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Adult leptomeningeal melanoma

MedGen UID:
231042
•Concept ID:
C1332204
•
Neoplastic Process
Synonyms: Adult Leptomeningeal Melanoma; adult leptomeningeal melanoma; Adult Meningeal Melanoma; adult meningeal melanoma; Melanoma of Adult Leptomeninges; melanoma of adult leptomeninges; Melanoma of the Adult Leptomeninges; melanoma of the adult leptomeninges
 
Monarch Initiative: MONDO:0003765

Definition

A melanoma that arises from leptomeningeal melanocytes and occurs in adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult leptomeningeal melanoma

Professional guidelines

PubMed

Primary intracranial malignant melanomas in solitary type: a tertiary center experience.
Huang YM, Yeh KY, Chen PY, Hsieh TY, Hsu LS, Wu CE, Yang CH, Zheng YC
J Clin Neurosci 2022 Jul;101:37-46. Epub 2022 May 5 doi: 10.1016/j.jocn.2022.03.037. PMID: 35526362
Targeted treatment and immunotherapy in leptomeningeal metastases from melanoma.
Geukes Foppen MH, Brandsma D, Blank CU, van Thienen JV, Haanen JB, Boogerd W
Ann Oncol 2016 Jun;27(6):1138-1142. Epub 2016 Mar 8 doi: 10.1093/annonc/mdw134. PMID: 26961150
Management of leptomeningeal metastases: Prognostic factors and associated outcomes.
Brower JV, Saha S, Rosenberg SA, Hullett CR, Ian Robins H
J Clin Neurosci 2016 May;27:130-7. Epub 2016 Jan 8 doi: 10.1016/j.jocn.2015.11.012. PMID: 26778048

Recent clinical studies

Etiology

Stereotactic Radiosurgery for Intracranial Primary Melanocytomas.
Dar N, Mantziaris G, Pikis S, Young L, Sheehan J
World Neurosurg 2022 Aug;164:160-166. Epub 2022 May 10 doi: 10.1016/j.wneu.2022.04.136. PMID: 35552031
Melanocytic lesions of the central nervous system: a case series.
Varela-Poblete J, Vidal-Tellez A, Cruz-Quiroga JP, Montoya-Salvadores F, Medina-Escobar J
Arq Neuropsiquiatr 2022 Feb;80(2):153-160. doi: 10.1590/0004-282X-ANP-2021-0082. PMID: 35352754Free PMC Article
Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.
Mitre V, Heym K, Clark GD, Venkatramani R
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e195-e197. doi: 10.1097/MPH.0000000000001680. PMID: 31764519
Neurocutaneous melanocytosis (melanosis).
Ruggieri M, Polizzi A, Catanzaro S, Bianco ML, Praticò AD, Di Rocco C
Childs Nerv Syst 2020 Oct;36(10):2571-2596. Epub 2020 Oct 13 doi: 10.1007/s00381-020-04770-9. PMID: 33048248
Primary leptomeningeal melanoma.
Xie ZY, Hsieh KL, Tsang YM, Cheung WK, Hsieh CH
J Clin Neurosci 2014 Jun;21(6):1051-2. Epub 2013 Oct 23 doi: 10.1016/j.jocn.2013.08.018. PMID: 24331626

Diagnosis

Meningeal Melanocytoma- A Clinicohistological Masquerader.
Chhabra R, Misra S, Prasad P, Khati S
Neurol India 2022 Sep-Oct;70(5):2153-2155. doi: 10.4103/0028-3886.359256. PMID: 36352627
CNS Tumors - clinical and radiological aspects.
Emmerová R, Engelová J, Vinakurau S, Ondrová B
Cesk Patol 2022 Fall;58(3):150-160. PMID: 36224037
Melanocytic lesions of the central nervous system: a case series.
Varela-Poblete J, Vidal-Tellez A, Cruz-Quiroga JP, Montoya-Salvadores F, Medina-Escobar J
Arq Neuropsiquiatr 2022 Feb;80(2):153-160. doi: 10.1590/0004-282X-ANP-2021-0082. PMID: 35352754Free PMC Article
Neurocutaneous melanocytosis (melanosis).
Ruggieri M, Polizzi A, Catanzaro S, Bianco ML, Praticò AD, Di Rocco C
Childs Nerv Syst 2020 Oct;36(10):2571-2596. Epub 2020 Oct 13 doi: 10.1007/s00381-020-04770-9. PMID: 33048248
Primary leptomeningeal melanoma.
Xie ZY, Hsieh KL, Tsang YM, Cheung WK, Hsieh CH
J Clin Neurosci 2014 Jun;21(6):1051-2. Epub 2013 Oct 23 doi: 10.1016/j.jocn.2013.08.018. PMID: 24331626

Therapy

CNS Tumors - clinical and radiological aspects.
Emmerová R, Engelová J, Vinakurau S, Ondrová B
Cesk Patol 2022 Fall;58(3):150-160. PMID: 36224037
Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.
Mitre V, Heym K, Clark GD, Venkatramani R
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e195-e197. doi: 10.1097/MPH.0000000000001680. PMID: 31764519
Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 study.
Long GV, Atkinson V, Lo S, Sandhu S, Guminski AD, Brown MP, Wilmott JS, Edwards J, Gonzalez M, Scolyer RA, Menzies AM, McArthur GA
Lancet Oncol 2018 May;19(5):672-681. Epub 2018 Mar 27 doi: 10.1016/S1470-2045(18)30139-6. PMID: 29602646
Targeted treatment and immunotherapy in leptomeningeal metastases from melanoma.
Geukes Foppen MH, Brandsma D, Blank CU, van Thienen JV, Haanen JB, Boogerd W
Ann Oncol 2016 Jun;27(6):1138-1142. Epub 2016 Mar 8 doi: 10.1093/annonc/mdw134. PMID: 26961150
Diagnosis and individualized therapy of neoplastic meningitis.
Strik H, Prömmel P
Expert Rev Anticancer Ther 2010 Jul;10(7):1137-48. doi: 10.1586/era.10.86. PMID: 20645702

