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Urinary bladder small cell neuroendocrine carcinoma

MedGen UID:
231950
Concept ID:
C1332564
Neoplastic Process
Synonyms: Bladder Small Cell Carcinoma; bladder small cell neuroendocrine cancer; Bladder Small Cell Neuroendocrine Carcinoma; bladder small cell neuroendocrine carcinoma; Poorly differentiated neuroendocrine carcinoma of the bladder; poorly differentiated neuroendocrine carcinoma of the bladder; SCCB; Small cell bladder cancer; small cell bladder cancer; Small cell bladder carcinoma; small cell bladder carcinoma; small cell carcinoma of the bladder; Small cell carcinoma of the bladder; Small cell carcinoma of the urinary bladder; small cell carcinoma of the urinary bladder; small cell carcinoma of urinary bladder; Small cell neuroendocrine carcinoma of bladder; Small Cell Neuroendocrine Carcinoma of the Urinary Bladder; small cell neuroendocrine carcinoma of the urinary bladder; Small Cell Neuroendocrine Carcinoma of Urinary Bladder; small cell neuroendocrine carcinoma of urinary bladder; small cell/neuroendocrine carcinoma of urinary bladder; urinary bladder small cell carcinoma; urinary bladder small cell neuroendocrine carcinoma
SNOMED CT: Small cell neuroendocrine carcinoma of bladder (718604008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0004114
Orphanet: ORPHA284400

Definition

Small cell carcinoma of the bladder (SCCB) is a very rare, poorly differentiated neuroendocrine epithelial bladder tumor characterized clinically by hematuria and/or dysuria and a highly aggressive course. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUrinary bladder small cell neuroendocrine carcinoma

Professional guidelines

PubMed

Smolensky D, Rathore K, Cekanova M
Drug Des Devel Ther 2016;10:3305-3322. Epub 2016 Oct 5 doi: 10.2147/DDDT.S112113. PMID: 27784990Free PMC Article
Celik O, Ekin G, Ipekci T, Budak S, Ilbey YO
Arch Ital Urol Androl 2016 Mar 31;88(1):52-5. doi: 10.4081/aiua.2016.1.52. PMID: 27072176
Fahed E, Hansel DE, Raghavan D, Quinn DI, Dorff TB
Semin Oncol 2012 Oct;39(5):615-8. doi: 10.1053/j.seminoncol.2012.08.009. PMID: 23040258

Recent clinical studies

Etiology

Su Z, Monshaugen I, Wilson B, Wang F, Klungland A, Ougland R, Dutta A
Nat Commun 2022 Apr 20;13(1):2165. doi: 10.1038/s41467-022-29790-8. PMID: 35444240Free PMC Article
Hoffman-Censits JH, Lombardo KA, Parimi V, Kamanda S, Choi W, Hahn NM, McConkey DJ, McGuire BM, Bivalacqua TJ, Kates M, Matoso A
Appl Immunohistochem Mol Morphol 2021 Sep 1;29(8):619-625. doi: 10.1097/PAI.0000000000000938. PMID: 33901032Free PMC Article
McConkey DJ, Choi W
Curr Oncol Rep 2018 Aug 20;20(10):77. doi: 10.1007/s11912-018-0727-5. PMID: 30128829
Jung K, Ghatalia P, Litwin S, Horwitz EM, Uzzo RG, Greenberg RE, Viterbo R, Geynisman DM, Kutikov A, Plimack ER, Smaldone MC, Wong YN, Bilusic M
Clin Genitourin Cancer 2017 Jun;15(3):e337-e343. Epub 2016 Sep 30 doi: 10.1016/j.clgc.2016.09.005. PMID: 27991416Free PMC Article
Gkirlemis K, Miliadou A, Koukourakis G, Sotiropoulou-Lontou A
J BUON 2013 Jan-Mar;18(1):220-6. PMID: 23613409

