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Childhood kidney cell carcinoma

MedGen UID:
232070
Concept ID:
C1333001
Neoplastic Process
Synonyms: Childhood Kidney Cell Carcinoma; childhood kidney cell carcinoma; Childhood Renal Cell Carcinoma; childhood renal cell carcinoma; childhood renal cell carcinoma (disease); paediatric kidney cell carcinoma; paediatric renal cell carcinoma; paediatric renal cell carcinoma (disease); Pediatric Kidney Cell Carcinoma; pediatric kidney cell carcinoma; Pediatric Renal Cell Carcinoma; pediatric renal cell carcinoma; pediatric renal cell carcinoma (disease); renal cell carcinoma (disease) of childhood
 
Monarch Initiative: MONDO:0003007

Definition

A renal cell carcinoma that occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Childhood kidney cell carcinoma

Professional guidelines

PubMed

Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Warren H, Olsburgh J
Curr Urol Rep 2020 Feb 11;21(1):8. doi: 10.1007/s11934-020-0959-4. PMID: 32048068
Ambalavanan M, Geller JI
Pediatr Blood Cancer 2019 Aug;66(8):e27766. Epub 2019 Apr 23 doi: 10.1002/pbc.27766. PMID: 31012542

Recent clinical studies

Etiology

Libes J, Hol J, Neto JCA, Vallance KL, Tinteren HV, Benedetti DJ, Villar GLR, Duncan C, Ehrlich PF
Pediatr Blood Cancer 2023 Jan;70(1):e30006. Epub 2022 Nov 3 doi: 10.1002/pbc.30006. PMID: 36326750
Louise M Binderup M, Smerdel M, Borgwadt L, Beck Nielsen SS, Madsen MG, Møller HU, Kiilgaard JF, Friis-Hansen L, Harbud V, Cortnum S, Owen H, Gimsing S, Friis Juhl HA, Munthe S, Geilswijk M, Rasmussen ÅK, Møldrup U, Graumann O, Donskov F, Grønbæk H, Stausbøl-Grøn B, Schaffalitzky de Muckadell O, Knigge U, Dam G, Wadt KA, Bøgeskov L, Bagi P, Lund L, Stochholm K, Ousager LB, Sunde L
Eur J Med Genet 2022 Aug;65(8):104538. Epub 2022 Jun 13 doi: 10.1016/j.ejmg.2022.104538. PMID: 35709961
Lee M, Wang Q, Wanchoo R, Eswarappa M, Deshpande P, Sise ME
Adv Chronic Kidney Dis 2021 Sep;28(5):469-476.e1. doi: 10.1053/j.ackd.2021.10.007. PMID: 35190113
Mitchell TJ, Turajlic S, Rowan A, Nicol D, Farmery JHR, O'Brien T, Martincorena I, Tarpey P, Angelopoulos N, Yates LR, Butler AP, Raine K, Stewart GD, Challacombe B, Fernando A, Lopez JI, Hazell S, Chandra A, Chowdhury S, Rudman S, Soultati A, Stamp G, Fotiadis N, Pickering L, Au L, Spain L, Lynch J, Stares M, Teague J, Maura F, Wedge DC, Horswell S, Chambers T, Litchfield K, Xu H, Stewart A, Elaidi R, Oudard S, McGranahan N, Csabai I, Gore M, Futreal PA, Larkin J, Lynch AG, Szallasi Z, Swanton C, Campbell PJ; TRACERx Renal Consortium
Cell 2018 Apr 19;173(3):611-623.e17. Epub 2018 Apr 12 doi: 10.1016/j.cell.2018.02.020. PMID: 29656891Free PMC Article
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Diagnosis

