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Papilloma of buccal mucosa

MedGen UID:
231971
•Concept ID:
C1332641
•
Neoplastic Process
Synonyms: Buccal Mucosa Papilloma; buccal mucosa papilloma; Buccal Squamous Cell Papilloma; Buccal Squamous Papilloma; Papilloma of Buccal Mucosa; papilloma of buccal mucosa; Papilloma of the Buccal Mucosa; papilloma of the buccal mucosa
SNOMED CT: Papilloma of buccal mucosa (448147005)
 
Monarch Initiative: MONDO:0021276

Definition

A benign, exophytic and polypoid growth that arises from the buccal mucosa. It is covered by hyperplastic epithelium. Some cases are caused by human papillomavirus infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPapilloma of buccal mucosa

Professional guidelines

PubMed

HPV Lesions and Other Issues in the Oral Cavity Treatment and Removal without Pain.
El Moussaoui S, Mallandrich M, Garrós N, Calpena AC, Rodríguez Lagunas MJ, Fernández-Campos F
Int J Mol Sci 2021 Oct 16;22(20) doi: 10.3390/ijms222011158. PMID: 34681818Free PMC Article
Transmission of human papillomavirus DNA from patient to surgical masks, gloves and oral mucosa of medical personnel during treatment of laryngeal papillomas and genital warts.
Ilmarinen T, Auvinen E, Hiltunen-Back E, Ranki A, Aaltonen LM, Pitkäranta A
Eur Arch Otorhinolaryngol 2012 Nov;269(11):2367-71. Epub 2012 May 16 doi: 10.1007/s00405-012-2049-9. PMID: 22588197
Low prevalence of high risk genotypes of human papilloma virus in normal oral mucosa, oral leukoplakia and verrucous carcinoma.
Saghravanian N, Ghazvini K, Babakoohi S, Firooz A, Mohtasham N
Acta Odontol Scand 2011 Nov;69(6):406-9. Epub 2011 Apr 5 doi: 10.3109/00016357.2011.572560. PMID: 21466259

Recent clinical studies

Etiology

HPV-Related Papillary Lesions of the Oral Mucosa: A Review.
Betz SJ
Head Neck Pathol 2019 Mar;13(1):80-90. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01003-7. PMID: 30693456Free PMC Article
Clinical implications of epigenetic regulation in oral cancer.
D'Souza W, Saranath D
Oral Oncol 2015 Dec;51(12):1061-8. Epub 2015 Oct 5 doi: 10.1016/j.oraloncology.2015.09.006. PMID: 26421863
The role of human papillomavirus in oral disease.
Pringle GA
Dent Clin North Am 2014 Apr;58(2):385-99. doi: 10.1016/j.cden.2013.12.008. PMID: 24655529
Human papilloma virus--role in precancerous and cancerous oral lesions of tobacco chewers.
Zil-A-Rubab, Baig S, Siddiqui A, Nayeem A, Salman M, Qidwai MA, Mallick R, Qidwai S
J Pak Med Assoc 2013 Oct;63(10):1295-8. PMID: 24392564
Human papillomavirus and oral disease - emerging evidence: a review.
Prabhu SR, Wilson DF
Aust Dent J 2013 Mar;58(1):2-10; quiz 125. Epub 2013 Jan 31 doi: 10.1111/adj.12020. PMID: 23441786

Diagnosis

HPV-Related Papillary Lesions of the Oral Mucosa: A Review.
Betz SJ
Head Neck Pathol 2019 Mar;13(1):80-90. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01003-7. PMID: 30693456Free PMC Article
Multifocal Epithelial Hyperplasia.
Agnew C, Alexander S, Prabhu N
J Dent Child (Chic) 2017 Jan 15;84(1):47-49. PMID: 28387191
Human papillomavirus and Epstein-Barr virus associated conditions of the oral mucosa.
Stojanov IJ, Woo SB
Semin Diagn Pathol 2015 Jan;32(1):3-11. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.003. PMID: 25749203
The role of human papillomavirus in oral disease.
Pringle GA
Dent Clin North Am 2014 Apr;58(2):385-99. doi: 10.1016/j.cden.2013.12.008. PMID: 24655529
Cowden syndrome.
Ravi Prakash SM, Suma GN, Goel S
Indian J Dent Res 2010 Jul-Sep;21(3):439-42. doi: 10.4103/0970-9290.70803. PMID: 20930359

