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Gastric gastrin-producing neuroendocrine tumor

MedGen UID:
232230
•Concept ID:
C1333767
•
Neoplastic Process
Synonyms: gastric G-cell gastrin producing tumor; gastric G-cell gastrin producing tumour; Gastric Gastrin Producing Tumor; gastric gastrin producing tumor; gastric gastrin producing tumour; Gastric Gastrin-Producing NET; gastric gastrin-producing NET; Gastric Gastrin-Producing Neuroendocrine Tumor; gastric gastrin-producing neuroendocrine tumor; Gastric Gastrinoma; gastric gastrinoma; Gastrin Producing Neuroendocrine Tumor of the Stomach; gastrin producing neuroendocrine tumor of the stomach; gastrin producing neuroendocrine tumour of the stomach; Gastrin Producing Tumor of the Stomach; gastrin producing tumor of the stomach; gastrin producing tumour of the stomach; gastrin-producing neuroendocrine tumor of stomach; Gastrin-Producing Neuroendocrine Tumor of the Stomach; gastrin-producing neuroendocrine tumor of the stomach; gastrin-producing neuroendocrine tumour of stomach; gastrin-producing neuroendocrine tumour of the stomach; stomach gastrin-producing neuroendocrine tumor; stomach gastrin-producing neuroendocrine tumour
 
Monarch Initiative: MONDO:0003524

Definition

A well differentiated neuroendocrine tumor that arises from the stomach. It produces gastrin and it may be associated with Zollinger-Ellison syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric gastrin-producing neuroendocrine tumor

Professional guidelines

PubMed

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger-Ellison Syndrome.
Lee L, Ramos-Alvarez I, Ito T, Jensen RT
Int J Mol Sci 2019 Oct 16;20(20) doi: 10.3390/ijms20205128. PMID: 31623145Free PMC Article
Gastrinomas: Medical or Surgical Treatment.
Norton JA, Foster DS, Ito T, Jensen RT
Endocrinol Metab Clin North Am 2018 Sep;47(3):577-601. doi: 10.1016/j.ecl.2018.04.009. PMID: 30098717Free PMC Article

Recent clinical studies

Etiology

Management of Gastric Neuroendocrine Tumors: A Review.
Sok C, Ajay PS, Tsagkalidis V, Kooby DA, Shah MM
Ann Surg Oncol 2024 Mar;31(3):1509-1518. Epub 2023 Dec 7 doi: 10.1245/s10434-023-14712-9. PMID: 38062290Free PMC Article
Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger-Ellison Syndrome.
Lee L, Ramos-Alvarez I, Ito T, Jensen RT
Int J Mol Sci 2019 Oct 16;20(20) doi: 10.3390/ijms20205128. PMID: 31623145Free PMC Article
Peptic ulcer pathophysiology.
Mertz HR, Walsh JH
Med Clin North Am 1991 Jul;75(4):799-814. doi: 10.1016/s0025-7125(16)30412-6. PMID: 2072787

Diagnosis

All you need to know about gastrinoma today | Gastrinoma and Zollinger-Ellison syndrome: A thorough update.
Chatzipanagiotou O, Schizas D, Vailas M, Tsoli M, Sakarellos P, Sotiropoulou M, Papalambros A, Felekouras E
J Neuroendocrinol 2023 Apr;35(4):e13267. Epub 2023 Apr 11 doi: 10.1111/jne.13267. PMID: 37042078
Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Gastric Carcinoids.
Grozinsky-Glasberg S, Alexandraki KI, Angelousi A, Chatzellis E, Sougioultzis S, Kaltsas G
Endocrinol Metab Clin North Am 2018 Sep;47(3):645-660. Epub 2018 Jul 11 doi: 10.1016/j.ecl.2018.04.013. PMID: 30098721
Gastrinoma--morphological aspects.
Klöppel G, Anlauf M
Wien Klin Wochenschr 2007;119(19-20):579-84. doi: 10.1007/s00508-007-0885-1. PMID: 17985091