Diagnosis

Lonati C, Simeone C, Suardi N, Briganti A, Montorsi F, Moschini M
Curr Opin Urol 2022 Sep 1;32(5):504-510. Epub 2022 Jul 18 doi: 10.1097/MOU.0000000000001023. PMID: 35855578
McConkey DJ, Choi W
Curr Oncol Rep 2018 Aug 20;20(10):77. doi: 10.1007/s11912-018-0727-5. PMID: 30128829
Celik O, Ekin G, Ipekci T, Budak S, Ilbey YO
Arch Ital Urol Androl 2016 Mar 31;88(1):52-5. doi: 10.4081/aiua.2016.1.52. PMID: 27072176
Wang X, MacLennan GT, Lopez-Beltran A, Cheng L
Appl Immunohistochem Mol Morphol 2007 Mar;15(1):8-18. doi: 10.1097/01.pai.0000213106.12731.d7. PMID: 17536302
Pan CX, Zhang H, Lara PN Jr, Cheng L
Expert Rev Anticancer Ther 2006 Dec;6(12):1707-13. doi: 10.1586/14737140.6.12.1707. PMID: 17181484

Therapy

Bureš J, Kohoutová D, Zavoral M
Klin Onkol 2022 Fall;35(5):346-357. doi: 10.48095/ccko2022346. PMID: 36443091
Subbiah V, Iannotti NO, Gutierrez M, Smith DC, Féliz L, Lihou CF, Tian C, Silverman IM, Ji T, Saleh M
Ann Oncol 2022 May;33(5):522-533. Epub 2022 Feb 14 doi: 10.1016/j.annonc.2022.02.001. PMID: 35176457
Banchereau R, Leng N, Zill O, Sokol E, Liu G, Pavlick D, Maund S, Liu LF, Kadel E 3rd, Baldwin N, Jhunjhunwala S, Nickles D, Assaf ZJ, Bower D, Patil N, McCleland M, Shames D, Molinero L, Huseni M, Sanjabi S, Cummings C, Mellman I, Mariathasan S, Hegde P, Powles T
Nat Commun 2021 Jun 25;12(1):3969. doi: 10.1038/s41467-021-24112-w. PMID: 34172722Free PMC Article
Balakrishna P, George S, Hatoum H, Mukherjee S
Int J Mol Sci 2021 Jan 28;22(3) doi: 10.3390/ijms22031268. PMID: 33525332Free PMC Article
Ott PA, Hu-Lieskovan S, Chmielowski B, Govindan R, Naing A, Bhardwaj N, Margolin K, Awad MM, Hellmann MD, Lin JJ, Friedlander T, Bushway ME, Balogh KN, Sciuto TE, Kohler V, Turnbull SJ, Besada R, Curran RR, Trapp B, Scherer J, Poran A, Harjanto D, Barthelme D, Ting YS, Dong JZ, Ware Y, Huang Y, Huang Z, Wanamaker A, Cleary LD, Moles MA, Manson K, Greshock J, Khondker ZS, Fritsch E, Rooney MS, DeMario M, Gaynor RB, Srinivasan L
Cell 2020 Oct 15;183(2):347-362.e24. doi: 10.1016/j.cell.2020.08.053. PMID: 33064988

Prognosis

Lonati C, Simeone C, Suardi N, Briganti A, Montorsi F, Moschini M
Curr Opin Urol 2022 Sep 1;32(5):504-510. Epub 2022 Jul 18 doi: 10.1097/MOU.0000000000001023. PMID: 35855578
McConkey DJ, Choi W
Curr Oncol Rep 2018 Aug 20;20(10):77. doi: 10.1007/s11912-018-0727-5. PMID: 30128829
Jung K, Ghatalia P, Litwin S, Horwitz EM, Uzzo RG, Greenberg RE, Viterbo R, Geynisman DM, Kutikov A, Plimack ER, Smaldone MC, Wong YN, Bilusic M
Clin Genitourin Cancer 2017 Jun;15(3):e337-e343. Epub 2016 Sep 30 doi: 10.1016/j.clgc.2016.09.005. PMID: 27991416Free PMC Article
Erdem GU, Özdemir NY, Demirci NS, Şahin S, Bozkaya Y, Zengin N
Curr Med Res Opin 2016 Jun;32(6):1013-21. Epub 2016 Mar 17 doi: 10.1185/03007995.2016.1155982. PMID: 26889739
Wang X, MacLennan GT, Lopez-Beltran A, Cheng L
Appl Immunohistochem Mol Morphol 2007 Mar;15(1):8-18. doi: 10.1097/01.pai.0000213106.12731.d7. PMID: 17536302

