Med Clin North Am 2017 Mar;101(2):333-350. doi: 10.1016/j.mcna.2016.09.006. PMID: 28189174Free PMC Article
Therapy-related myelodysplastic syndromes, or are they?
Abou Zahr A, Kavi AM, Mukherjee S, Zeidan AM
Blood Rev 2017 May;31(3):119-128. Epub 2016 Nov 24 doi: 10.1016/j.blre.2016.11.002. PMID: 27923516
Therapy-related myeloid leukemia.
Godley LA, Larson RA
Semin Oncol 2008 Aug;35(4):418-29. doi: 10.1053/j.seminoncol.2008.04.012. PMID: 18692692Free PMC Article
Myelodysplastic syndrome.
Legare RD, Gilliland DG
Curr Opin Hematol 1995 Jul;2(4):283-92. doi: 10.1097/00062752-199502040-00008. PMID: 9372009

Prognosis

Targeting TP53 Mutations in Myelodysplastic Syndromes.
Hunter AM, Sallman DA
Hematol Oncol Clin North Am 2020 Apr;34(2):421-440. Epub 2019 Dec 12 doi: 10.1016/j.hoc.2019.11.004. PMID: 32089220
Therapy-related myeloid neoplasms in lymphoma survivors: Reducing risks.
Al-Juhaishi T, Khurana A, Shafer D
Best Pract Res Clin Haematol 2019 Mar;32(1):47-53. Epub 2019 Feb 16 doi: 10.1016/j.beha.2019.02.008. PMID: 30927975
Myelodysplastic Syndromes: Updates and Nuances.
Dao KT
Med Clin North Am 2017 Mar;101(2):333-350. doi: 10.1016/j.mcna.2016.09.006. PMID: 28189174Free PMC Article
Therapy-related myelodysplastic syndromes, or are they?
Abou Zahr A, Kavi AM, Mukherjee S, Zeidan AM
Blood Rev 2017 May;31(3):119-128. Epub 2016 Nov 24 doi: 10.1016/j.blre.2016.11.002. PMID: 27923516
Therapy-related myelodysplastic syndrome.
Candelaria M, Dueñas-Gonzalez A
Expert Opin Drug Saf 2015 May;14(5):655-65. Epub 2015 Feb 12 doi: 10.1517/14740338.2015.1014340. PMID: 25675961

Clinical prediction guides

Secondary myeloid neoplasms after CD19 CAR T therapy in patients with refractory/relapsed B-cell lymphoma: Case series and review of literature.
Zhao A, Zhao M, Qian W, Liang A, Li P, Liu H
Front Immunol 2022;13:1063986. Epub 2023 Jan 13 doi: 10.3389/fimmu.2022.1063986. PMID: 36713414Free PMC Article
Targeting TP53 Mutations in Myelodysplastic Syndromes.
Hunter AM, Sallman DA
Hematol Oncol Clin North Am 2020 Apr;34(2):421-440. Epub 2019 Dec 12 doi: 10.1016/j.hoc.2019.11.004. PMID: 32089220
Therapy-related myelodysplastic syndrome following primary breast cancer.
Malmgren JA, Calip GS, Pyott SM, Atwood MK, Kaplan HG
Leuk Res 2016 Aug;47:178-84. Epub 2016 Jun 23 doi: 10.1016/j.leukres.2016.06.005. PMID: 27414978
Azathioprine: association with therapy-related myelodysplastic syndrome and acute myeloid leukemia.
Kwong YL
J Rheumatol 2010 Mar;37(3):485-90. Epub 2010 Jan 15 doi: 10.3899/jrheum.090834. PMID: 20080917
Therapy-related myeloid leukemia.
Godley LA, Larson RA
Semin Oncol 2008 Aug;35(4):418-29. doi: 10.1053/j.seminoncol.2008.04.012. PMID: 18692692Free PMC Article

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