Therapy

Management of Functional Pancreatic Neuroendocrine Neoplasms.
Magi L, Marasco M, Rinzivillo M, Faggiano A, Panzuto F
Curr Treat Options Oncol 2023 Jul;24(7):725-741. Epub 2023 Apr 27 doi: 10.1007/s11864-023-01085-0. PMID: 37103745Free PMC Article
Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger-Ellison Syndrome.
Lee L, Ramos-Alvarez I, Ito T, Jensen RT
Int J Mol Sci 2019 Oct 16;20(20) doi: 10.3390/ijms20205128. PMID: 31623145Free PMC Article
Pharmacotherapy of Zollinger-Ellison syndrome.
Ito T, Igarashi H, Uehara H, Jensen RT
Expert Opin Pharmacother 2013 Feb;14(3):307-21. Epub 2013 Jan 30 doi: 10.1517/14656566.2013.767332. PMID: 23363383Free PMC Article
Medical treatment of gastrinomas.
Auernhammer CJ, Göke B
Wien Klin Wochenschr 2007;119(19-20):609-15. doi: 10.1007/s00508-007-0877-1. PMID: 17985097
Gastrinoma.
Li ML, Norton JA
Curr Treat Options Oncol 2001 Aug;2(4):337-46. doi: 10.1007/s11864-001-0027-3. PMID: 12057114

Prognosis

Management of Gastric Neuroendocrine Tumors: A Review.
Sok C, Ajay PS, Tsagkalidis V, Kooby DA, Shah MM
Ann Surg Oncol 2024 Mar;31(3):1509-1518. Epub 2023 Dec 7 doi: 10.1245/s10434-023-14712-9. PMID: 38062290Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Gastric Carcinoids.
Grozinsky-Glasberg S, Alexandraki KI, Angelousi A, Chatzellis E, Sougioultzis S, Kaltsas G
Endocrinol Metab Clin North Am 2018 Sep;47(3):645-660. Epub 2018 Jul 11 doi: 10.1016/j.ecl.2018.04.013. PMID: 30098721
Zollinger-Ellison syndrome: recent advances and controversies.
Ito T, Igarashi H, Jensen RT
Curr Opin Gastroenterol 2013 Nov;29(6):650-61. doi: 10.1097/MOG.0b013e328365efb1. PMID: 24100728Free PMC Article
Gastrinoma--morphological aspects.
Klöppel G, Anlauf M
Wien Klin Wochenschr 2007;119(19-20):579-84. doi: 10.1007/s00508-007-0885-1. PMID: 17985091

Clinical prediction guides

Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger-Ellison Syndrome.
Lee L, Ramos-Alvarez I, Ito T, Jensen RT
Int J Mol Sci 2019 Oct 16;20(20) doi: 10.3390/ijms20205128. PMID: 31623145Free PMC Article
Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis.
Chen WC, Warner RRP, Harpaz N, Zhu H, Roayaie S, Kim MK
Pancreas 2019 Jan;48(1):131-134. doi: 10.1097/MPA.0000000000001204. PMID: 30531243
Neuroendocrine pathology of the stomach: the Parma contribution.
Bordi C
Endocr Pathol 2014 Jun;25(2):171-80. doi: 10.1007/s12022-014-9315-x. PMID: 24782101
The consequences of hypergastrinemia.
Creutzfeldt W
Yale J Biol Med 1994 May-Aug;67(3-4):181-94. PMID: 7502528Free PMC Article

Recent systematic reviews

Radioguided Surgery for Gastroenteropancreatic Neuroendocrine Tumours: a Systematic Literature Review.
Cockburn KC, Toumi Z, Mackie A, Julyan P
J Gastrointest Surg 2021 Dec;25(12):3244-3257. Epub 2021 Sep 10 doi: 10.1007/s11605-021-05115-w. PMID: 34506015Free PMC Article

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