Clinical prediction guides

Banchereau R, Leng N, Zill O, Sokol E, Liu G, Pavlick D, Maund S, Liu LF, Kadel E 3rd, Baldwin N, Jhunjhunwala S, Nickles D, Assaf ZJ, Bower D, Patil N, McCleland M, Shames D, Molinero L, Huseni M, Sanjabi S, Cummings C, Mellman I, Mariathasan S, Hegde P, Powles T
Nat Commun 2021 Jun 25;12(1):3969. doi: 10.1038/s41467-021-24112-w. PMID: 34172722Free PMC Article
Hoffman-Censits JH, Lombardo KA, Parimi V, Kamanda S, Choi W, Hahn NM, McConkey DJ, McGuire BM, Bivalacqua TJ, Kates M, Matoso A
Appl Immunohistochem Mol Morphol 2021 Sep 1;29(8):619-625. doi: 10.1097/PAI.0000000000000938. PMID: 33901032Free PMC Article
Ott PA, Hu-Lieskovan S, Chmielowski B, Govindan R, Naing A, Bhardwaj N, Margolin K, Awad MM, Hellmann MD, Lin JJ, Friedlander T, Bushway ME, Balogh KN, Sciuto TE, Kohler V, Turnbull SJ, Besada R, Curran RR, Trapp B, Scherer J, Poran A, Harjanto D, Barthelme D, Ting YS, Dong JZ, Ware Y, Huang Y, Huang Z, Wanamaker A, Cleary LD, Moles MA, Manson K, Greshock J, Khondker ZS, Fritsch E, Rooney MS, DeMario M, Gaynor RB, Srinivasan L
Cell 2020 Oct 15;183(2):347-362.e24. doi: 10.1016/j.cell.2020.08.053. PMID: 33064988
Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, Hinoue T, Laird PW, Hoadley KA, Akbani R, Castro MAA, Gibb EA, Kanchi RS, Gordenin DA, Shukla SA, Sanchez-Vega F, Hansel DE, Czerniak BA, Reuter VE, Su X, de Sa Carvalho B, Chagas VS, Mungall KL, Sadeghi S, Pedamallu CS, Lu Y, Klimczak LJ, Zhang J, Choo C, Ojesina AI, Bullman S, Leraas KM, Lichtenberg TM, Wu CJ, Schultz N, Getz G, Meyerson M, Mills GB, McConkey DJ; TCGA Research Network, Weinstein JN, Kwiatkowski DJ, Lerner SP
Cell 2017 Oct 19;171(3):540-556.e25. Epub 2017 Oct 5 doi: 10.1016/j.cell.2017.09.007. PMID: 28988769Free PMC Article
Jung K, Ghatalia P, Litwin S, Horwitz EM, Uzzo RG, Greenberg RE, Viterbo R, Geynisman DM, Kutikov A, Plimack ER, Smaldone MC, Wong YN, Bilusic M
Clin Genitourin Cancer 2017 Jun;15(3):e337-e343. Epub 2016 Sep 30 doi: 10.1016/j.clgc.2016.09.005. PMID: 27991416Free PMC Article

Recent systematic reviews

Zalay O, Yan M, Sigurdson S, Malone S, Vera-Badillo FE, Mahmud A
Curr Oncol 2022 Dec 20;30(1):19-36. doi: 10.3390/curroncol30010002. PMID: 36661651Free PMC Article
Mori K, Abufaraj M, Mostafaei H, Quhal F, Karakiewicz PI, Briganti A, Kimura S, Egawa S, Shariat SF
J Urol 2020 Dec;204(6):1129-1140. Epub 2020 Jul 27 doi: 10.1097/JU.0000000000001305. PMID: 32716694
Svatek RS, Hollenbeck BK, Holmäng S, Lee R, Kim SP, Stenzl A, Lotan Y
Eur Urol 2014 Aug;66(2):253-62. Epub 2014 Jan 21 doi: 10.1016/j.eururo.2014.01.006. PMID: 24472711
Rai BP, Shelley M, Coles B, Biyani CS, El-Mokadem I, Nabi G
Cochrane Database Syst Rev 2011 Apr 13;(4):CD007349. doi: 10.1002/14651858.CD007349.pub2. PMID: 21491399
Widmark A, Flodgren P, Damber JE, Hellsten S, Cavallin-Ståhl E
Acta Oncol 2003;42(5-6):567-81. doi: 10.1080/02841860310014408. PMID: 14596515

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