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Urinary bladder small cell neuroendocrine carcinoma

MedGen UID:
231950
•Concept ID:
C1332564
•
Neoplastic Process
Synonyms: Bladder Small Cell Carcinoma; bladder small cell neuroendocrine cancer; Bladder Small Cell Neuroendocrine Carcinoma; bladder small cell neuroendocrine carcinoma; Poorly differentiated neuroendocrine carcinoma of the bladder; poorly differentiated neuroendocrine carcinoma of the bladder; SCCB; Small cell bladder cancer; small cell bladder cancer; Small cell bladder carcinoma; small cell bladder carcinoma; small cell carcinoma of the bladder; Small cell carcinoma of the bladder; Small cell carcinoma of the urinary bladder; small cell carcinoma of the urinary bladder; small cell carcinoma of urinary bladder; Small cell neuroendocrine carcinoma of bladder; Small Cell Neuroendocrine Carcinoma of the Urinary Bladder; small cell neuroendocrine carcinoma of the urinary bladder; Small Cell Neuroendocrine Carcinoma of Urinary Bladder; Small cell neuroendocrine carcinoma of urinary bladder; small cell neuroendocrine carcinoma of urinary bladder; small cell/neuroendocrine carcinoma of urinary bladder; urinary bladder small cell carcinoma; urinary bladder small cell neuroendocrine carcinoma
SNOMED CT: Small cell neuroendocrine carcinoma of bladder (718604008); Small cell neuroendocrine carcinoma of urinary bladder (718604008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0004114
Orphanet: ORPHA284400

Definition

Small cell carcinoma of the bladder (SCCB) is a very rare, poorly differentiated neuroendocrine epithelial bladder tumor characterized clinically by hematuria and/or dysuria and a highly aggressive course. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUrinary bladder small cell neuroendocrine carcinoma

Professional guidelines

PubMed

Comparative Effectiveness Analysis of Treatment Strategies for Surgically Resectable Neuroendocrine Carcinoma of the Urinary Tract.
Alhalabi O, Wilson N, Xiao L, Lin Y, Khandelwal J, Moussa MJ, Msaouel P, Navai N, Gao J, Kamat AM, Pilie P, Shah AY, Goswami S, Matin S, Kovitz C, Holla V, Guo C, Czerniak B, Logothetis C, Corn PG, Dinney CPN, Campbell MT, Hansel DE, Tannir NM, Siefker-Radtke AO
Eur Urol Oncol 2023 Dec;6(6):611-620. Epub 2023 Oct 11 doi: 10.1016/j.euo.2023.09.004. PMID: 37833193
Challenges and opportunities in the management of non-urothelial bladder cancers.
Brown JT, Narayan VM, Joshi SS, Harik L, Jani AB, Bilen MA
Cancer Treat Res Commun 2023;34:100663. Epub 2022 Dec 5 doi: 10.1016/j.ctarc.2022.100663. PMID: 36527979
Diagnosis and treatment in primary bladder small cell carcinoma: Literature review.
Celik O, Ekin G, Ipekci T, Budak S, Ilbey YO
Arch Ital Urol Androl 2016 Mar 31;88(1):52-5. doi: 10.4081/aiua.2016.1.52. PMID: 27072176