Prognosis

Meningeal Melanocytoma- A Clinicohistological Masquerader.
Chhabra R, Misra S, Prasad P, Khati S
Neurol India 2022 Sep-Oct;70(5):2153-2155. doi: 10.4103/0028-3886.359256. PMID: 36352627
Stereotactic Radiosurgery for Intracranial Primary Melanocytomas.
Dar N, Mantziaris G, Pikis S, Young L, Sheehan J
World Neurosurg 2022 Aug;164:160-166. Epub 2022 May 10 doi: 10.1016/j.wneu.2022.04.136. PMID: 35552031
Leptomeningeal disease from melanoma-Poor prognosis despite new therapeutic modalities.
Chorti E, Kebir S, Ahmed MS, Keyvani K, Umutlu L, Kanaki T, Zaremba A, Reinboldt-Jockenhoefer F, Knispel S, Gratsias E, Roesch A, Ugurel S, Scheffler B, Schadendorf D, Livingstone E, Meier F, Glas M, Zimmer L
Eur J Cancer 2021 May;148:395-404. Epub 2021 Mar 28 doi: 10.1016/j.ejca.2021.02.016. PMID: 33789203
Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.
Mitre V, Heym K, Clark GD, Venkatramani R
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e195-e197. doi: 10.1097/MPH.0000000000001680. PMID: 31764519
Primary leptomeningeal melanoma.
Xie ZY, Hsieh KL, Tsang YM, Cheung WK, Hsieh CH
J Clin Neurosci 2014 Jun;21(6):1051-2. Epub 2013 Oct 23 doi: 10.1016/j.jocn.2013.08.018. PMID: 24331626

Clinical prediction guides

CNS Tumors - clinical and radiological aspects.
Emmerová R, Engelová J, Vinakurau S, Ondrová B
Cesk Patol 2022 Fall;58(3):150-160. PMID: 36224037
Primary intracranial malignant melanomas in solitary type: a tertiary center experience.
Huang YM, Yeh KY, Chen PY, Hsieh TY, Hsu LS, Wu CE, Yang CH, Zheng YC
J Clin Neurosci 2022 Jul;101:37-46. Epub 2022 May 5 doi: 10.1016/j.jocn.2022.03.037. PMID: 35526362
Leptomeningeal metastases arising from gynecological cancers.
Yano H, Nagao S, Yamaguchi S
Int J Clin Oncol 2020 Feb;25(2):391-395. Epub 2019 Oct 4 doi: 10.1007/s10147-019-01556-1. PMID: 31586282
Predictors of survival in metastatic melanoma patients with leptomeningeal disease (LMD).
Ferguson SD, Bindal S, Bassett RL Jr, Haydu LE, McCutcheon IE, Heimberger AB, Li J, O'Brien BJ, Guha-Thakurta N, Tetzlaff MT, Tawbi H, Davies MA, Glitza IC
J Neurooncol 2019 May;142(3):499-509. Epub 2019 Mar 7 doi: 10.1007/s11060-019-03121-2. PMID: 30847840
Targeted treatment and immunotherapy in leptomeningeal metastases from melanoma.
Geukes Foppen MH, Brandsma D, Blank CU, van Thienen JV, Haanen JB, Boogerd W
Ann Oncol 2016 Jun;27(6):1138-1142. Epub 2016 Mar 8 doi: 10.1093/annonc/mdw134. PMID: 26961150

Recent systematic reviews

Efficacy of neoadjuvant stereotactic radiotherapy in brain metastases from solid cancer: a systematic review of literature and meta-analysis.
Gagliardi F, De Domenico P, Snider S, Nizzola MG, Mortini P
Neurosurg Rev 2023 May 31;46(1):130. doi: 10.1007/s10143-023-02031-2. PMID: 37256368
Stereotactic Radiosurgery for Intracranial Primary Melanocytomas.
Dar N, Mantziaris G, Pikis S, Young L, Sheehan J
World Neurosurg 2022 Aug;164:160-166. Epub 2022 May 10 doi: 10.1016/j.wneu.2022.04.136. PMID: 35552031
The Role of Immune Checkpoint Inhibitors in Leptomeningeal Disease: A Systematic Review.
Palmisciano P, Haider AS, Nwagwu CD, Wahood W, Yu K, Ene CI, O'Brien BJ, Aoun SG, Cohen-Gadol AA, El Ahmadieh TY
Anticancer Res 2021 Nov;41(11):5333-5342. doi: 10.21873/anticanres.15346. PMID: 34732403Free PMC Article
Pituitary metastasis of malignant melanoma misdiagnosed as pituitary adenoma: A case report and systematic review of the literature.
Ng S, Boetto J, Rigau V, Raingeard I, Crampette L, Favier V, Poulen G
Neurochirurgie 2020 Nov;66(5):383-390. Epub 2020 Aug 7 doi: 10.1016/j.neuchi.2020.06.129. PMID: 32777231
Amelanotic Meningeal Melanoma with Leptomeningeal Dissemination: A Case Report and Systematic Literature Review.
Zhang S, Wang W, Su X, Tan Q, Sun H, Liu Z, Chen N, Gong Q, Yue Q
World Neurosurg 2019 Feb;122:229-239. Epub 2018 Nov 4 doi: 10.1016/j.wneu.2018.10.199. PMID: 30404049

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