Louise M Binderup M, Smerdel M, Borgwadt L, Beck Nielsen SS, Madsen MG, Møller HU, Kiilgaard JF, Friis-Hansen L, Harbud V, Cortnum S, Owen H, Gimsing S, Friis Juhl HA, Munthe S, Geilswijk M, Rasmussen ÅK, Møldrup U, Graumann O, Donskov F, Grønbæk H, Stausbøl-Grøn B, Schaffalitzky de Muckadell O, Knigge U, Dam G, Wadt KA, Bøgeskov L, Bagi P, Lund L, Stochholm K, Ousager LB, Sunde L
Eur J Med Genet 2022 Aug;65(8):104538. Epub 2022 Jun 13 doi: 10.1016/j.ejmg.2022.104538. PMID: 35709961
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Trnka P, Kennedy SE
Pediatr Nephrol 2021 Jun;36(6):1427-1438. Epub 2020 Oct 1 doi: 10.1007/s00467-020-04775-1. PMID: 33006051
Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, Ammerlaan C, van Ineveld RL, Derakhshan S, de Haan S, Dolman E, Lijnzaad P, Custers L, Begthel H, Kerstens HHD, Visser LL, Rookmaaker M, Verhaar M, Tytgat GAM, Kemmeren P, de Krijger RR, Al-Saadi R, Pritchard-Jones K, Kool M, Rios AC, van den Heuvel-Eibrink MM, Molenaar JJ, van Boxtel R, Holstege FCP, Clevers H, Drost J
Nat Commun 2020 Mar 11;11(1):1310. doi: 10.1038/s41467-020-15155-6. PMID: 32161258Free PMC Article
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Therapy

Zhang T, Forde PM, Sullivan RJ, Sharon E, Barksdale E, Selig W, Ebbinghaus S, Fusaro G, Gunenc D, Battle D, Burns R, Hurlbert MS, Stewart M, Atkins MB
J Immunother Cancer 2023 May;11(5) doi: 10.1136/jitc-2022-006555. PMID: 37137552Free PMC Article
Lee M, Wang Q, Wanchoo R, Eswarappa M, Deshpande P, Sise ME
Adv Chronic Kidney Dis 2021 Sep;28(5):469-476.e1. doi: 10.1053/j.ackd.2021.10.007. PMID: 35190113
van der Beek JN, Hol JA, Coulomb-l'Hermine A, Graf N, van Tinteren H, Pritchard-Jones K, Houwing ME, de Krijger RR, Vujanic GM, Dzhuma K, Schenk JP, Littooij AS, Ramírez-Villar GL, Murphy D, Ray S, Al-Saadi R, Gessler M, Godzinski J, Ruebe C, Collini P, Verschuur AC, Frisk T, Vokuhl C, Hulsbergen-van de Kaa CA, de Camargo B, Sandstedt B, Selle B, Tytgat GAM, van den Heuvel-Eibrink MM
Int J Cancer 2021 Jun 1;148(11):2724-2735. Epub 2021 Feb 3 doi: 10.1002/ijc.33476. PMID: 33460450Free PMC Article
Ambalavanan M, Geller JI
Pediatr Blood Cancer 2019 Aug;66(8):e27766. Epub 2019 Apr 23 doi: 10.1002/pbc.27766. PMID: 31012542
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Prognosis

Alchahin AM, Mei S, Tsea I, Hirz T, Kfoury Y, Dahl D, Wu CL, Subtelny AO, Wu S, Scadden DT, Shin JH, Saylor PJ, Sykes DB, Kharchenko PV, Baryawno N
Nat Commun 2022 Sep 30;13(1):5747. doi: 10.1038/s41467-022-33375-w. PMID: 36180422Free PMC Article
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Pawel BR
Pediatr Dev Pathol 2018 Jan-Feb;21(1):6-28. Epub 2017 Dec 27 doi: 10.1177/1093526617749671. PMID: 29280680
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Clinical prediction guides

Alchahin AM, Mei S, Tsea I, Hirz T, Kfoury Y, Dahl D, Wu CL, Subtelny AO, Wu S, Scadden DT, Shin JH, Saylor PJ, Sykes DB, Kharchenko PV, Baryawno N
Nat Commun 2022 Sep 30;13(1):5747. doi: 10.1038/s41467-022-33375-w. PMID: 36180422Free PMC Article
Benhamouda N, Sam I, Epaillard N, Gey A, Phan L, Pham HP, Gruel N, Saldmann A, Pineau J, Hasan M, Quiniou V, Nevoret C, Verkarre V, Libri V, Mella S, Granier C, Broudin C, Ravel P, De Guillebon E, Mauge L, Helley D, Jabla B, Chaput N, Albiges L, Katsahian S, Adam J, Mejean A, Adotevi O, Vano YA, Oudard S, Tartour E
Clin Cancer Res 2022 Nov 14;28(22):4983-4994. doi: 10.1158/1078-0432.CCR-22-0905. PMID: 36067339
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Royer-Pokora B
Pediatr Nephrol 2013 Jan;28(1):13-23. Epub 2012 Mar 30 doi: 10.1007/s00467-012-2146-4. PMID: 22461142
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

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