Therapy

Multiple oral papillomas after antiretroviral treatment resumption.
Ea C, Agbo-Godeau S, Rochefort J
BMJ Case Rep 2022 Aug 5;15(8) doi: 10.1136/bcr-2022-250506. PMID: 36367816Free PMC Article
Role of Transoral Robotic Surgery in the Work-up of the Unknown Primary.
de Almeida JR
Otolaryngol Clin North Am 2020 Dec;53(6):965-980. Epub 2020 Sep 18 doi: 10.1016/j.otc.2020.07.008. PMID: 32951898
Human papillomavirus vaccination induces neutralising antibodies in oral mucosal fluids.
Handisurya A, Schellenbacher C, Haitel A, Senger T, Kirnbauer R
Br J Cancer 2016 Feb 16;114(4):409-16. Epub 2016 Feb 11 doi: 10.1038/bjc.2015.462. PMID: 26867163Free PMC Article
Oral HPV infection: current strategies for prevention and therapy.
Syrjanen S, Termine N, Capra G, Paderni C, Panzarella V, Campisi G
Curr Pharm Des 2012;18(34):5452-69. doi: 10.2174/138161212803307581. PMID: 22632393
Oral premalignant lesions: from a clinical perspective.
Amagasa T, Yamashiro M, Uzawa N
Int J Clin Oncol 2011 Feb;16(1):5-14. Epub 2011 Jan 12 doi: 10.1007/s10147-010-0157-3. PMID: 21225307

Prognosis

Access to dental care is still complex in 2022 for patients living with HIV despite the need for careful monitoring of pathologies of the oral mucosa. Results of a monocentric cross-sectional study in the Infectious Diseases Department of Clermont-Ferrand University Hospital.
Pinet V, Lambert C, Goncalves É, Jacomet C, Devoize L
Clin Oral Investig 2023 Dec 29;28(1):57. doi: 10.1007/s00784-023-05456-7. PMID: 38157049
Retrospective Study of Buccal Mucosal Salivary Neoplasms.
Alramadhan SA, Fitzpatrick SG, Cohen DM, Bhattacharyya I, Islam MN
Head Neck Pathol 2020 Dec;14(4):1013-1020. Epub 2020 Jun 6 doi: 10.1007/s12105-020-01190-8. PMID: 32506376Free PMC Article
Herpes simplex and human papilloma virus coinfections in oral mucosa of men-A 6-year follow-up study.
Mäki J, Paavilainen H, Kero K, Hukkanen V, Syrjänen S
J Med Virol 2018 Mar;90(3):564-570. Epub 2017 Oct 20 doi: 10.1002/jmv.24965. PMID: 28975630
Human papillomavirus and Epstein-Barr virus associated conditions of the oral mucosa.
Stojanov IJ, Woo SB
Semin Diagn Pathol 2015 Jan;32(1):3-11. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.003. PMID: 25749203
Role of human papilloma virus in the oral carcinogenesis: an Indian perspective.
Chocolatewala NM, Chaturvedi P
J Cancer Res Ther 2009 Apr-Jun;5(2):71-7. doi: 10.4103/0973-1482.52788. PMID: 19542661

Clinical prediction guides

HPV Lesions and Other Issues in the Oral Cavity Treatment and Removal without Pain.
El Moussaoui S, Mallandrich M, Garrós N, Calpena AC, Rodríguez Lagunas MJ, Fernández-Campos F
Int J Mol Sci 2021 Oct 16;22(20) doi: 10.3390/ijms222011158. PMID: 34681818Free PMC Article
Human papillomavirus and Epstein-Barr virus associated conditions of the oral mucosa.
Stojanov IJ, Woo SB
Semin Diagn Pathol 2015 Jan;32(1):3-11. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.003. PMID: 25749203
Human papillomavirus infections of the oral mucosa and upper respiratory tract.
Nguyen HP, McNiece KL, Duong AA, Khan F
Curr Probl Dermatol 2014;45:132-53. Epub 2014 Mar 13 doi: 10.1159/000357904. PMID: 24643183
Role of beta-defensins in oral epithelial health and disease.
Abiko Y, Saitoh M, Nishimura M, Yamazaki M, Sawamura D, Kaku T
Med Mol Morphol 2007 Dec;40(4):179-84. Epub 2007 Dec 21 doi: 10.1007/s00795-007-0381-8. PMID: 18085375
Prevalence of human papillomavirus (HPV) in oral cavity and oropharynx.
Castro TP, Bussoloti Filho I
Braz J Otorhinolaryngol 2006 Mar-Apr;72(2):272-82. doi: 10.1016/s1808-8694(15)30068-9. PMID: 16951865Free PMC Article

Recent systematic reviews

Primary Tumour Detection in Carcinoma of Unknown Primary with Transoral Robotic Surgery (TORS) Tongue Base Mucosectomy: A Meta-analysis.
Gupta KK, Khan H, Mughal Z, De M, Sharma N, Garas G
Ann Surg Oncol 2024 Sep;31(9):6065-6076. Epub 2024 Jul 9 doi: 10.1245/s10434-024-15758-z. PMID: 38980583

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