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Esophageal High Grade Intraepithelial Neoplasia

MedGen UID:
232161
Concept ID:
C1333450
Neoplastic Process
Synonyms: Esophageal High-Grade Dysplasia; Esophageal High-Grade Intraepithelial Neoplasia

Definition

A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal mucosa. It includes lesions termed moderate dysplasia, and carcinoma in situ (severe dysplasia). (WHO, 2000) [from NCI]

Professional guidelines

PubMed

Porschen R, Fischbach W, Gockel I, Hollerbach S, Hölscher A, Jansen PL, Miehlke S, Pech O, Stahl M, Vanhoefer U, Ebert MPA
United European Gastroenterol J 2024 Apr;12(3):399-411. Epub 2024 Jan 29 doi: 10.1002/ueg2.12523. PMID: 38284661Free PMC Article
Zhu J, Ma S, Chen R, Xie S, Liu Z, Li X, Wei W
Sci Rep 2021 Aug 23;11(1):17015. doi: 10.1038/s41598-021-96548-5. PMID: 34426626Free PMC Article
May A, Ell C
Curr Opin Gastroenterol 2006 Jul;22(4):433-6. doi: 10.1097/01.mog.0000231821.48890.e6. PMID: 16760763

Recent clinical studies

Etiology

Zheng JY, Chen YH, Chen YY, Zheng XL, Zhong SS, Deng WY, Zheng JH, Guo XB, Gao LY, Liang W
Saudi J Gastroenterol 2019 Mar-Apr;25(2):113-118. doi: 10.4103/sjg.SJG_274_18. PMID: 30588952Free PMC Article
Sang HM, Cao JL, Soyfoo MD, Zhang WM, Jiang JX, Xu SF
Dig Surg 2019;36(5):384-393. Epub 2018 Jun 26 doi: 10.1159/000490112. PMID: 29945127
Zhang YM, Boerwinkel DF, Qin X, He S, Xue L, Weusten BL, Dawsey SM, Fleischer DE, Dou LZ, Liu Y, Lu N, Bergman JJ, Wang GQ
Endoscopy 2016 Apr;48(4):330-8. Epub 2015 Nov 6 doi: 10.1055/s-0034-1393358. PMID: 26545174Free PMC Article
Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170

Diagnosis

Zheng JY, Chen YH, Chen YY, Zheng XL, Zhong SS, Deng WY, Zheng JH, Guo XB, Gao LY, Liang W
Saudi J Gastroenterol 2019 Mar-Apr;25(2):113-118. doi: 10.4103/sjg.SJG_274_18. PMID: 30588952Free PMC Article
Sang HM, Cao JL, Soyfoo MD, Zhang WM, Jiang JX, Xu SF
Dig Surg 2019;36(5):384-393. Epub 2018 Jun 26 doi: 10.1159/000490112. PMID: 29945127
Zhang YM, Boerwinkel DF, Qin X, He S, Xue L, Weusten BL, Dawsey SM, Fleischer DE, Dou LZ, Liu Y, Lu N, Bergman JJ, Wang GQ
Endoscopy 2016 Apr;48(4):330-8. Epub 2015 Nov 6 doi: 10.1055/s-0034-1393358. PMID: 26545174Free PMC Article
Ishihara R, Yamada T, Iishi H, Kato M, Yamamoto S, Yamamoto S, Masuda E, Tatsumi K, Takeuchi Y, Higashino K, Uedo N, Tatsuta M, Ishiguro S
Gastrointest Endosc 2009 Feb;69(2):213-8. Epub 2008 Aug 20 doi: 10.1016/j.gie.2008.04.052. PMID: 18718584
Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170

Therapy

Zhang YM, Boerwinkel DF, Qin X, He S, Xue L, Weusten BL, Dawsey SM, Fleischer DE, Dou LZ, Liu Y, Lu N, Bergman JJ, Wang GQ
Endoscopy 2016 Apr;48(4):330-8. Epub 2015 Nov 6 doi: 10.1055/s-0034-1393358. PMID: 26545174Free PMC Article

Prognosis

Zhang YM, Boerwinkel DF, Qin X, He S, Xue L, Weusten BL, Dawsey SM, Fleischer DE, Dou LZ, Liu Y, Lu N, Bergman JJ, Wang GQ
Endoscopy 2016 Apr;48(4):330-8. Epub 2015 Nov 6 doi: 10.1055/s-0034-1393358. PMID: 26545174Free PMC Article
Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170

Clinical prediction guides

Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170

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