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

Recent clinical studies

Etiology

Photodynamic Diagnosis-Assisted Transurethral Resection - Lights Out?
Dahm P, Narayan VM
NEJM Evid 2022 Oct;1(10):EVIDe2200194. Epub 2022 Sep 27 doi: 10.1056/EVIDe2200194. PMID: 38319828
TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer.
Su Z, Monshaugen I, Wilson B, Wang F, Klungland A, Ougland R, Dutta A
Nat Commun 2022 Apr 20;13(1):2165. doi: 10.1038/s41467-022-29790-8. PMID: 35444240Free PMC Article
Expression of Nectin-4 in Bladder Urothelial Carcinoma, in Morphologic Variants, and Nonurothelial Histotypes.
Hoffman-Censits JH, Lombardo KA, Parimi V, Kamanda S, Choi W, Hahn NM, McConkey DJ, McGuire BM, Bivalacqua TJ, Kates M, Matoso A
Appl Immunohistochem Mol Morphol 2021 Sep 1;29(8):619-625. doi: 10.1097/PAI.0000000000000938. PMID: 33901032Free PMC Article
Molecular Subtypes of Bladder Cancer.
McConkey DJ, Choi W
Curr Oncol Rep 2018 Aug 20;20(10):77. doi: 10.1007/s11912-018-0727-5. PMID: 30128829
Small-Cell Carcinoma of the Bladder: 20-Year Single-Institution Retrospective Review.
Jung K, Ghatalia P, Litwin S, Horwitz EM, Uzzo RG, Greenberg RE, Viterbo R, Geynisman DM, Kutikov A, Plimack ER, Smaldone MC, Wong YN, Bilusic M
Clin Genitourin Cancer 2017 Jun;15(3):e337-e343. Epub 2016 Sep 30 doi: 10.1016/j.clgc.2016.09.005. PMID: 27991416Free PMC Article

Diagnosis

Molecular profile of bladder cancer progression to clinically aggressive subtypes.
Guo CC, Lee S, Lee JG, Chen H, Zaleski M, Choi W, McConkey DJ, Wei P, Czerniak B
Nat Rev Urol 2024 Jul;21(7):391-405. Epub 2024 Feb 6 doi: 10.1038/s41585-023-00847-7. PMID: 38321289
Photodynamic Diagnosis-Assisted Transurethral Resection - Lights Out?
Dahm P, Narayan VM
NEJM Evid 2022 Oct;1(10):EVIDe2200194. Epub 2022 Sep 27 doi: 10.1056/EVIDe2200194. PMID: 38319828
Micropapillary bladder cancer: an evolving biology.
Lonati C, Simeone C, Suardi N, Briganti A, Montorsi F, Moschini M
Curr Opin Urol 2022 Sep 1;32(5):504-510. Epub 2022 Jul 18 doi: 10.1097/MOU.0000000000001023. PMID: 35855578
Molecular Subtypes of Bladder Cancer.
McConkey DJ, Choi W
Curr Oncol Rep 2018 Aug 20;20(10):77. doi: 10.1007/s11912-018-0727-5. PMID: 30128829
Genitourinary small cell malignancies: prostate and bladder.
Shatagopam K, Kaimakliotis HZ, Cheng L, Koch MO
Future Oncol 2015;11(3):479-88. doi: 10.2217/fon.14.277. PMID: 25675127

Therapy

FGFR-targeted therapeutics: clinical activity, mechanisms of resistance and new directions.
Katoh M, Loriot Y, Brandi G, Tavolari S, Wainberg ZA, Katoh M
Nat Rev Clin Oncol 2024 Apr;21(4):312-329. Epub 2024 Feb 29 doi: 10.1038/s41571-024-00869-z. PMID: 38424198
Photodynamic Diagnosis-Assisted Transurethral Resection - Lights Out?
Dahm P, Narayan VM
NEJM Evid 2022 Oct;1(10):EVIDe2200194. Epub 2022 Sep 27 doi: 10.1056/EVIDe2200194. PMID: 38319828
FIGHT-101, a first-in-human study of potent and selective FGFR 1-3 inhibitor pemigatinib in pan-cancer patients with FGF/FGFR alterations and advanced malignancies.
Subbiah V, Iannotti NO, Gutierrez M, Smith DC, Féliz L, Lihou CF, Tian C, Silverman IM, Ji T, Saleh M
Ann Oncol 2022 May;33(5):522-533. Epub 2022 Feb 14 doi: 10.1016/j.annonc.2022.02.001. PMID: 35176457
Serotonin Pathway in Cancer.
Balakrishna P, George S, Hatoum H, Mukherjee S
Int J Mol Sci 2021 Jan 28;22(3) doi: 10.3390/ijms22031268. PMID: 33525332Free PMC Article
A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer.
Ott PA, Hu-Lieskovan S, Chmielowski B, Govindan R, Naing A, Bhardwaj N, Margolin K, Awad MM, Hellmann MD, Lin JJ, Friedlander T, Bushway ME, Balogh KN, Sciuto TE, Kohler V, Turnbull SJ, Besada R, Curran RR, Trapp B, Scherer J, Poran A, Harjanto D, Barthelme D, Ting YS, Dong JZ, Ware Y, Huang Y, Huang Z, Wanamaker A, Cleary LD, Moles MA, Manson K, Greshock J, Khondker ZS, Fritsch E, Rooney MS, DeMario M, Gaynor RB, Srinivasan L
Cell 2020 Oct 15;183(2):347-362.e24. doi: 10.1016/j.cell.2020.08.053. PMID: 33064988

