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Mantle cell lymphoma

MedGen UID:
1668377
•Concept ID:
C4721414
•
Neoplastic Process
Synonyms: Centrocytic Small-Cell Lymphoma; Centrocytic Small-Cell Lymphomas; Diffuse Lymphocytic Lymphoma, Poorly Differentiated; Diffuse Lymphocytic Lymphoma, Poorly-Differentiated; Lymphocytic Lymphoma, Diffuse, Poorly Differentiated; Lymphocytic Lymphoma, Diffuse, Poorly-Differentiated; Lymphoma, Centrocytic Small Cell; Lymphoma, Centrocytic Small-Cell; Lymphoma, Lymphocytic, Diffuse, Intermediate Differentiated; Lymphoma, Lymphocytic, Diffuse, Poorly-Differentiated; Lymphoma, Mantle Cell; Lymphoma, Mantle-Cell; Lymphoma, Mantle-Zone; Lymphoma, Small-Cell, Centrocytic; Lymphomas, Centrocytic Small-Cell; Lymphomas, Mantle-Cell; Lymphomas, Mantle-Zone; Mantle Cell Lymphoma; Mantle Zone Lymphoma; Mantle-Cell Lymphoma; Mantle-Cell Lymphomas; Mantle-Zone Lymphoma; Mantle-Zone Lymphomas; Small-Cell Lymphoma, Centrocytic; Small-Cell Lymphomas, Centrocytic
SNOMED CT: Mantle cell lymphoma (74654000); Mantle cell lymphoma (443487006)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Non-Mendelian inheritance (Orphanet)
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018876
OMIM®: 607585
Orphanet: ORPHA52416

Definition

Mantle cell lymphoma is a rare form of malignant non-Hodgkin lymphoma (see this term) affecting B lymphocytes in the lymph nodes in a region called the ``mantle zone''. [from ORDO]

Professional guidelines

PubMed

Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA).
Hayden PJ, Roddie C, Bader P, Basak GW, Bonig H, Bonini C, Chabannon C, Ciceri F, Corbacioglu S, Ellard R, Sanchez-Guijo F, Jäger U, Hildebrandt M, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Rees J, Rioufol C, Saccardi R, Snowden JA, Styczynski J, Subklewe M, Thieblemont C, Topp M, Ispizua ÁU, Chen D, Vrhovac R, Gribben JG, Kröger N, Einsele H, Yakoub-Agha I
Ann Oncol 2022 Mar;33(3):259-275. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.003. PMID: 34923107
Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management.
Jain P, Wang M
Am J Hematol 2019 Jun;94(6):710-725. Epub 2019 Apr 19 doi: 10.1002/ajh.25487. PMID: 30963600
Management of adverse effects/toxicity of ibrutinib.
Paydas S
Crit Rev Oncol Hematol 2019 Apr;136:56-63. Epub 2019 Feb 10 doi: 10.1016/j.critrevonc.2019.02.001. PMID: 30878129

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2023

Recent clinical studies

Etiology

New Directions for Mantle Cell Lymphoma in 2022.
Kumar A, Eyre TA, Lewis KL, Thompson MC, Cheah CY
Am Soc Clin Oncol Educ Book 2022 Apr;42:1-15. doi: 10.1200/EDBK_349509. PMID: 35561299
Mantle cell lymphoma in 2022-A comprehensive update on molecular pathogenesis, risk stratification, clinical approach, and current and novel treatments.
Jain P, Wang ML
Am J Hematol 2022 May;97(5):638-656. doi: 10.1002/ajh.26523. PMID: 35266562
Mantle cell lymphoma - advances in molecular biology, prognostication and treatment approaches.
Silkenstedt E, Linton K, Dreyling M
Br J Haematol 2021 Oct;195(2):162-173. Epub 2021 Mar 30 doi: 10.1111/bjh.17419. PMID: 33783838
Blastoid Mantle Cell Lymphoma.
Jain P, Wang M
Hematol Oncol Clin North Am 2020 Oct;34(5):941-956. Epub 2020 Aug 5 doi: 10.1016/j.hoc.2020.06.009. PMID: 32861288
Update on mantle cell lymphoma.
Maddocks K
Blood 2018 Oct 18;132(16):1647-1656. Epub 2018 Aug 28 doi: 10.1182/blood-2018-03-791392. PMID: 30154113

Diagnosis

New Directions for Mantle Cell Lymphoma in 2022.
Kumar A, Eyre TA, Lewis KL, Thompson MC, Cheah CY
Am Soc Clin Oncol Educ Book 2022 Apr;42:1-15. doi: 10.1200/EDBK_349509. PMID: 35561299
Blastoid Mantle Cell Lymphoma.
Jain P, Wang M
Hematol Oncol Clin North Am 2020 Oct;34(5):941-956. Epub 2020 Aug 5 doi: 10.1016/j.hoc.2020.06.009. PMID: 32861288
Molecular Pathogenesis of Mantle Cell Lymphoma.
Navarro A, Beà S, Jares P, Campo E
Hematol Oncol Clin North Am 2020 Oct;34(5):795-807. Epub 2020 Jul 22 doi: 10.1016/j.hoc.2020.05.002. PMID: 32861278Free PMC Article
Orbital lymphoma.
Olsen TG, Heegaard S
Surv Ophthalmol 2019 Jan-Feb;64(1):45-66. Epub 2018 Aug 23 doi: 10.1016/j.survophthal.2018.08.002. PMID: 30144455
Update on mantle cell lymphoma.
Maddocks K
Blood 2018 Oct 18;132(16):1647-1656. Epub 2018 Aug 28 doi: 10.1182/blood-2018-03-791392. PMID: 30154113

