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Childhood Benign Cerebral Neoplasm

MedGen UID:
231427
•Concept ID:
C1332484
•
Neoplastic Process
Synonyms: Benign Childhood Cerebral Hemispheric Neoplasm; Benign Childhood Cerebral Hemispheric Tumor; Benign Childhood Cerebral Neoplasm; Benign Childhood Cerebral Tumor; Benign Childhood Neoplasm of Cerebral Hemispheres; Benign Childhood Neoplasm of Cerebrum; Benign Childhood Neoplasm of the Cerebral Hemispheres; Benign Childhood Neoplasm of the Cerebrum; Benign Childhood Tumor of Cerebral Hemispheres; Benign Childhood Tumor of Cerebrum; Benign Childhood Tumor of the Cerebral Hemispheres; Benign Childhood Tumor of the Cerebrum; Benign Pediatric Cerebral Hemispheric Neoplasm; Benign Pediatric Cerebral Hemispheric Tumor; Benign Pediatric Cerebral Neoplasm; Benign Pediatric Cerebral Tumor; Benign Pediatric Neoplasm of Cerebral Hemispheres; Benign Pediatric Neoplasm of Cerebrum; Benign Pediatric Neoplasm of the Cerebral Hemispheres; Benign Pediatric Neoplasm of the Cerebrum; Benign Pediatric Tumor of Cerebral Hemispheres; Benign Pediatric Tumor of Cerebrum; Benign Pediatric Tumor of the Cerebral Hemispheres; Benign Pediatric Tumor of the Cerebrum

Definition

A childhood neoplasm that arises from the cerebrum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Benign Cerebral Neoplasm

Professional guidelines

PubMed

National UK guidelines for the management of paediatric craniopharyngioma.
Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Diagnostic criteria for constitutional mismatch repair deficiency (CMMRD): recommendations from the international consensus working group.
Aronson M, Colas C, Shuen A, Hampel H, Foulkes WD, Baris Feldman H, Goldberg Y, Muleris M, Wolfe Schneider K, McGee RB, Jasperson K, Rangaswami A, Brugieres L, Tabori U
J Med Genet 2022 Apr;59(4):318-327. Epub 2021 Feb 23 doi: 10.1136/jmedgenet-2020-107627. PMID: 33622763
Multidisciplinary management of childhood brain tumors: a review of outcomes, recent advances, and challenges.
Pollack IF
J Neurosurg Pediatr 2011 Aug;8(2):135-48. doi: 10.3171/2011.5.PEDS1178. PMID: 21806354

Recent clinical studies

Etiology

National UK guidelines for the management of paediatric craniopharyngioma.
Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Diagnostic criteria for constitutional mismatch repair deficiency (CMMRD): recommendations from the international consensus working group.
Aronson M, Colas C, Shuen A, Hampel H, Foulkes WD, Baris Feldman H, Goldberg Y, Muleris M, Wolfe Schneider K, McGee RB, Jasperson K, Rangaswami A, Brugieres L, Tabori U
J Med Genet 2022 Apr;59(4):318-327. Epub 2021 Feb 23 doi: 10.1136/jmedgenet-2020-107627. PMID: 33622763
Neurocutaneous melanocytosis (melanosis).
Ruggieri M, Polizzi A, Catanzaro S, Bianco ML, Praticò AD, Di Rocco C
Childs Nerv Syst 2020 Oct;36(10):2571-2596. Epub 2020 Oct 13 doi: 10.1007/s00381-020-04770-9. PMID: 33048248
Risk factors for childhood and adult primary brain tumors.
Ostrom QT, Adel Fahmideh M, Cote DJ, Muskens IS, Schraw JM, Scheurer ME, Bondy ML
Neuro Oncol 2019 Nov 4;21(11):1357-1375. doi: 10.1093/neuonc/noz123. PMID: 31301133Free PMC Article

Diagnosis

National UK guidelines for the management of paediatric craniopharyngioma.
Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Diagnostic criteria for constitutional mismatch repair deficiency (CMMRD): recommendations from the international consensus working group.
Aronson M, Colas C, Shuen A, Hampel H, Foulkes WD, Baris Feldman H, Goldberg Y, Muleris M, Wolfe Schneider K, McGee RB, Jasperson K, Rangaswami A, Brugieres L, Tabori U
J Med Genet 2022 Apr;59(4):318-327. Epub 2021 Feb 23 doi: 10.1136/jmedgenet-2020-107627. PMID: 33622763
Risk factors for childhood and adult primary brain tumors.
Ostrom QT, Adel Fahmideh M, Cote DJ, Muskens IS, Schraw JM, Scheurer ME, Bondy ML
Neuro Oncol 2019 Nov 4;21(11):1357-1375. doi: 10.1093/neuonc/noz123. PMID: 31301133Free PMC Article
Pediatric Suprasellar Tumors.
McCrea HJ, George E, Settler A, Schwartz TH, Greenfield JP
J Child Neurol 2016 Oct;31(12):1367-76. Epub 2015 Dec 15 doi: 10.1177/0883073815620671. PMID: 26676303
Craniopharyngioma in childhood.
May JA, Krieger MD, Bowen I, Geffner ME
Adv Pediatr 2006;53:183-209. doi: 10.1016/j.yapd.2006.04.013. PMID: 17089867