Prognosis

Mutational signature and prognosis in adenocarcinoma of the bladder.
Yang G, Shahatiaili A, Bai S, Wang L, Jin D, Cao M, Su P, Liu Q, Tao K, Long Q, Shi Y, Xiao J, Tian F, Zhang L, Chen H, Su X
J Pathol 2024 Mar;262(3):334-346. Epub 2024 Jan 5 doi: 10.1002/path.6239. PMID: 38180342
Micropapillary bladder cancer: an evolving biology.
Lonati C, Simeone C, Suardi N, Briganti A, Montorsi F, Moschini M
Curr Opin Urol 2022 Sep 1;32(5):504-510. Epub 2022 Jul 18 doi: 10.1097/MOU.0000000000001023. PMID: 35855578
Molecular Subtypes of Bladder Cancer.
McConkey DJ, Choi W
Curr Oncol Rep 2018 Aug 20;20(10):77. doi: 10.1007/s11912-018-0727-5. PMID: 30128829
Small-Cell Carcinoma of the Bladder: 20-Year Single-Institution Retrospective Review.
Jung K, Ghatalia P, Litwin S, Horwitz EM, Uzzo RG, Greenberg RE, Viterbo R, Geynisman DM, Kutikov A, Plimack ER, Smaldone MC, Wong YN, Bilusic M
Clin Genitourin Cancer 2017 Jun;15(3):e337-e343. Epub 2016 Sep 30 doi: 10.1016/j.clgc.2016.09.005. PMID: 27991416Free PMC Article
Genitourinary small cell malignancies: prostate and bladder.
Shatagopam K, Kaimakliotis HZ, Cheng L, Koch MO
Future Oncol 2015;11(3):479-88. doi: 10.2217/fon.14.277. PMID: 25675127

