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Blastoid Variant Mantle Cell Lymphoma

MedGen UID:
231447
•Concept ID:
C1332569
•
Neoplastic Process
Synonym: Classic Blastoid Variant Mantle Cell Lymphoma

Definition

An aggressive mantle cell lymphoma characterized by the presence of neoplastic B-lymphocytes resembling lymphoblasts. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBlastoid Variant Mantle Cell Lymphoma

Professional guidelines

PubMed

Upfront Management of Blastoid Variant Mantle Cell Lymphoma: Making the Case for 2nd/3rd-Generation Bruton Tyrosine Kinase Inhibitor-Based Therapies.
Lee BJ, Liu J, Griffin SP, Doh J, Ciurea SO, Kongtim P, Brem EA
Cancer Med 2024 Oct;13(19):e70310. doi: 10.1002/cam4.70310. PMID: 39394843Free PMC Article

Recent clinical studies

Etiology

Upfront Management of Blastoid Variant Mantle Cell Lymphoma: Making the Case for 2nd/3rd-Generation Bruton Tyrosine Kinase Inhibitor-Based Therapies.
Lee BJ, Liu J, Griffin SP, Doh J, Ciurea SO, Kongtim P, Brem EA
Cancer Med 2024 Oct;13(19):e70310. doi: 10.1002/cam4.70310. PMID: 39394843Free PMC Article
Spontaneous Tumor Lysis Syndrome in Blastoid-Variant Mantle Cell Lymphoma: Considerations for the General Internist.
Patel V, Case R
J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620944709. doi: 10.1177/2324709620944709. PMID: 32720820Free PMC Article

Diagnosis

Blastoid variant mantle cell lymphoma with aberrant expression of CD10.
Podvin B, Bossard JB, Pucalowski C, Bouchez G
Ann Biol Clin (Paris) 2023 May 16;81(2):222-223. doi: 10.1684/abc.2023.1796. PMID: 37184256
Aggressive Cyclin D1 Negative Blastoid Variant Mantle Cell Lymphoma-A Case Report.
Loungani L, Mundhe R, Chinoy R
Int J Surg Pathol 2022 Apr;30(2):190-194. Epub 2021 Jun 28 doi: 10.1177/10668969211027409. PMID: 34180720
CD5-negative blastoid variant mantle cell lymphoma: a diagnostic dilemma.
Yamamoto N, Maeshima AM, Taniguchi H, Makita S, Fukuhara S, Munakata W, Suzuki T, Maruyama D, Izutsu K
Hum Pathol 2021 May;111:84-91. Epub 2021 Mar 13 doi: 10.1016/j.humpath.2021.03.005. PMID: 33727166
Unusual concomitant rearrangements of Cyclin D1 and MYC genes in blastoid variant of mantle cell lymphoma: Case report and review of literature.
Delas A, Sophie D, Brousset P, Laurent C
Pathol Res Pract 2013 Feb 15;209(2):115-9. Epub 2013 Jan 11 doi: 10.1016/j.prp.2012.12.001. PMID: 23313364
CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations.
Seok Y, Kim J, Choi JR, Kim YR, Park SJ, Kim SJ, Song J, Lee KA
Ann Lab Med 2012 Jan;32(1):95-8. Epub 2011 Dec 20 doi: 10.3343/alm.2012.32.1.95. PMID: 22259787Free PMC Article

Therapy

Upfront Management of Blastoid Variant Mantle Cell Lymphoma: Making the Case for 2nd/3rd-Generation Bruton Tyrosine Kinase Inhibitor-Based Therapies.
Lee BJ, Liu J, Griffin SP, Doh J, Ciurea SO, Kongtim P, Brem EA
Cancer Med 2024 Oct;13(19):e70310. doi: 10.1002/cam4.70310. PMID: 39394843Free PMC Article
Spontaneous Tumor Lysis Syndrome in Blastoid-Variant Mantle Cell Lymphoma: Considerations for the General Internist.
Patel V, Case R
J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620944709. doi: 10.1177/2324709620944709. PMID: 32720820Free PMC Article
In-111 ibritumomab scintigraphy (planar and SPECT) and FDG PET/CT before Y-90 ibritumomab treatment in a patient with mantle cell lymphoma.
Jiménez-Bonilla JF, Quirce R, Banzo I, Martínez-Rodríguez I, Sainz-Esteban A, Barragán JE, López-Cordovilla JJ, Carril JM
Clin Nucl Med 2007 Dec;32(12):952-3. doi: 10.1097/RLU.0b013e31815976a5. PMID: 18030051

Prognosis

Upfront Management of Blastoid Variant Mantle Cell Lymphoma: Making the Case for 2nd/3rd-Generation Bruton Tyrosine Kinase Inhibitor-Based Therapies.
Lee BJ, Liu J, Griffin SP, Doh J, Ciurea SO, Kongtim P, Brem EA
Cancer Med 2024 Oct;13(19):e70310. doi: 10.1002/cam4.70310. PMID: 39394843Free PMC Article
Classical type and blastoid variant mantle cell lymphoma in the same lymph node: Histology and cytological findings from a touch imprint specimen.
Nakatsuka SI, Nagatomo T, Nagano T, Goto T, Hashimoto K
Diagn Cytopathol 2017 Apr;45(4):364-370. Epub 2017 Jan 31 doi: 10.1002/dc.23672. PMID: 28140514
CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations.
Seok Y, Kim J, Choi JR, Kim YR, Park SJ, Kim SJ, Song J, Lee KA
Ann Lab Med 2012 Jan;32(1):95-8. Epub 2011 Dec 20 doi: 10.3343/alm.2012.32.1.95. PMID: 22259787Free PMC Article

Clinical prediction guides

Upfront Management of Blastoid Variant Mantle Cell Lymphoma: Making the Case for 2nd/3rd-Generation Bruton Tyrosine Kinase Inhibitor-Based Therapies.
Lee BJ, Liu J, Griffin SP, Doh J, Ciurea SO, Kongtim P, Brem EA
Cancer Med 2024 Oct;13(19):e70310. doi: 10.1002/cam4.70310. PMID: 39394843Free PMC Article
CD5-negative blastoid variant mantle cell lymphoma: a diagnostic dilemma.
Yamamoto N, Maeshima AM, Taniguchi H, Makita S, Fukuhara S, Munakata W, Suzuki T, Maruyama D, Izutsu K
Hum Pathol 2021 May;111:84-91. Epub 2021 Mar 13 doi: 10.1016/j.humpath.2021.03.005. PMID: 33727166
Classical type and blastoid variant mantle cell lymphoma in the same lymph node: Histology and cytological findings from a touch imprint specimen.
Nakatsuka SI, Nagatomo T, Nagano T, Goto T, Hashimoto K
Diagn Cytopathol 2017 Apr;45(4):364-370. Epub 2017 Jan 31 doi: 10.1002/dc.23672. PMID: 28140514
In-111 ibritumomab scintigraphy (planar and SPECT) and FDG PET/CT before Y-90 ibritumomab treatment in a patient with mantle cell lymphoma.
Jiménez-Bonilla JF, Quirce R, Banzo I, Martínez-Rodríguez I, Sainz-Esteban A, Barragán JE, López-Cordovilla JJ, Carril JM
Clin Nucl Med 2007 Dec;32(12):952-3. doi: 10.1097/RLU.0b013e31815976a5. PMID: 18030051

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