Therapy

Oral atenolol compared to oral propranolol for infantile hemangioma.
Meza Viteri V, Aranibar L
Medwave 2023 Dec 7;23(11):e2753. doi: 10.5867/medwave.2023.11.2753. PMID: 38061014
The Health Care Utilization and Medical Costs in Long-Term Follow-Up of Children Diagnosed With Leukemia, Solid Tumor, or Brain Tumor: Population-Based Study Using the National Health Insurance Claims Data.
Miser JS, Shia BC, Kao YW, Liu YL, Chen SY, Ho WL
JMIR Public Health Surveill 2023 Mar 2;9:e42350. doi: 10.2196/42350. PMID: 36862495Free PMC Article
GH and Childhood-onset Craniopharyngioma: When to Initiate GH Replacement Therapy?
Nguyen Quoc A, Beccaria K, González Briceño L, Pinto G, Samara-Boustani D, Stoupa A, Beltrand J, Besançon A, Thalassinos C, Puget S, Blauwblomme T, Alapetite C, Bolle S, Doz F, Grill J, Dufour C, Bourdeaut F, Abbou S, Guerrini-Rousseau L, Leruste A, Brabant S, Cavadias I, Viaud M, Boddaert N, Polak M, Kariyawasam D
J Clin Endocrinol Metab 2023 Jul 14;108(8):1929-1936. doi: 10.1210/clinem/dgad079. PMID: 36794424
Craniopharyngioma in childhood.
May JA, Krieger MD, Bowen I, Geffner ME
Adv Pediatr 2006;53:183-209. doi: 10.1016/j.yapd.2006.04.013. PMID: 17089867
Catastrophic epilepsy in childhood.
Shields WD
Epilepsia 2000;41 Suppl 2:S2-6. doi: 10.1111/j.1528-1157.2000.tb01518.x. PMID: 10885734

Prognosis

Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Revived Attention for Adult Craniopharyngioma.
Mende KC, Pantel TF, Flitsch J
Exp Clin Endocrinol Diabetes 2021 Mar;129(3):172-177. Epub 2020 Aug 4 doi: 10.1055/a-1217-7282. PMID: 32750720
Surgery of Intracranial Gliomas in Children.
Balogun JA, Rutka JT
Prog Neurol Surg 2018;30:204-217. Epub 2017 Dec 14 doi: 10.1159/000464437. PMID: 29241176
Central nervous system tumors.
Jacques G, Cormac O
Handb Clin Neurol 2013;112:931-58. doi: 10.1016/B978-0-444-52910-7.00015-5. PMID: 23622303
Teratomas in childhood.
Bale PM, Painter DM, Cohen D
Pathology 1975 Jul;7(3):209-18. doi: 10.3109/00313027509094411. PMID: 1196679

Clinical prediction guides

Oral atenolol compared to oral propranolol for infantile hemangioma.
Meza Viteri V, Aranibar L
Medwave 2023 Dec 7;23(11):e2753. doi: 10.5867/medwave.2023.11.2753. PMID: 38061014
GH and Childhood-onset Craniopharyngioma: When to Initiate GH Replacement Therapy?
Nguyen Quoc A, Beccaria K, González Briceño L, Pinto G, Samara-Boustani D, Stoupa A, Beltrand J, Besançon A, Thalassinos C, Puget S, Blauwblomme T, Alapetite C, Bolle S, Doz F, Grill J, Dufour C, Bourdeaut F, Abbou S, Guerrini-Rousseau L, Leruste A, Brabant S, Cavadias I, Viaud M, Boddaert N, Polak M, Kariyawasam D
J Clin Endocrinol Metab 2023 Jul 14;108(8):1929-1936. doi: 10.1210/clinem/dgad079. PMID: 36794424
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Cancer and Central Nervous System Tumor Surveillance in Pediatric Neurofibromatosis 2 and Related Disorders.
Evans DGR, Salvador H, Chang VY, Erez A, Voss SD, Druker H, Scott HS, Tabori U
Clin Cancer Res 2017 Jun 15;23(12):e54-e61. doi: 10.1158/1078-0432.CCR-17-0590. PMID: 28620005
Craniopharyngioma in childhood.
May JA, Krieger MD, Bowen I, Geffner ME
Adv Pediatr 2006;53:183-209. doi: 10.1016/j.yapd.2006.04.013. PMID: 17089867

Recent systematic reviews

Ionizing radiation exposure during adulthood and risk of developing central nervous system tumors: systematic review and meta-analysis.
Lopes J, Baudin C, Leuraud K, Klokov D, Bernier MO
Sci Rep 2022 Sep 28;12(1):16209. doi: 10.1038/s41598-022-20462-7. PMID: 36171442Free PMC Article
Childhood ependymoma: a systematic review of treatment options and strategies.
Grill J, Pascal C, Chantal K
Paediatr Drugs 2003;5(8):533-43. doi: 10.2165/00148581-200305080-00004. PMID: 12895136

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