Therapy

Frontline Therapy in Mantle Cell Lymphoma: When Clinical Trial and Real-World Data Collide.
Fenske TS
J Clin Oncol 2023 Jan 20;41(3):452-459. Epub 2022 Sep 28 doi: 10.1200/JCO.22.01661. PMID: 36170622
New Directions for Mantle Cell Lymphoma in 2022.
Kumar A, Eyre TA, Lewis KL, Thompson MC, Cheah CY
Am Soc Clin Oncol Educ Book 2022 Apr;42:1-15. doi: 10.1200/EDBK_349509. PMID: 35561299
Blastoid Mantle Cell Lymphoma.
Jain P, Wang M
Hematol Oncol Clin North Am 2020 Oct;34(5):941-956. Epub 2020 Aug 5 doi: 10.1016/j.hoc.2020.06.009. PMID: 32861288
Bruton Tyrosine Kinase Inhibitors: Present and Future.
Burger JA
Cancer J 2019 Nov/Dec;25(6):386-393. doi: 10.1097/PPO.0000000000000412. PMID: 31764119Free PMC Article
Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management.
Vose JM
Am J Hematol 2017 Aug;92(8):806-813. doi: 10.1002/ajh.24797. PMID: 28699667

Prognosis

Mantle cell lymphoma - advances in molecular biology, prognostication and treatment approaches.
Silkenstedt E, Linton K, Dreyling M
Br J Haematol 2021 Oct;195(2):162-173. Epub 2021 Mar 30 doi: 10.1111/bjh.17419. PMID: 33783838
Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management.
Jain P, Wang M
Am J Hematol 2019 Jun;94(6):710-725. Epub 2019 Apr 19 doi: 10.1002/ajh.25487. PMID: 30963600
Management of adverse effects/toxicity of ibrutinib.
Paydas S
Crit Rev Oncol Hematol 2019 Apr;136:56-63. Epub 2019 Feb 10 doi: 10.1016/j.critrevonc.2019.02.001. PMID: 30878129
Orbital lymphoma.
Olsen TG, Heegaard S
Surv Ophthalmol 2019 Jan-Feb;64(1):45-66. Epub 2018 Aug 23 doi: 10.1016/j.survophthal.2018.08.002. PMID: 30144455
Update on mantle cell lymphoma.
Maddocks K
Blood 2018 Oct 18;132(16):1647-1656. Epub 2018 Aug 28 doi: 10.1182/blood-2018-03-791392. PMID: 30154113

Clinical prediction guides

Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management.
Jain P, Wang M
Am J Hematol 2019 Jun;94(6):710-725. Epub 2019 Apr 19 doi: 10.1002/ajh.25487. PMID: 30963600
Update on mantle cell lymphoma.
Maddocks K
Blood 2018 Oct 18;132(16):1647-1656. Epub 2018 Aug 28 doi: 10.1182/blood-2018-03-791392. PMID: 30154113
Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma.
Tam CS, Anderson MA, Pott C, Agarwal R, Handunnetti S, Hicks RJ, Burbury K, Turner G, Di Iulio J, Bressel M, Westerman D, Lade S, Dreyling M, Dawson SJ, Dawson MA, Seymour JF, Roberts AW
N Engl J Med 2018 Mar 29;378(13):1211-1223. doi: 10.1056/NEJMoa1715519. PMID: 29590547
Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management.
Vose JM
Am J Hematol 2017 Aug;92(8):806-813. doi: 10.1002/ajh.24797. PMID: 28699667
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article

Recent systematic reviews

Late relapse after CAR-T cell therapy for adult patients with hematologic malignancies: A definite evidence from systematic review and meta-analysis on individual data.
Zinzi A, Gaio M, Liguori V, Cagnotta C, Paolino D, Paolisso G, Castaldo G, Nicoletti GF, Rossi F, Capuano A, Rafaniello C
Pharmacol Res 2023 Apr;190:106742. Epub 2023 Mar 22 doi: 10.1016/j.phrs.2023.106742. PMID: 36963592
Efficacy and safety of ibrutinib in mantle cell lymphoma: A systematic review and meta-analysis.
Roufarshbaf M, Javeri M, Akbari V, Matin PH, Farrokhi P, Sadeghi E, Heidari Z, Moghaddas A
Daru 2022 Dec;30(2):367-378. Epub 2022 Sep 3 doi: 10.1007/s40199-022-00444-w. PMID: 36057010Free PMC Article
Clinical efficacy and safety of first-line treatments in patients with mantle cell lymphoma: A systematic literature review.
Monga N, Tam C, Garside J, Davids MS, Ward K, Quigley J, Parisi L, Tapprich C
Crit Rev Oncol Hematol 2021 Feb;158:103212. Epub 2020 Dec 28 doi: 10.1016/j.critrevonc.2020.103212. PMID: 33383209
Genetic mutations and features of mantle cell lymphoma: a systematic review and meta-analysis.
Hill HA, Qi X, Jain P, Nomie K, Wang Y, Zhou S, Wang ML
Blood Adv 2020 Jul 14;4(13):2927-2938. doi: 10.1182/bloodadvances.2019001350. PMID: 32598477Free PMC Article
Clinical efficacy and safety in relapsed/refractory mantle cell lymphoma: a systematic literature review.
Njue A, Colosia A, Trask PC, Olivares R, Khan S, Abbe A, Police R, Wang J, Ruiz-Soto R, Kaye JA, Awan F
Clin Lymphoma Myeloma Leuk 2015 Jan;15(1):1-12.e7. Epub 2014 Jun 11 doi: 10.1016/j.clml.2014.03.006. PMID: 25052050

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2023

    Reviews

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