Clinical prediction guides

Pan-cancer analysis predicts CANT1 as a potential prognostic, immunologic biomarker.
Yang W, Liu Z, Liu T
Cell Signal 2024 May;117:111107. Epub 2024 Feb 16 doi: 10.1016/j.cellsig.2024.111107. PMID: 38369265
Expression of Nectin-4 in Bladder Urothelial Carcinoma, in Morphologic Variants, and Nonurothelial Histotypes.
Hoffman-Censits JH, Lombardo KA, Parimi V, Kamanda S, Choi W, Hahn NM, McConkey DJ, McGuire BM, Bivalacqua TJ, Kates M, Matoso A
Appl Immunohistochem Mol Morphol 2021 Sep 1;29(8):619-625. doi: 10.1097/PAI.0000000000000938. PMID: 33901032Free PMC Article
A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer.
Ott PA, Hu-Lieskovan S, Chmielowski B, Govindan R, Naing A, Bhardwaj N, Margolin K, Awad MM, Hellmann MD, Lin JJ, Friedlander T, Bushway ME, Balogh KN, Sciuto TE, Kohler V, Turnbull SJ, Besada R, Curran RR, Trapp B, Scherer J, Poran A, Harjanto D, Barthelme D, Ting YS, Dong JZ, Ware Y, Huang Y, Huang Z, Wanamaker A, Cleary LD, Moles MA, Manson K, Greshock J, Khondker ZS, Fritsch E, Rooney MS, DeMario M, Gaynor RB, Srinivasan L
Cell 2020 Oct 15;183(2):347-362.e24. doi: 10.1016/j.cell.2020.08.053. PMID: 33064988
(89)Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer.
Bensch F, van der Veen EL, Lub-de Hooge MN, Jorritsma-Smit A, Boellaard R, Kok IC, Oosting SF, Schröder CP, Hiltermann TJN, van der Wekken AJ, Groen HJM, Kwee TC, Elias SG, Gietema JA, Bohorquez SS, de Crespigny A, Williams SP, Mancao C, Brouwers AH, Fine BM, de Vries EGE
Nat Med 2018 Dec;24(12):1852-1858. Epub 2018 Nov 26 doi: 10.1038/s41591-018-0255-8. PMID: 30478423
Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer.
Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, Hinoue T, Laird PW, Hoadley KA, Akbani R, Castro MAA, Gibb EA, Kanchi RS, Gordenin DA, Shukla SA, Sanchez-Vega F, Hansel DE, Czerniak BA, Reuter VE, Su X, de Sa Carvalho B, Chagas VS, Mungall KL, Sadeghi S, Pedamallu CS, Lu Y, Klimczak LJ, Zhang J, Choo C, Ojesina AI, Bullman S, Leraas KM, Lichtenberg TM, Wu CJ, Schultz N, Getz G, Meyerson M, Mills GB, McConkey DJ; TCGA Research Network, Weinstein JN, Kwiatkowski DJ, Lerner SP
Cell 2017 Oct 19;171(3):540-556.e25. Epub 2017 Oct 5 doi: 10.1016/j.cell.2017.09.007. PMID: 28988769Free PMC Article

Recent systematic reviews

A Systematic Review on the Diagnostic Value of Fibroblast Activation Protein Inhibitor PET/CT in Genitourinary Cancers.
Hagens MJ, van Leeuwen PJ, Wondergem M, Boellaard TN, Sanguedolce F, Oprea-Lager DE, Bex A, Vis AN, van der Poel HG, Mertens LS; EAU Section of Urological Imaging
J Nucl Med 2024 Jun 3;65(6):888-896. doi: 10.2967/jnumed.123.267260. PMID: 38637140
Do proton pump inhibitors alter the response to immune checkpoint inhibitors in cancer patients? A meta-analysis.
Lopes S, Pabst L, Dory A, Klotz M, Gourieux B, Michel B, Mascaux C
Front Immunol 2023;14:1070076. Epub 2023 Jan 26 doi: 10.3389/fimmu.2023.1070076. PMID: 36776847Free PMC Article
Adjuvant Radiotherapy for Upper Tract Urothelial Carcinoma: Systematic Review and Meta-Analysis.
Zalay O, Yan M, Sigurdson S, Malone S, Vera-Badillo FE, Mahmud A
Curr Oncol 2022 Dec 20;30(1):19-36. doi: 10.3390/curroncol30010002. PMID: 36661651Free PMC Article
The economics of bladder cancer: costs and considerations of caring for this disease.
Svatek RS, Hollenbeck BK, Holmäng S, Lee R, Kim SP, Stenzl A, Lotan Y
Eur Urol 2014 Aug;66(2):253-62. Epub 2014 Jan 21 doi: 10.1016/j.eururo.2014.01.006. PMID: 24472711
A systematic overview of radiation therapy effects in urinary bladder cancer.
Widmark A, Flodgren P, Damber JE, Hellsten S, Cavallin-Ståhl E
Acta Oncol 2003;42(5-6):567-81. doi: 10.1080/02841860310014408. PMID: 14596515

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    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

    Reviews

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