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Classic variant of chromophobe renal cell carcinoma

MedGen UID:
232080
•Concept ID:
C1333062
•
Neoplastic Process
Synonyms: Classic Variant of Chromophobe Renal Cell Carcinoma; classic variant of chromophobe renal cell carcinoma
 
Monarch Initiative: MONDO:0003941

Definition

A variant of chromophobe renal cell carcinoma. It is characterized by the presence of large pale cells with thickened cell membranes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClassic variant of chromophobe renal cell carcinoma

Professional guidelines

PubMed

Stauffer's syndrome: A comprehensive review and proposed updated diagnostic criteria.
Fontes-Sousa M, Magalhães H, da Silva FC, Maurício MJ
Urol Oncol 2018 Jul;36(7):321-326. Epub 2018 Apr 12 doi: 10.1016/j.urolonc.2018.01.019. PMID: 29657090
On the differential diagnosis of clear cell tumours of the head and neck.
Eversole LR
Eur J Cancer B Oral Oncol 1993 Jul;29B(3):173-9. doi: 10.1016/0964-1955(93)90019-b. PMID: 8298420

Recent clinical studies

Etiology

Ten uncommon and unusual variants of renal angiomyolipoma (AML): radiologic-pathologic correlation.
Schieda N, Kielar AZ, Al Dandan O, McInnes MD, Flood TA
Clin Radiol 2015 Feb;70(2):206-20. Epub 2014 Nov 15 doi: 10.1016/j.crad.2014.10.001. PMID: 25468637
Pathology of renal cell carcinoma: an update.
Lopez-Beltran A, Cheng L, Vidal A, Scarpelli M, Kirkali Z, Blanca A, Montironi R
Anal Quant Cytopathol Histpathol 2013 Apr;35(2):61-76. PMID: 23700715
Current pathology keys of renal cell carcinoma.
Algaba F, Akaza H, López-Beltrán A, Martignoni G, Moch H, Montironi R, Reuter V
Eur Urol 2011 Oct;60(4):634-43. Epub 2011 Jul 3 doi: 10.1016/j.eururo.2011.06.047. PMID: 21741159
2009 update on the classification of renal epithelial tumors in adults.
Lopez-Beltran A, Carrasco JC, Cheng L, Scarpelli M, Kirkali Z, Montironi R
Int J Urol 2009 May;16(5):432-43. Epub 2009 Apr 20 doi: 10.1111/j.1442-2042.2009.02302.x. PMID: 19453547
On the differential diagnosis of clear cell tumours of the head and neck.
Eversole LR
Eur J Cancer B Oral Oncol 1993 Jul;29B(3):173-9. doi: 10.1016/0964-1955(93)90019-b. PMID: 8298420

Diagnosis

Nephrogenic Adenoma Intermixed With Urothelial Carcinoma.
Kryvenko ON, Wasco MJ, Williamson SR
Arch Pathol Lab Med 2022 May 1;147(5):552-558. doi: 10.5858/arpa.2021-0620-OA. PMID: 35976666
Small cell variant of chromophobe renal cell carcinoma: Clinicopathologic and molecular-genetic analysis of 10 cases.
Rogala J, Kojima F, Alaghehbandan R, Ptakova N, Bravc A, Bulimbasic S, Perez Montiel D, Slisarenko M, Ali L, Kuthi L, Pivovarcikova K, Michalova K, Bartovic B, Bartos Vesela A, Dolejsova O, Michal M, Hes O
Bosn J Basic Med Sci 2022 Jul 29;22(4):531-539. doi: 10.17305/bjbms.2021.6935. PMID: 35276058Free PMC Article
Comprehensive Review of Numerical Chromosomal Aberrations in Chromophobe Renal Cell Carcinoma Including Its Variant Morphologies.
Alaghehbandan R, Trpkov K, Tretiakova M, Luis AS, Rogala JD, Hes O
Adv Anat Pathol 2021 Jan;28(1):8-20. doi: 10.1097/PAP.0000000000000286. PMID: 33021507
Ten uncommon and unusual variants of renal angiomyolipoma (AML): radiologic-pathologic correlation.
Schieda N, Kielar AZ, Al Dandan O, McInnes MD, Flood TA
Clin Radiol 2015 Feb;70(2):206-20. Epub 2014 Nov 15 doi: 10.1016/j.crad.2014.10.001. PMID: 25468637
Current pathology keys of renal cell carcinoma.
Algaba F, Akaza H, López-Beltrán A, Martignoni G, Moch H, Montironi R, Reuter V
Eur Urol 2011 Oct;60(4):634-43. Epub 2011 Jul 3 doi: 10.1016/j.eururo.2011.06.047. PMID: 21741159

Therapy

The Role of CK7, S100A1, and CD82 (KAI1) Expression in the Differential Diagnosis of Chromophobe Renal Cell Carcinoma and Renal Oncocytoma.
Sari ZB, Açikalin MF, Arik D, Özen A, Can C, Çolak E
Appl Immunohistochem Mol Morphol 2021 Aug 1;29(7):534-540. doi: 10.1097/PAI.0000000000000916. PMID: 33605572
TGF-β1 expression in chromophobe renal cell carcinoma and renal oncocytoma.
Demirović A, Cesarec S, Marušić Z, Tomas D, Milošević M, Hudolin T, Krušlin B
Eur J Histochem 2014 Jan 31;58(1):2265. doi: 10.4081/ejh.2014.2265. PMID: 24704995Free PMC Article
Sarcomatoid renal cell carcinoma. A treatable entity.
Sella A, Logothetis CJ, Ro JY, Swanson DA, Samuels ML
Cancer 1987 Sep 15;60(6):1313-8. doi: 10.1002/1097-0142(19870915)60:6<1313::aid-cncr2820600625>3.0.co;2-1. PMID: 2441841

Prognosis

Small cell variant of chromophobe renal cell carcinoma: Clinicopathologic and molecular-genetic analysis of 10 cases.
Rogala J, Kojima F, Alaghehbandan R, Ptakova N, Bravc A, Bulimbasic S, Perez Montiel D, Slisarenko M, Ali L, Kuthi L, Pivovarcikova K, Michalova K, Bartovic B, Bartos Vesela A, Dolejsova O, Michal M, Hes O
Bosn J Basic Med Sci 2022 Jul 29;22(4):531-539. doi: 10.17305/bjbms.2021.6935. PMID: 35276058Free PMC Article
Ten uncommon and unusual variants of renal angiomyolipoma (AML): radiologic-pathologic correlation.
Schieda N, Kielar AZ, Al Dandan O, McInnes MD, Flood TA
Clin Radiol 2015 Feb;70(2):206-20. Epub 2014 Nov 15 doi: 10.1016/j.crad.2014.10.001. PMID: 25468637
Pathology of renal cell carcinoma: an update.
Lopez-Beltran A, Cheng L, Vidal A, Scarpelli M, Kirkali Z, Blanca A, Montironi R
Anal Quant Cytopathol Histpathol 2013 Apr;35(2):61-76. PMID: 23700715
Current pathology keys of renal cell carcinoma.
Algaba F, Akaza H, López-Beltrán A, Martignoni G, Moch H, Montironi R, Reuter V
Eur Urol 2011 Oct;60(4):634-43. Epub 2011 Jul 3 doi: 10.1016/j.eururo.2011.06.047. PMID: 21741159
Renal epithelioid angiomyolipoma: a malignant disease.
Varma S, Gupta S, Talwar J, Forte F, Dhar M
J Nephrol 2011 Jan-Feb;24(1):18-22. doi: 10.5301/jn.2010.5451. PMID: 20349413

Clinical prediction guides

Ten uncommon and unusual variants of renal angiomyolipoma (AML): radiologic-pathologic correlation.
Schieda N, Kielar AZ, Al Dandan O, McInnes MD, Flood TA
Clin Radiol 2015 Feb;70(2):206-20. Epub 2014 Nov 15 doi: 10.1016/j.crad.2014.10.001. PMID: 25468637
TGF-β1 expression in chromophobe renal cell carcinoma and renal oncocytoma.
Demirović A, Cesarec S, Marušić Z, Tomas D, Milošević M, Hudolin T, Krušlin B
Eur J Histochem 2014 Jan 31;58(1):2265. doi: 10.4081/ejh.2014.2265. PMID: 24704995Free PMC Article
Pathology of renal cell carcinoma: an update.
Lopez-Beltran A, Cheng L, Vidal A, Scarpelli M, Kirkali Z, Blanca A, Montironi R
Anal Quant Cytopathol Histpathol 2013 Apr;35(2):61-76. PMID: 23700715
Renal epithelioid angiomyolipoma: a malignant disease.
Varma S, Gupta S, Talwar J, Forte F, Dhar M
J Nephrol 2011 Jan-Feb;24(1):18-22. doi: 10.5301/jn.2010.5451. PMID: 20349413
Chromophobe renal cell carcinoma: histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 145 cases.
Amin MB, Paner GP, Alvarado-Cabrero I, Young AN, Stricker HJ, Lyles RH, Moch H
Am J Surg Pathol 2008 Dec;32(12):1822-34. doi: 10.1097/PAS.0b013e3181831e68. PMID: 18813125

Recent systematic reviews

Current pathology keys of renal cell carcinoma.
Algaba F, Akaza H, López-Beltrán A, Martignoni G, Moch H, Montironi R, Reuter V
Eur Urol 2011 Oct;60(4):634-43. Epub 2011 Jul 3 doi: 10.1016/j.eururo.2011.06.047. PMID: 21741159

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